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  1. Artikel ; Online: Glial plasticity in the zebrafish central nervous system.

    Mutschler, Clara / Telerman, Stephanie B

    Trends in cell biology

    2024  

    Abstract: Glial cells have a remarkable plasticity. Recent studies using zebrafish as a model highlight conserved cellular behavior in health and disease in the central nervous system (CNS) between zebrafish and humans. These findings inform our understanding of ... ...

    Abstract Glial cells have a remarkable plasticity. Recent studies using zebrafish as a model highlight conserved cellular behavior in health and disease in the central nervous system (CNS) between zebrafish and humans. These findings inform our understanding of their function and how their dysregulation in pathogenesis can be determinant.
    Sprache Englisch
    Erscheinungsdatum 2024-05-16
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 30122-x
    ISSN 1879-3088 ; 0962-8924
    ISSN (online) 1879-3088
    ISSN 0962-8924
    DOI 10.1016/j.tcb.2024.04.006
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Schwann cells are axo-protective after injury irrespective of myelination status in mouse Schwann cell-neuron cocultures.

    Mutschler, Clara / Fazal, Shaline V / Schumacher, Nathalie / Loreto, Andrea / Coleman, Michael P / Arthur-Farraj, Peter

    Journal of cell science

    2023  Band 136, Heft 18

    Abstract: Myelinating Schwann cell (SC)-dorsal root ganglion (DRG) neuron cocultures are an important technique for understanding cell-cell signalling and interactions during peripheral nervous system (PNS) myelination, injury, and regeneration. Although methods ... ...

    Abstract Myelinating Schwann cell (SC)-dorsal root ganglion (DRG) neuron cocultures are an important technique for understanding cell-cell signalling and interactions during peripheral nervous system (PNS) myelination, injury, and regeneration. Although methods using rat SCs and neurons or mouse DRG explants are commonplace, there are no established protocols for compartmentalised myelinating cocultures with dissociated mouse cells. There consequently is a need for a coculture protocol that allows separate genetic manipulation of mouse SCs or neurons, or use of cells from different transgenic animals to complement in vivo mouse experiments. However, inducing myelination of dissociated mouse SCs in culture is challenging. Here, we describe a new method to coculture dissociated mouse SCs and DRG neurons in microfluidic chambers and induce robust myelination. Cocultures can be axotomised to study injury and used for drug treatments, and cells can be lentivirally transduced for live imaging. We used this model to investigate axon degeneration after traumatic axotomy and find that SCs, irrespective of myelination status, are axo-protective. At later timepoints after injury, live imaging of cocultures shows that SCs break up, ingest and clear axonal debris.
    Mesh-Begriff(e) Animals ; Mice ; Rats ; Coculture Techniques ; Neurons ; Schwann Cells ; Axons ; Animals, Genetically Modified
    Sprache Englisch
    Erscheinungsdatum 2023-09-20
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2993-2
    ISSN 1477-9137 ; 0021-9533
    ISSN (online) 1477-9137
    ISSN 0021-9533
    DOI 10.1242/jcs.261557
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Emerging Role of HDACs in Regeneration and Ageing in the Peripheral Nervous System: Repair Schwann Cells as Pivotal Targets.

    Gomez-Sanchez, Jose A / Patel, Nikiben / Martirena, Fernanda / Fazal, Shaline V / Mutschler, Clara / Cabedo, Hugo

    International journal of molecular sciences

    2022  Band 23, Heft 6

    Abstract: The peripheral nervous system (PNS) has a remarkable regenerative capacity in comparison to the central nervous system (CNS), a phenomenon that is impaired during ageing. The ability of PNS axons to regenerate after injury is due to Schwann cells (SC) ... ...

    Abstract The peripheral nervous system (PNS) has a remarkable regenerative capacity in comparison to the central nervous system (CNS), a phenomenon that is impaired during ageing. The ability of PNS axons to regenerate after injury is due to Schwann cells (SC) being reprogrammed into a repair phenotype called Repair Schwann cells. These repair SCs are crucial for supporting axonal growth after injury, myelin degradation in a process known as myelinophagy, neurotropic factor secretion, and axonal growth guidance through the formation of Büngner bands. After regeneration, repair SCs can remyelinate newly regenerated axons and support nonmyelinated axons. Increasing evidence points to an epigenetic component in the regulation of repair SC gene expression changes, which is necessary for SC reprogramming and regeneration. One of these epigenetic regulations is histone acetylation by histone acetyl transferases (HATs) or histone deacetylation by histone deacetylases (HDACs). In this review, we have focused particularly on three HDAC classes (I, II, and IV) that are Zn
    Mesh-Begriff(e) Axons/metabolism ; Histone Deacetylases/genetics ; Histone Deacetylases/metabolism ; Histones/metabolism ; Nerve Regeneration/physiology ; Peripheral Nervous System/metabolism ; Schwann Cells/metabolism
    Chemische Substanzen Histones ; Histone Deacetylases (EC 3.5.1.98)
    Sprache Englisch
    Erscheinungsdatum 2022-03-10
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23062996
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel: SARM1 detection in myelinating glia:

