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Article ; Online: The therapeutic effects of attending a one-day outpatient service on patients with gestational diabetes and different pre-pregnancy body mass indices

Yan-Min Cao / Min Ma / Wei Wang / Na-Na Cai

Frontiers in Public Health, Vol

2023 Volume 10

Abstract: PurposeThis study investigated the effects of attending a one-day outpatient service on the outcomes of patients with gestational diabetes mellitus (GDM) and different pre-pregnancy body mass indices (BMIs).MethodsThe study recruited 311 pregnant women ... ...

Abstract	PurposeThis study investigated the effects of attending a one-day outpatient service on the outcomes of patients with gestational diabetes mellitus (GDM) and different pre-pregnancy body mass indices (BMIs).MethodsThe study recruited 311 pregnant women with GDM into a one-day outpatient service at The Fourth Hospital of Shijiazhuang from September 2019 to December 2021. They were randomly assigned to three groups, based on their pre-pregnancy BMI as follows: group A, BMI < 18.5 kg/m2; group B, 18.5 ≥ BMI > 25.0 kg/m2; group C, BMI ≥25 kg/m2. The following information was collected from all the participants: fasting blood glucose, hemoglobin A1c (HbA1C), insulin dose, gestational weight gain, weight gain after the one-day outpatient service, and perinatal outcomes.ResultsThe three groups showed significant differences in fasting blood glucose and HbA1C, insulin treatment rate, and the incidence of pregnancy hypertension/preeclampsia and neonatal jaundice (all P < 0.05). The rate of excessive gestational weight gain in all of the groups also reflected significant differences (P < 0.05). Group A showed the lowest weight gain, while group C gained the most weight. There is no significant difference in the incidences of hypertension/preeclampsia, neonatal jaundice, or premature birth between patients with weight loss/no weight gain and those with positive weight gain.ConclusionOne-day diabetes outpatient integrated management may effectively help to manage weight gain and blood glucose in patients with GDM and different pre-pregnancy BMIs. Dietary control after a GDM diagnosis may have helped to avoid weight gain entirely, as well as negative weight gain, but did not increase the risk of maternal and infant-related complications.
Keywords	gestational diabetes mellitus ; one-day clinic ; body mass index ; gestational weight gain ; blood sugar ; Public aspects of medicine ; RA1-1270
Subject code	610
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A comparative study of the efficacy and safety of high-flow nasal cannula and nasal continuous positive airway pressure in neonatal respiratory distress syndrome

Jiang-Jiang Wang, MD / Lei Zhang, BD / Na Cai, BD

Medicine, Vol 101, Iss 15, p e

2022 Volume 29109

Abstract: Abstract. Background:. When it comes to preterm newborns, respiratory distress syndrome (RDS) is the most frequent respiratory condition. Despite the fact that it is well acknowledged that preterm delivery plays a significant role, the causes of lung ... ...

Abstract	Abstract. Background:. When it comes to preterm newborns, respiratory distress syndrome (RDS) is the most frequent respiratory condition. Despite the fact that it is well acknowledged that preterm delivery plays a significant role, the causes of lung damage are still not completely understood. In newborns with extremely low birth weight and neonatal RDS, nasal continuous positive airway pressure has been suggested as the first respiratory assistance for spontaneous breathing. In the current research, we aim to carry out a meta-analysis to assess the effectiveness and safety of high-flow nasal cannula (HFNC) and non-invasive continuous positive airway pressure (nCPAP) in patients with neonatal respiratory distress syndrome (NRDS). Methods:. We intend to search the following databases: PubMed, EMBASE, Cochrane Library, Wanfang database, China National Knowledge Infrastructure (CNKI), and Google Scholar, starting from their initial publication until February 2022, to identify randomized controlled trials comparing HFNC to nCPAP in patients with NRDS. The suitable papers will be chosen by 2 writers who will work independently of one another. Using the Cochrane updated technique for risk of bias, each included article will be subjected to an independent data extraction process by the 2 writers who will then independently evaluate the risk of bias. Consequently, a third author will be asked to address any discrepancies that may arise between the writers. It will be necessary to pool the data and do a meta-analysis with the help of the RevMan 5.3 software. Results:. In this study, the effectiveness and safety of HFNC will be compared with those of nCPAP in patients with NRDS. Conclusion:. If the results of this research are confirmed, they may serve as a summary of the most recent data for non-invasive respiratory assistance in NRDS. Ethics and dissemination:. The study will require ethical approval. Registration number:. DOI 10.17605/OSF.IO/BKSQ5
Keywords	Medicine ; R
Subject code	610
Language	English
Publishing date	2022-04-01T00:00:00Z
Publisher	Wolters Kluwer
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A significant decrease in hemoglobin concentrations may predict occurrence of necrotizing enterocolitis in preterm infants with late-onset sepsis

