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  1. AU="Naama, Moriyah"
  2. AU=Khan Israr
  3. AU="Ansary, Delwar"
  4. AU="Gamerra, Mario"
  5. AU="Eric M. Yoshida"
  6. AU="Raj, Rahul"
  7. AU="Semaan, Marie"
  8. AU="Trafton, Jodie"
  9. AU="Victoria Walker-Sperling"
  10. AU="Song, Wuqi"
  11. AU="Pham, K.‐C"
  12. AU="Boria Alegre, Felix"
  13. AU="Vecsey-Nagy, Milán"
  14. AU=Bazak Remon
  15. AU="Shaaban, Mahmoud"
  16. AU="Perminow, Gøri"
  17. AU="Akrim, Faraz"
  18. AU="Haider, Najm"
  19. AU="Jain, Divyanu"
  20. AU="Halpert, Richard"
  21. AU="Alkorta, Ibon"
  22. AU="Kwon, Kyungmi"
  23. AU="Bernardo Salasnich"
  24. AU="Hassan, Zurina"
  25. AU="Belarbi, M"
  26. AU="Rout, Ranjeet K"
  27. AU="Moreira, Catarina"
  28. AU=Warn-Cramer Bonnie J
  29. AU="Morral, Núria"
  30. AU="Silman, Miles R."
  31. AU="Palfi Salavat, Mădălina-Casiana"
  32. AU="Mohamed, Eid"
  33. AU="Hudson, Lance"
  34. AU="Imane Mihoub" AU="Imane Mihoub"
  35. AU="D. M. Wuchenich"

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  1. Artikel ; Online: Human trophoblast stem cell-state acquisition from pluripotent stem cells and somatic cells.

    Naama, Moriyah / Buganim, Yosef

    Current opinion in genetics & development

    2023  Band 81, Seite(n) 102084

    Abstract: For an extended period of time, research on human embryo implantation and early placentation was hindered by ethical limitation and lack of appropriate in vitro models. Recently, an explosion of new research has significantly expanded our knowledge of ... ...

    Abstract For an extended period of time, research on human embryo implantation and early placentation was hindered by ethical limitation and lack of appropriate in vitro models. Recently, an explosion of new research has significantly expanded our knowledge of early human trophoblast development and facilitated the derivation and culture of self-renewing human trophoblast stem cells (hTSCs). Multiple approaches have been undertaken in efforts to derive and understand hTSCs, including from blastocysts, early trophoblast tissue, and, more recently, from human pluripotent stem cells (hPSCs) and somatic cells. In this concise review, we summarize recent advances in derivation of hTSCs, with a focus on derivation from naive and primed hPSCs, as well as via reprogramming of somatic cells into induced hTSCs. Each of these methods harbors distinct advantages and setbacks, which are discussed. Finally, we briefly explore the possibility of the existence of trophectoderm-like hTSCs corresponding to earlier, preimplantation trophoblast cells.
    Mesh-Begriff(e) Pregnancy ; Female ; Humans ; Trophoblasts ; Pluripotent Stem Cells ; Blastocyst ; Embryo, Mammalian ; Cell Differentiation/genetics
    Sprache Englisch
    Erscheinungsdatum 2023-07-12
    Erscheinungsland England
    Dokumenttyp Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 1077312-5
    ISSN 1879-0380 ; 0959-437X
    ISSN (online) 1879-0380
    ISSN 0959-437X
    DOI 10.1016/j.gde.2023.102084
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 3240: Hefte anzeigen Standort:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  2. Artikel ; Online: Pluripotency-independent induction of human trophoblast stem cells from fibroblasts.

    Naama, Moriyah / Rahamim, Moran / Zayat, Valery / Sebban, Shulamit / Radwan, Ahmed / Orzech, Dana / Lasry, Rachel / Ifrah, Annael / Jaber, Mohammad / Sabag, Ofra / Yassen, Hazar / Khatib, Areej / Epsztejn-Litman, Silvina / Novoselsky-Persky, Michal / Makedonski, Kirill / Deri, Noy / Goldman-Wohl, Debra / Cedar, Howard / Yagel, Simcha /
    Eiges, Rachel / Buganim, Yosef

    Nature communications

    2023  Band 14, Heft 1, Seite(n) 3359

    Abstract: Human trophoblast stem cells (hTSCs) can be derived from embryonic stem cells (hESCs) or be induced from somatic cells by OCT4, SOX2, KLF4 and MYC (OSKM). Here we explore whether the hTSC state can be induced independently of pluripotency, and what are ... ...

