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  1. AU="Nachiappan, Nachal"
  2. AU="Aguilar, Gislani Mateus Oliveira"
  3. AU=Roknic Nikola
  4. AU="Bommireddy, Vikram Simha"
  5. AU="Healy, Jeremiah C."
  6. AU="Noelle Enright"
  7. AU="Yue Leon Guo"
  8. AU="Selph, Shelley S"
  9. AU="Eric A Weingarten"
  10. AU="Agus, Marcello"
  11. AU="Pan, Fupeng"
  12. AU="Picus, Roberto"
  13. AU="Manai, Marwa"
  14. AU=Gimenez-Mascarell Paula
  15. AU="Kazem Asadollahi"
  16. AU="Tomaino, Elisabetta"
  17. AU="Bao, Xingce"
  18. AU="Santos, Ohanna Thays de Medeiros"
  19. AU="Bou-Cabo, M."
  20. AU="Hwang, Young"
  21. AU="Jia, Lingyue"
  22. AU="Qiao, Haoran"
  23. AU=Ning Li
  24. AU="Djillali, Salih"

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  1. Artikel ; Online: Moyamoya syndrome in a Malaysian child with Down syndrome.

    Vimalesvaran, Sunitha / Nachiappan, Nachal / Sithamparanathan, Yogeswery

    Journal of paediatrics and child health

    2013  Band 49, Heft 10, Seite(n) 865–7; quiz 867–8

    Mesh-Begriff(e) Brain/diagnostic imaging ; Brain/pathology ; Cerebral Angiography ; Child ; Diagnosis, Differential ; Down Syndrome/complications ; Female ; Humans ; Magnetic Resonance Imaging ; Moyamoya Disease/complications ; Moyamoya Disease/diagnostic imaging
    Sprache Englisch
    Erscheinungsdatum 2013-10
    Erscheinungsland Australia
    Dokumenttyp Case Reports ; Journal Article
    ZDB-ID 1024476-1
    ISSN 1440-1754 ; 1034-4810
    ISSN (online) 1440-1754
    ISSN 1034-4810
    DOI 10.1111/jpc.12239
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Volltext online

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 227: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Artikel ; Online: Extended Versus Standard Antibiotic Course Duration in Children <5 Years of Age Hospitalized With Community-acquired Pneumonia in High-risk Settings: Four-week Outcomes of a Multicenter, Double-blind, Parallel, Superiority Randomized Controlled Trial.

    McCallum, Gabrielle B / Fong, Siew M / Grimwood, Keith / Nathan, Anna M / Byrnes, Catherine A / Ooi, Mong H / Nachiappan, Nachal / Saari, Noorazlina / Morris, Peter S / Yeo, Tsin W / Ware, Robert S / Elogius, Blueren W / Oguoma, Victor M / Yerkovich, Stephanie T / de Bruyne, Jessie / Lawrence, Katrina A / Lee, Bilawara / Upham, John W / Torzillo, Paul J /
    Chang, Anne B

    The Pediatric infectious disease journal

    2022  Band 41, Heft 7, Seite(n) 549–555

    Abstract: Background: High-level evidence is limited for antibiotic duration in children hospitalized with community-acquired pneumonia (CAP) from First Nations and other at-risk populations of chronic respiratory disorders. As part of a larger study, we ... ...

