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  1. Book ; Thesis: Autosomal rezessive und X-chromosomal rezessive Ursachen der psychomotorischen Entwicklungsstörung in konsanguinen und nicht-konsanguinen Familien

    Matthies, Lars / Nöthen, Markus Maria

    2022  

    Institution Rheinische Friedrich-Wilhelms-Universität Bonn
    Author's details Lars Christian Matthies ; 1. Gutachter: Prof. Dr. med. Markus Nöthen
    Language German
    Size 133 Seiten
    Publishing place Bonn
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Rheinische Friedrich-Wilhelms-Universität Bonn, 2022
    HBZ-ID HT021377034
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2022 D 346 order for loan Magazin

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  2. Book ; Thesis: Analyse seltener genetischer Varianten im Schizophrenie-Kandidatengen RB1CC1

    Pfohl, Marvin Alexander / Nöthen, Markus Maria

    2020  

    Institution Rheinische Friedrich-Wilhelms-Universität Bonn
    Author's details Marvin Alexander Pfohl ; 1. Gutachter: Prof. Dr. med. Markus M. Nöthen
    Language German
    Size 91 Seiten, Diagramme
    Publishing place Bonn
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Rheinische Friedrich-Wilhelms-Universität Bonn, 2020
    HBZ-ID HT020559302
    Database Catalogue ZB MED Medicine, Health

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    2021 D 140 order for loan Magazin

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  3. Article: Out of the lab and into the clinic: steps to a pragmatic new era in psychiatric genetics

    Nöthen, Markus M.

    Medizinische Genetik

    2020  Volume 32, Issue 1, Page(s) 5

    Language German
    Document type Article
    ZDB-ID 1083376-6
    ISSN 0936-5931
    Database Current Contents Medicine

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3294: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  4. Article ; Online: Analysis of associations between dietary patterns, genetic disposition, and cognitive function in data from UK Biobank

    Schulz, Christina-Alexandra / Weinhold, Leonie / Schmid, Matthias / Nöthen, Markus M. / Nöthlings, Ute

    Eur J Nutr. 2023 Feb., v. 62, no. 1 p.511-521

    2023  

    Abstract: PURPOSE: Research suggests that diet influences cognitive function and the risk for neurodegenerative disease. The present study aimed to determine whether a recently developed diet score, based on recommendations for dietary priorities for cardio ... ...

    Abstract PURPOSE: Research suggests that diet influences cognitive function and the risk for neurodegenerative disease. The present study aimed to determine whether a recently developed diet score, based on recommendations for dietary priorities for cardio metabolic health, was associated with fluid intelligence, and whether these associations were modified by individual genetic disposition. METHODS: This research has been conducted using the UK Biobank Resource. Analyses were performed using self-report data on diet and the results for the verbal-numerical reasoning test of fluid intelligence of 104,895 individuals (46% male: mean age at recruitment 57.1 years (range 40–70)). For each participant, a diet score and a polygenic score (PGS) were constructed, which evaluated predefined cut-offs for the intake of fruit, vegetables, fish, processed meat, unprocessed meat, whole grain, and refined grain, and ranged from 0 (unfavorable) to 7 (favorable). To investigate whether the diet score was associated with fluid intelligence, and whether the association was modified by PGS, linear regression analyses were performed. RESULTS: The average diet score was 3.9 (SD 1.4). After adjustment for selected confounders, a positive association was found between baseline fluid intelligence and PGS (P < 0.001). No association was found between baseline fluid intelligence and diet score (P = 0.601), even after stratification for PGS, or in participants with longitudinal data available (n = 9,482). CONCLUSION: In this middle-aged cohort, no evidence was found for an association between the investigated diet score and either baseline or longitudinal fluid intelligence. However, as in previous reports, fluid intelligence was strongly associated with a PGS for general cognitive function.
    Keywords cognition ; diet ; fish ; fruits ; males ; meat ; neurodegenerative diseases ; refined grains ; regression analysis ; risk ; whole grain foods
    Language English
    Dates of publication 2023-02
    Size p. 511-521.
    Publishing place Springer Berlin Heidelberg
    Document type Article ; Online
    ZDB-ID 1466536-0
    ISSN 1436-6215 ; 1436-6207
    ISSN (online) 1436-6215
    ISSN 1436-6207
    DOI 10.1007/s00394-022-02976-y
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 2281: Show issues

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  5. Article: Male-pattern hair loss: Comprehensive identification of the associated genes as a basis for understanding pathophysiology

    Henne, Sabrina K. / Nöthen, Markus M. / Heilmann-Heimbach, Stefanie

    Medizinische Genetik

    2023  Volume 35, Issue 1, Page(s) 3

    Language German
    Document type Article
    ZDB-ID 1083376-6
    ISSN 0936-5931
    Database Current Contents Medicine

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3294: Show issues Location:
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  6. Article ; Online: Association between urinary iodine excretion, genetic disposition and fluid intelligence in children, adolescents and young adults: the DONALD study.

