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Article ; Online: Case Report: Chemoimmunotherapy in microsatellite-instability-high advanced goblet cell carcinoma of the colon.

Mutlu, Arda Ulaş / Aytaç, Erman / Gülmez, Mehmet / Erdamar, Sibel / Özer, Leyla

2023 Volume 14, Page(s) 1160586

Abstract: Background: Mismatch repair (MMR) deficiency is a fundamental factor affecting the management treatment outcomes of colorectal cancer (CRC). MMR status can be diagnosed by both immunohistochemistry (IHC) polymerase chain reaction (PCR). Since tumors ... ...

Abstract	Background: Mismatch repair (MMR) deficiency is a fundamental factor affecting the management treatment outcomes of colorectal cancer (CRC). MMR status can be diagnosed by both immunohistochemistry (IHC) polymerase chain reaction (PCR). Since tumors with MMR deficiency are prone to respond to immunotherapy immune checkpoint inhibitors are used to treat such tumors. Case presentation: A 69-year-old male patient presented to an outside clinic with weight loss and abdominal pain. Radiological investigations detected a mesenteric mass of 10 cm, peritoneal implants, and mediastinal lymphadenopathy. The eventual biopsy result from the mesenteric mass was mucinous adenocarcinoma with a goblet cell pattern. Since the IHC result was unclear for deficiency in mismatch repair (dMMR) metastatic CRC (mCRC), the diagnosis was confirmed with PCR. The patient received 8 cycles of FOLFIRINOX + bevacizumab followed by FOLFOX combined with pembrolizumab. No adverse effect was reported related to immunotherapy which resulted in radiologic and metabolic regression. The patient underwent cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC). The final pathology results revealed a pathological complete response and R0 resection. In the 6 Conclusion: Chemotherapy and immunotherapy combination is a promising treatment modality which can also be used for mCRC. This is the index case who received chemotherapy in combination with immunotherapy for mucinous adenocarcinoma of the colon with a goblet cell pattern and had pCR.
MeSH term(s)	Humans ; Male ; Aged ; Carcinoid Tumor/therapy ; Abdominal Pain/etiology ; Colonic Neoplasms/therapy ; Antineoplastic Combined Chemotherapy Protocols ; Immunotherapy ; Microsatellite Repeats ; Microsatellite Instability ; Weight Loss
Language	English
Publishing date	2023-07-07
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1160586
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Article ; Online: Posterior fixation of gastric tube with fibrin sealant in laparoscopic sleeve gastrectomy: a promising method to prevent revision surgeries.

Kizilkaya, Mehmet Celal / Gokay, Ridvan / Mutlu, Arda Ulaş / Sonmez, Suleyman / Yilmaz, Serhan / Kocatas, Ali / Saracoglu, Can / Aytac, Erman

Langenbeck's archives of surgery

2024 Volume 409, Issue 1, Page(s) 60

Abstract: Background: We aim to assess the effects of gastric posterior fixation with fibrin sealant in laparoscopic sleeve gastrectomy in aspects of 12th-month body mass index and gastric volume.: Methods: The patients who underwent laparoscopic sleeve ... ...

