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  1. Article ; Online: Short report

    Chen Makranz / Asael Lubotzky / Hai Zemmour / Ruth Shemer / Benjamin Glaser / Jonathan Cohen / Myriam Maoz / Eli Sapir / Marc Wygoda / Tamar Peretz / Noam Weizman / Jon Feldman / Ross A. Abrams / Alexander Lossos / Yuval Dor / Aviad Zick

    PLoS ONE, Vol 18, Iss

    Plasma based biomarkers detect radiation induced brain injury in cancer patients treated for brain metastasis: A pilot study

    2023  Volume 11

    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: The Role of Methionine Aminopeptidase 2 in Lymphangiogenesis

    Rawnaq Esa / Eliana Steinberg / Dvir Dror / Ouri Schwob / Mehrdad Khajavi / Myriam Maoz / Yael Kinarty / Adi Inbal / Aviad Zick / Ofra Benny

    International Journal of Molecular Sciences, Vol 21, Iss 5148, p

    2020  Volume 5148

    Abstract: During the metastasis process, tumor cells invade the blood circulatory system directly from venous capillaries or indirectly via lymphatic vessels. Understanding the relative contribution of each pathway and identifying the molecular targets that affect ...

    Abstract During the metastasis process, tumor cells invade the blood circulatory system directly from venous capillaries or indirectly via lymphatic vessels. Understanding the relative contribution of each pathway and identifying the molecular targets that affect both processes is critical for reducing cancer spread. Methionine aminopeptidase 2 (MetAp2) is an intracellular enzyme known to modulate angiogenesis. In this study, we investigated the additional role of MetAp2 in lymphangiogenesis. A histological staining of tumors from human breast-cancer donors was performed in order to detect the level and the localization of MetAp2 and lymphatic capillaries. The basal enzymatic level and activity in vascular and lymphatic endothelial cells were compared, followed by loss of function studies determining the role of MetAp2 in lymphangiogenesis in vitro and in vivo. The results from the histological analyses of the tumor tissues revealed a high MetAp2 expression, with detectable sites of co-localization with lymphatic capillaries. We showed slightly reduced levels of the MetAp2 enzyme and MetAp2 mRNA expression and activity in primary lymphatic cells when compared to the vascular endothelial cells. The genetic and biochemical manipulation of MetAp2 confirmed the dual activity of the enzyme in both vascular and lymphatic remodulation in cell function assays and in a zebrafish model. We found that cancer-related lymphangiogenesis is inhibited in murine models following MetAp2 inhibition treatment. Taken together, our study provides an indication that MetAp2 is a significant contributor to lymphangiogenesis and carries a dual role in both vascular and lymphatic capillary formation. Our data suggests that MetAp2 inhibitors can be effectively used as anti-metastatic broad-spectrum drugs.
    Keywords MetAp2 ; angiogenesis ; lymphangiogenesis ; metastasis ; cancer ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 570
    Language English
    Publishing date 2020-07-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Author Correction

    Myriam Maoz / Michal Devir / Michal Inbar / Ziva Inbar-Daniel / Dana Sherill-Rofe / Idit Bloch / Karen Meir / David Edelman / Salah Azzam / Hovav Nechushtan / Ofra Maimon / Beatrice Uziely / Luna Kadouri / Amir Sonnenblick / Amir Eden / Tamar Peretz / Aviad Zick

    Scientific Reports, Vol 10, Iss 1, Pp 1-

    Clinical Implications of Sub-grouping HER2 Positive Tumors by Amplicon Structure and Co-amplified Genes

    2020  Volume 1

    Abstract: An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    Abstract An amendment to this paper has been published and can be accessed via a link at the top of the paper.
    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2020-02-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: G Protein-Coupled Receptors in Cancer

    Rachel Bar-Shavit / Myriam Maoz / Arun Kancharla / Jeetendra Kumar Nag / Daniel Agranovich / Sorina Grisaru-Granovsky / Beatrice Uziely

    International Journal of Molecular Sciences, Vol 17, Iss 8, p

    2016  Volume 1320

    Abstract: Despite the fact that G protein-coupled receptors (GPCRs) are the largest signal-conveying receptor family and mediate many physiological processes, their role in tumor biology is underappreciated. Numerous lines of evidence now associate GPCRs and their ...