    Fazal, Shaline V / Mutschler, Clara / Chen, Civia Z / Turmaine, Mark / Chen, Chiung-Ya / Hsueh, Yi-Ping / Ibañez-Grau, Andrea / Loreto, Andrea / Casillas-Bajo, Angeles / Cabedo, Hugo / Franklin, Robin J M / Barker, Roger A / Monk, Kelly R / Steventon, Benjamin J / Coleman, Michael P / Gomez-Sanchez, Jose A / Arthur-Farraj, Peter

    Frontiers in cellular neuroscience

    2023  Band 17, Seite(n) 1158388

    Abstract: Since SARM1 mutations have been identified in human neurological disease, SARM1 inhibition has become an attractive therapeutic strategy to preserve axons in a variety of disorders of the peripheral (PNS) and central nervous system (CNS). While SARM1 has ...

    Abstract Since SARM1 mutations have been identified in human neurological disease, SARM1 inhibition has become an attractive therapeutic strategy to preserve axons in a variety of disorders of the peripheral (PNS) and central nervous system (CNS). While SARM1 has been extensively studied in neurons, it remains unknown whether SARM1 is present and functional in myelinating glia? This is an important question to address. Firstly, to identify whether SARM1 dysfunction in other cell types in the nervous system may contribute to neuropathology in SARM1 dependent diseases? Secondly, to ascertain whether therapies altering SARM1 function may have unintended deleterious impacts on PNS or CNS myelination? Surprisingly, we find that oligodendrocytes express
    Sprache Englisch
    Erscheinungsdatum 2023-04-05
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2452963-1
    ISSN 1662-5102
    ISSN 1662-5102
    DOI 10.3389/fncel.2023.1158388
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Adipo-glial signaling mediates metabolic adaptation in peripheral nerve regeneration.

    Sundaram, Venkat Krishnan / Schütza, Vlad / Schröter, Nele H / Backhaus, Aline / Bilsing, Annika / Joneck, Lisa / Seelbach, Anna / Mutschler, Clara / Gomez-Sanchez, Jose A / Schäffner, Erik / Sánchez, Eva Ernst / Akkermann, Dagmar / Paul, Christina / Schwagarus, Nancy / Müller, Silvana / Odle, Angela / Childs, Gwen / Ewers, David / Kungl, Theresa /
    Sitte, Maren / Salinas, Gabriela / Sereda, Michael W / Nave, Klaus-Armin / Schwab, Markus H / Ost, Mario / Arthur-Farraj, Peter / Stassart, Ruth M / Fledrich, Robert

    Cell metabolism

    2023  Band 35, Heft 12, Seite(n) 2136–2152.e9

    Abstract: The peripheral nervous system harbors a remarkable potential to regenerate after acute nerve trauma. Full functional recovery, however, is rare and critically depends on peripheral nerve Schwann cells that orchestrate breakdown and resynthesis of myelin ... ...

    Abstract The peripheral nervous system harbors a remarkable potential to regenerate after acute nerve trauma. Full functional recovery, however, is rare and critically depends on peripheral nerve Schwann cells that orchestrate breakdown and resynthesis of myelin and, at the same time, support axonal regrowth. How Schwann cells meet the high metabolic demand required for nerve repair remains poorly understood. We here report that nerve injury induces adipocyte to glial signaling and identify the adipokine leptin as an upstream regulator of glial metabolic adaptation in regeneration. Signal integration by leptin receptors in Schwann cells ensures efficient peripheral nerve repair by adjusting injury-specific catabolic processes in regenerating nerves, including myelin autophagy and mitochondrial respiration. Our findings propose a model according to which acute nerve injury triggers a therapeutically targetable intercellular crosstalk that modulates glial metabolism to provide sufficient energy for successful nerve repair.
    Mesh-Begriff(e) Peripheral Nerves ; Myelin Sheath/metabolism ; Neuroglia ; Schwann Cells/metabolism ; Nerve Regeneration/physiology
    Sprache Englisch
    Erscheinungsdatum 2023-11-20
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2176834-1
    ISSN 1932-7420 ; 1550-4131
    ISSN (online) 1932-7420
    ISSN 1550-4131
    DOI 10.1016/j.cmet.2023.10.017
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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