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  1. Article ; Online: Editorial Comment.

    Mysorekar, Indira U

    The Journal of urology

    2023  Volume 209, Issue 5, Page(s) 949

    Language English
    Publishing date 2023-02-23
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 3176-8
    ISSN 1527-3792 ; 0022-5347
    ISSN (online) 1527-3792
    ISSN 0022-5347
    DOI 10.1097/JU.0000000000003189.01
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Killing the Pathogen and Sparing the Placenta.

    Mysorekar, Indira U

    The New England journal of medicine

    2020  Volume 383, Issue 21, Page(s) 2080–2082

    MeSH term(s) Bacteria ; Female ; Humans ; Killer Cells, Natural ; Placenta ; Placenta Accreta ; Pregnancy ; Trophoblasts
    Language English
    Publishing date 2020-12-16
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMcibr2028357
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Zika Virus Takes a Transplacental Route to Infect Fetuses: Insights from an Animal Model.

    Mysorekar, Indira U

    Missouri medicine

    2018  Volume 114, Issue 3, Page(s) 168–170

    Abstract: Zika virus (ZIKV) has been linked to intrauterine growth restriction (IUGR), spontaneous miscarriage, and microcephaly in infants of women infected during pregnancy. To determine how ZIKV affects the fetus, we infected pregnant mice subcutaneously ( ... ...

    Abstract Zika virus (ZIKV) has been linked to intrauterine growth restriction (IUGR), spontaneous miscarriage, and microcephaly in infants of women infected during pregnancy. To determine how ZIKV affects the fetus, we infected pregnant mice subcutaneously (mimicking a mosquito bite) with ZIKV. Multiple techniques revealed that ZIKV replicated within placental trophoblasts, fetal endothelial cells, and the fetal neocortex. We also noted severe placental defects, IUGR, and fetal death. Thus, our mouse model recapitulated ZIKV infection in human pregnancy and demonstrated that ZIKV can be transmitted from mother to fetus via the placenta.
    MeSH term(s) Abortion, Spontaneous/epidemiology ; Abortion, Spontaneous/virology ; Animals ; Female ; Fetal Death/etiology ; Fetal Growth Retardation/epidemiology ; Fetal Growth Retardation/virology ; Fetus ; Humans ; Infectious Disease Transmission, Vertical/prevention & control ; Mice ; Microcephaly/epidemiology ; Microcephaly/virology ; Models, Animal ; Placenta/virology ; Pregnancy ; Pregnancy Complications, Infectious/epidemiology ; Trophoblasts/virology ; World Health Organization/organization & administration ; Zika Virus/genetics ; Zika Virus/isolation & purification ; Zika Virus Infection/complications ; Zika Virus Infection/transmission
    Language English
    Publishing date 2018-09-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 427362-x
    ISSN 0026-6620
    ISSN 0026-6620
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Golden Syrian Hamsters as a Model for Revisiting the Role of Biological Sex Differences in SARS-CoV-2 Infection.

    Michita, Rafael Tomoya / Mysorekar, Indira U

    mBio

    2021  Volume 12, Issue 6, Page(s) e0184821

    Abstract: There is growing evidence that coronavirus disease 2019 (COVID-19) affects males more severely than females, including compelling evidence indicating that biological sex is an important clinical factor influencing disease pathology and outcomes. In their ...

    Abstract There is growing evidence that coronavirus disease 2019 (COVID-19) affects males more severely than females, including compelling evidence indicating that biological sex is an important clinical factor influencing disease pathology and outcomes. In their recent article in
    MeSH term(s) Animals ; Antibodies, Viral/blood ; COVID-19/immunology ; COVID-19/physiopathology ; Cricetinae ; Disease Models, Animal ; Female ; Lung/pathology ; Male ; Mesocricetus ; SARS-CoV-2/immunology ; SARS-CoV-2/pathogenicity ; Sex Factors ; Viral Load
    Chemical Substances Antibodies, Viral
    Language English
    Publishing date 2021-11-23
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mBio.01848-21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Group therapy on in utero colonization: seeking common truths and a way forward.