    Abstract Despite the fact that G protein-coupled receptors (GPCRs) are the largest signal-conveying receptor family and mediate many physiological processes, their role in tumor biology is underappreciated. Numerous lines of evidence now associate GPCRs and their downstream signaling targets in cancer growth and development. Indeed, GPCRs control many features of tumorigenesis, including immune cell-mediated functions, proliferation, invasion and survival at the secondary site. Technological advances have further substantiated GPCR modifications in human tumors. Among these are point mutations, gene overexpression, GPCR silencing by promoter methylation and the number of gene copies. At this point, it is imperative to elucidate specific signaling pathways of “cancer driver” GPCRs. Emerging data on GPCR biology point to functional selectivity and “biased agonism”; hence, there is a diminishing enthusiasm for the concept of “one drug per GPCR target” and increasing interest in the identification of several drug options. Therefore, determining the appropriate context-dependent conformation of a functional GPCR as well as the contribution of GPCR alterations to cancer development remain significant challenges for the discovery of dominant cancer genes and the development of targeted therapeutics.
    Keywords G protein-coupled receptors (GPCRs) ; protease ; protease-activated receptor ; protease-activated receptors (PARs) ; PH-domain ; oncogenes ; cancer ; LPA(1-6) ; CXCR4 ; Wnt/β-catenin ; Hippo/YAP ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 572
    Language English
    Publishing date 2016-08-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Clinical Implications of Sub-grouping HER2 Positive Tumors by Amplicon Structure and Co-amplified Genes

    Myriam Maoz / Michal Devir / Michal Inbar / Ziva Inbar-Daniel / Dana Sherill-Rofe / Idit Bloch / Karen Meir / David Edelman / Salah Azzam / Hovav Nechushtan / Ofra Maimon / Beatrice Uziely / Luna Kadouri / Amir Sonnenblick / Amir Eden / Tamar Peretz / Aviad Zick

    Scientific Reports, Vol 9, Iss 1, Pp 1-

    2019  Volume 15

    Abstract: Abstract ERBB2 amplification is a prognostic marker for aggressive tumors and a predictive marker for prolonged survival following treatment with HER2 inhibitors. We attempt to sub-group HER2+ tumors based on amplicon structures and co-amplified genes. ... ...

    Abstract Abstract ERBB2 amplification is a prognostic marker for aggressive tumors and a predictive marker for prolonged survival following treatment with HER2 inhibitors. We attempt to sub-group HER2+ tumors based on amplicon structures and co-amplified genes. We examined five HER2+ cell lines, three HER2+ xenographs and 57 HER2+ tumor tissues. ERBB2 amplification was analyzed using digital droplet PCR and low coverage whole genome sequencing. In some HER2+ tumors PPM1D, that encodes WIP1, is co-amplified. Cell lines were treated with HER2 and WIP1 inhibitors. We find that inverted duplication is the amplicon structure in the majority of HER2+ tumors. In patients suffering from an early stage disease the ERBB2 amplicon is composed of a single segment while in patients suffering from advanced cancer the amplicon is composed of several different segments. We find robust WIP1 inhibition in some HER2+ PPM1D amplified cell lines. Sub-grouping HER2+ tumors using low coverage whole genome sequencing identifies inverted duplications as the main amplicon structure and based on the number of segments, differentiates between local and advanced tumors. In addition, we found that we could determine if a tumor is a recurrent tumor or second primary tumor and identify co-amplified oncogenes that may serve as targets for therapy.
    Keywords Medicine ; R ; Science ; Q
    Subject code 616
    Language English
    Publishing date 2019-12-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: PAR Genes

    Rachel Bar-Shavit / Bella Maly / Irit Cohen / Myriam Maoz / Hagit Turm / Beatrice Uziely