Abstract	Background: We aim to assess the effects of gastric posterior fixation with fibrin sealant in laparoscopic sleeve gastrectomy in aspects of 12th-month body mass index and gastric volume. Methods: The patients who underwent laparoscopic sleeve gastrectomy between January 2019 and February 2021 were divided into two groups preoperatively. The first 75 patients were appointed to the posterior fixation group, and the second 75 were to the control group. Changes in gastric volume and body mass index were assessed in the postoperative 12th month. Results: There were 110 patients in the final analysis. Fifty-four patients had posterior fixation, and 56 had only laparoscopic sleeve gastrectomy. The posterior fixation group was superior in terms of total weight loss rate (39.1% vs. 34.5%, p<0.001) and less gastric volume increase rate (39.8% vs. 164.7%, p<0.001) in the postoperative 12th month. Conclusion: Our study suggests that posterior fixation with fibrin sealant in laparoscopic sleeve gastrectomy is a promising method for preventing weight regain and creating a need for revision surgery.
MeSH term(s)	Humans ; Reoperation ; Fibrin Tissue Adhesive/therapeutic use ; Gastrectomy ; Stomach ; Laparoscopy
Chemical Substances	Fibrin Tissue Adhesive
Language	English
Publishing date	2024-02-14
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1423681-3
ISSN	1435-2451 ; 1435-2443
ISSN (online)	1435-2451
ISSN	1435-2443
DOI	10.1007/s00423-024-03253-8
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Article ; Online: Learning curve analysis of robotic transabdominal preperitoneal inguinal hernia repair.

Aghayeva, Afag / Aytac, Erman / Dinc, Taha / Mutlu, Arda Ulas / Sahin, Inci / Bilgin, Ismail Ahmet / Hamzaoglu, Ismail / Baca, Bilgi

The international journal of medical robotics + computer assisted surgery : MRCAS

2020 Volume 16, Issue 6, Page(s) 1–5

Abstract: Background: The purpose of this study was to assess the learning curve (LC) for inguinal hernia repair with robotic transabdominal preperitoneal (R-TAPP) approach.: Methods: Between April 2016 and October 2019, patients who underwent R-TAPP were ... ...

Abstract	Background: The purpose of this study was to assess the learning curve (LC) for inguinal hernia repair with robotic transabdominal preperitoneal (R-TAPP) approach. Methods: Between April 2016 and October 2019, patients who underwent R-TAPP were retrieved. Patient demographics, operative variables and postoperative outcomes were assessed. The moving average method and cumulative sum of operation times (OT) were used to evaluate the LC. The surgeon (BB) in this study had completed his laparoscopic (Lap) TAPP experience. Results: There were 50 (two females) consecutive patients (mean age was 51.7 ± 16.9 years). The first phase (learning phase) included initial 35 operations. The second phase included the next 15 operations. It was observed that, with increasing experience, a statistically significant shortening in the average OT by about 25 min was achieved (p = 0.041). Conclusion: The LC phase for R-TAPP, for surgeon with previous experience in Lap TAPP, seems to be very quick without compromising the operative morbidity.
MeSH term(s)	Adult ; Aged ; Female ; Hernia, Inguinal/surgery ; Herniorrhaphy ; Humans ; Laparoscopy ; Learning Curve ; Male ; Middle Aged ; Retrospective Studies ; Robotic Surgical Procedures
Language	English
Publishing date	2020-09-08
Publishing country	England
Document type	Journal Article
ZDB-ID	2151860-9
ISSN	1478-596X ; 1478-5951
ISSN (online)	1478-596X
ISSN	1478-5951
DOI	10.1002/rcs.2150
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Article ; Online: Intramural Component of Venous, Lymphatic, and Perineural Invasion in Colon Cancer: A Threat or an Illusion?

Özer, Leyla / Şenocak Taşçı, Elif / Mutlu, Arda Ulaş / Piyade, Betül / Ramoğlu, Nur / Ajredini, Miraç / Gürleyik, Damla / Çeçen, Recep / Dinçer, Sena Nur / Musevitoğlu, Turan / Göksel, Süha / İnce, Ümit / Kayhan, Cavit Kerem / Erdamar, Sibel / Yıldız, İbrahim / Aytaç, Erman

Balkan medical journal

2022 Volume 39, Issue 6, Page(s) 436–443

Abstract: Background: Extramural venous invasion is an independent predictor of poor outcome in colorectal cancer, whereas the significance of the intramural component of venous and lymphatic and perineural invasion is unclear.: Aims: To evaluate the ... ...

