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  1. AU="Musinguzi, Nicholas"
  2. AU=Lee Edward Y
  3. AU="Raval, Urdhva"
  4. AU="Senn, L Kirsten"
  5. AU="Matsutani, Noriyuki"
  6. AU="Bernstein, Herbert J"
  7. AU="Elisa Impresari"
  8. AU="Feldman, Noa"
  9. AU="Dhingra, Mandeep Singh"

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  1. Artikel ; Online: Evaluating disparities by social determinants in hospital admission decisions for patients with COVID-19 quaternary hospital early in the pandemic.

    Olds, Peter K / Musinguzi, Nicholas / Geisler, Benjamin P / Haberer, Jessica E

    Medicine

    2023  Band 102, Heft 10, Seite(n) e33178

    Abstract: The COVID-19 pandemic has highlighted significant disparities in hospital outcomes when focusing on social determinants of health. Better understanding the drivers of these disparities is not only critical for COVID-19 care but also to ensure equitable ... ...

    Abstract The COVID-19 pandemic has highlighted significant disparities in hospital outcomes when focusing on social determinants of health. Better understanding the drivers of these disparities is not only critical for COVID-19 care but also to ensure equitable treatment more generally. In this paper, we look at how hospital admission patterns, both to the medical ward and the intensive care unit (ICU), may have differed by race, ethnicity, and social determinants of health. We conducted a retrospective chart review of all patients who presented to the Emergency Department of a large quaternary hospital between March 8 and June 3, 2020. We built logistic regression models to analyze how race, ethnicity, area deprivation index, English as a primary language, homelessness, and illicit substance use impacted the likelihood of admission while controlling for disease severity and timing of admission in relation to the start of data collection. We had 1302 recorded Emergency Department visits of patients diagnosed with SARS-CoV-2. White, Hispanic, and African American patients made up 39.2%, 37.5%, and 10.4% of the population respectively. Primary language was recorded as English for 41.2% and non-English for 30% of patients. Among the social determinants of health assessed, we found that illicit drug use significantly increased the likelihood for admission to the medical ward (odds ratio 4.4, confidence interval 1.1-17.1, P = .04), and that having a language other than English as a primary language significantly increased the likelihood of ICU admission (odds ratio 2.6, confidence interval 1.2-5.7, P = .02). Illicit drug use was associated with an increased likelihood of medical ward admission, potentially due to clinician concerns for complicated withdrawal or blood-stream infections from intravenous drug use. The increased likelihood of ICU admission associated with a primary language other than English may have been driven by communication difficulties or differences in disease severity that our model did not detect. Further work is required to better understand drivers of disparities in hospital COVID-19 care.
    Mesh-Begriff(e) Humans ; COVID-19 ; SARS-CoV-2 ; Pandemics ; Retrospective Studies ; Social Determinants of Health ; Hospitals
    Sprache Englisch
    Erscheinungsdatum 2023-03-10
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 80184-7
    ISSN 1536-5964 ; 0025-7974
    ISSN (online) 1536-5964
    ISSN 0025-7974
    DOI 10.1097/MD.0000000000033178
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Evaluating disparities in code status designation among patients admitted with COVID-19 at a quaternary care center early in the pandemic.

    Olds, Peter K / Musinguzi, Nicholas / Geisler, Benjamin P / Sarin, Pankaj / Haberer, Jessica E

    Medicine

    2023  Band 102, Heft 30, Seite(n) e34447

    Abstract: The COVID-19 pandemic has highlighted disparities in outcomes by social determinants to health. It is unclear how much end-of-life discussions and a patient's decision about code status ("do not resuscitate," do not resuscitate, or "comfort measures only, ...

