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Book: Die bedrohte Zukunft

Colborn, Theo / Dumanoski, Dianne / Myers, John Peterson

gefährden wir unsere Fruchtbarkeit und Überlebensfähigkeit?

1996

Title translation	Our stolen future
Author's details	Theo Colborn ; Dianne Dumanoski ; John Peterson Myers
Keywords	Reproduction / drug effects ; Environmental Health ; Environmental Pollution / adverse effects ; Ecology ; Fertilität ; Umweltverschmutzung ; Auswirkung
Subject	Fortwirken ; Nachwirkung ; Folge ; Umweltverunreinigung ; Pollution ; Umweltkontamination ; Fruchtbarkeit
Language	German
Size	398 S. : Ill., Kt.
Publisher	Droemer Knaur
Publishing place	München
Document type	Book
Note	Aus dem Engl. übers.
HBZ-ID	HT007268535
ISBN	3-426-26864-7 ; 978-3-426-26864-3
Database	Catalogue ZB MED Medicine, Health

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Article ; Online: European Medicines Agency Conflicts With the European Food Safety Authority (EFSA) on Bisphenol A Regulation.

Zoeller, R Thomas / Birnbaum, Linda S / Collins, Terrence J / Heindel, Jerrold / Hunt, Patricia A / Iguchi, Taisen / Kortenkamp, Andreas / Myers, John Peterson / Vom Saal, Frederick S / Sonnenschein, Carlos / Soto, Ana M

Journal of the Endocrine Society

2023 Volume 7, Issue 9, Page(s) bvad107

Abstract: The European Food Safety Authority (EFSA) has revised their estimate of the toxicity of bisphenol A (BPA) and, as a result, have recommended reducing the tolerable daily intake (TDI) by 20 000-fold. This would essentially ban the use of BPA in food ... ...

Abstract	The European Food Safety Authority (EFSA) has revised their estimate of the toxicity of bisphenol A (BPA) and, as a result, have recommended reducing the tolerable daily intake (TDI) by 20 000-fold. This would essentially ban the use of BPA in food packaging such as can liners, plastic food containers, and in consumer products. To come to this conclusion, EFSA used a systematic approach according to a pre-established protocol and included all guideline and nonguideline studies in their analysis. They found that Th-17 immune cells increased with very low exposure to BPA and used this endpoint to revise the TDI to be human health protective. A number of regulatory agencies including the European Medicines Agency (EMA) have written formal disagreements with several elements of EFSA's proposal. The European Commission will now decide whether to accept EFSA's recommendation over the objections of EMA. If the Commission accepts EFSA's recommendation, it will be a landmark action using knowledge acquired through independent scientific studies focused on biomarkers of chronic disease to protect human health. The goal of this Perspective is to clearly articulate the monumental nature of this debate and decision and to explain what is at stake. Our perspective is that the weight of evidence clearly supports EFSA's proposal to reduce the TDI by 20 000-fold.
Language	English
Publishing date	2023-08-12
Publishing country	United States
Document type	Journal Article
ISSN	2472-1972
ISSN (online)	2472-1972
DOI	10.1210/jendso/bvad107
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Article ; Online: Systematic evidence on migrating and extractable food contact chemicals: Most chemicals detected in food contact materials are not listed for use

Geueke, Birgit / Groh, Ksenia J. / Maffini, Maricel V. / Martin, Olwenn V. / Boucher, Justin M. / Chiang, Yu-Ting / Gwosdz, Frank / Jieh, Phoenix / Kassotis, Christopher D. / Łańska, Paulina / Myers, John Peterson / Odermatt, Alex / Parkinson, Lindsey V. / Schreier, Verena N. / Srebny, Vanessa / Zimmermann, Lisa / Scheringer, Martin / Muncke, Jane

Critical Reviews in Food Science and Nutrition. 2023 Nov. 6, v. 63, no. 28 p.9425-9435

2023

Abstract: Food packaging is important for today’s globalized food system, but food contact materials (FCMs) can also be a source of hazardous chemicals migrating into foodstuffs. Assessing the impacts of FCMs on human health requires a comprehensive identification ...

