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  1. Article ; Online: Should liver metastases of pancreatic adenocarcinoma be resected?

    Muzzolini, Milena / Lupinacci, Renato / Bachet, Jean-Baptiste / Lassoued, Donia / Sauvanet, Alain / Gaujoux, Sébastien

    Journal of visceral surgery

    2024  Volume 161, Issue 2, Page(s) 129–140

    MeSH term(s) Humans ; Pancreatic Neoplasms/surgery ; Pancreatic Neoplasms/pathology ; Pancreatic Neoplasms/secondary ; Liver Neoplasms/secondary ; Liver Neoplasms/surgery ; Adenocarcinoma/surgery ; Adenocarcinoma/secondary ; Adenocarcinoma/pathology ; Hepatectomy/methods
    Language English
    Publishing date 2024-01-22
    Publishing country France
    Document type Editorial ; Journal Article
    ISSN 1878-7886
    ISSN (online) 1878-7886
    DOI 10.1016/j.jviscsurg.2023.12.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Pancreatic cancer orthotopic graft in a murine model.

    Muzzolini, Milena / Belhabib, Ismahane / Cardot, Victoire / Tijeras-Raballand, Annemilaï / Neuzillet, Cindy / Bousquet, Corinne / Lupinacci, Renato Micelli / Jean, Christine

    Acta cirurgica brasileira

    2023  Volume 38, Page(s) e382823

    Abstract: Purpose: Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers with increasing incidence. Even if progress have been made, the five-year overall survival remains lower than 10%. There is a desperate need in therapeutic improvements. In ...

    Abstract Purpose: Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers with increasing incidence. Even if progress have been made, the five-year overall survival remains lower than 10%. There is a desperate need in therapeutic improvements. In the last two decades, new in-vitro models have been developed and improved, including tridimensional-culture spheroids and organoids. However, animal studies remain mandatory in the upscaling before clinical studies. Orthotopic and syngeneic grafting is a robust model to test a drug efficiency in a tumor and its microenvironment.
    Methods: We described a method for orthotopic and syngeneic graft of KRAS mutated, p53 wildtype, 8305 cells in a C57BL/6J mouse model.
    Results: With this microsurgical method, 30 mice were grafted, 24 by a junior and six by a senior, resulting in 95,8 and 100% of (partial and total) successful tumoral implantation, respectively. Twenty mice underwent ultrasound follow-up. It was an efficient method for the tumoral growth evaluation. At day 16 after grafting, 85% of the tumors were detectable by ultrasound, and at day 22 all tumors were detected.
    Conclusions: The presented method appears to be a robust and reliable method for pre-clinical studies. A junior master student can provide positive results using this technique, which can be improved with training.
    MeSH term(s) Mice ; Animals ; Disease Models, Animal ; Mice, Inbred C57BL ; Pancreatic Neoplasms/surgery ; Carcinoma, Pancreatic Ductal/surgery ; Carcinoma, Pancreatic Ductal/pathology ; Cell Line, Tumor ; Tumor Microenvironment ; Pancreatic Neoplasms
    Language English
    Publishing date 2023-08-04
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 2012156-8
    ISSN 1678-2674 ; 1678-2674
    ISSN (online) 1678-2674
    ISSN 1678-2674
    DOI 10.1590/acb382823
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The immunological landscape in pancreatic ductal adenocarcinoma and overcoming resistance to immunotherapy.

    Hilmi, Marc / Delaye, Matthieu / Muzzolini, Milena / Nicolle, Rémy / Cros, Jérôme / Hammel, Pascal / Cardot-Ruffino, Victoire / Neuzillet, Cindy

    The lancet. Gastroenterology & hepatology

    2023  Volume 8, Issue 12, Page(s) 1129–1142

    Abstract: Pancreatic ductal adenocarcinoma is associated with a poor prognosis and there are few treatment options. The development of immunotherapy in pancreatic ductal adenocarcinoma has been difficult, and immune checkpoint inhibitors are only effective in a ... ...

    Abstract Pancreatic ductal adenocarcinoma is associated with a poor prognosis and there are few treatment options. The development of immunotherapy in pancreatic ductal adenocarcinoma has been difficult, and immune checkpoint inhibitors are only effective in a very small subset of patients. Most obstacles for treatment have been related to intertumoural and intratumoural heterogeneity, the composition of tumour stroma, and crosstalk with cancer cells. Improved molecular characterisation of pancreatic ductal adenocarcinoma and a better understanding of its microenvironment have paved the way for novel immunotherapy strategies, including the identification of predictive biomarkers, the development of rational combinations to optimise effectiveness, and the targeting of new mechanisms. Future immunotherapy strategies should consider individual characteristics to move beyond the traditional immune targets and circumvent the resistance to therapies that have been developed so far.
    MeSH term(s) Humans ; Pancreatic Neoplasms/therapy ; Pancreatic Neoplasms/pathology ; Carcinoma, Pancreatic Ductal/therapy ; Carcinoma, Pancreatic Ductal/pathology ; Immunotherapy ; Tumor Microenvironment ; Pancreatic Neoplasms
    Language English
    Publishing date 2023-10-19
    Publishing country Netherlands
    Document type Journal Article ; Review
    ISSN 2468-1253
    ISSN (online) 2468-1253
    DOI 10.1016/S2468-1253(23)00207-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Incidence and risk factors for Chyle leak after pancreatic surgery for cancer: A comprehensive systematic review.

