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  1. Article ; Online: Cutaneous Granulomatosis Revealing Whipple’s Disease

    Souheil Zayet / Pierre Isnard / Jacinta Bustamante / David Boutboul / Sarra Abroug / Nabil Belfeki

    Pathogens, Vol 10, Iss 1438, p

    Value of Tropheryma whipplei Polymerase Chain Reaction Assay for the Diagnosis

    2021  Volume 1438

    Abstract: Whipple’s Disease is a rare systemic infectious disease caused by the ubiquitous actinomycetes Tropheryma whipplei (T. whipplei). We report herein a rare case of a cutaneous granulo matosis with hypercalcemia as an unusual presenting feature of Whipple’s ...

    Abstract Whipple’s Disease is a rare systemic infectious disease caused by the ubiquitous actinomycetes Tropheryma whipplei (T. whipplei). We report herein a rare case of a cutaneous granulo matosis with hypercalcemia as an unusual presenting feature of Whipple’s disease. The diagnosis of the bacteria was obtained from skin and inguinal lymph node biopsy (16 rDNA PCR screening and histological examination using PAS staining). T. whipplei was also identified on saliva and stool specimens, using specific PCR and colonic biopsies. Treatment with hydroxychloroquine and doxycycline allowed a rapid resolution of symptoms with a complete recovery.
    Keywords granulomatosis ; polymerase chain reaction ; skin ; Whipple’s disease ; Tropheryma whipplei ; Medicine ; R
    Language English
    Publishing date 2021-11-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Cardiovascular Magnetic Resonance Imaging Pattern in Campylobacter jejuni -related Myocarditis

    Nabil Belfeki / Souheil Zayet / Mohannad Yassin / Mazen Alloujami / Audrey Lefoulon / Théo Pezel / Jerôme Garot / Cyrus Moini

    Microorganisms, Vol 10, Iss 208, p

    2022  Volume 208

    Abstract: Background: Campylobacter jejuni ( C. jejuni ) is a common cause of mostly self-limiting enterocolitis. Although rare, myocarditis has been increasingly documented as a complication following campylobacteriosis. Such cases have occurred predominantly in ... ...

    Abstract Background: Campylobacter jejuni ( C. jejuni ) is a common cause of mostly self-limiting enterocolitis. Although rare, myocarditis has been increasingly documented as a complication following campylobacteriosis. Such cases have occurred predominantly in younger males and involved a single causative species, namely C. jejuni . Case report: We report herein a case of myocarditis complicating gastroenteritis in a 23-year-old immunocompetent patient, caused by this bacterium with a favorable outcome. Cardiac magnetic resonance imagining was useful in establishing an early diagnosis. Conclusions: Myocarditis should be considered in younger patients presenting with chest pain and plasmatic troponin elevations. The occurrence of myocarditis complicating C. jejuni is reviewed.
    Keywords Campylobacter jejuni ; enteritis ; myocarditis ; CMR imaging ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Primary Sjögren’s syndrome complicated by anti-neutrophil cytoplasmic antibody-mediated crescentic glomerulonephritis

    Imed Ben Ghorbel / Nabil Belfeki / Thouraya Ben Salem / Mohamed Habib Houman

    Saudi Journal of Kidney Diseases and Transplantation, Vol 28, Iss 5, Pp 1184-

    2017  Volume 1187

    Abstract: Ocular and oral dryness are the hallmark of Sjögren’s syndrome (SS). However, SS can be associated with a variety of complications, affecting organs such as the liver, kidneys, lungs, muscle, and nervous system. Renal involvement has been usually in the ... ...

    Abstract Ocular and oral dryness are the hallmark of Sjögren’s syndrome (SS). However, SS can be associated with a variety of complications, affecting organs such as the liver, kidneys, lungs, muscle, and nervous system. Renal involvement has been usually in the form of tubulointerstitial nephritis. However, glomerulonephritis is rare in primary SS. We report three clinical cases of SS with anti-neutrophil cytoplasmic antibody-mediated crescentic glomerulo-nephritis treated with prednisone and cyclophosphamide, with favorable outcome.
    Keywords Medicine ; R
    Language English
    Publishing date 2017-01-01T00:00:00Z
    Publisher Wolters Kluwer Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Post-COVID-19 Syndrome

    Souheil Zayet / Hajer Zahra / Pierre-Yves Royer / Can Tipirdamaz / Julien Mercier / Vincent Gendrin / Quentin Lepiller / Solène Marty-Quinternet / Molka Osman / Nabil Belfeki / Lynda Toko / Pauline Garnier / Alix Pierron / Julie Plantin / Louise Messin / Marc Villemain / Kevin Bouiller / Timothée Klopfenstein

    Microorganisms, Vol 9, Iss 1719, p

    Nine Months after SARS-CoV-2 Infection in a Cohort of 354 Patients: Data from the First Wave of COVID-19 in Nord Franche-Comté Hospital, France

    2021  Volume 1719

    Abstract: 1) Background. Post-COVID-19 syndrome is defined as the persistence of symptoms after confirmed SARS-CoV-2 infection. (2) Methods. ANOSVID is an observational retrospective study in Nord Franche-Comté Hospital in France that included adult COVID-19 ... ...

