Article: Hyperferritinemia as a factor associated with poor prognosis in COVID-19 patients.
2024 Volume 73, Issue 1, Page(s) 223–232
Abstract: Worldwide, hundreds of millions of people have been infected with COVID-19 since December 2019; however, about 20% or less developed severe symptoms. The main aim of the current study was to assess the relationship between the severity of Covid-19 ... ...
| Title translation | Hyperferitinemie jako faktor spojený se špatnou prognózou u pacientů s COVID-19. |
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| Abstract | Worldwide, hundreds of millions of people have been infected with COVID-19 since December 2019; however, about 20% or less developed severe symptoms. The main aim of the current study was to assess the relationship between the severity of Covid-19 and different clinical and laboratory parameters. A total number of 466 Arabs have willingly joined this prospective cohort. Out of the total number, 297 subjects (63.7%) had negative COVID-19 tests, and thus, they were recruited as controls, while 169 subjects (36.3%) who tested positive for COVID-19 were enrolled as cases. Out of the total number of COVID-19 patients, 127 (75.15%) presented with mild symptoms, and 42 (24.85%) had severe symptoms. The age range for the participants was 20 to 82 years. Compared with controls, the severity of the disease was associated with significantly high ferritin levels (P < 0.001). The severity of the disease was also associated with a significant increase in C-reactive protein (P < 0.001), D-dimer (P < 0.001), white blood cell count (WBC) (P < 0.01), IgM (P < 0.001), and Granulocytes (P < 0.01). In addition, severe COVID-19 symptoms in the current study were associated with a significant decrease in lymphocytes (P < 0.01). There was a four-fold increase in serum ferritin levels in COVID-19 patients presented with severe symptoms upon admission. The former was associated with significantly high levels of CRP and D-dimer. Thus, hyperferritinemia, together with high CRP and D-dimer concentrations, may serve as reliable predictors for disease severity and poor prognosis in Arabs with COVID-19. |
| MeSH term(s) | Humans ; Young Adult ; Adult ; Middle Aged ; Aged ; Aged, 80 and over ; Hyperferritinemia ; Prospective Studies ; COVID-19 ; Ferritins ; Prognosis |
| Chemical Substances | Ferritins (9007-73-2) |
| Language | English |
| Publishing date | 2024-01-07 |
| Publishing country | Czech Republic |
| Document type | Journal Article |
| ZDB-ID | 1187133-7 |
| ISSN | 1210-7816 ; 0009-0530 |
| ISSN | 1210-7816 ; 0009-0530 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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