    Abstract The COVID-19 pandemic has highlighted disparities in outcomes by social determinants to health. It is unclear how much end-of-life discussions and a patient's decision about code status ("do not resuscitate," do not resuscitate, or "comfort measures only," [CMO] orders) might contribute to in hospital disparities in care, especially given know racial inequities in end-of-life care. Here, we looked at factors associated with code status orders at the end of hospitalization for patients with COVID-19. We conducted a retrospective chart review of all patients who presented to the Emergency Department of a large quaternary hospital between 8 March and 3 June 2020. We used logistic regression modeling to quantify the degree to which social determinants of health, including race, ethnicity, area deprivation index (ADI), English as a primary language, homelessness, and illicit substance use might impact the likelihood of a particular code status at the end-of a patient's hospitalization, while controlling for disease severity. Among social determinants to health, only white race (odds ratio [OR] 2.0; P = .03) and higher ADI (OR 1.2; P = .03) were associated with having a do not resuscitate or a CMO order. Additionally, we found that patients with white race (OR 2.9; P = .02) were more likely to carry a CMO order. Patient race and ADI were associated with different code status orders at the end of hospitalization. Differences in code status might have contributed to disparities in COVID-19 outcomes early in the pandemic, though further investigations are warranted.
    Mesh-Begriff(e) Humans ; COVID-19/epidemiology ; Pandemics ; Retrospective Studies ; Ethnicity ; Hospitalization
    Sprache Englisch
    Erscheinungsdatum 2023-07-27
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 80184-7
    ISSN 1536-5964 ; 0025-7974
    ISSN (online) 1536-5964
    ISSN 0025-7974
    DOI 10.1097/MD.0000000000034447
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  3. Artikel ; Online: Trajectories of Oral PrEP Adherence Among Young Kenyan Women: Implications for Promoting Effective PrEP Use.

    Musinguzi, Nicholas / Pyra, Maria / Bukusi, Elizabeth A / Mugo, Nelly R / Baeten, Jared M / Haberer, Jessica E

    AIDS and behavior

    2022  Band 27, Heft 1, Seite(n) 171–181

    Abstract: Using data from a 2-year study of young women at high HIV risk in Thika and Kisumu, Kenya, we identified group-based trajectories of PrEP adherence based on electronic pillcap-monitoring and assessed potentially associated demographic and socio- ... ...

    Abstract Using data from a 2-year study of young women at high HIV risk in Thika and Kisumu, Kenya, we identified group-based trajectories of PrEP adherence based on electronic pillcap-monitoring and assessed potentially associated demographic and socio-behavioral factors. Among 348 women, we selected a three-trajectory adherence model: low and declining (N = 211, 61%), moderate but declining (N = 119, 34%) and steady high adherers (N = 18, 5%). We also identified a two-trajectory HIV risk model based on self-perceived risk in the past week: high and increasing (N = 28, 8%) and steady low (N = 320, 92%) risk. The Kisumu site was associated with the moderate but declining and steady high adherence trajectories, while increasing VOICE risk score was associated with the low and declining adherence trajectory. We found no association between the adherence and risk trajectories. Our findings suggest adherence support may need tailoring by setting. Early, sustained support may also help those at highest risk of non-adherence.
    Mesh-Begriff(e) Humans ; Female ; Kenya/epidemiology ; HIV Infections/epidemiology ; HIV Infections/prevention & control ; HIV Infections/drug therapy ; Anti-HIV Agents/therapeutic use ; Pre-Exposure Prophylaxis ; Risk Factors ; Medication Adherence
    Chemische Substanzen Anti-HIV Agents
    Sprache Englisch
    Erscheinungsdatum 2022-07-16
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 1339885-4
    ISSN 1573-3254 ; 1090-7165
    ISSN (online) 1573-3254
    ISSN 1090-7165
    DOI 10.1007/s10461-022-03753-y
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Development of a transition readiness score for adolescents living with perinatally-acquired HIV and transitioning to adult care.