Abstract	Food packaging is important for today’s globalized food system, but food contact materials (FCMs) can also be a source of hazardous chemicals migrating into foodstuffs. Assessing the impacts of FCMs on human health requires a comprehensive identification of the chemicals they contain, the food contact chemicals (FCCs). We systematically compiled the “database on migrating and extractable food contact chemicals” (FCCmigex) using information from 1210 studies. We found that to date 2881 FCCs have been detected, in a total of six FCM groups (Plastics, Paper & Board, Metal, Multi-materials, Glass & Ceramic, and Other FCMs). 65% of these detected FCCs were previously not known to be used in FCMs. Conversely, of the more than 12’000 FCCs known to be used, only 1013 are included in the FCCmigex database. Plastic is the most studied FCM with 1975 FCCs detected. Our findings expand the universe of known FCCs to 14,153 chemicals. This knowledge contributes to developing non-hazardous FCMs that lead to safer food and support a circular economy.
Keywords	ceramics ; circular economy ; databases ; food science ; glass ; human health ; nutrition ; paper ; plastics ; Chemical migration ; food contact chemicals ; food contact materials ; food packaging ; systematic evidence map ; database
Language	English
Dates of publication	2023-1106
Size	p. 9425-9435.
Publishing place	Taylor & Francis
Document type	Article ; Online
ZDB-ID	1037504-1
ISSN	1549-7852 ; 1040-8398
ISSN (online)	1549-7852
ISSN	1040-8398
DOI	10.1080/10408398.2022.2067828
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Systematic evidence on migrating and extractable food contact chemicals: Most chemicals detected in food contact materials are not listed for use.

Geueke, Birgit / Groh, Ksenia J / Maffini, Maricel V / Martin, Olwenn V / Boucher, Justin M / Chiang, Yu-Ting / Gwosdz, Frank / Jieh, Phoenix / Kassotis, Christopher D / Łańska, Paulina / Myers, John Peterson / Odermatt, Alex / Parkinson, Lindsey V / Schreier, Verena N / Srebny, Vanessa / Zimmermann, Lisa / Scheringer, Martin / Muncke, Jane

Critical reviews in food science and nutrition

2022 Volume 63, Issue 28, Page(s) 9425–9435

Abstract: Food packaging is important for today's globalized food system, but food contact materials (FCMs) can also be a source of hazardous chemicals migrating into foodstuffs. Assessing the impacts of FCMs on human health requires a comprehensive identification ...

Abstract	Food packaging is important for today's globalized food system, but food contact materials (FCMs) can also be a source of hazardous chemicals migrating into foodstuffs. Assessing the impacts of FCMs on human health requires a comprehensive identification of the chemicals they contain, the food contact chemicals (FCCs). We systematically compiled the "database on migrating and extractable food contact chemicals" (FCCmigex) using information from 1210 studies. We found that to date 2881 FCCs have been detected, in a total of six FCM groups (Plastics, Paper & Board, Metal, Multi-materials, Glass & Ceramic, and Other FCMs). 65% of these detected FCCs were previously not known to be used in FCMs. Conversely, of the more than 12'000 FCCs known to be used, only 1013 are included in the FCCmigex database. Plastic is the most studied FCM with 1975 FCCs detected. Our findings expand the universe of known FCCs to 14,153 chemicals. This knowledge contributes to developing non-hazardous FCMs that lead to safer food and support a circular economy.
MeSH term(s)	Humans ; Food Contamination/analysis ; Food Packaging ; Hazardous Substances/analysis ; Databases, Factual ; Plastics
Chemical Substances	Hazardous Substances ; Plastics
Language	English
Publishing date	2022-05-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	1037504-1
ISSN	1549-7852 ; 1040-8398
ISSN (online)	1549-7852
ISSN	1040-8398
DOI	10.1080/10408398.2022.2067828
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Article ; Online: Environmental exposures and gene regulation in disease etiology.