    Silverstein, Rachel B / Mysorekar, Indira U

    Microbiome

    2021  Volume 9, Issue 1, Page(s) 7

    Abstract: The human microbiome refers to the genetic composition of microorganisms in a particular location in the human body. Emerging evidence over the past many years suggests that the microbiome constitute drivers of human fate almost at par with our genome ... ...

    Abstract The human microbiome refers to the genetic composition of microorganisms in a particular location in the human body. Emerging evidence over the past many years suggests that the microbiome constitute drivers of human fate almost at par with our genome and epigenome. It is now well accepted after decades of disbelief that a broad understanding of human development, health, physiology, and disease requires understanding of the microbiome along with the genome and epigenome. We are learning daily of the interdependent relationships between microbiome/microbiota and immune responses, mood, cancer progression, response to therapies, aging, obesity, antibiotic usage, and overusage and much more. The next frontier in microbiome field is understanding when does this influence begin? Does the human microbiome initiate at the time of birth or are developing human fetuses already primed with microbes and their products in utero. In this commentary, we reflect on evidence gathered thus far on this question and identify the unknown common truths. We present a way forward to continue understanding our microbial colleagues and our interwoven fates.
    MeSH term(s) Consensus ; Female ; Fetus/microbiology ; Humans ; Microbiota/physiology ; Uncertainty ; Uterus/microbiology
    Language English
    Publishing date 2021-01-12
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2697425-3
    ISSN 2049-2618 ; 2049-2618
    ISSN (online) 2049-2618
    ISSN 2049-2618
    DOI 10.1186/s40168-020-00968-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: PITing it forward: A new link in the journey of uropathogenic E. coli in the urothelium.

    Joshi, Chetanchandra S / Cegelski, Lynette / Mysorekar, Indira U

    Cell reports

    2022  Volume 39, Issue 4, Page(s) 110758

    Abstract: Urinary tract infections (UTIs) are a cause for alarm given the high rates of treatment failure. In a recent issue of Cell Reports, Pang et al. uncovered dueling molecular machinery at the host-pathogen interface in response to phosphate that points to ... ...

    Abstract Urinary tract infections (UTIs) are a cause for alarm given the high rates of treatment failure. In a recent issue of Cell Reports, Pang et al. uncovered dueling molecular machinery at the host-pathogen interface in response to phosphate that points to new anti-infective strategies against UTIs.
    MeSH term(s) Escherichia coli Infections ; Female ; Humans ; Male ; Urinary Tract Infections ; Uropathogenic Escherichia coli/physiology ; Urothelium
    Language English
    Publishing date 2022-04-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2022.110758
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: COVID-19 and pregnancy: clinical outcomes; mechanisms, and vaccine efficacy.

    Kumar, Deepak / Verma, Sonam / Mysorekar, Indira U

    Translational research : the journal of laboratory and clinical medicine

    2022  Volume 251, Page(s) 84–95

    Abstract: As the COVID-19 pandemic continues into its third year, emerging data indicates increased risks associated with SARS-CoV-2 infection during pregnancy, including pre-eclampsia, intrauterine growth restriction, preterm birth, stillbirth, and risk of ... ...