    Zanoni, Brian C / Musinguzi, Nicholas / Archary, Moherndran / Sibaya, Thobekile / Haberer, Jessica E

    AIDS and behavior

    2022  Band 26, Heft 9, Seite(n) 3131–3138

    Abstract: We created a transition readiness score for adolescents with perinatally-acquired HIV as they transition from pediatric to adult care. Of the 199 adolescents who transitioned to adult care, 84 (42%) had viral suppression (< 200 copies/ml) one year after ... ...

    Abstract We created a transition readiness score for adolescents with perinatally-acquired HIV as they transition from pediatric to adult care. Of the 199 adolescents who transitioned to adult care, 84 (42%) had viral suppression (< 200 copies/ml) one year after transition. Adolescents on first-line ART, with documented HIV status disclosure, and higher rating on the HIV Adolescent Readiness to Transition Scale had significantly higher odds of viral suppression after transition. Conversely, females, those with older age at ART initiation, and those with prior alcohol use had significantly lower odds of viral suppression after transition. Using these data, we created a transition readiness score organized into low, intermediate, and high levels of transition readiness. This transition readiness score can be used to identify adolescents who are likely ready to transition to adult care and identify additional areas for intervention to improve the likelihood of successful transition for those with lower transition readiness scores.
    Mesh-Begriff(e) Adolescent ; Adult ; Child ; Disclosure ; Female ; HIV Infections/epidemiology ; HIV Infections/therapy ; Humans ; Transition to Adult Care
    Sprache Englisch
    Erscheinungsdatum 2022-04-01
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 1339885-4
    ISSN 1573-3254 ; 1090-7165
    ISSN (online) 1573-3254
    ISSN 1090-7165
    DOI 10.1007/s10461-022-03650-4
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Performance of Multiple Adherence Measures for pre-exposure Prophylaxis (PrEP) Among Young Women in Kenya.

    Musinguzi, Nicholas / Ngure, Kenneth / Bukusi, Elizabeth A / Mugo, Nelly R / Baeten, Jared M / Anderson, Peter L / Haberer, Jessica E

    AIDS and behavior

    2023  Band 27, Heft 12, Seite(n) 3961–3969

    Abstract: Understanding PrEP adherence is key in the formulation of HIV prevention strategies; however, measurement of adherence can be challenging. We compared multiple adherence measures in a two-year study of young Kenyan women at high risk of HIV acquisition. ... ...

    Abstract Understanding PrEP adherence is key in the formulation of HIV prevention strategies; however, measurement of adherence can be challenging. We compared multiple adherence measures in a two-year study of young Kenyan women at high risk of HIV acquisition. Among 289 participants, concordance between electronic adherence monitoring (EAM) and tenofovir diphosphate (TFV-DP) in dried blood spots ranged from 57 to 72% depending on selected thresholds. Using area under the receiver operating curve, discrimination of quantifiable TFV-DP was high at 0.85 with EAM and low at 0.49-0.54 for multiple self-reported measures. Correlation between EAM and self-reported measures was low (r < 0.11) although correlation within self-reported measures was moderate (r > 0.69). These findings indicate that both TFV-DP and EAM are useful PrEP adherence tools. Adherence would benefit from better availability of less expensive versions of both measurement tools. Additionally, further research on TFV-DP thresholds is needed to inform interpretation and use in understanding PrEP adherence in this population.
    Mesh-Begriff(e) Humans ; Female ; Anti-HIV Agents/therapeutic use ; HIV Infections/epidemiology ; HIV Infections/prevention & control ; Kenya/epidemiology ; Pre-Exposure Prophylaxis ; Medication Adherence
    Chemische Substanzen Anti-HIV Agents ; tenofovir diphosphate
    Sprache Englisch
    Erscheinungsdatum 2023-06-23
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 1339885-4
    ISSN 1573-3254 ; 1090-7165
    ISSN (online) 1573-3254
    ISSN 1090-7165
    DOI 10.1007/s10461-023-04111-2
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  6. Artikel ; Online: The feasibility, acceptability, and preliminary impact of real-time monitors and SMS on tuberculosis medication adherence in southwestern Uganda: Findings from a mixed methods pilot randomized controlled trial.