    Pathology Research International, Vol

    Molecular Probes to Pathological Assessment in Breast Cancer Progression

    2011  Volume 2011

    Keywords Pathology ; RB1-214 ; Medicine ; R ; DOAJ:Pathology ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Language English
    Publishing date 2011-01-01T00:00:00Z
    Publisher Hindawi Publishing Corporation
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Comprehensive human cell-type methylation atlas reveals origins of circulating cell-free DNA in health and disease

    Joshua Moss / Judith Magenheim / Daniel Neiman / Hai Zemmour / Netanel Loyfer / Amit Korach / Yaacov Samet / Myriam Maoz / Henrik Druid / Peter Arner / Keng-Yeh Fu / Endre Kiss / Kirsty L. Spalding / Giora Landesberg / Aviad Zick / Albert Grinshpun / A. M. James Shapiro / Markus Grompe / Avigail Dreazan Wittenberg /
    Benjamin Glaser / Ruth Shemer / Tommy Kaplan / Yuval Dor

    Nature Communications, Vol 9, Iss 1, Pp 1-

    2018  Volume 12

    Abstract: The methylation status of circulating cell-free DNA (cfDNA) can be informative about recent cell death events. Here the authors present an approach to determine the tissue origins of cfDNA, using a reference methylation atlas of 25 human tissues and cell ...

    Abstract The methylation status of circulating cell-free DNA (cfDNA) can be informative about recent cell death events. Here the authors present an approach to determine the tissue origins of cfDNA, using a reference methylation atlas of 25 human tissues and cell types, and find that cfDNA from patients reveals tissue contributions that agree with clinical findings.
    Keywords Science ; Q
    Language English
    Publishing date 2018-11-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Comprehensive human cell-type methylation atlas reveals origins of circulating cell-free DNA in health and disease

    Joshua Moss / Judith Magenheim / Daniel Neiman / Hai Zemmour / Netanel Loyfer / Amit Korach / Yaacov Samet / Myriam Maoz / Henrik Druid / Peter Arner / Keng-Yeh Fu / Endre Kiss / Kirsty L. Spalding / Giora Landesberg / Aviad Zick / Albert Grinshpun / A. M. James Shapiro / Markus Grompe / Avigail Dreazan Wittenberg /
    Benjamin Glaser / Ruth Shemer / Tommy Kaplan / Yuval Dor

    Nature Communications, Vol 9, Iss 1, Pp 1-

    2018  Volume 12

    Abstract: The methylation status of circulating cell-free DNA (cfDNA) can be informative about recent cell death events. Here the authors present an approach to determine the tissue origins of cfDNA, using a reference methylation atlas of 25 human tissues and cell ...

    Abstract The methylation status of circulating cell-free DNA (cfDNA) can be informative about recent cell death events. Here the authors present an approach to determine the tissue origins of cfDNA, using a reference methylation atlas of 25 human tissues and cell types, and find that cfDNA from patients reveals tissue contributions that agree with clinical findings.
    Keywords Science ; Q
    Language English
    Publishing date 2018-11-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Correction

    Irit Cohen / Myriam Maoz / Hagit Turm / Sorina Grisaru-Granovsky / Bella Maly / Beatrice Uziely / Einat Weiss / Rinat Abramovitch / Eithan Gross / Oded Barzilay / Yun Qiu / Rachel Bar-Shavit

    PLoS ONE, Vol 5, Iss

    Etk/Bmx Regulates Proteinase-Activated-Receptor1 (PAR1) in Breast Cancer Invasion: Signaling Partners, Hierarchy and Physiological Significance.

    2010  Volume 12

    Keywords Medicine ; R ; Science ; Q
    Language English
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Correction

    Irit Cohen / Myriam Maoz / Hagit Turm / Sorina Grisaru-Granovsky / Bella Maly / Beatrice Uziely / Einat Weiss / Rinat Abramovitch / Eithan Gross / Oded Barzilay / Yun Qiu / Rachel Bar-Shavit

    PLoS ONE, Vol 5, Iss

    Etk/Bmx Regulates Proteinase-Activated-Receptor1 (PAR1) in Breast Cancer Invasion: Signaling Partners, Hierarchy and Physiological Significance

    2010  Volume 12

    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2010-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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