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  1. Article ; Online: Precapillary Pulmonary Arterial Hypertension Despite Contrary Anchoring Bias.

    Keller, Patrick / Shah, Nilay S / Sweis, Ranya / Mylvaganam, Ruben J

    JACC. Case reports

    2023  Volume 22, Page(s) 101977

    Abstract: We present the case of a patient with risk factors and a noninvasive evaluation that suggested postcapillary pulmonary hypertension, but in fact had invasive hemodynamics consistent with precapillary pulmonary hypertension. A thorough hemodynamic ... ...

    Abstract We present the case of a patient with risk factors and a noninvasive evaluation that suggested postcapillary pulmonary hypertension, but in fact had invasive hemodynamics consistent with precapillary pulmonary hypertension. A thorough hemodynamic evaluation of pulmonary hypertension must be performed, as treatment is linked to the underlying physiology. (
    Language English
    Publishing date 2023-08-10
    Publishing country Netherlands
    Document type Case Reports
    ISSN 2666-0849
    ISSN (online) 2666-0849
    DOI 10.1016/j.jaccas.2023.101977
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Revisiting Old Friends: Adjunctive Therapies in Acute Respiratory Distress Syndrome.

    Gao, Catherine A / Mylvaganam, Ruben J / Poor, Taylor A / Walter, James M

    American journal of respiratory and critical care medicine

    2022  Volume 204, Issue 4, Page(s) 473–475

    MeSH term(s) Combined Modality Therapy ; Friends ; Humans ; Respiration, Artificial ; Respiratory Distress Syndrome/drug therapy
    Language English
    Publishing date 2022-02-01
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202009-3722RR
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uh II Zs.80: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Recovering from a pandemic: pulmonary fibrosis after SARS-CoV-2 infection.

    Mylvaganam, Ruben J / Bailey, Joseph I / Sznajder, Jacob I / Sala, Marc A

    European respiratory review : an official journal of the European Respiratory Society

    2021  Volume 30, Issue 162

    Abstract: Acute manifestations of SARS-CoV-2 infection continue to impact the lives of many across the world. Post-acute sequelae of coronavirus disease 2019 (COVID-19) may affect 10-30% of survivors of COVID-19, and post-acute sequelae of COVID-19 (PASC)- ... ...

    Abstract Acute manifestations of SARS-CoV-2 infection continue to impact the lives of many across the world. Post-acute sequelae of coronavirus disease 2019 (COVID-19) may affect 10-30% of survivors of COVID-19, and post-acute sequelae of COVID-19 (PASC)-pulmonary fibrosis is a long-term outcome associated with major morbidity. Data from prior coronavirus outbreaks (severe acute respiratory syndrome and Middle East respiratory syndrome) suggest that pulmonary fibrosis will contribute to long-term respiratory morbidity, suggesting that PASC-pulmonary fibrosis should be thoroughly screened for through pulmonary function testing and cross-sectional imaging. As data accumulates on the unique pathobiologic mechanisms underlying critical COVID-19, a focus on corollaries to the subacute and chronic profibrotic phenotype must be sought as well. Key aspects of acute COVID-19 pathobiology that may account for increased rates of pulmonary fibrosis include monocyte/macrophage-T-cell circuits, profibrotic RNA transcriptomics, protracted elevated levels of inflammatory cytokines, and duration of illness and ventilation. Mechanistic understanding of PASC-pulmonary fibrosis will be central in determining therapeutic options and will ultimately play a role in transplant considerations. Well-designed cohort studies and prospective clinical registries are needed. Clinicians, researchers and healthcare systems must actively address this complication of PASC to minimise disability, maximise quality of life and confront a post-COVID-19 global health crisis.
    MeSH term(s) COVID-19 ; Humans ; Pandemics ; Prospective Studies ; Pulmonary Fibrosis/diagnosis ; Pulmonary Fibrosis/epidemiology ; Quality of Life ; SARS-CoV-2
    Language English
    Publishing date 2021-12-15
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1077620-5
    ISSN 1600-0617 ; 0905-9180
    ISSN (online) 1600-0617
    ISSN 0905-9180
    DOI 10.1183/16000617.0194-2021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3265: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Timing of Intubation in Coronavirus Disease 2019: A Study of Ventilator Mechanics, Imaging, Findings, and Outcomes.

    Bavishi, Avni A / Mylvaganam, Ruben J / Agarwal, Rishi / Avery, Ryan J / Cuttica, Michael J

    Critical care explorations

    2021  Volume 3, Issue 5, Page(s) e0415

    Abstract: Objectives: Determine the variation in outcomes and respiratory mechanics between the subjects who are intubated earlier versus later in their coronavirus disease 2019 course.: Design: Retrospective cohort study.: Setting: Northwestern Memorial ... ...

    Abstract Objectives: Determine the variation in outcomes and respiratory mechanics between the subjects who are intubated earlier versus later in their coronavirus disease 2019 course.
    Design: Retrospective cohort study.
    Setting: Northwestern Memorial Hospital ICUs.
    Patients: All patients intubated for coronavirus disease 2019 between March 2020 and June 2020.
    Interventions: Patients were stratified by time to intubation: 30 subjects were intubated 4-24 hours after presentation and 24 subjects were intubated 5-10 days after presentation. Baseline characteristics, hospitalization, ventilator mechanics, and outcomes were extracted and analyzed. Ten clinically available CT scans were manually reviewed to identify evidence of pulmonary vascular thrombosis and intussusceptive angiogenesis.
    Measurements and main results: Median time from symptom onset to intubation was significantly different between the early and late intubation cohorts, with the latter being intubated later in the course of their illness (7.9 vs 11.8 d;
    Conclusions: The question as to whether delaying intubation is beneficial or harmful for patients with coronavirus disease 2019-induced hypoxemic respiratory failure has yet to be answered. As our approaches to coronavirus disease 2019 continue to evolve, the decision of timing of intubation remains paramount. Although noninvasive ventilation may allow for delaying intubation, it is possible that there are downstream effects of delayed intubation that should be considered, including the potential for pulmonary vascular thrombosis and intussusceptive angiogenesis with delayed intubation.
    Language English
    Publishing date 2021-05-12
    Publishing country United States
    Document type Journal Article
    ISSN 2639-8028
    ISSN (online) 2639-8028
    DOI 10.1097/CCE.0000000000000415
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Major Publications in the Critical Care Pharmacotherapy Literature: 2020.