    Musiimenta, Angella / Tumuhimbise, Wilson / Atukunda, Esther C / Mugaba, Aaron T / Musinguzi, Nicholas / Muzoora, Conrad / Bangsberg, David / Davis, J Lucian / Haberer, Jessica E

    PLOS global public health

    2023  Band 3, Heft 12, Seite(n) e0001813

    Abstract: We conducted a pilot randomized controlled trial among patients initiating treatment for drug-sensitive tuberculosis (TB). Participants received real-time electronic adherence monitors and were randomized (1:1:1) to: (i) daily SMS (reminders to TB ... ...

    Abstract We conducted a pilot randomized controlled trial among patients initiating treatment for drug-sensitive tuberculosis (TB). Participants received real-time electronic adherence monitors and were randomized (1:1:1) to: (i) daily SMS (reminders to TB patients and notifications to social supporters sent daily for 3 months, then triggered by late or missed dosing for 3 months); (ii) weekly SMS (reminders to TB patients and notifications to social supporters sent weekly for 3 months, then triggered by late or missed dosing for 3 months); or (iii) control (no SMS). Feasibility was mainly verified by the technical function of the intervention at Month 6. The primary outcome was percent adherence as ascertained by the real time monitor. Quantitative feasibility/acceptability data were summarized descriptively. Percentage adherence and adherence patterns were assessed and compared by linear regression models. Qualitative acceptability data was collected through interviews and analyzed using content analysis. Among 63 participants, the median age was 35 years, 75% had no regular income, and 84% were living with HIV. Feasibility was demonstrated as most of the daily [1913/2395 (80%)] and weekly [631/872 (72%)] SMS reminders to TB patients were sent successfully. Also, most of the daily [1577/2395 (66%)] and weekly [740/872 (85%)] SMS notifications to social supporters and adherence data (96%) were sent successfully. Challenges included TB status disclosure, and financial constraints. All patients perceived the intervention to be useful in reminding and motivating them to take medication. Median adherence (IQR) in the daily SMS, weekly SMS, and control arms was 96.1% (84.8, 98.0), 92.5% (80.6, 96.3), and 92.2% (56.3, 97.8), respectively; however, differences between the intervention and control arms were not statistically significant. Real-time monitoring linked to SMS was feasible and acceptable and may have improved TB medication adherence. Larger studies are needed to further assess impact on adherence and clinical outcomes. Trial registration. ClinicalTrials.gov registration number: NCT03800888. https://ichgcp.net/clinical-trials-registry/NCT03800888.
    Sprache Englisch
    Erscheinungsdatum 2023-12-05
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 2767-3375
    ISSN (online) 2767-3375
    DOI 10.1371/journal.pgph.0001813
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  7. Artikel ; Online: Acceptability and feasibility of long-term, real-time electronic adherence monitoring of HIV pre-exposure prophylaxis (PrEP) use among young women in Kenya: A mixed methods study.

    Ogello, Vallery A / Rono, Bernard Kipkoech / Ngure, Kenneth / Sedah, Eric / Thuo, Nicholas B / Musinguzi, Nicholas / Baeten, Jared M / Bukusi, Elizabeth A / Mugo, Nelly R / Haberer, Jessica E

    PloS one

    2024  Band 19, Heft 3, Seite(n) e0299168

    Abstract: Real-time electronic adherence monitoring involves "smart" pill boxes that record and monitor openings as a proxy for pill taking and may be useful in understanding and supporting PrEP use; however, acceptability and/or feasibility for PrEP users is ... ...