Abstract	Background: Extramural venous invasion is an independent predictor of poor outcome in colorectal cancer, whereas the significance of the intramural component of venous and lymphatic and perineural invasion is unclear. Aims: To evaluate the prognostic impact of intramural components for venous, lymphatic, and perineural invasions and the relation of these invasion patterns with clinicopathological features in patients with colon cancer. Study design: A retrospective cross-sectional study. Methods: The analysis included 626 patients with colon cancer in stages II and III. All patients were divided into four categories (no invasion, intramural invasion only, extramural invasion only, or both intramural and extramural invasions) for vascular invasion, lymphatic invasion and perineural invasion. The primary outcomes were 5-year disease-free and overall survival. Results: Right-sided (for vascular invasion, 24.7% vs. 33.9%, Conclusion: Our data strongly advocates the importance of reporting intramural and extramural components of invasion since the presence of intramural invasion alone may not be considered as a high-risk factor for systemic recurrence.
MeSH term(s)	Humans ; Colonic Neoplasms/pathology ; Cross-Sectional Studies ; Neoplasm Invasiveness/pathology ; Neoplasm Staging ; Retrospective Studies
Language	English
Publishing date	2022-11-01
Publishing country	Turkey
Document type	Journal Article
ZDB-ID	2612982-6
ISSN	2146-3131 ; 2146-3131
ISSN (online)	2146-3131
ISSN	2146-3131
DOI	10.4274/balkanmedj.galenos.2022.2022-6-94
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Article ; Online: Correction: Comparing the efficacy of regorafenib and 5-fluorouracil-based rechallenge chemotherapy in the third-line treatment of metastatic colorectal cancer.

Taşçı, Elif Şenocak / Oyan, Başak / Sönmez, Özlem / Mutlu, Arda Ulaş / Atcı, Muhammed Mustafa / Sakin, Abdullah / Öner, İrem / Çınkır, Havva Yeşil / Eryılmaz, Melek Karakurt / Çağlayan, Dilek / Balçık, Onur Yazdan / Paksoy, Nail / Karabulut, Senem / Salim, Derya Kıvrak / Bilir, Cemil / Özen, Miraç / Özçelik, Melike / Arıcan, Ali / Akagündüz, Baran /

İnal, Ali / Aydın, Dinçer / Özer, Leyla / Gülmez, Ahmet / Turhal, Nazım Serdar / Esen, Selin Aktürk / Algın, Efnan / Akbaş, Sinem / İriağaç, Yakup / Şakalar, Teoman / Ünal, Çağlar / Er, Özlem / Seçmeler, Şaban / Bozkurt, Mustafa

BMC cancer

2024 Volume 24, Issue 1, Page(s) 114

Language	English
Publishing date	2024-01-23
Publishing country	England
Document type	Published Erratum
ZDB-ID	2041352-X
ISSN	1471-2407 ; 1471-2407
ISSN (online)	1471-2407
ISSN	1471-2407
DOI	10.1186/s12885-024-11863-0
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Article ; Online: Comparing the efficacy of regorafenib and 5-fluorouracil-based rechallenge chemotherapy in the third-line treatment of metastatic colorectal cancer.

BMC cancer

2024 Volume 24, Issue 1, Page(s) 16

Abstract: Background: The optimal treatment for metastatic colorectal cancer (mCRC) after the second line is still controversial. Regorafenib has been the standard of care in this setting as it improved overall survival (OS) compared to placebo. In real-world ... ...