    Abstract (1) Background. Post-COVID-19 syndrome is defined as the persistence of symptoms after confirmed SARS-CoV-2 infection. (2) Methods. ANOSVID is an observational retrospective study in Nord Franche-Comté Hospital in France that included adult COVID-19 patients confirmed by RT-PCR from 1 March 2020 to 31 May 2020. The aim was to describe patients with post-COVID-19 syndrome with persistent symptoms (PS group) and to compare them with the patients without persistent symptoms (no-PS group). (3) Results. Of the 354 COVID-19 patients, 35.9% ( n = 127) reported persistence of at least one symptom after a mean of 289.1 ± 24.5 days after symptom onset. Moreover, 115 patients reported a recurrence of symptoms after recovery, and only 12 patients reported continuous symptoms. The mean age of patients was 48.6 years (19–93) ± 19.4, and 81 patients (63.8%) were female. Patients in the PS group had a longer duration of symptoms of initial acute SARS-CoV-2 infection than patients in the no-PS group (respectively, 57.1 ± 82.1 days versus 29.7 ± 42.1 days, p < 0.001). A majority of patients ( n = 104, 81.9%) reported three or more symptoms. The most prevalent persistent symptoms were loss of smell (74.0%, n = 94), fatigue (53.5%, n = 68), loss of taste (31.5%, n = 40), and dyspnea (30.7%, n = 39). These were followed by pain symptoms (26.8% ( n = 34), 26.0% ( n = 33), 24.4% ( n = 31); headache, arthralgia, and myalgia, respectively). More than half of patients reporting persistent symptoms (58%, n = 73) were healthcare workers (HCWs). Among outpatients, this population was more present in the PS group than the no-PS group ((86.6%) n = 71/82 versus (72.2%) n = 109/151, p = 0.012). Post-COVID-19 syndrome was more frequent in patients with a past history of chronic rhinosinusitis (8.7% ( n = 11%) versus 1.3% ( n = 3), p < 0.001). No significant difference was found regarding clinical characteristics and outcome, laboratory, imaging findings, and treatment received in the two groups. (4) Conclusions. More than a third of our ...
    Keywords post-COVID-19 ; long COVID-19 ; follow-up ; fatigue ; dyspnea ; health care workers ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2021-08-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: USAID Associated with Myeloid Neoplasm and VEXAS Syndrome

    Marion Delplanque / Achille Aouba / Pierre Hirsch / Pierre Fenaux / Julie Graveleau / Florent Malard / Damien Roos-Weil / Nabil Belfeki / Louis Drevon / Artem Oganesyan / Matthieu Groh / Matthieu Mahévas / Jerome Razanamahery / Gwenola Maigne / Matthieu Décamp / Sébastien Miranda / Thomas Quemeneur / Julien Rossignol / Laurent Sailler /
    Marie Sébert / Louis Terriou / Anna Sevoyan / Yervand Hakobyan / Sophie Georgin-Lavialle / Arsène Mekinian

    Journal of Clinical Medicine, Vol 10, Iss 5586, p

    Two Differential Diagnoses of Suspected Adult Onset Still’s Disease in Elderly Patients

    2021  Volume 5586

    Abstract: Background: Patients with solid cancers and hematopoietic malignancy can experience systemic symptoms compatible with adult-onset Still’s disease (AOSD). The newly described VEXAS, associated with somatic UBA1 mutations, exhibits an overlap of clinical ... ...

    Abstract Background: Patients with solid cancers and hematopoietic malignancy can experience systemic symptoms compatible with adult-onset Still’s disease (AOSD). The newly described VEXAS, associated with somatic UBA1 mutations, exhibits an overlap of clinical and/or biological pictures with auto inflammatory signs and myelodysplastic syndrome (MDS). Objectives: To describe a cohort of patients with signs of undifferentiated systemic autoinflammatory disorder (USAID) concordant with AOSD and MDS/chronic myelomonocytic leukemia (CMML) and the prevalence of VEXAS proposed management and outcome. Methods: A French multicenter retrospective study from the MINHEMON study group also used for other published works with the support of multidisciplinary and complementary networks of physicians and a control group of 104 MDS/CMML. Results: Twenty-six patients were included with a median age at first signs of USAID of 70.5 years with male predominance (4:1). Five patients met the criteria for confirmed AOSD. The most frequent subtypes were MDS with a blast excess (31%) and MDS with multilineage dysplasia (18%). Seven patients presented with acute myeloid leukemia and twelve died during a median follow-up of 2.5 years. Six out of 18 tested patients displayed a somatic UBA1 mutation concordant with VEXAS, including one woman. High-dose corticosteroids led to a response in 13/16 cases and targeted biological therapy alone or in association in 10/12 patients (anakinra, tocilizumab, and infliximab). Azacytidine resulted in complete or partial response in systemic symptoms for 10/12 (83%) patients including 3 VEXAS. Conclusions: Systemic form of VEXAS syndrome can mimic AOSD. The suspicion of USAID or AOSD in older males with atypia should prompt an evaluation of underlying MDS and assessment of somatic UBA1 mutation.
    Keywords adult-onset Still’s disease ; myelodysplastic syndrome ; SAID ; USAID ; VEXAS ; azacytidine ; Medicine ; R
    Subject code 610 ; 616
    Language English
    Publishing date 2021-11-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Inter-library loan at ZB MED

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