    Abstract Real-time electronic adherence monitoring involves "smart" pill boxes that record and monitor openings as a proxy for pill taking and may be useful in understanding and supporting PrEP use; however, acceptability and/or feasibility for PrEP users is uncertain. We sought to understand the experiences of using a real-time electronic adherence monitor for PrEP delivery among young women in Kisumu and Thika, Kenya. We used the Wisepill device to monitor PrEP use among 18-24-year-old women for two years. Half of the participants were randomized to also receive SMS adherence reminders (daily or as needed for missed doses). We assessed acceptability quantitatively and qualitatively according to the four constructs of Unified Theory of Acceptance and Use of Technology (UTAUT): performance expectancy, effort expectancy, social influence, and facilitating conditions. We assessed feasibility by monitor functionality during periods of PrEP use. We analyzed quantitative data descriptively and compared by site and over time; qualitative data were analyzed inductively and deductively. The median age was 21 years (IQR 19-22), median education was 12 years (IQR 10-13), 182 (53%) had disclosed PrEP use, and 55 (16%) reported recent intimate partner violence. Most participants reported high levels of usefulness and high interest in using the monitor with few problems or worries reported throughout follow-up. Feasibility was high overall with some differences by site (96% functional monitor days in Kisumu vs 88% in Thika). Few monitors were reported lost (N = 29; 8%) or dysfunctional (N = 11; 3%). In qualitative interviews, electronic monitoring was perceived as useful because it supported privacy, confidentiality, easy storage, and PrEP adherence. Effort was generally considered low. Participants expressed some concern for stigma from monitor and/or PrEP use. Facilitating conditions involved the monitor size, color, and battery life. Overall, real-time electronic adherence monitoring was a highly acceptable and feasible approach to understand PrEP adherence among young women in a sub-Saharan African setting.
    Mesh-Begriff(e) Humans ; Female ; Young Adult ; Adult ; Adolescent ; HIV Infections/prevention & control ; HIV Infections/drug therapy ; Pre-Exposure Prophylaxis/methods ; Kenya ; Feasibility Studies ; Anti-HIV Agents/therapeutic use ; Medication Adherence ; Electronics
    Chemische Substanzen Anti-HIV Agents
    Sprache Englisch
    Erscheinungsdatum 2024-03-07
    Erscheinungsland United States
    Dokumenttyp Randomized Controlled Trial ; Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0299168
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  8. Artikel ; Online: My Way: development and preliminary evaluation of a novel delivery system for PrEP and other sexual health needs of young women in Western Kenya.

    Haberer, Jessica E / Oware, Kevin / Juma, Lawrence / Nyerere, Bernard / Momanyi, Vincent / Odoyo, Josephine / Garrison, Lindsey / Bhagat, Julita / Musinguzi, Nicholas / Baeten, Jared M / Siegler, Aaron / Bukusi, Elizabeth A

    Journal of the International AIDS Society

    2024  Band 27, Heft 2, Seite(n) e26217

    Abstract: Introduction: Young women in sub-Saharan Africa are a priority population for HIV prevention, yet challenges with adherence and persistence to HIV pre-exposure prophylaxis (PrEP) are common. This study involved the development and pilot testing of My ... ...