Abstract	Background: The optimal treatment for metastatic colorectal cancer (mCRC) after the second line is still controversial. Regorafenib has been the standard of care in this setting as it improved overall survival (OS) compared to placebo. In real-world practice chemotherapy rechallenge is also a preferred option even though supporting evidence is not enough. We aim to compare the efficacy of regorafenib and 5-fluorouracil-based (5-FU) rechallenge treatment in the third line setting of mCRC. Methods: In this retrospective multi-institutional trial, mCRC patients from 21 oncology centers who progressed after 2 lines of chemotherapy were analyzed. Patients who were treated with regorafenib or rechallenge therapy in the third-line setting were eligible. Rechallenge chemotherapy was identified as the re-use of the 5-FU based regimen which was administered in one of the previous treatment lines. OS, disease control rate (DCR), progression free survival (PFS) and toxicity were analyzed. Results: Three hundred ninety-four mCRC patients were included in the study. 128 (32.5%) were in the rechallenge, and 266 (67.5%) were in the regorafenib group. Median PFS was 5.82 months in rechallenge and 4 months in regorafenib arms (hazard ratio:1.45,95% CI, p = 0.167). DCR was higher in the rechallenge group than regorafenib (77% vs 49.5%, respectively, p = < 0.001). Median OS after the third-line treatment was 11.99 (95% CI, 9.49-14.49) and 8.08 months (95% CI, 6.88-9.29) for rechallenge and regorafenib groups, respectively (hazard ratio:1.51, 95% CI, p < 0.001). More adverse effects and discontinuation were seen with regorafenib treatment. Conclusion: Our study revealed that higher disease control and OS rates were achieved with rechallenge treatment compared to regorafenib, especially in patients who achieved disease control in one of the first two lines of therapy.
MeSH term(s)	Humans ; Fluorouracil/adverse effects ; Colorectal Neoplasms/drug therapy ; Colorectal Neoplasms/pathology ; Retrospective Studies ; Colonic Neoplasms/drug therapy ; Phenylurea Compounds/adverse effects ; Rectal Neoplasms/drug therapy
Chemical Substances	Fluorouracil (U3P01618RT) ; regorafenib (24T2A1DOYB) ; Phenylurea Compounds
Language	English
Publishing date	2024-01-02
Publishing country	England
Document type	Journal Article
ZDB-ID	2041352-X
ISSN	1471-2407 ; 1471-2407
ISSN (online)	1471-2407
ISSN	1471-2407
DOI	10.1186/s12885-023-11783-5
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Article ; Online: Efficacy of adjuvant capecitabine in residual triple negative breast cancer: a multicenter observational Turkish Oncology Group (TOG) study.

Taşçı, Elif Şenocak / Kutlu, Yasin / Ölmez, Ömer Fatih / Mutlu, Arda Ulaş / Gündoğdu, Yasemin / Seyyar, Mustafa / Şahin, Elif / Çabuk, Devrim / Majidova, Nargiz / Uğurlu, İrem / Demirci, Ayşe / Aydın, Dinçer / Çavdar, Eyyüp / Bayram, Selami / Yıldırım, Nilgün / Karataş, Fatih / Eryılmaz, Melek Karakurt / Çağlayan, Dilek / Menekşe, Serkan /

Kut, Engin / Arak, Hacı / Keser, Murat / Sunar, Veli / Perkin, Perihan / Şakalar, Teoman / Oyan, Başak / Sönmez, Özlem / Özer, Leyla / Yıldız, İbrahim

Expert opinion on pharmacotherapy

2024 Volume 25, Issue 4, Page(s) 477–484

Abstract: Background: Triple negative breast cancer (TNBC) is characterized by high rates of recurrence, especially in patients with residual disease after neoadjuvant chemotherapy (NAC). Capecitabine is being used as standard adjuvant treatment in residual TNBC. ...