Na Cai / Wenting Fan / Min Tao / Wei Liao

Journal of International Medical Research, Vol

2020 Volume 48

Abstract: Objective This study aimed to examine the clinical value of a decrease in hemoglobin concentration (HC) after the onset of sepsis for predicting occurrence of necrotizing enterocolitis (NEC) in preterm infants with late-onset sepsis. Methods We performed ...

Abstract	Objective This study aimed to examine the clinical value of a decrease in hemoglobin concentration (HC) after the onset of sepsis for predicting occurrence of necrotizing enterocolitis (NEC) in preterm infants with late-onset sepsis. Methods We performed a retrospective cohort study between January 2015 and January 2020. Premature neonates (gestational age <37 weeks) with late-onset sepsis (age >3 days) were enrolled. According to the degree of reduction in HC, neonates were divided into the non-decrease group, mild decrease group, and severe decrease group. Demographic data, perinatal conditions, blood cell count analysis, blood culture, and treatment measures were compared. Results Eighty premature infants with sepsis were studied. The mortality rate and incidence of NEC were significantly higher in the severe decrease group than in the non-decrease and mild decrease groups. Significant differences were observed in the decrease in HC, red blood cell transfusion, and ventilator application between the NEC and non-NEC groups. A significant decrease in HC was an independent risk factor for NEC in preterm infants with sepsis. Conclusion A significant decrease in HC is an independent risk factor for NEC and may predict the occurrence of NEC in preterm infants with sepsis.
Keywords	Medicine (General) ; R5-920
Subject code	610 ; 690
Language	English
Publishing date	2020-09-01T00:00:00Z
Publisher	SAGE Publishing
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Nucleation and stability of skyrmions in three-dimensional chiral nanostructures

Yan Liu / Na Cai / Xingxing Yu / Shengjie Xuan

Scientific Reports, Vol 10, Iss 1, Pp 1-

2020 Volume 10

Abstract: Abstract We studied the magnetization evolution in three-dimensional chiral nanostructures, including nanotubes and circularly curved thin films, by micromagnetic simulations. We found that in a nanotube skyrmions can be formed by broken of the helical ... ...

Abstract	Abstract We studied the magnetization evolution in three-dimensional chiral nanostructures, including nanotubes and circularly curved thin films, by micromagnetic simulations. We found that in a nanotube skyrmions can be formed by broken of the helical stripes on the left and right sides of the nanotube, and the formation of skyrmions doesn’t correspond to any abrupt change of topological number. Skyrmions can exist in a large range of magnetic field, and the thinner nanotube has a larger field range for skyrmion existence. The configuration of a skyrmion in nanotubes is different from the one in thin film. From the outer to the inner circular layer, the size of the skyrmion becomes larger, and the deformation becomes more obvious. In circularly curved magnetic films with fixed arc length, there are three kinds of hysteresis processes are found. For the curved films with a large radius, the magnetization evolution behavior is similar to the case in two-dimensional thin films. For the curved films with a small radius, the skyrmions are created by broken of the helical stripes on the left and right sides of the curved film. For the curved film with a medium radius, no skyrmion is formed in the hysteresis process.
Keywords	Medicine ; R ; Science ; Q
Subject code	539
Language	English
Publishing date	2020-12-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Development and validation of a PLE scale from academic administrative perspective (PLES-AA) in tertiary education

Xiaoshu Xu / Kimberly Kolletar-Zhu / Jia Liu / YunFeng Zhang / Na Cai

PLoS ONE, Vol 17, Iss 8, p e

A pilot study in China.

