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  1. Article ; Online: Retraction: Opposing signaling pathways regulate morphology in response to temperature in the fungal pathogen Histoplasma capsulatum.

    Rodriguez, Lauren / Voorhies, Mark / Gilmore, Sarah / Beyhan, Sinem / Myint, Anthony / Sil, Anita

    PLoS biology

    2023  Volume 21, Issue 3, Page(s) e3002060

    Language English
    Publishing date 2023-03-21
    Publishing country United States
    Document type Retraction of Publication
    ZDB-ID 2126776-5
    ISSN 1545-7885 ; 1544-9173
    ISSN (online) 1545-7885
    ISSN 1544-9173
    DOI 10.1371/journal.pbio.3002060
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  2. Article ; Online: The role of vitamin D in inflammatory bowel disease: a guide for clinical practice.

    Myint, Anthony / Sauk, Jenny S / Limketkai, Berkeley N

    Expert review of gastroenterology & hepatology

    2020  Volume 14, Issue 7, Page(s) 539–552

    Abstract: Introduction: Inflammatory bowel disease (IBD) is a chronic inflammatory condition of the gastrointestinal tract that carries significant morbidity and mortality. Given the need to identify modifiable risk factors to prevent IBD development and to ... ...

    Abstract Introduction: Inflammatory bowel disease (IBD) is a chronic inflammatory condition of the gastrointestinal tract that carries significant morbidity and mortality. Given the need to identify modifiable risk factors to prevent IBD development and to mitigate disease severity, vitamin D has become a major candidate of interest.
    Areas covered: In this review, we discuss the regulatory role played by vitamin D in intestinal immune homeostasis, updates in the recent literature exploring its role in
    Expert opinion: In contrast to findings from earlier studies suggesting a causal role in IBD, recent findings indicate that vitamin D deficiency may be a sequela rather than a cause of IBD. Additionally, clinical trials exploring vitamin D therapy in reducing disease activity remain inconclusive thus far, with the current evidence best supporting a therapeutic role of vitamin D in bone health. Future studies are needed to clarify the role of vitamin D in IBD development and disease activity and to determine its therapeutic potential for IBD disease activity.
    MeSH term(s) Bone and Bones/metabolism ; Disease Progression ; Gastrointestinal Tract/drug effects ; Gastrointestinal Tract/immunology ; Gastrointestinal Tract/metabolism ; Gastrointestinal Tract/physiopathology ; Homeostasis ; Humans ; Inflammatory Bowel Diseases/drug therapy ; Inflammatory Bowel Diseases/etiology ; Inflammatory Bowel Diseases/immunology ; Inflammatory Bowel Diseases/physiopathology ; Vitamin D/metabolism ; Vitamin D/pharmacology ; Vitamin D/physiology ; Vitamin D Deficiency/drug therapy ; Vitamin D Deficiency/immunology ; Vitamin D Deficiency/physiopathology
    Chemical Substances Vitamin D (1406-16-2)
    Language English
    Publishing date 2020-06-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 2481021-6
    ISSN 1747-4132 ; 1747-4124
    ISSN (online) 1747-4132
    ISSN 1747-4124
    DOI 10.1080/17474124.2020.1775580
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  3. Article: Reactivation of Hepatitis B Virus: A Review of Clinical Guidelines.

    Myint, Anthony / Tong, Myron J / Beaven, Simon W

    Clinical liver disease

    2020  Volume 15, Issue 4, Page(s) 162–167

    Abstract: http://aasldpubs.onlinelibrary.wiley.com/hub/journal/10.1002/(ISSN)2046-2484/video/15-4-reading-myint a video presentation of this article https://www.wileyhealthlearning.com/Activity/7088610/disclaimerspopup.aspx questions and earn CME. ...

    Abstract http://aasldpubs.onlinelibrary.wiley.com/hub/journal/10.1002/(ISSN)2046-2484/video/15-4-reading-myint a video presentation of this article https://www.wileyhealthlearning.com/Activity/7088610/disclaimerspopup.aspx questions and earn CME.
    Language English
    Publishing date 2020-05-07
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2657644-2
    ISSN 2046-2484
    ISSN 2046-2484
    DOI 10.1002/cld.883
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  4. Article ; Online: Getting Colorectal Cancer Screening Right: A Teachable Moment.

