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  1. Article ; Online: Proposing Clinicopathological Staging and Mitotic Count as Prognostic Factors for Canine Soft Tissue Sarcomas.

    Cardoso de Almeida Moreira, Andrea Regina / Franzoni, Mayara Simão / Dos Anjos, Denner Santos / César-Jark, Paulo / Nóbrega, Juliano / Laufer-Amorim, Renée / Valsecchi Henriques, Marina / Neto, Osmar Pinto / Fonseca-Alves, Carlos Eduardo

    Veterinary sciences

    2023  Volume 10, Issue 5

    Abstract: Soft tissue sarcomas (STSs) are a heterogeneous group of malignant mesenchymal tumors with similar histological features and biological behaviors. They are characterized by a low to moderate local recurrence rate and low metastasis, affecting ... ...

    Abstract Soft tissue sarcomas (STSs) are a heterogeneous group of malignant mesenchymal tumors with similar histological features and biological behaviors. They are characterized by a low to moderate local recurrence rate and low metastasis, affecting approximately 20% of patients. Although this tumor set is vital in veterinary medicine, no previous unified staging system or mitotic count has been associated with patient prognosis. Therefore, this study proposed a new clinicopathological staging method and evaluated a cut-off value for mitosis related to the survival of dogs affected by STS. This study included 105 dogs affected by STS, treated only with surgery, and a complete follow-up evaluation. The new clinicopathological staging system evaluated tumor size (T), nodal involvement (N), distant metastasis (M), and histological grading criteria (G) to categorize the tumor stage into four groups (stages I, II, III, and IV). The proposed tumor staging system was able to differentiate patients' prognoses, with dogs with stage IV disease experiencing the lowest survival time and dogs with stage I disease having the highest survival time (
    Language English
    Publishing date 2023-05-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2768971-2
    ISSN 2306-7381 ; 2306-7381
    ISSN (online) 2306-7381
    ISSN 2306-7381
    DOI 10.3390/vetsci10050327
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Microbial Complexity of Oral Cavity of Healthy Dogs Identified by Mass Spectrometry and Next-Generation Sequencing.

    Portilho, Fábio V R / Nóbrega, Juliano / de Almeida, Beatriz O / Mota, André R / de Paula, Carolina L / Listoni, Fernando J P / Bosco, Sandra M G / Oliveira, Alana L / Cunha, Maria de Lourdes R S / Ribeiro, Márcio G

    Animals : an open access journal from MDPI

    2023  Volume 13, Issue 15

    Abstract: The high complexity of the oral microbiota of healthy dogs and the close exposure of humans to companion animals represent a risk of the transmission of potential zoonotic microorganisms to humans, especially through dog bites, including multidrug- ... ...

    Abstract The high complexity of the oral microbiota of healthy dogs and the close exposure of humans to companion animals represent a risk of the transmission of potential zoonotic microorganisms to humans, especially through dog bites, including multidrug-resistant ones. Nonetheless, a limited number of comprehensive studies have focused on the diversity of the microorganisms that inhabit the oral cavities of healthy dogs, particularly based on modern molecular techniques. We investigated bacterial and fungal organisms in the oral cavities of 100 healthy dogs based on a combination of conventional and selective microbiological culture, mass spectrometry (MALDI-TOF MS), and next-generation sequencing. In addition, in vitro antimicrobial susceptibility patterns of isolates and
    Language English
    Publishing date 2023-07-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606558-7
    ISSN 2076-2615
    ISSN 2076-2615
    DOI 10.3390/ani13152467
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Microbial Complexity of Oral Cavity of Healthy Dogs Identified by Mass Spectrometry and Next-Generation Sequencing

    Portilho, Fábio V. R. / Nóbrega, Juliano / de Almeida, Beatriz O. / Mota, André R. / de Paula, Carolina L. / Listoni, Fernando J. P. / Bosco, Sandra M. G. / Oliveira, Alana L. / Cunha, Maria de Lourdes R. S. / Ribeiro, Márcio G.

    Animals. 2023 July 31, v. 13, no. 15

    2023  

    Abstract: The high complexity of the oral microbiota of healthy dogs and the close exposure of humans to companion animals represent a risk of the transmission of potential zoonotic microorganisms to humans, especially through dog bites, including multidrug- ... ...