Edwards, Thea M / Myers, John Peterson

Ciencia & saude coletiva

2008 Volume 13, Issue 1, Page(s) 269–281

Abstract: Health or disease is shaped for all individuals by interactions between their genes and environment. Exactly how the environment changes gene expression and how this can lead to disease are being explored in a fruitful new approach to environmental ... ...

Abstract	Health or disease is shaped for all individuals by interactions between their genes and environment. Exactly how the environment changes gene expression and how this can lead to disease are being explored in a fruitful new approach to environmental health research, representative studies of which are reviewed here. We searched Web of Science and references of relevant publications to understand the diversity of gene regulatory mechanisms affected by environmental exposures with disease implications. Pharmaceuticals, pesticides, air pollutants, industrial chemicals, heavy metals, hormones, nutrition, and behavior can change gene expression through a broad array of gene regulatory mechanisms. Furthermore, chemically induced changes in gene regulation are associated with serious and complex human diseases, including cancer, diabetes and obesity, infertility, respiratory diseases, allergies, and neurodegenerative disorders such as Parkinson and Alzheimer diseases. The reviewed studies indicate that genetic predisposition for disease is best predicted in the context of environmental exposures. And the genetic mechanisms investigated in these studies offer new avenues for risk assessment research. Finally, we are likely to witness dramatic improvements in human health, and reductions in medical costs, if environmental pollution is decreased.
MeSH term(s)	DNA Methylation ; Disease/genetics ; Environmental Exposure/adverse effects ; Gene Expression Regulation ; Humans
Language	English
Publishing date	2008-09-10
Publishing country	Brazil
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2078799-6
ISSN	1678-4561 ; 1413-8123
ISSN (online)	1678-4561
ISSN	1413-8123
DOI	10.1590/s1413-81232008000100030
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Article ; Online: Food packaging and migration of food contact materials: will epidemiologists rise to the neotoxic challenge?

Muncke, Jane / Myers, John Peterson / Scheringer, Martin / Porta, Miquel

Journal of epidemiology and community health

2014 Volume 68, Issue 7, Page(s) 592–594

MeSH term(s)	Epidemiologic Studies ; Epidemiology ; Food Contamination/analysis ; Food Packaging
Language	English
Publishing date	2014-07
Publishing country	England
Document type	Journal Article
ZDB-ID	391868-3
ISSN	1470-2738 ; 0142-467X ; 0141-7681 ; 0143-005X
ISSN (online)	1470-2738
ISSN	0142-467X ; 0141-7681 ; 0143-005X
DOI	10.1136/jech-2013-202593
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Article ; Online: Experimental BPA Exposure and Glucose-Stimulated Insulin Response in Adult Men and Women.

Stahlhut, Richard W / Myers, John Peterson / Taylor, Julia A / Nadal, Angel / Dyer, Jonathan A / Vom Saal, Frederick S

Journal of the Endocrine Society

2018 Volume 2, Issue 10, Page(s) 1173–1187

Abstract: Context: Human cross-sectional and animal studies have shown an association of the chemical bisphenol A (BPA) with insulin resistance, type 2 diabetes, and other metabolic diseases, but no human experimental study has investigated whether BPA alters ... ...