    Myint, Anthony / Aby, Elizabeth S / May, Folasade

    JAMA internal medicine

    2019  Volume 179, Issue 10, Page(s) 1417–1418

    Language English
    Publishing date 2019-04-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2699338-7
    ISSN 2168-6114 ; 2168-6106
    ISSN (online) 2168-6114
    ISSN 2168-6106
    DOI 10.1001/jamainternmed.2019.3457
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  5. Article ; Online: Race, Ethnicity, and Socioeconomic Status Are Associated With Prolonged Time to Treatment After a Diagnosis of Colorectal Cancer: A Large Population-Based Study.

    Bui, Aileen / Yang, Liu / Myint, Anthony / May, Folasade P

    Gastroenterology

    2020  Volume 160, Issue 4, Page(s) 1394–1396.e3

    MeSH term(s) Adult ; Aged ; Colorectal Neoplasms/diagnosis ; Colorectal Neoplasms/mortality ; Colorectal Neoplasms/therapy ; Cross-Sectional Studies ; Ethnicity/statistics & numerical data ; Female ; Healthcare Disparities/statistics & numerical data ; Humans ; Male ; Middle Aged ; Quality of Life ; Racial Groups/statistics & numerical data ; SEER Program/statistics & numerical data ; Social Class ; Time-to-Treatment/statistics & numerical data ; United States/epidemiology ; Young Adult
    Language English
    Publishing date 2020-10-12
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 80112-4
    ISSN 1528-0012 ; 0016-5085
    ISSN (online) 1528-0012
    ISSN 0016-5085
    DOI 10.1053/j.gastro.2020.10.010
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  6. Article ; Online: Noninvasive Colorectal Cancer Screening Tests Help Close Screening Gaps During Coronavirus Disease 2019 Pandemic.

    Myint, Anthony / Roh, Lily / Yang, Liu / Connolly, Lynn / Esrailian, Eric / May, Folasade P

    Gastroenterology

    2021  Volume 161, Issue 2, Page(s) 712–714.e1

    MeSH term(s) COVID-19/prevention & control ; Colonography, Computed Tomographic/statistics & numerical data ; Colonoscopy/statistics & numerical data ; Colorectal Neoplasms/diagnosis ; Colorectal Neoplasms/prevention & control ; DNA/analysis ; Early Detection of Cancer/methods ; Early Detection of Cancer/statistics & numerical data ; Feces/chemistry ; Humans ; Immunochemistry/statistics & numerical data ; Retrospective Studies ; SARS-CoV-2 ; Sigmoidoscopy/statistics & numerical data
    Chemical Substances DNA (9007-49-2)
    Language English
    Publishing date 2021-04-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80112-4
    ISSN 1528-0012 ; 0016-5085
    ISSN (online) 1528-0012
    ISSN 0016-5085
    DOI 10.1053/j.gastro.2021.04.026
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  7. Article ; Online: Nocturnal Dyspnea as a Result of a Hypopharyngeal Mass.

    Aaron, Ksenia A / Myint, Anthony / Reder, Lindsay S

    JAMA otolaryngology-- head & neck surgery

    2017  Volume 143, Issue 9, Page(s) 948–949

    MeSH term(s) Airway Obstruction/complications ; Airway Obstruction/diagnosis ; Biopsy ; Diagnosis, Differential ; Dyspnea/diagnosis ; Dyspnea/etiology ; Humans ; Hypopharyngeal Neoplasms/complications ; Hypopharyngeal Neoplasms/diagnosis ; Male ; Middle Aged ; Rhabdomyoma/complications ; Rhabdomyoma/diagnosis ; Tomography, X-Ray Computed
    Language English
    Publishing date 2017-07-17
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2701825-8
    ISSN 2168-619X ; 2168-6181
    ISSN (online) 2168-619X
    ISSN 2168-6181
    DOI 10.1001/jamaoto.2016.4737
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  8. Article ; Online: Pneumococcal Vaccination Recommendation and Completion Rates Among Patients With Inflammatory Bowel Disease and Barriers to Vaccination.

