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  1. Article ; Online: Idiopathic autoimmune hemolytic anemia along with concomitant vitamin B12 deficiency in an adolescent girl

    Kapil Bhalla / Nisha Verma / Sanjiv Nanda / Ashish Gupta / Shuchi Mehra

    Journal of Family Medicine and Primary Care, Vol 9, Iss 7, Pp 3756-

    A rare occurrence

    2020  Volume 3758

    Abstract: Vitamin B12 deficiency is seen in countries like India mainly because of predominantly vegetarian diet and is a significant health problem. Patients present with various neurological and hematological manifestations of megaloblastic anemia. In this case ... ...

    Abstract Vitamin B12 deficiency is seen in countries like India mainly because of predominantly vegetarian diet and is a significant health problem. Patients present with various neurological and hematological manifestations of megaloblastic anemia. In this case report, we present a 14-year-old girl child having a history of past blood transfusions and iron deficiency anemia currently presenting with severe anemia due to idiopathic autoimmune hemolytic anemia (AIHA) and later found to have concomitant vitamin B12 deficiency. On investigating, she had vitamin B12 deficiency, raised homocysteine and methylmalonic acid levels, positive Direct Coombs Test (DCT), and negative glucose-6-phoshphatase deficiency and osmotic fragility tests. Thyroid profile and tissue transglutaminase IgA (tTg-IgA) tests were negative. Antinuclear antibodies (ANA) and anti-double stranded DNA antibody (anti-dsDNA) serum immunoglobulin were also normal. Bone marrow showed megaloblastic anemia picture. Although AIHA and vitamin B12 deficiency anemia are not common, clinicians should have a high index of suspicion when patients present with hemolytic picture and severe megaloblastic anemia.
    Keywords anemia ; child ; homocysteine ; vitamin b 12 deficiency ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2020-01-01T00:00:00Z
    Publisher Wolters Kluwer Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Achieving Food and Livelihood Security and Enhancing Profitability through an Integrated Farming System Approach

    Poonam Kashyap / Ashisa K. Prusty / Azad S. Panwar / Venkatesh Paramesh / Ravisankar Natesan / M. Shamim / Nisha Verma / Phool Chand Jat / Mahendra Pal Singh

    Sustainability, Vol 14, Iss 6653, p

    A Case Study from Western Plains of Uttar Pradesh, India

    2022  Volume 6653

    Abstract: The integrated farming system (IFS) is a comprehensive farm practice to improve small and marginal farmers’ livelihoods. The IFS enhances nutrient recycling and food security and promotes greater efficiency of fertilizers and natural resources. To ... ...

    Abstract The integrated farming system (IFS) is a comprehensive farm practice to improve small and marginal farmers’ livelihoods. The IFS enhances nutrient recycling and food security and promotes greater efficiency of fertilizers and natural resources. To improve livelihood, profits, and employment generation holistically through an IFS method, a study was conducted over four years, from 2016 to 2019, to define the farming condition in 1036 households in the Muzzafarnagar district of Western Uttar Pradesh. Crop + dairy was the most frequent farming method (68%) followed by crop + dairy + horticulture + goatary. Compared to older cultivars, improved rice, maize, wheat, and barley cultivars enhanced crop yield by 17 to 42%. Transplanting sugarcane and intercropping of mustard increased system yield from 58.89% to 86.17% compared to the sole sugarcane crop. Nutritional kitchen gardening resulted in an average saving of $20 to $25 during the Kharif season and $20 to $27 during Rabi season. Exotic vegetables such as broccoli, Chinese cabbage, cherry tomato, kale, parsley, and lettuce were introduced, which increased regular income. With the adoption of a multi-tier-based system, the net returns from the system improved from 0.6 lakh to 2.20 lakhs per ha. Enhancing the fodder availability resulted in a 27.5% milk yield improvement. The study’s outcomes demonstrated that a five-member family’s annual protein (110–125 kg) and carbohydrate (550 to 575 kg) requirements can be easily met using the IFS technique. According to the study, IFS approaches combined with better technical interventions can ensure the long-term viability of farming systems and improve livelihoods.
    Keywords crop–livestock integration ; food security ; livelihood security ; sustainability ; Uttar Pradesh ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
    Language English
    Publishing date 2022-05-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Feminine farm operational methods, involvement, hardships and sensitivity in farming systems analysis

    NISHA VERMA / M P SINGH / AMIT NATH / POONAM KASHYAP / S P SINGH / A S PANWAR

    The Indian Journal of Agricultural Sciences, Vol 90, Iss

    2020  Volume 1

    Abstract: The present study has been conducted to identify the sensitivity in the pre-dominant farming systems of Western plain zone of Uttar Pradesh (WPZ) considering the importance of gender specific technologies much needed for better efficiency and ... ...

