Article ; Online: An Observational Study on the Pharmacokinetics of Oseltamivir in Lactating Influenza Patients.
Clinical pharmacology and therapeutics
2023 Volume 115, Issue 2, Page(s) 318–323
Abstract: Influenza infection may lead to serious complications in the postpartum period, therefore, oseltamivir treatment in these patients and their breastfed infants is of great importance. However, the pharmacokinetics of oseltamivir in postpartum lactating ... ...
| Abstract | Influenza infection may lead to serious complications in the postpartum period, therefore, oseltamivir treatment in these patients and their breastfed infants is of great importance. However, the pharmacokinetics of oseltamivir in postpartum lactating women with acute influenza infection, and the consequent infant exposure to oseltamivir are still unknown, and these data would help in assessing risk and the need for dose adjustment in breastfed infants. Six lactating women with influenza-like symptoms, at a standard dose of 75 mg oral oseltamivir twice daily for 5 days, were recruited in this phase IV clinical study during the 2011/2012 H1N1 pandemic seasons. Breast milk/colostrum and venous blood samples were taken at multiple timepoints, maternal urine samples were obtained from total output within the 12-hour observational period following the seventh dose of oseltamivir. Oseltamivir phosphate (OP) reached a maximum 69.5 ± 29.4 ng/mL concentration in breast milk, higher than that found in the plasma, and showed elimination within ~ 8 hours. Oseltamivir carboxylate (active metabolite of OP) showed a lower, nearly steady-state concentration in breast milk during the observational period (maximum plasma concentration (C |
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| MeSH term(s) | Infant ; Humans ; Female ; Oseltamivir ; Influenza, Human/drug therapy ; Antiviral Agents/pharmacokinetics ; Lactation ; Influenza A Virus, H1N1 Subtype | |||||
| Chemical Substances | Oseltamivir (20O93L6F9H) ; Antiviral Agents | |||||
| Language | English | |||||
| Publishing date | 2023-12-03 | |||||
| Publishing country | United States | |||||
| Document type | Clinical Trial, Phase IV ; Observational Study ; Journal Article ; Research Support, Non-U.S. Gov't | |||||
| ZDB-ID | 123793-7 | |||||
| ISSN | 1532-6535 ; 0009-9236 | |||||
| ISSN (online) | 1532-6535 | |||||
| ISSN | 0009-9236 | |||||
| DOI | 10.1002/cpt.3107 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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