    Bissell, Brittany D / Campbell, Jeannee / Collins, Reagan / Cook, Charles / Desai, Dharati / DeWitt, Jessica / Eche, Ifeoma Mary / Eche, Ijeoma Julie / Elsamadisi, Pansy / Juul, Janelle / Kim, Soyoung / Makowski, Courtney T / Mylvaganam, Ruben J / Smith, Adam / Stancati, Jennifer / Stonesifer, Katherine / Tawil, Justin / Smith Condeni, Melanie

    Critical care explorations

    2021  Volume 3, Issue 12, Page(s) e0590

    Abstract: Objectives: To summarize selected meta-analyses and trials related to critical care pharmacotherapy published in 2020.: Data sources: The Clinical Pharmacy and Pharmacology Pharmacotherapy Literature Update group screened 36 journals monthly for ... ...

    Abstract Objectives: To summarize selected meta-analyses and trials related to critical care pharmacotherapy published in 2020.
    Data sources: The Clinical Pharmacy and Pharmacology Pharmacotherapy Literature Update group screened 36 journals monthly for impactful publications.
    Study selection: The group reviewed a total of 119 articles during 2020 according to relevance for practice.
    Data extraction: Articles were selected with consensus and importance to clinical practice from those included in the monthly Clinical Pharmacy and Pharmacology Pharmacotherapy Literature Update. The group reviewed articles according to Grading of Recommendations, Assessment, Development, and Evaluations criteria. Articles with a 1A grade were selected.
    Data synthesis: Several trials were summarized, including two meta-analyses and five original research trials. Original research trials evaluating vitamin C, hydrocortisone, and thiamine versus hydrocortisone in sepsis, the use of nonsedation strategies, dexmedetomidine in cardiac surgery, remdesivir for severe acute respiratory syndrome coronavirus 2, and thrombectomy in acute ischemic stroke. Two meta-analyses determining the impact of norepinephrine initiation in patients with septic shock and the use of corticosteroids in severe acute respiratory syndrome coronavirus 2 was included.
    Conclusions: This clinical review provides summary and perspectives of clinical practice impact on influential critical care pharmacotherapy publications in 2020.
    Language English
    Publishing date 2021-12-09
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2639-8028
    ISSN (online) 2639-8028
    DOI 10.1097/CCE.0000000000000590
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Expansion of profibrotic monocyte-derived alveolar macrophages in patients with persistent respiratory symptoms and radiographic abnormalities after COVID-19

    Bailey, Joseph I. / Puritz, Connor H. / Senkow, Karolina J. / Markov, Nikolay S. / Diaz, Estefani / Jonasson, Emmy / Yu, Zhan / Swaminathan, Suchitra / Lu, Ziyan / Fenske, Samuel / Grant, Rogan A. / Abdala-Valencia, Hiam / Mylvaganam, Ruben J. / Miller, Janet / Cumming, R. Ian / Tighe, Robert M. / Gowdy, Kymberly M. / Kalhan, Ravi / Jain, Manu /
    Bharat, Ankit / Kurihara, Chitaru / San Jose Estepar, Ruben / San Jose Estepar, Raul / Washko, George R. / Shilatifard, Ali / Sznajder, Jacob I. / Ridge, Karen M. / Budinger, GR Scott / Braun, Rosemary / Misharin, Alexander V. / Sala, Marc A.

    bioRxiv

    Abstract: As many as 10-30% of the over 760 million survivors of COVID-19 develop persistent symptoms, of which respiratory symptoms are among the most common. To understand the cellular and molecular basis for respiratory PASC, we combined a machine learning- ... ...

    Abstract As many as 10-30% of the over 760 million survivors of COVID-19 develop persistent symptoms, of which respiratory symptoms are among the most common. To understand the cellular and molecular basis for respiratory PASC, we combined a machine learning-based analysis of lung computed tomography (CT) with flow cytometry, single-cell RNA-sequencing analysis of bronchoalveolar lavage fluid and nasal curettage samples, and alveolar cytokine profiling in a cohort of thirty-five patients with respiratory symptoms and radiographic abnormalities more than 90 days after infection with COVID-19. CT images from patients with PASC revealed abnormalities involving 73% of the lung, which improved on subsequent imaging. Interstitial abnormalities suggestive of fibrosis on CT were associated with the increased numbers of neutrophils and presence of profibrotic monocyte-derived alveolar macrophages in BAL fluid, reflecting unresolved epithelial injury. Persistent infection with SARS-CoV-2 was identified in six patients and secondary bacterial or viral infections in two others. These findings suggest that despite its heterogenous clinical presentations, respiratory PASC with radiographic abnormalities results from a common pathobiology characterized by the ongoing recruitment of neutrophils and profibrotic monocyte-derived alveolar macrophages driving lung fibrosis with implications for diagnosis and therapy.
    Keywords covid19
    Language English
    Publishing date 2023-07-31
    Publisher Cold Spring Harbor Laboratory
    Document type Article ; Online
    DOI 10.1101/2023.07.30.551145
    Database COVID19

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