    Abstract The present study has been conducted to identify the sensitivity in the pre-dominant farming systems of Western plain zone of Uttar Pradesh (WPZ) considering the importance of gender specific technologies much needed for better efficiency and productivity of farming systems. Four pre-dominant farming systems have been identified in WPZ of Uttar Pradesh with the highest area share (57.1%) and highest farmer distribution (62.9%) in FS1: Crop + Dairy (1C+1-2B). The highest net return was found in FS2: Crop + Horticulture (Fruits) + Dairy (2C+ 1-2 B), whereas the lowest net return was noticed in FS3: Crop + Horticulture (Vegetables) + Dairy (1C + 1B). Load carrying through head load was found extensively performed by the women of FS3 followed by FS4: Horticulture + Crop + Dairy (1C+1B) and FS2 respectively. Chopper (hand tool) for chaff cutting, winnowing through natural wind, power operated winnowing without safety gadgets was performed in FS4 (33%), FS3 (22.8%) and FS4 (17%) respectively by family female workers. Threshing through hand beating was maximally performed by FS2 (81%) as hired female labour. Work involvement in farming system studies shows that female workers (family and hired) of FS3 contributed maximum (44.7%) followed by FS1 (41.5%). Also, the women participation index on drudgery prone activities was found highest amongst female workers (family and hired) of FS3 (87.8%) followed by FS1 (83.21%). The results indicate that FS3 may be tagged as sensitive farming system with respect to maximum number of female headed households contributing maximum work and hardships followed by FS1.
    Keywords Farming Systems ; Farm operations ; Feminine ; Pre-dominant ; Women participation index ; Agriculture ; S
    Subject code 571
    Language English
    Publishing date 2020-03-01T00:00:00Z
    Publisher Indian Council of Agricultural Research
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: On-farm Agro-meteorological evaluation of late sown wheat (Triticum aestivum) under irrigated agro-ecosystem of Upper Indo-Gangetic Plains

    M SHAMIM / A S PANWAR / N RAVISANKAR / PC JAT / A K PRUSTY / M P SINGH / POONAM KASHYAP / NISHA VERMA / SHIV DATT / M A ANSARI / SUNIL KUMAR

    The Indian Journal of Agricultural Sciences, Vol 92, Iss

    2021  Volume 6

    Abstract: In Indo-Gangetic Plains (IGP, ~18 mha geographical area), wheat (Triticum aestivum L.) is a predominant crop grown in rabi. Improving the productivity of wheat in a rice-based farming system through a suitable cultivar in IGP is necessary to evaluate ... ...

    Abstract In Indo-Gangetic Plains (IGP, ~18 mha geographical area), wheat (Triticum aestivum L.) is a predominant crop grown in rabi. Improving the productivity of wheat in a rice-based farming system through a suitable cultivar in IGP is necessary to evaluate under the agro-ecological condition of IGP of India. A farmer’s participatory field experiment was studied at three villages Saunta, Sathedi and Bhangela situated in Khatauli block of Muzaffarnagar (Uttar Pradesh) under two crop environments (low rainfall and high temperature, LRHT and heavy rainfall and low temperature, HRLT) with four wheat varieties during rabi of 2017–18 and 2018–19. In this study we have evaluated the productivity in isolation as well as in combination of prevailing weather scenario (2017–18 and 2018–19) under irrigated agro-ecosystems of Western Plain Zone of Uttar Pradesh. Interaction studied between crop environments and varieties indicated that PBW-550 and PBW 658 registered higher grain yield of 5514 and 5475 kg/ha, respectively than farmers practice (PBW-226, 4659 kg/ha) and DBW-90 (4647 kg/ha) in LRHT. However, under HRLT, PBW-658 performed better (5326 kg/ha) over other cultivars. Mean grain yield of all four cultivars were recorded significantly higher under LRHT with 5074 kg/ha compared to HRLT where mean grain yield was 4710 kg/ha. A highly significant (P=0.01) negative association was found between grain yield and monthly rainfall (except December month) and cumulative rainfall of the crop season (-0.322**). Prevailing mean monthly air temperature during grain filling to maturity phenophase was found to be positively associated with grain yield (r = -0.322*).
    Keywords Crop Environment ; Indo Gangetic Plains ; Growing degree days ; Productivity ; Wheat ; Agriculture ; S
    Subject code 669
    Language English
    Publishing date 2021-09-01T00:00:00Z
    Publisher Indian Council of Agricultural Research
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Benzo[a]pyrene-induced metabolic shift from glycolysis to pentose phosphate pathway in the human bladder cancer cell line RT4

    Nisha Verma / Mario Pink / Stefan Boland / Albert W. Rettenmeier / Simone Schmitz-Spanke

    Scientific Reports, Vol 7, Iss 1, Pp 1-

    2017  Volume 14

    Abstract: Abstract Benzo[a]pyrene (B[a]P), a well-known polyaromatic hydrocarbon, is known for its lung carcinogenicity, however, its role in bladder cancer development is still discussed. Comparative two-dimensional blue native SDS-PAGE analysis of protein ... ...

    Abstract Abstract Benzo[a]pyrene (B[a]P), a well-known polyaromatic hydrocarbon, is known for its lung carcinogenicity, however, its role in bladder cancer development is still discussed. Comparative two-dimensional blue native SDS-PAGE analysis of protein complexes isolated from subcellular fractions of 0.5 µM B[a]P-exposed cells indicated a differential regulation of proteins involved in carbohydrate, fatty acid, and nucleotide metabolism, suggesting a possible metabolic flux redistribution. It appeared that B[a]P exposure led to a repression of enzymes (fructose-bisphosphate aldolase A, glucose-6-phosphate isomerase, lactate dehydrogenase) involved in glycolysis, and an up-regulation of proteins (glucose-6-phosphate 1-dehydrogenase, 6-phosphogluconolactonase) catalyzing the pentose phosphate pathway and one carbon metabolism (10-formyltetrahydrofolate dehydrogenase, bifunctional purine biosynthesis protein). Untargeted metabolomics further supported the proteomic data, a lower concentration of glycolytic metabolite was observed as compared to glutamine, xylulose and fatty acids. The analysis of the glutathione and NADPH/NADP+ content of the cells revealed a significant increase of these cofactors. Concomitantly, we did not observe any detectable increase in the production of ROS. With the present work, we shed light on an early phase of the metabolic stress response in which the urothelial cells are capable of counteracting oxidative stress by redirecting the metabolic flux from glycolysis to pentose phosphate pathway.
    Keywords Medicine ; R ; Science ; Q
    Subject code 570
    Language English
    Publishing date 2017-08-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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