    Abstract Introduction: Young women in sub-Saharan Africa are a priority population for HIV prevention, yet challenges with adherence and persistence to HIV pre-exposure prophylaxis (PrEP) are common. This study involved the development and pilot testing of My Way-a novel delivery system for PrEP and co-packaged sexual health services.
    Methods: My Way was developed in Kisumu, Kenya through a user-centred design process (2020). The intervention involves peer-delivery and support for HIV testing and PrEP use, self-collected vaginal swabs for sexually transmitted infection (STI) testing, pregnancy testing, oral contraceptive pills, self-injectable medroxyprogesterone and/or condoms. My Way was assessed among 16- to 24-year-old sexually active women in a randomized controlled trial versus standard of care (SoC; 2021-2022). Use of PrEP and other sexual health services were tracked at 1, 3 and 6 months for feasibility. Acceptability was determined by questionnaire. The effect of the intervention on tenofovir diphosphate (TFV-DP) levels was assessed by chi-square test (primary outcome); other predictors were explored with regression analysis.
    Results: Among 150 women, the median age was 22 years and the median number of sexual partners was 2. Moderate/severe depression was common (60%). In the intervention arm, peers made 88% (198/225) of possible kit deliveries (177 with PrEP) and 49 STIs were diagnosed. In the SoC arm, 24% (55/225) of expected clinic visits occurred (53 with PrEP); no STI testing was performed. TVF-DP was detected in 16 participants at 6 months: 16% (12/75) in the intervention arm versus 5% (4/75) in the SoC arm (p = 0.03). Persistence among those with ongoing HIV prevention needs (i.e. prevention-effective persistence) was 18% (12/67) versus 7% (4/56; p = 0.08). No women acquired HIV. The intervention was significantly associated with detectable TFV-DP (OR 3.5, 1.1-11.4; p = 0.04); moderate/severe depression trended towards an association with TFV-DP (OR 0.2, 0.03-1.6; p = 0.13).
    Conclusions: My Way is a promising delivery system for PrEP and other sexual health services among young women in Western Kenya. We found high feasibility and acceptability. PrEP use was modest, but higher with My Way compared to SoC. Long-acting PrEP formulations may overcome important barriers to PrEP use and should be explored in combination with the My Way delivery model.
    Mesh-Begriff(e) Humans ; Female ; Young Adult ; Adult ; Adolescent ; HIV Infections/diagnosis ; HIV Infections/prevention & control ; HIV Infections/drug therapy ; Anti-HIV Agents/therapeutic use ; Sexual Health ; Kenya/epidemiology ; Sexually Transmitted Diseases/diagnosis ; Sexually Transmitted Diseases/prevention & control ; Pre-Exposure Prophylaxis ; Adenine/analogs & derivatives ; Organophosphates
    Chemische Substanzen Anti-HIV Agents ; tenofovir diphosphate ; Adenine (JAC85A2161) ; Organophosphates
    Sprache Englisch
    Erscheinungsdatum 2024-02-20
    Erscheinungsland Switzerland
    Dokumenttyp Randomized Controlled Trial ; Journal Article
    ZDB-ID 2467110-1
    ISSN 1758-2652 ; 1758-2652
    ISSN (online) 1758-2652
    ISSN 1758-2652
    DOI 10.1002/jia2.26217
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel: Social networks and HIV treatment adherence among people with HIV initiating treatment in rural Uganda and peri-urban South Africa.

    Comfort, Alison B / Asiimwe, Stephen / Amaniyre, Gideon / Orrell, Catherine / Moody, James / Musinguzi, Nicholas / Bwana, Mwebesa Bosco / Bangsberg, David R / Haberer, Jessica E / Tsai, Alexander C

    SSM - population health

    2024  Band 25, Seite(n) 101593

    Abstract: Timely initiation of and adherence to antiretroviral therapy (ART) is critical for improving HIV outcomes and reducing HIV transmissibility. Social networks, or the social relationships individuals have with each other, have been linked with positive ... ...