Abstract	Context: Human cross-sectional and animal studies have shown an association of the chemical bisphenol A (BPA) with insulin resistance, type 2 diabetes, and other metabolic diseases, but no human experimental study has investigated whether BPA alters insulin/C-peptide secretion. Design: Men and postmenopausal women (without diabetes) were orally administered either the vehicle or a BPA dose of 50 µg/kg body weight, which has been predicted by US regulators (Food and Drug Administration, Environmental Protection Agency) to be the maximum, safe daily oral BPA dose over the lifetime. Insulin response was assessed in two cross-over experiments using an oral glucose tolerance test (OGTT; experiment 1) and a hyperglycemic (HG) clamp (experiment 2). Main outcomes were the percentage change of BPA session measures relative to those of the control session. Results: Serum bioactive BPA after experimental exposure was at levels detected in human biomonitoring studies. In the OGTT, a strong positive correlation was found between hemoglobin A1c(HbA1c) and the percentage change in the insulinogenic index (Spearman = 0.92), an indicator of early-phase insulin response, and the equivalent C-peptide index (Pearson = 0.97). In the HG clamp study, focusing on the later-phase insulin response to a stable level of glucose, several measures of insulin and C-peptide appeared suppressed during the BPA session relative to the control session; the change in insulin maximum concentration (Cmax) was negatively correlated with HbA1c and the Cmax of bioactive serum BPA. Conclusions: This exploratory study suggests that BPA exposure to a dose considered safe by US regulators may alter glucose-stimulated insulin response in humans.
Language	English
Publishing date	2018-09-12
Publishing country	United States
Document type	Journal Article
ISSN	2472-1972
ISSN (online)	2472-1972
DOI	10.1210/js.2018-00151
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Article: Environmental exposures and gene regulation in disease etiology.

Edwards, Thea M / Myers, John Peterson

Environmental health perspectives

2007 Volume 115, Issue 9, Page(s) 1264–1270

Abstract: Objective: Health or disease is shaped for all individuals by interactions between their genes and environment. Exactly how the environment changes gene expression and how this can lead to disease are being explored in a fruitful new approach to ... ...

Abstract	Objective: Health or disease is shaped for all individuals by interactions between their genes and environment. Exactly how the environment changes gene expression and how this can lead to disease are being explored in a fruitful new approach to environmental health research, representative studies of which are reviewed here. Data sources: We searched Web of Science and references of relevant publications to understand the diversity of gene regulatory mechanisms affected by environmental exposures with disease implications. Data synthesis: Pharmaceuticals, pesticides, air pollutants, industrial chemicals, heavy metals, hormones, nutrition, and behavior can change gene expression through a broad array of gene regulatory mechanisms. Mechanisms include regulation of gene translocation, histone modifications, DNA methylation, DNA repair, transcription, RNA stability, alternative RNA splicing, protein degradation, gene copy number, and transposon activation. Furthermore, chemically induced changes in gene regulation are associated with serious and complex human diseases, including cancer, diabetes and obesity, infertility, respiratory diseases, allergies, and neurodegenerative disorders such as Parkinson and Alzheimer diseases. One of the best-studied areas of gene regulation is epigenetics, especially DNA methylation. Our examples of environmentally induced changes in DNA methylation are presented in the context of early development, when methylation patterns are initially laid down. This approach highlights the potential role for altered DNA methylation in fetal origins of adult disease and inheritance of acquired genetic change. Conclusions: The reviewed studies indicate that genetic predisposition for disease is best predicted in the context of environmental exposures. Second, the genetic mechanisms investigated in these studies offer new avenues for risk assessment research. Finally, we are likely to witness dramatic improvements in human health, and reductions in medical costs, if environmental pollution is decreased.
MeSH term(s)	Animals ; Diabetes Mellitus/etiology ; Drug Resistance ; Environmental Exposure/adverse effects ; Environmental Pollutants/toxicity ; Female ; Gene Expression Regulation ; Genetic Predisposition to Disease ; Humans ; Hypersensitivity/etiology ; Hypersensitivity/immunology ; Lymphoma, Non-Hodgkin/genetics ; Neoplasms/genetics ; Parkinson Disease/etiology ; Pregnancy ; Prenatal Exposure Delayed Effects ; Reproduction/drug effects ; Respiratory Tract Diseases/genetics
Chemical Substances	Environmental Pollutants
Language	English
Publishing date	2007-09
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	195189-0
ISSN	1552-9924 ; 0091-6765 ; 1078-0475
ISSN (online)	1552-9924
ISSN	0091-6765 ; 1078-0475
DOI	10.1289/ehp.9951
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Article ; Online: Good laboratory practices are not synonymous with good scientific practices, accurate reporting, or valid data.