    Abstract As the COVID-19 pandemic continues into its third year, emerging data indicates increased risks associated with SARS-CoV-2 infection during pregnancy, including pre-eclampsia, intrauterine growth restriction, preterm birth, stillbirth, and risk of developmental defects in neonates. Here, we review clinical reports to date that address different COVID-19 pregnancy complications. We also document placental pathologies induced by SARS-CoV-2 infection, entry mechanisms in placental cells, and immune responses at the maternal-fetal interface. Since new variants of SARS-CoV-2 are emerging with characteristics of higher transmissibility and more effective immune escape strategies, we also briefly highlight the genomic and proteomic features of SARS-CoV-2 investigated to date. Vector and mRNA-based COVID-19 vaccines continue to be rolled out globally. However, because pregnant individuals were not included in the vaccine clinical trials, some pregnant individuals have safety concerns and are hesitant to take these vaccines. We describe the recent studies that have addressed the effectiveness and safety of the current vaccines during pregnancy. This review also sheds light on important areas that need to be carefully or more fully considered with respect to understanding SARS-CoV-2 disease mechanisms of concern during pregnancy.
    MeSH term(s) Female ; Humans ; Pregnancy ; COVID-19/complications ; COVID-19/prevention & control ; COVID-19 Vaccines ; Pandemics/prevention & control ; Placenta/pathology ; Placenta/virology ; Proteomics ; SARS-CoV-2 ; Vaccine Efficacy ; Pregnancy Complications, Infectious/pathology ; Pregnancy Complications, Infectious/virology
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2022-08-12
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 2246684-8
    ISSN 1878-1810 ; 1532-6543 ; 1931-5244
    ISSN (online) 1878-1810 ; 1532-6543
    ISSN 1931-5244
    DOI 10.1016/j.trsl.2022.08.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Bacteria make T cell memories in utero.

    Parker, Elaine L / Silverstein, Rachel B / Mysorekar, Indira U

    Cell

    2021  Volume 184, Issue 13, Page(s) 3356–3357

    Abstract: Education of the human immune system begins in utero via T cell activation and memory development. However, whether part of the education is provided by exposure to microbes in utero remains controversial and unclear. In this issue of Cell, Mishra et al. ...

    Abstract Education of the human immune system begins in utero via T cell activation and memory development. However, whether part of the education is provided by exposure to microbes in utero remains controversial and unclear. In this issue of Cell, Mishra et al. provide new evidence that the fetal gut may be colonized by bacteria that prime T cell memories.
    MeSH term(s) Bacteria ; Fetus ; Humans ; Lymphocyte Activation ; T-Lymphocytes/immunology
    Language English
    Publishing date 2021-06-24
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2021.05.044
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  9. Article ; Online: The maternal gut microbiome in pregnancy: implications for the developing immune system.

    Koren, Omry / Konnikova, Liza / Brodin, Petter / Mysorekar, Indira U / Collado, Maria Carmen

    Nature reviews. Gastroenterology & hepatology

    2023  Volume 21, Issue 1, Page(s) 35–45

    Abstract: The gut microbiome has important roles in host metabolism and immunity, and microbial dysbiosis affects human physiology and health. Maternal immunity and microbial metabolites during pregnancy, microbial transfer during birth, and transfer of immune ... ...

    Abstract The gut microbiome has important roles in host metabolism and immunity, and microbial dysbiosis affects human physiology and health. Maternal immunity and microbial metabolites during pregnancy, microbial transfer during birth, and transfer of immune factors, microorganisms and metabolites via breastfeeding provide critical sources of early-life microbial and immune training, with important consequences for human health. Only a few studies have directly examined the interactions between the gut microbiome and the immune system during pregnancy, and the subsequent effect on offspring development. In this Review, we aim to describe how the maternal microbiome shapes overall pregnancy-associated maternal, fetal and early neonatal immune systems, focusing on the existing evidence and highlighting current gaps to promote further research.
    MeSH term(s) Pregnancy ; Female ; Infant, Newborn ; Humans ; Gastrointestinal Microbiome/physiology ; Immune System ; Microbiota ; Breast Feeding
    Language English
    Publishing date 2023-12-14
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2493722-8
    ISSN 1759-5053 ; 1759-5045
    ISSN (online) 1759-5053
    ISSN 1759-5045
    DOI 10.1038/s41575-023-00864-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Reflections on the void: the art of micturition analysis.

    Fashemi, Bisiayo E / Mysorekar, Indira U

    American journal of physiology. Renal physiology

    2018  Volume 315, Issue 5, Page(s) F1446–F1448

    MeSH term(s) Animals ; Mice ; Urinary Bladder ; Urination ; Urodynamics
    Language English
    Publishing date 2018-10-10
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 603837-2
    ISSN 1522-1466 ; 0363-6127
    ISSN (online) 1522-1466
    ISSN 0363-6127
    DOI 10.1152/ajprenal.00469.2018
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