2022 Volume 0272214

Abstract: The study aims to construct and validate a rubric to assess the effectiveness of PLEs from an academic administrative perspective (PLER-AA) in tertiary education in China. A qualitative-quantitative sequential mixed-method design was used for the scale ... ...

Abstract	The study aims to construct and validate a rubric to assess the effectiveness of PLEs from an academic administrative perspective (PLER-AA) in tertiary education in China. A qualitative-quantitative sequential mixed-method design was used for the scale validation. A total of 206 teachers and administrative staff participated in the Confirmative Factor Analysis (CFA), which supported the 4-dimensional scale, with policy (n = 4), program design (n = 4), curriculum/instruction (n = 4), and capacity (n = 4). Meanwhile, another 189 teachers and administrative staff participated in the current sequence of PLE applications in higher education surveys, revealing a developing phase in China. Consequently, the rubric can be used as a benchmark that provides insight to educators and administrators in developing PLEs in tertiary education in China and worldwide.
Keywords	Medicine ; R ; Science ; Q
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Collagen Peptide in a Combinatorial Treatment with Lactobacillus rhamnosus Inhibits the Cariogenic Properties of Streptococcus mutans

Hee-Young Jung / Jian-Na Cai / Sung Chul Yoo / Seon-Hwa Kim / Jae-Gyu Jeon / Dongyeop Kim

International Journal of Molecular Sciences, Vol 23, Iss 1860, p

An In Vitro Study

2022 Volume 1860

Abstract: Dental caries is caused by the formation of cariogenic biofilm, leading to localized areas of enamel demineralization. Streptococcus mutans , a cariogenic pathogen, has long been considered as a microbial etiology of dental caries. We hypothesized that ... ...

Abstract	Dental caries is caused by the formation of cariogenic biofilm, leading to localized areas of enamel demineralization. Streptococcus mutans , a cariogenic pathogen, has long been considered as a microbial etiology of dental caries. We hypothesized that an antagonistic approach using a prebiotic collagen peptide in combination with probiotic Lactobacillus rhamnosus would modulate the virulence of this cariogenic biofilm. In vitro S. mutans biofilms were formed on saliva-coated hydroxyapatite discs, and the inhibitory effect of a combination of L. rhamnosus and collagen peptide on S. mutans biofilms were evaluated using microbiological, biochemical, confocal imaging, and transcriptomic analyses. The combination of L. rhamnosus with collagen peptide altered acid production by S. mutans , significantly increasing culture pH at an early stage of biofilm formation. Moreover, the 3D architecture of the S. mutans biofilm was greatly compromised when it was in the presence of L. rhamnosus with collagen peptide, resulting in a significant reduction in exopolysaccharide with unstructured and mixed bacterial organization. The presence of L. rhamnosus with collagen peptide modulated the virulence potential of S. mutans via down-regulation of eno , ldh , and atpD corresponding to acid production and proton transportation, whereas aguD associated with alkali production was up-regulated. Gly-Pro-Hyp, a common tripeptide unit of collagen, consistently modulated the cariogenic potential of S. mutans by inhibiting acid production, similar to the bioactivity of a collagen peptide. It also enhanced the relative abundance of commensal streptococci ( S. oralis ) in a mixed-species biofilm by inhibiting S. mutans colonization and dome-like microcolony formation. This work demonstrates that food-derived synbiotics may offer a useful means of disrupting cariogenic communities and maintaining microbial homeostasis.
Keywords	synbiotics ; probiotics ; prebiotics ; cariogenic biofilms ; metabolic interference ; acidogenicity ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	540
Language	English
Publishing date	2022-02-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Exploring Quercetin Anti-Osteoporosis Pharmacological Mechanisms with In Silico and In Vivo Models

Ying Hu / Wei Yuan / Na Cai / Kun Jia / Yunlong Meng / Fei Wang / Yurui Ge / Huiqiang Lu

Life, Vol 12, Iss 980, p

2022 Volume 980

Abstract: Since osteoporosis critically influences the lives of patients with a high incidence, effective therapeutic treatments are important. Quercetin has been well recognized as a bone-sparing agent and thus the underlying mechanisms warrant further ... ...