Abstract	Background: Triple negative breast cancer (TNBC) is characterized by high rates of recurrence, especially in patients with residual disease after neoadjuvant chemotherapy (NAC). Capecitabine is being used as standard adjuvant treatment in residual TNBC. We aimed to investigate the real-life data regarding the efficacy of capecitabine in residual TNBC. Design and methods: In this retrospective multicenter study, TNBC patients with residual disease were evaluated. Patients, who received standard anthracycline and taxane-based NAC and adjuvant capecitabine were eligible. Overall survival (OS), disease free survival (DFS) and toxicity were analyzed. Results: 170 TNBC patients with residual disease were included. Of these, 62.9% were premenopausal. At the time of analysis, the recurrence rate was 30% and death rate was 18%. The 3-year DFS and OS were 66% and 74%, respectively. In patients treated with adjuvant capecitabine, residual node positive disease stood out as an independent predictor of DFS ( Conclusion: The efficacy of capecitabine was found lower compared to previous studies. Selected patients may have further benefit from addition of capecitabine. The toxicity associated with capecitabine was found lower than anticipated.
MeSH term(s)	Humans ; Capecitabine/therapeutic use ; Capecitabine/administration & dosage ; Capecitabine/adverse effects ; Triple Negative Breast Neoplasms/drug therapy ; Triple Negative Breast Neoplasms/pathology ; Female ; Retrospective Studies ; Middle Aged ; Adult ; Chemotherapy, Adjuvant/methods ; Antimetabolites, Antineoplastic/therapeutic use ; Antimetabolites, Antineoplastic/adverse effects ; Antimetabolites, Antineoplastic/administration & dosage ; Disease-Free Survival ; Turkey ; Aged ; Neoplasm Recurrence, Local/drug therapy ; Neoplasm, Residual ; Survival Rate ; Neoadjuvant Therapy ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Mastectomy
Chemical Substances	Capecitabine (6804DJ8Z9U) ; Antimetabolites, Antineoplastic
Language	English
Publishing date	2024-04-03
Publishing country	England
Document type	Journal Article ; Multicenter Study ; Observational Study
ZDB-ID	2001535-5
ISSN	1744-7666 ; 1465-6566
ISSN (online)	1744-7666
ISSN	1465-6566
DOI	10.1080/14656566.2024.2337261
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Article ; Online: THOUGHTS AND AWARENESS OF MEDICAL STUDENTS ABOUT THE COVID-19 PANDEMIC

Volume: 7, Issue: 2 44-64 ; 2148-4724 ; 2548-0030 ; Turkish Medical Student Journal

2020

Abstract: Aims: This study aims to evaluate medical students’ knowledge, thoughts, and awareness of the COVID-19 pandemic. Metho- ds: A questionnaire consisting of 31 questions was prepared for this descriptive study. In the questionnaire, medical students’ ... ...

Abstract	Aims: This study aims to evaluate medical students’ knowledge, thoughts, and awareness of the COVID-19 pandemic. Metho- ds: A questionnaire consisting of 31 questions was prepared for this descriptive study. In the questionnaire, medical students’ knowledge, attitudes and behaviors during the COVID-19 pandemic were investigated. Categorical variables are demonstrated as numbers and percentages, whereas continuous variables are presented as minimum, maximum, and mean values. Results: A total of 575 participants completed the questionnaire. The mean participant age was 21.7 years. Fifty-two percent of participants knew about the coronaviridae family before the outbreak and 38.8% were informed about COVID-19 in their medical schools. Of the students, 99.7% stated that the first case’s origin was in China. Eighty percent of the participants stated that droplet spread is the transmission route of COVID-19. The most common opinion about the incubation period of the SARS CoV-2 was two to twelve days. Being older than 65 years old, having a comorbidity, being immunosuppressed, or working in the healthcare sector were the most particular risk factors to get infected. The majority of the participants follow the vaccine developments from social media, radio and television. According to 75.83% of the participants, all people should wear a mask in daily life for protection. Conclusion: The epidemiology and diagnostic factors of COVID-19 are well known by medical students. To minimize informa- tion pollution and raise awareness, medical students should be educated about pandemic and management of it. Further evalu- ation with various methods and more participants may help to better understand the awareness of the COVID-19 pandemic in medical students.
Keywords	COVID-19,SARS CoV-2,medical student,pandemic ; covid19
Language	English
Publishing date	2020-06-30T00:00:00Z
Publisher	Trakya University
Publishing country	tr
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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