    Dasharathy, Sonya S / May, Folasade P / Myint, Anthony / Yang, Liu / Rahal, Harman K / Cusumano, Vivy / Kozan, Philip A / Lowe, Sarina C / Beah, Peter Y / Limketkai, Berkeley N / Sauk, Jenny S

    Journal of clinical gastroenterology

    2023  Volume 57, Issue 10, Page(s) 1031–1037

    Abstract: Background: Guidelines for inflammatory bowel disease (IBD) patients receiving immunosuppression encouraged both the pneumococcal polysaccharide vaccine (PPSV23) and the pneumococcal conjugate vaccine (PCV13). We aimed to evaluate which pneumococcal ... ...

    Abstract Background: Guidelines for inflammatory bowel disease (IBD) patients receiving immunosuppression encouraged both the pneumococcal polysaccharide vaccine (PPSV23) and the pneumococcal conjugate vaccine (PCV13). We aimed to evaluate which pneumococcal vaccines are recommended and administered, and to understand provider and IBD patient knowledge regarding pneumococcal vaccinations.
    Methods: We performed a retrospective, cross-sectional analysis of 357 adult IBD patients on immunosuppression in our health care system. Patient demographics and clinical characteristics were collected. The primary outcome was rate of documented vaccinations recommended by providers; the secondary outcome was rate of receipt of the vaccines. We identified factors associated with receipt of any pneumococcal vaccine through multivariable logistic regression. We also performed provider and IBD patient surveys to understand provider and patient knowledge regarding pneumococcal vaccines. We used χ 2 and Fisher exact tests to assess survey responses.
    Results: Fifty seven percent of IBD patients had any pneumococcal vaccination recommended and 35% had recommendations for both PPSV23 and PCV13. Forty percent received any pneumococcal vaccine and 18% received both vaccines. In multivariable analyses, increasing age (adjusted odds ratio: 1.03, 95% CI: 1.01-1.05) was associated with receipt of any pneumococcal vaccine, after adjusting for gender, race, insurance, disease activity, and time seen in our gastroenterology clinics. In the survey study, on average, 59% of providers correctly answered questions regarding pneumococcal vaccination indications.
    Conclusion: In our health care system, while recommendation for any pneumococcal vaccination was >50%, receipt of both PPSV23 and PCV13 was low. Simplified vaccine regimens (ie, PCV20) will likely improve vaccination rates.
    MeSH term(s) Adult ; Humans ; Retrospective Studies ; Cross-Sectional Studies ; Vaccination ; Pneumococcal Vaccines ; Inflammatory Bowel Diseases
    Chemical Substances Pneumococcal Vaccines
    Language English
    Publishing date 2023-01-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 448460-5
    ISSN 1539-2031 ; 0192-0790
    ISSN (online) 1539-2031
    ISSN 0192-0790
    DOI 10.1097/MCG.0000000000001783
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  9. Article ; Online: Opposing signaling pathways regulate morphology in response to temperature in the fungal pathogen Histoplasma capsulatum.

    Rodriguez, Lauren / Voorhies, Mark / Gilmore, Sarah / Beyhan, Sinem / Myint, Anthony / Sil, Anita

    publication RETRACTED

    PLoS biology

    2019  Volume 17, Issue 9, Page(s) e3000168

    Abstract: Phenotypic switching between 2 opposing cellular states is a fundamental aspect of biology, and fungi provide facile systems to analyze the interactions between regulons that control this type of switch. A long-standing mystery in fungal pathogens of ... ...