Abstract	Since osteoporosis critically influences the lives of patients with a high incidence, effective therapeutic treatments are important. Quercetin has been well recognized as a bone-sparing agent and thus the underlying mechanisms warrant further investigation. In the current study, the network pharmacology strategy and zebrafish model were utilized to explain the potential pharmacological effects of quercetin on osteoporosis. The potential targets and related signaling pathways were explored through overlapping target prediction, protein–protein interaction network construction, and functional enrichment analysis. Furthermore, we performed docking studies to verify the specific interactions between quercetin and crucial targets. Consequently, 55 targets were related to osteoporosis disease among the 159 targets of quercetin obtained by three database sources. Thirty hub targets were filtered through the cytoNCA plugin. Additionally, the Gene Ontology functions in the top 10 respective biological processes, molecular functions, and cell components as well as the top 20 Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways were depicted. The most significance difference in the KEGG pathways was the TNF signaling pathway, consisting of the Nuclear Factor Kappa B Subunit (NF-κB), Extracellular Regulated Protein Kinases (ERK) 1/2, Activator Protein 1 (AP-1), Interleukin 6 (IL6), Transcription factor AP-1 (Jun), and Phosphatidylinositol 3 Kinase (PI3K), which were probably involved in the pharmacological effects. Moreover, molecular docking studies revealed that the top three entries were Interleukin 1 Beta (IL1B), the Nuclear Factor NF-Kappa-B p65 Subunit (RelA), and the Nuclear Factor Kappa B Subunit 1 (NFKB1), respectively. Finally, these results were verified by alizarin red-stained mineralized bone in zebrafish and related qPCR experiments. The findings probably facilitate the mechanism elucidation related to quercetin anti-osteoporosis action.
Keywords	quercetin ; osteoporosis ; pharmacological mechanism ; network pharmacology ; zebrafish ; Science ; Q
Subject code	570
Language	English
Publishing date	2022-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: GF-1 Satellite Observations of Suspended Sediment Injection of Yellow River Estuary, China

Ru Yao / LiNa Cai / JianQiang Liu / MinRui Zhou

Remote Sensing, Vol 12, Iss 3126, p

2020 Volume 3126

Abstract: We analyzed the distribution of suspended sediments concentration (SSC) in the Yellow River Estuary based on data from GaoFen-1 (GF-1), which is a high-resolution satellite carrying a wide field-of-view (WFV) sensor and panchromatic and a multispectral ( ... ...

Abstract	We analyzed the distribution of suspended sediments concentration (SSC) in the Yellow River Estuary based on data from GaoFen-1 (GF-1), which is a high-resolution satellite carrying a wide field-of-view (WFV) sensor and panchromatic and a multispectral (PMS) sensor on it. A new SSC retrieval model for the wide field-of-view sensor (M-WFV) was established based on the relationship between in-situ SSC and the reflectance in blue and near infrared bands. SSC obtained from 16 WFV1 images were analyzed in the Yellow River Estuary. The results show that (1) SSC in the study area is mainly 100–3500 mg/L, with the highest value being around 4500 mg/L. (2) The details of suspended sediment injection phenomenon were found in the Yellow River Estuary. The SSC distribution in the coastal water has two forms. One is that the high SSC water evenly distributes near the coast and the gradient of the SSC is similar. The other is that the high SSC water concentrates at the right side of the estuary (Laizhou Bay) with a significantly large area. Usually, there is a clear-water notch at the left side of the estuary. (3) Currents clearly influenced the SSC distribution in the Yellow River Estuary. The SSC gradient in the estuary was high against the local current direction. On the contrary, the SSC gradient in the estuary was small towards the local current direction. Eroding the coast and resuspension of the bottom sediments, together with currents, are the major factors influencing the SSC distribution in nearshore water in the Yellow River Estuary.
Keywords	GF-1 ; suspended sediment injection ; Yellow River ; Science ; Q
Subject code	550
Language	English
Publishing date	2020-09-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Effects of renal denervation on blood-pressure response to hemorrhagic shock in spontaneously hypertensive rats

Xiao-Na Cai / Chao-Yi Wang / Yuan Cai / Fang Peng

Chinese Journal of Traumatology, Vol 21, Iss 5, Pp 293-

2018 Volume 300

Abstract: Purpose: Renal denervation (RD) has been demonstrated to be an effective approach to reduce blood pressure for those with resistant hypertension. Yet, we aimed to explore the effect and possible mechanism of RD on blood-pressure response to hemorrhagic ... ...