    Muzzolini, Milena / Araujo, Raphael L C / Kingham, T Peter / Peschaud, Frédérique / Paye, François / Lupinacci, Renato M

    European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

    2021  Volume 48, Issue 4, Page(s) 707–717

    Abstract: Background: Chyle leak (CL) is a clinically relevant complication after pancreatectomy. Its incidence and the associated risk factors are ill defined, and various treatments options have been described. There is no consensus, however, regarding optimal ... ...

    Abstract Background: Chyle leak (CL) is a clinically relevant complication after pancreatectomy. Its incidence and the associated risk factors are ill defined, and various treatments options have been described. There is no consensus, however, regarding optimal management. The present study aims to systematically review the literature on CL after pancreatectomy.
    Methods: A systematic review from PubMed, Scopus and Embase database was performed. Studies using a clear definition for CL and published from January 2000 to January 2021 were included. The PRISMA guidelines were followed during all stages of this systematic review. The MINORS score was used to assess methodological quality.
    Results: Literature search found 361 reports, 99 of which were duplicates. The titles and abstracts of 262 articles were finally screened. The references from the remaining 181 articles were manually assessed. After the exclusions, 43 articles were thoroughly assessed. A total of 23 articles were ultimately included for this review. The number of patients varied from 54 to 3532. Incidence of post pancreatectomy CL varied from 1.3% to 22.1%. Main risk factors were the extent of the surgery and early oral or enteral feeding. CL dried up spontaneously or after conservative management within 14 days in 53% to 100% of the cases.
    Conclusions: The extent of surgery is the most common predictor of risk of CL. Conservative treatment has been shown to be effective in most cases and can be considered the treatment of choice. We propose a management algorithm based on the current available evidence.
    MeSH term(s) Chyle ; Humans ; Incidence ; Pancreatic Neoplasms/surgery ; Pancreaticoduodenectomy/adverse effects ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology ; Postoperative Complications/therapy ; Risk Factors
    Language English
    Publishing date 2021-12-03
    Publishing country England
    Document type Journal Article ; Review ; Systematic Review
    ZDB-ID 632519-1
    ISSN 1532-2157 ; 0748-7983
    ISSN (online) 1532-2157
    ISSN 0748-7983
    DOI 10.1016/j.ejso.2021.11.136
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1149: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 549: Show issues

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  5. Article ; Online: Somatostatin vs. Octreotide for Prevention of Postoperative Pancreatic Fistula The PREFIPS Randomized Clinical Trial A FRENCH 007 - ACHBT Study.

    Gaujoux, Sébastien / Regimbeau, Jean-Marc / Piessen, Guillaume / Truant, Stéphanie / Foissac, Frantz / Barbier, Louise / Buc, Emmanuel / Adham, Mustapha / Fuks, David / Deguelte, Sophie / Muscari, Fabrice / Sulpice, Laurent / Vaillant, Jean-Christophe / Schwarz, Lilian / Sa Cunha, Antonio / Muzzolini, Milena / Dousset, Bertrand / Sauvanet, Alain

    Annals of surgery

    2024  

    Abstract: Objective: Pharmacological prevention of postoperative pancreatic fistula (POPF) after pancreatectomy is open to debate. The present study compares clinically significant POPF rates in patients randomized between somatostatin versus octreotide as ... ...

    Abstract Objective: Pharmacological prevention of postoperative pancreatic fistula (POPF) after pancreatectomy is open to debate. The present study compares clinically significant POPF rates in patients randomized between somatostatin versus octreotide as prophylactic treatment.
    Patients and methods: Multicentric randomized controlled open study in patient's candidate for pancreaticoduodenectomy (PD) or distal pancreatectomy (DP) comparing somatostatin continuous intravenous infusion for 7 days versus octreotid 100 μg, every 8 hours subcutaneous injection for 7 days, stratified by procedure (PD vs. DP) and size of the main pancreatic duct (>4 mm) on grade B/C POPF rates at 90 days based on an intention-to-treat analysis.
    Results: Of 763 eligible patients, 651 were randomized: 327 in the octreotide arm and 324 in the somatostatin arm, with comparable the stratification criteria - type of surgery and main pancreatic duct dilatation. Most patients had PD (n=480; 73.8%), on soft/normal pancreas (n=367; 63.2%) with a non-dilated main pancreatic duct (n=472; 72.5%), most often for pancreatic adenocarcinoma (n=311; 47.8%). Almost all patients had abdominal drainage (n=621; 96.1%) and 121 (19.5%) left the hospital with the drain in place (median length of stay=16 d). A total of 153 patients (23.5%) developed a grade B/C POPF with no difference between both groups: 24.1%: somatostatin arm and 22.9%: octreotide arm (Chi-2 test, P=0.73, ITT analysis). Absence of statistically significant difference persisted after adjustment for stratification variables and in per-protocol analysis.
    Conclusions: Continuous intravenous somatostatin is not statistically different from subcutaneous octreotide in the prevention of grade B/C POPF after pancreatectomy.
    Language English
    Publishing date 2024-04-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 340-2
    ISSN 1528-1140 ; 0003-4932
    ISSN (online) 1528-1140
    ISSN 0003-4932
    DOI 10.1097/SLA.0000000000006313
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    In stock of ZB MED Cologne/Königswinter

    Uk I Zs.35/1: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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