vom Saal, Frederick S / Myers, John Peterson

Environmental health perspectives

2010 Volume 118, Issue 2, Page(s) A60; author reply A61

MeSH term(s)	Animals ; Benzhydryl Compounds ; Clinical Laboratory Techniques/standards ; Guideline Adherence ; Guidelines as Topic ; Male ; Mice ; Organ Size/drug effects ; Phenols/toxicity ; Prostate/drug effects ; Validation Studies as Topic
Chemical Substances	Benzhydryl Compounds ; Phenols ; bisphenol A (MLT3645I99)
Language	English
Publishing date	2010-01-29
Publishing country	United States
Document type	Comment ; Letter
ZDB-ID	195189-0
ISSN	1552-9924 ; 0091-6765 ; 1078-0475
ISSN (online)	1552-9924
ISSN	0091-6765 ; 1078-0475
DOI	10.1289/ehp.0901495
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Article ; Online: Should oral gavage be abandoned in toxicity testing of endocrine disruptors?

Vandenberg, Laura N / Welshons, Wade V / Vom Saal, Frederick S / Toutain, Pierre-Louis / Myers, John Peterson

Environmental health : a global access science source

2014 Volume 13, Issue 1, Page(s) 46

Abstract: For decades, hazard assessments for environmental chemicals have used intra-gastric gavage to assess the effects of 'oral' exposures. It is now widely used--and in some cases required--by US federal agencies to assess potential toxicity of endocrine ... ...

Abstract	For decades, hazard assessments for environmental chemicals have used intra-gastric gavage to assess the effects of 'oral' exposures. It is now widely used--and in some cases required--by US federal agencies to assess potential toxicity of endocrine disrupting chemicals (EDCs). In this review we enumerate several reasons why gavage is not appropriate for the assessment of EDCs using bisphenol A (BPA) as a main example. First, whereas human dietary exposures interact with the oral mucosa, gavage exposures avoid these interactions, leading to dramatic differences in absorption, bioavailability and metabolism with implications for toxicokinetic assumptions and models. Additionally, there are well acknowledged complications associated with gavage, such as perforation of the esophagus that diminish its value in toxicological experiments. Finally, the gavage protocol itself can induce stress responses by the endocrine system and confound the assessment of EDCs. These serious flaws have not been taken into account in interpreting results of EDC research. We propose the exploration of alternatives to mimic human exposures when there are multiple exposure routes/sources and when exposures are chronic. We conclude that gavage may be preferred over other routes for some environmental chemicals in some circumstances, but it does not appropriately model human dietary exposures for many chemicals. Because it avoids exposure pathways, is stressful, and thus interferes with endocrine responses, gavage should be abandoned as the default route of administration for hazard assessments of EDCs.
MeSH term(s)	Administration, Oral ; Animals ; Diet ; Endocrine Disruptors/administration & dosage ; Endocrine Disruptors/pharmacokinetics ; Endocrine Disruptors/toxicity ; Environmental Pollutants/administration & dosage ; Environmental Pollutants/pharmacokinetics ; Environmental Pollutants/toxicity ; Humans ; Stress, Psychological ; Toxicity Tests/methods
Chemical Substances	Endocrine Disruptors ; Environmental Pollutants
Language	English
Publishing date	2014-06-25
Publishing country	England
Document type	Editorial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ISSN	1476-069X
ISSN (online)	1476-069X
DOI	10.1186/1476-069X-13-46
Database	MEDical Literature Analysis and Retrieval System OnLINE

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