Abstract	Purpose: Renal denervation (RD) has been demonstrated to be an effective approach to reduce blood pressure for those with resistant hypertension. Yet, we aimed to explore the effect and possible mechanism of RD on blood-pressure response to hemorrhagic shock in spontaneously hypertensive rats. Methods: A total of 48 male spontaneously hypertensive rats were randomized to three groups: study group, sham-operation group and control group. RD was achieved by cutting off renal nerves and swabbing phenol on it. Ten weeks after RD, 8 rats in each group were sacrificed to collect the kidney and heart tissues. The remaining rats were subjected to an operation to induce hemorrhagic shock which would lead to 40% loss of total blood volume, and observed for 120 min. The serum concentration of norepinephrine was measured before and three weeks after RD. Results: The blood-pressure and norepinephrine levels were reduced significantly after RD (p < 0.05). Systolic blood pressure and diastolic blood pressure of the surgery group were higher than those in the sham and control groups at 15, 30 and 45 min after hemorrhagic shock (p < 0.05), while no significant difference was observed at 60, 90 and 120 min (p > 0.05). Additionally, the beta-1 adrenergic receptor (β1-AR) in the study group was significantly higher than those in the other two groups (p < 0.05) after hemorrhagic shock. Conclusion: This study demonstrated that RD could to some extent improve blood-pressure response to hemorrhagic shock in an established model of severe hemorrhagic shock in spontaneously hypertensive rats. The mechanism might be associated with up-regulation of β1-AR. Keywords: Renal denervation, Hemorrhage, Beta-1 adrenergic receptor, Spontaneously hypertensive rats
Keywords	Medicine (General) ; R5-920
Subject code	616 ; 630
Language	English
Publishing date	2018-10-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Leveraging eQTLs to identify individual-level tissue of interest for a complex trait.

Arunabha Majumdar / Claudia Giambartolomei / Na Cai / Tanushree Haldar / Tommer Schwarz / Michael Gandal / Jonathan Flint / Bogdan Pasaniuc

PLoS Computational Biology, Vol 17, Iss 5, p e

2021 Volume 1008915

Abstract: Genetic predisposition for complex traits often acts through multiple tissues at different time points during development. As a simple example, the genetic predisposition for obesity could be manifested either through inherited variants that control ... ...

Abstract	Genetic predisposition for complex traits often acts through multiple tissues at different time points during development. As a simple example, the genetic predisposition for obesity could be manifested either through inherited variants that control metabolism through regulation of genes expressed in the brain, or that control fat storage through dysregulation of genes expressed in adipose tissue, or both. Here we describe a statistical approach that leverages tissue-specific expression quantitative trait loci (eQTLs) corresponding to tissue-specific genes to prioritize a relevant tissue underlying the genetic predisposition of a given individual for a complex trait. Unlike existing approaches that prioritize relevant tissues for the trait in the population, our approach probabilistically quantifies the tissue-wise genetic contribution to the trait for a given individual. We hypothesize that for a subgroup of individuals the genetic contribution to the trait can be mediated primarily through a specific tissue. Through simulations using the UK Biobank, we show that our approach can predict the relevant tissue accurately and can cluster individuals according to their tissue-specific genetic architecture. We analyze body mass index (BMI) and waist to hip ratio adjusted for BMI (WHRadjBMI) in the UK Biobank to identify subgroups of individuals whose genetic predisposition act primarily through brain versus adipose tissue, and adipose versus muscle tissue, respectively. Notably, we find that these individuals have specific phenotypic features beyond BMI and WHRadjBMI that distinguish them from random individuals in the data, suggesting biological effects of tissue-specific genetic contribution for these traits.
Keywords	Biology (General) ; QH301-705.5
Subject code	616
Language	English
Publishing date	2021-05-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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