    Abstract Human trophoblast stem cells (hTSCs) can be derived from embryonic stem cells (hESCs) or be induced from somatic cells by OCT4, SOX2, KLF4 and MYC (OSKM). Here we explore whether the hTSC state can be induced independently of pluripotency, and what are the mechanisms underlying its acquisition. We identify GATA3, OCT4, KLF4 and MYC (GOKM) as a combination of factors that can generate functional hiTSCs from fibroblasts. Transcriptomic analysis of stable GOKM- and OSKM-hiTSCs reveals 94 hTSC-specific genes that are aberrant specifically in OSKM-derived hiTSCs. Through time-course-RNA-seq analysis, H3K4me2 deposition and chromatin accessibility, we demonstrate that GOKM exert greater chromatin opening activity than OSKM. While GOKM primarily target hTSC-specific loci, OSKM mainly induce the hTSC state via targeting hESC and hTSC shared loci. Finally, we show that GOKM efficiently generate hiTSCs from fibroblasts that harbor knockout for pluripotency genes, further emphasizing that pluripotency is dispensable for hTSC state acquisition.
    Mesh-Begriff(e) Humans ; Cellular Reprogramming/genetics ; Trophoblasts ; Fibroblasts ; Embryonic Stem Cells ; Chromatin/genetics ; Induced Pluripotent Stem Cells ; Octamer Transcription Factor-3/genetics
    Chemische Substanzen Chromatin ; Octamer Transcription Factor-3
    Sprache Englisch
    Erscheinungsdatum 2023-06-08
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-023-39104-1
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Human Induced Pluripotent Stem Cell Models of Neurodegenerative Disorders for Studying the Biomedical Implications of Autophagy.

    Seranova, Elena / Palhegyi, Adina Maria / Verma, Surbhi / Dimova, Simona / Lasry, Rachel / Naama, Moriyah / Sun, Congxin / Barrett, Timothy / Rosenstock, Tatiana Rosado / Kumar, Dhiraj / Cohen, Malkiel A / Buganim, Yosef / Sarkar, Sovan

    Journal of molecular biology

    2020  Band 432, Heft 8, Seite(n) 2754–2798

    Abstract: Autophagy is an intracellular degradation process that is essential for cellular survival, tissue homeostasis, and human health. The housekeeping functions of autophagy in mediating the clearance of aggregation-prone proteins and damaged organelles are ... ...

    Abstract Autophagy is an intracellular degradation process that is essential for cellular survival, tissue homeostasis, and human health. The housekeeping functions of autophagy in mediating the clearance of aggregation-prone proteins and damaged organelles are vital for post-mitotic neurons. Improper functioning of this process contributes to the pathology of myriad human diseases, including neurodegeneration. Impairment in autophagy has been reported in several neurodegenerative diseases where pharmacological induction of autophagy has therapeutic benefits in cellular and transgenic animal models. However, emerging studies suggest that the efficacy of autophagy inducers, as well as the nature of the autophagy defects, may be context-dependent, and therefore, studies in disease-relevant experimental systems may provide more insights for clinical translation to patients. With the advancements in human stem cell technology, it is now possible to establish disease-affected cellular platforms from patients for investigating disease mechanisms and identifying candidate drugs in the appropriate cell types, such as neurons that are otherwise not accessible. Towards this, patient-derived human induced pluripotent stem cells (hiPSCs) have demonstrated considerable promise in constituting a platform for effective disease modeling and drug discovery. Multiple studies have utilized hiPSC models of neurodegenerative diseases to study autophagy and evaluate the therapeutic efficacy of autophagy inducers in neuronal cells. This review provides an overview of the regulation of autophagy, generation of hiPSCs via cellular reprogramming, and neuronal differentiation. It outlines the findings in various neurodegenerative disorders where autophagy has been studied using hiPSC models.
    Mesh-Begriff(e) Animals ; Autophagy ; Cell Differentiation ; Cellular Reprogramming ; Humans ; Induced Pluripotent Stem Cells/cytology ; Models, Biological ; Neurodegenerative Diseases/pathology ; Neurons/pathology
    Sprache Englisch
    Erscheinungsdatum 2020-02-07
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 80229-3
    ISSN 1089-8638 ; 0022-2836
    ISSN (online) 1089-8638
    ISSN 0022-2836
    DOI 10.1016/j.jmb.2020.01.024
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 867: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

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