    Schulz, Christina-Alexandra / Weinhold, Leonie / Schmid, Matthias / Nöthen, Markus M / Nöthlings, Ute

    European journal of nutrition

    2023  Volume 62, Issue 6, Page(s) 2375–2385

    Abstract: Purpose: Iodine deficiency increases the risk of cognitive impairment and delayed physical development in children. It is also associated with cognitive impairment in adults. Cognitive abilities are among the most inheritable behavioural traits. However, ...

    Abstract Purpose: Iodine deficiency increases the risk of cognitive impairment and delayed physical development in children. It is also associated with cognitive impairment in adults. Cognitive abilities are among the most inheritable behavioural traits. However, little is known about the consequences of insufficient postnatal iodine intake and whether the individual genetic disposition modifies the association between iodine intake and fluid intelligence in children and young adults.
    Methods: The cultural fair intelligence test was used to assess fluid intelligence in the participants of the DONALD study (n = 238; mean age, 16.5 [SD = 7.7] years). Urinary iodine excretion, a surrogate iodine intake marker, was measured in 24-h urine. Individual genetic disposition (n = 162) was assessed using a polygenic score, associated with general cognitive function. Linear regression analyses were conducted to determine whether Urinary iodine excretion was associated with fluid intelligence and whether this association was modified by individual genetic disposition.
    Results: Urinary iodine excretion above the age-specific estimated average requirement was associated with a five-point higher fluid intelligence score than that below the estimated average requirement (P = 0.02). The polygenic score was positively associated with the fluid intelligence score (β = 2.3; P = 0.03). Participants with a higher polygenic score had a higher fluid intelligence score.
    Conclusion: Urinary iodine excretion above the estimated average requirement in childhood and adolescence is beneficial for fluid intelligence. In adults, fluid intelligence was positively associated with a polygenic score for general cognitive function. No evidence showed that the individual genetic disposition modifies the association between Urinary iodine excretion and fluid intelligence.
    MeSH term(s) Humans ; Child ; Adolescent ; Young Adult ; Iodine ; Intelligence ; Nutritional Status ; Cognitive Dysfunction ; Malnutrition
    Chemical Substances Iodine (9679TC07X4)
    Language English
    Publishing date 2023-04-27
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1466536-0
    ISSN 1436-6215 ; 1436-6207
    ISSN (online) 1436-6215
    ISSN 1436-6207
    DOI 10.1007/s00394-023-03152-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ue I Zs.262: Show issues Location:
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  7. Book ; Thesis: Molekulargenetische Untersuchungen bei bipolaren affektiven und schizophrenen Psychosen

    Nöthen, Markus M.

    Beiträge zur Ursachenforschung neuropsychiatrischer Erkrankungen

    1995  

    Author's details vorgelegt von Markus M. Nöthen
    Language German
    Size 4, I, 45 Bl.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Bonn, Univ., Habil.-Schr., 1996
    HBZ-ID HT007607314
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    97 E 1774 order for loan Magazin

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  8. Book ; Online ; Thesis: Identification of Genetic Risk Variants for the Development of Gastric Adenocarcinoma

    Heß, Timo [Verfasser] / Nöthen, Markus M. [Akademischer Betreuer] / Witke, Walter [Gutachter]

    2023  

    Author's details Timo Heß ; Gutachter: Walter Witke ; Betreuer: Markus M. Nöthen
    Keywords Biowissenschaften, Biologie ; Life Science, Biology
    Subject code sg570
    Language English
    Publisher Universitäts- und Landesbibliothek Bonn
    Publishing place Bonn
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

    Full text online

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  9. Book ; Thesis: Experimentelles akutes Nierenversagen nach Cyclosporin A

    Nöthen, Markus M.

    Effekte des atrialen natriuretischen Peptids (ANP) auf Nierenfunktion und Elektrolythaushalt

    1992  

    Author's details vorgelegt von Markus Maria Nöthen
    Size IV, 99 S. : graph. Darst.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Würzburg, Univ., Diss., 1992
    HBZ-ID HT004226900
    Database Catalogue ZB MED Medicine, Health

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    92 D 2948 order for loan Magazin

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  10. Article ; Online: Insights Into the Biology of Persistent Chemotherapy-Induced Alopecia via Genomic Approaches-An Avenue to Clinical Translation?

    Basmanav, Fitnat Buket / Nöthen, Markus M / Betz, Regina C

    JAMA dermatology

    2020  Volume 156, Issue 9, Page(s) 947–948

    MeSH term(s) ATP Binding Cassette Transporter, Subfamily B/therapeutic use ; Alopecia/chemically induced ; Alopecia/drug therapy ; Alopecia/genetics ; Antineoplastic Agents/adverse effects ; Breast Neoplasms/drug therapy ; Female ; Genomics ; Humans
    Chemical Substances ABCB1 protein, human ; ATP Binding Cassette Transporter, Subfamily B ; Antineoplastic Agents
    Language English
    Publishing date 2020-08-02
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2701761-8
    ISSN 2168-6084 ; 2168-6068
    ISSN (online) 2168-6084
    ISSN 2168-6068
    DOI 10.1001/jamadermatol.2020.1866
    Database MEDical Literature Analysis and Retrieval System OnLINE

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