    Abstract The high complexity of the oral microbiota of healthy dogs and the close exposure of humans to companion animals represent a risk of the transmission of potential zoonotic microorganisms to humans, especially through dog bites, including multidrug-resistant ones. Nonetheless, a limited number of comprehensive studies have focused on the diversity of the microorganisms that inhabit the oral cavities of healthy dogs, particularly based on modern molecular techniques. We investigated bacterial and fungal organisms in the oral cavities of 100 healthy dogs based on a combination of conventional and selective microbiological culture, mass spectrometry (MALDI-TOF MS), and next-generation sequencing. In addition, in vitro antimicrobial susceptibility patterns of isolates and mecA resistance gene were assessed. A total of 213 bacteria and 20 fungi were isolated. Staphylococcus pseudintermedius (40/100 = 40%), α-hemolytic Streptococcus (37/100 = 37%), and Pasteurella stomatis (22/100 = 22%) were the most prevalent bacteria diagnosed by microbiological culture and MALDI-TOF MS, whereas Aspergillus (10/100 = 10%) was the most common fungi identified. Based on next-generation sequencing of selected 20 sampled dogs, Porphyromonas (32.5%), Moraxella (16.3%), Fusobacterium (12.8%), Conchiformibius (9.5%), Bergeyella (5%), Campylobacter (3.8%), and Capnocytophaga (3.4%) genera were prevalent. A high multidrug resistance rate was observed in Staphylococcus pseudintermedius isolates, particularly to azithromycin (19/19 = 100%), penicillin (15/19 = 78.9%), and sulfamethoxazole/trimethoprim (15/19 = 78.9%). In addition, the mecA resistance gene was detected in 6.1% (3/49) of coagulase-positive staphylococci. Here, we highlight the microbial complexity of the oral mucosa of healthy dogs, including potential zoonotic microorganisms and multidrug-resistant bacteria, contributing with the investigation of the microbiota and antimicrobial resistance patterns of the microorganisms that inhabit the oral cavity of healthy dogs.
    Keywords Aspergillus ; Bergeyella ; Campylobacter ; Capnocytophaga ; Fusobacterium ; Moraxella ; Pasteurella stomatis ; Porphyromonas ; Staphylococcus pseudintermedius ; Streptococcus ; antibiotic resistance ; azithromycin ; dogs ; fungi ; mass spectrometry ; mouth ; mucosa ; multiple drug resistance ; penicillins ; resistance genes ; risk ; sulfamethoxazole ; trimethoprim
    Language English
    Dates of publication 2023-0731
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article ; Online
    ZDB-ID 2606558-7
    ISSN 2076-2615
    ISSN 2076-2615
    DOI 10.3390/ani13152467
    Database NAL-Catalogue (AGRICOLA)

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  4. Article ; Online: Hepatic myelolipoma in two Goeldi's monkeys from South America held captive.

    Martins, Mariana Castilho / Rahal, Sheila Canevese / Mamprim, Maria Jaqueline / Teixeira, Rodrigo Hidalgo Friciello / Teixeira, Carlos Roberto / Sequeira, Júlio Lopes / Nóbrega, Juliano

    Journal of medical primatology

    2016  Volume 45, Issue 4, Page(s) 202–205

    Abstract: Two cases of hepatic myelolipoma in Goeldi's monkeys from South America are described. One was a female evaluated due progressive abdominal distension. Ultrasound and computed tomography detected hepatic mass. Partial hepatectomy was performed, but the ... ...

    Abstract Two cases of hepatic myelolipoma in Goeldi's monkeys from South America are described. One was a female evaluated due progressive abdominal distension. Ultrasound and computed tomography detected hepatic mass. Partial hepatectomy was performed, but the monkey died after surgery. Case 2 was a male that died suddenly, showing non-specific clinical signs.
    MeSH term(s) Adrenal Gland Neoplasms/diagnostic imaging ; Adrenal Gland Neoplasms/surgery ; Adrenal Gland Neoplasms/veterinary ; Animals ; Animals, Zoo ; Brazil ; Callimico ; Female ; Liver Neoplasms/diagnostic imaging ; Liver Neoplasms/surgery ; Liver Neoplasms/veterinary ; Male ; Monkey Diseases/diagnosis ; Monkey Diseases/surgery ; Myelolipoma/diagnostic imaging ; Myelolipoma/surgery ; Myelolipoma/veterinary
    Language English
    Publishing date 2016-08
    Publishing country Denmark
    Document type Case Reports
    ZDB-ID 121206-0
    ISSN 1600-0684 ; 0047-2565
    ISSN (online) 1600-0684
    ISSN 0047-2565
    DOI 10.1111/jmp.12226
    Database MEDical Literature Analysis and Retrieval System OnLINE

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