    Abstract Timely initiation of and adherence to antiretroviral therapy (ART) is critical for improving HIV outcomes and reducing HIV transmissibility. Social networks, or the social relationships individuals have with each other, have been linked with positive health outcomes, but less is known about the extent to which social network composition and structure are associated with improved ART adherence among people living with HIV (PLWH). We conducted an ego-centric network study among 828 previously ART-naïve PLWH presenting for ART initiation at 11 clinics in Mbarara, Uganda (rural population) and Gugulethu, South Africa (peri-urban population). We collected social network data using name generator and name interpreter questions. ART adherence was monitored over 12 months using wireless monitors (Wisepill). Our primary outcome of interest was ART adherence during the 12-month follow-up period. We used generalized linear models to estimate the associations between network measures and ART adherence. PLWH at the Uganda site (compared with the South Africa site) were less isolated, had larger social networks, and had more social ties providing sufficient social support; they were also more likely to bridge different social groups whereby not all social ties were connected to each other. In Uganda, social isolation was associated with a 5.5 percentage point reduction in ART adherence (95% confidence interval [CI] -9.95 to -1.13; p = 0.014), while having more same gender social ties was associated with higher ART adherence (b = 0.13, 95% CI 0.02-0.25, p = 0.025). In South Africa, there was no association between social isolation and ART adherence, and having more friendship ties (vs. family ties) was associated with lower ART adherence (b = -2.20, 95% CI -3.56 to -0.84; p = 0.002). Identifying and supporting PLWH who are isolated may facilitate optimal adherence, but understanding how networks differentially affect ART adherence by country context is important.
    Sprache Englisch
    Erscheinungsdatum 2024-01-01
    Erscheinungsland England
    Dokumenttyp Journal Article
    ISSN 2352-8273
    ISSN 2352-8273
    DOI 10.1016/j.ssmph.2023.101593
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: Transition from pediatric to adult care for adolescents living with HIV in South Africa: A natural experiment and survival analysis.

    Zanoni, Brian C / Archary, Moherndran / Sibaya, Thobekile / Musinguzi, Nicholas / Haberer, Jessica E

    PloS one

    2020  Band 15, Heft 10, Seite(n) e0240918

    Abstract: Objective: To determine rates of retention and viral suppression among adolescents living with perinatally-acquired HIV who remained in pediatric care compared to those who transitioned to adult care.: Methods: We evaluated a natural experiment ... ...

    Abstract Objective: To determine rates of retention and viral suppression among adolescents living with perinatally-acquired HIV who remained in pediatric care compared to those who transitioned to adult care.
    Methods: We evaluated a natural experiment involving adolescents living with perinatally-acquired HIV who were attending a government-supported antiretroviral clinic in KwaZulu-Natal, South Africa. Prior to 2011, all adolescents transitioned to adult care at 12 years of age. Due to a policy change, all adolescents were retained in pediatric care after 2011. We analyzed adolescents two years before and two years after this policy change. Outcomes were retention in care and HIV viral suppression one year after transition to adult care or the 13th birthday if remaining in pediatric care.
    Results: In the natural experiment, 180 adolescents who turned 12 years old between 2011 and 2014 were evaluated; 35 (20%) transitioned to adult care under the old policy and 145 (80%) remained in pediatric care under the new policy. Adolescents who transitioned to the adult clinic had lower rates of retention in care (49%; 17/35) compared to adolescents remaining in the pediatric clinic (92%; 134/145; p<0.001). Retention in care was lower (ARR 0.59; 95%CI 0.43-0.82; p = 0.001) and viral suppression was similar (ARR = 1.06, 95%CI 0.89-1.26; p = 0.53) for adolescents who transitioned to adult care compared to adolescents remaining in pediatric care.
    Conclusion: Adolescents living with perinatally-acquired HIV appear to have higher retention in care when cared for in pediatric clinics compared to adult clinics. Longer-term follow-up is needed to fully assess viral suppression.
    Mesh-Begriff(e) Adolescent ; Adult ; Ambulatory Care Facilities ; Anti-HIV Agents/therapeutic use ; Child ; Female ; HIV Infections/drug therapy ; Health Policy ; Humans ; Male ; Retention in Care/statistics & numerical data ; South Africa ; Survival Analysis ; Transition to Adult Care/legislation & jurisprudence ; Transition to Adult Care/statistics & numerical data ; Treatment Outcome
    Chemische Substanzen Anti-HIV Agents
    Sprache Englisch
    Erscheinungsdatum 2020-10-27
    Erscheinungsland United States
    Dokumenttyp Comparative Study ; Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0240918
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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