    Abstract Phenotypic switching between 2 opposing cellular states is a fundamental aspect of biology, and fungi provide facile systems to analyze the interactions between regulons that control this type of switch. A long-standing mystery in fungal pathogens of humans is how thermally dimorphic fungi switch their developmental form in response to temperature. These fungi, including the subject of this study, Histoplasma capsulatum, are temperature-responsive organisms that utilize unknown regulatory pathways to couple their cell shape and associated attributes to the temperature of their environment. H. capsulatum grows as a multicellular hypha in the soil that switches to a pathogenic yeast form in response to the temperature of a mammalian host. These states can be triggered in the laboratory simply by growing the fungus either at room temperature (RT; which promotes hyphal growth) or at 37 °C (which promotes yeast-phase growth). Prior worked revealed that 15% to 20% of transcripts are differentially expressed in response to temperature, but it is unclear which transcripts are linked to specific phenotypic changes, such as cell morphology or virulence. To elucidate temperature-responsive regulons, we previously identified 4 transcription factors (required for yeast-phase growth [Ryp]1-4) that are required for yeast-phase growth at 37 °C; in each ryp mutant, the fungus grows constitutively as hyphae regardless of temperature, and the cells fail to express genes that are normally induced in response to growth at 37 °C. Here, we perform the first genetic screen to identify genes required for hyphal growth of H. capsulatum at RT and find that disruption of the signaling mucin MSB2 results in a yeast-locked phenotype. RNA sequencing (RNAseq) experiments reveal that MSB2 is not required for the majority of gene expression changes that occur when cells are shifted to RT. However, a small subset of temperature-responsive genes is dependent on MSB2 for its expression, thereby implicating these genes in the process of filamentation. Disruption or knockdown of an Msb2-dependent mitogen-activated protein (MAP) kinase (HOG2) and an APSES transcription factor (STU1) prevents hyphal growth at RT, validating that the Msb2 regulon contains genes that control filamentation. Notably, the Msb2 regulon shows conserved hyphal-specific expression in other dimorphic fungi, suggesting that this work defines a small set of genes that are likely to be conserved regulators and effectors of filamentation in multiple fungi. In contrast, a few yeast-specific transcripts, including virulence factors that are normally expressed only at 37 °C, are inappropriately expressed at RT in the msb2 mutant, suggesting that expression of these genes is coupled to growth in the yeast form rather than to temperature. Finally, we find that the yeast-promoting transcription factor Ryp3 associates with the MSB2 promoter and inhibits MSB2 transcript expression at 37 °C, whereas Msb2 inhibits accumulation of Ryp transcripts and proteins at RT. These findings indicate that the Ryp and Msb2 circuits antagonize each other in a temperature-dependent manner, thereby allowing temperature to govern cell shape and gene expression in this ubiquitous fungal pathogen of humans.
    MeSH term(s) Fungal Proteins/metabolism ; Gene Expression Profiling ; Gene Expression Regulation, Fungal ; Genes, Fungal ; Histoplasma/cytology ; Histoplasma/physiology ; Hyphae/growth & development ; Mitogen-Activated Protein Kinases/metabolism ; Mucins/genetics ; Mucins/metabolism ; Signal Transduction ; Temperature
    Chemical Substances Fungal Proteins ; Mucins ; Mitogen-Activated Protein Kinases (EC 2.7.11.24)
    Language English
    Publishing date 2019-09-30
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Retracted Publication
    ZDB-ID 2126776-5
    ISSN 1545-7885 ; 1544-9173
    ISSN (online) 1545-7885
    ISSN 1544-9173
    DOI 10.1371/journal.pbio.3000168
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  10. Article ; Online: Leveraging Electronic Health Records to Measure Low-Value Screening Colonoscopy.

    Soroudi, Camille / Mafi, John / Myint, Anthony / Gardner, Juliana / Kahlon, Sartajdeep / Mongare, Margaret / Yang, Liu / Tseng, Chi-Hong / Reynolds, Courtney / Nair, Vishnu / Villaflores, Chad / Cates, Reinalyn / Gupta, Reshma / Sarkisian, Catherine / May, Folasade P

    The American journal of medicine

    2022  Volume 135, Issue 6, Page(s) 715–720.e2

    MeSH term(s) Colonoscopy ; Colorectal Neoplasms/diagnosis ; Early Detection of Cancer ; Electronic Health Records ; Humans ; Mass Screening
    Language English
    Publishing date 2022-02-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80015-6
    ISSN 1555-7162 ; 1873-2178 ; 0002-9343 ; 1548-2766
    ISSN (online) 1555-7162 ; 1873-2178
    ISSN 0002-9343 ; 1548-2766
    DOI 10.1016/j.amjmed.2021.12.008
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