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  1. Article: In Vitro Potential Virucidal Effect Evaluation of Xibornol on Human Adenovirus Type 5, Human Rhinovirus Type 13, Human Coronavirus 229E, Human Parainfluenza Virus Type 1, and Human Respiratory Syncytial Virus.

    Verani, Marco / Federigi, Ileana / Lauretani, Giulia / Muzio, Sara / Carducci, Annalaura

    Advances in experimental medicine and biology

    2022  Volume 1370, Page(s) 19–28

    Abstract: The availability of virucidal compounds to reduce the impact of respiratory viruses is a relevant topic for public health, especially during the recent coronavirus disease (COVID-19) pandemic. Antimicrobial properties of Xibornol are known since the ... ...

    Abstract The availability of virucidal compounds to reduce the impact of respiratory viruses is a relevant topic for public health, especially during the recent coronavirus disease (COVID-19) pandemic. Antimicrobial properties of Xibornol are known since the 1970s, but its activity on viruses is currently little explored. In this study, Xibornol activity at a fixed concentration of 0.03 mg/100 ml has been evaluated on five respiratory viruses (Human Adenovirus 5, Human Rhinovirus type 13, Human Coronavirus 229E, Human Parainfluenza Virus type 1, and Human Respiratory Syncytial Virus) through in vitro experiments based on adapted European standard UNI EN 14476-20019. The experiments were carried out under two different environmental conditions, one with the addition of fetal bovine serum to simulate an in vivo condition (dirty condition) and the other without the addition of any organic substances (clean condition). The viral abatement of Xibornol (expressed as Log
    MeSH term(s) Humans ; Respiratory Syncytial Virus, Human ; Parainfluenza Virus 1, Human ; Coronavirus 229E, Human ; Rhinovirus ; Adenoviruses, Human ; Respiratory Tract Infections ; COVID-19
    Chemical Substances xibornol (RQ12GMY0FZ)
    Language English
    Publishing date 2022-06-10
    Publishing country United States
    Document type Journal Article
    ISSN 2214-8019 ; 0065-2598
    ISSN (online) 2214-8019
    ISSN 0065-2598
    DOI 10.1007/5584_2022_722
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Critical Needs for Integrated Surveillance: Wastewater-Based and Clinical Epidemiology in Evolving Scenarios with Lessons Learned from SARS-CoV-2.

    Carducci, Annalaura / Federigi, Ileana / Lauretani, Giulia / Muzio, Sara / Pagani, Alessandra / Atomsa, Nebiyu Tariku / Verani, Marco

    Food and environmental virology

    2024  Volume 16, Issue 1, Page(s) 38–49

    Abstract: During the COVID-19 pandemic, wastewater-based epidemiology (WBE) and clinical surveillance have been used as tools for analyzing the circulation of SARS-CoV-2 in the community, but both approaches can be strongly influenced by some sources of ... ...

    Abstract During the COVID-19 pandemic, wastewater-based epidemiology (WBE) and clinical surveillance have been used as tools for analyzing the circulation of SARS-CoV-2 in the community, but both approaches can be strongly influenced by some sources of variability. From the challenging perspective of integrating environmental and clinical data, we performed a correlation analysis between SARS-CoV-2 concentrations in raw sewage and incident COVID-19 cases in areas served by medium-size wastewater treatment plants (WWTPs) from 2021 to 2023. To this aim, both datasets were adjusted for several sources of variability: WBE data were adjusted for factors including the analytical protocol, sewage flow, and population size, while clinical data adjustments considered the demographic composition of the served population. Then, we addressed the impact on the correlation of differences among sewerage networks and variations in the frequency and type of swab tests due to changes in political and regulatory scenarios. Wastewater and clinical data were significantly correlated when restrictive containment measures and limited movements were in effect (ρ = 0.50) and when COVID-19 cases were confirmed exclusively through molecular testing (ρ = 0.49). Moreover, a positive (although weak) correlation arose for WWTPs located in densely populated areas (ρ = 0.37) and with shorter sewerage lengths (ρ = 0.28). This study provides methodological approaches for interpreting WBE and clinical surveillance data, which could also be useful for other infections. Data adjustments and evaluation of possible sources of bias need to be carefully considered from the perspective of integrated environmental and clinical surveillance of infections.
    MeSH term(s) Humans ; SARS-CoV-2 ; Wastewater ; COVID-19/epidemiology ; Sewage ; Pandemics ; RNA, Viral
    Chemical Substances Wastewater ; Sewage ; RNA, Viral
    Language English
    Publishing date 2024-01-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2487173-4
    ISSN 1867-0342 ; 1867-0334
    ISSN (online) 1867-0342
    ISSN 1867-0334
    DOI 10.1007/s12560-023-09573-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Calibration of Methods for SARS-CoV-2 Environmental Surveillance: A Case Study from Northwest Tuscany.

    Verani, Marco / Federigi, Ileana / Muzio, Sara / Lauretani, Giulia / Calà, Piergiuseppe / Mancuso, Fabrizio / Salvadori, Roberto / Valentini, Claudia / La Rosa, Giuseppina / Suffredini, Elisabetta / Carducci, Annalaura

    International journal of environmental research and public health

    2022  Volume 19, Issue 24

    Abstract: The current pandemic has provided an opportunity to test wastewater-based epidemiology (WBE) as a complementary method to SARS-CoV-2 monitoring in the community. However, WBE infection estimates can be affected by uncertainty factors, such as ... ...

    Abstract The current pandemic has provided an opportunity to test wastewater-based epidemiology (WBE) as a complementary method to SARS-CoV-2 monitoring in the community. However, WBE infection estimates can be affected by uncertainty factors, such as heterogeneity in analytical procedure, wastewater volume, and population size. In this paper, raw sewage SARS-CoV-2 samples were collected from four wastewater treatment plants (WWTPs) in Tuscany (Northwest Italy) between February and December 2021. During the surveillance period, viral concentration was based on polyethylene glycol (PEG), but its precipitation method was modified from biphasic separation to centrifugation. Therefore, in parallel, the recovery efficiency of each method was evaluated at lab-scale, using two spiking viruses (human coronavirus 229E and mengovirus vMC
    MeSH term(s) Humans ; SARS-CoV-2/genetics ; COVID-19/epidemiology ; Sewage ; Calibration ; Environmental Monitoring ; RNA, Viral
    Chemical Substances Sewage ; RNA, Viral
    Language English
    Publishing date 2022-12-09
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph192416588
    Database MEDical Literature Analysis and Retrieval System OnLINE

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