    Abstract Background: High-level evidence is limited for antibiotic duration in children hospitalized with community-acquired pneumonia (CAP) from First Nations and other at-risk populations of chronic respiratory disorders. As part of a larger study, we determined whether an extended antibiotic course is superior to a standard course for achieving clinical cure at 4 weeks in children 3 months to ≤5 years old hospitalized with CAP.
    Methods: In our multinational (Australia, New Zealand, Malaysia), double-blind, superiority randomized controlled trial, children hospitalized with uncomplicated, radiographic-confirmed, CAP received 1-3 days of intravenous antibiotics followed by 3 days of oral amoxicillin-clavulanate (80 mg/kg, amoxicillin component, divided twice daily) and then randomized to extended (13-14 days duration) or standard (5-6 days) antibiotics. The primary outcome was clinical cure (complete resolution of respiratory symptoms/signs) 4 weeks postenrollment. Secondary outcomes included adverse events, nasopharyngeal bacterial pathogens and antimicrobial resistance at 4 weeks.
    Results: Of 372 children enrolled, 324 fulfilled the inclusion criteria and were randomized. Using intention-to-treat analysis, between-group clinical cure rates were similar (extended course: n = 127/163, 77.9%; standard course: n = 131/161, 81.3%; relative risk = 0.96, 95% confidence interval = 0.86-1.07). There were no significant between-group differences for adverse events (extended course: n = 43/163, 26.4%; standard course, n = 32/161, 19.9%) or nasopharyngeal carriage of Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis and Staphylococcus aureus or antimicrobial resistance.
    Conclusions: Among children hospitalized with pneumonia and at-risk of chronic respiratory illnesses, an extended antibiotic course was not superior to a standard course at achieving clinical cure at 4 weeks. Additional research will identify if an extended course provides longer-term benefits.
    Mesh-Begriff(e) Amoxicillin/therapeutic use ; Amoxicillin-Potassium Clavulanate Combination/adverse effects ; Anti-Bacterial Agents ; Child ; Community-Acquired Infections/drug therapy ; Community-Acquired Infections/microbiology ; Double-Blind Method ; Humans ; Infant ; Pneumonia/drug therapy
    Chemische Substanzen Anti-Bacterial Agents ; Amoxicillin-Potassium Clavulanate Combination (74469-00-4) ; Amoxicillin (804826J2HU)
    Sprache Englisch
    Erscheinungsdatum 2022-06-07
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Multicenter Study ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 392481-6
    ISSN 1532-0987 ; 0891-3668
    ISSN (online) 1532-0987
    ISSN 0891-3668
    DOI 10.1097/INF.0000000000003558
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 1852: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Artikel ; Online: HOspitalised Pneumonia Extended (HOPE) Study to reduce the long-term effects of childhood pneumonia: protocol for a multicentre, double-blind, parallel, superiority randomised controlled trial.

    Chang, Anne B / Fong, Siew Moy / Yeo, Tsin Wen / Ware, Robert S / McCallum, Gabrielle B / Nathan, Anna M / Ooi, Mong H / de Bruyne, Jessie / Byrnes, Catherine A / Lee, Bilawara / Nachiappan, Nachal / Saari, Noorazlina / Torzillo, Paul / Smith-Vaughan, Heidi / Morris, Peter S / Upham, John W / Grimwood, Keith

    BMJ open

    2019  Band 9, Heft 4, Seite(n) e026411

    Abstract: Introduction: Early childhood pneumonia is a common problem globally with long-term complications that include bronchiectasis and chronic obstructive pulmonary disease. It is biologically plausible that these long-term effects may be minimised in young ... ...

    Abstract Introduction: Early childhood pneumonia is a common problem globally with long-term complications that include bronchiectasis and chronic obstructive pulmonary disease. It is biologically plausible that these long-term effects may be minimised in young children at increased risk of such sequelae if any residual lower airway infection and inflammation in their developing lungs can be treated successfully by longer antibiotic courses. In contrast, shortened antibiotic treatments are being promoted because of concerns over inducing antimicrobial resistance. Nevertheless, the optimal treatment duration remains unknown. Outcomes from randomised controlled trials (RCTs) on paediatric pneumonia have focused on short-term (usually <2 weeks) results. Indeed, no long-term RCT-generated outcome data are available currently. We hypothesise that a longer antibiotic course, compared with the standard treatment course, reduces the risk of chronic respiratory symptoms/signs or bronchiectasis 24 months after the original pneumonia episode.
    Methods and analysis: This multicentre, parallel, double-blind, placebo-controlled randomised trial involving seven hospitals in six cities from three different countries commenced in May 2016. Three-hundred-and-fourteen eligible Australian Indigenous, New Zealand Māori/Pacific and Malaysian children (aged 0.25 to 5 years) hospitalised for community-acquired, chest X-ray (CXR)-proven pneumonia are being recruited. Following intravenous antibiotics and 3 days of amoxicillin-clavulanate, they are randomised (stratified by site and age group, allocation-concealed) to receive either: (i) amoxicillin-clavulanate (80 mg/kg/day (maximum 980 mg of amoxicillin) in two-divided doses or (ii) placebo (equal volume and dosing frequency) for 8 days. Clinical data, nasopharyngeal swab, bloods and CXR are collected. The primary outcome is the proportion of children without chronic respiratory symptom/signs of bronchiectasis at 24 months. The main secondary outcomes are 'clinical cure' at 4 weeks, time-to-next respiratory-related hospitalisation and antibiotic resistance of nasopharyngeal respiratory bacteria.
    Ethics and dissemination: The Human Research Ethics Committees of all the recruiting institutions (Darwin: Northern Territory Department of Health and Menzies School of Health Research; Auckland: Starship Children's and KidsFirst Hospitals; East Malaysia: Likas Hospital and Sarawak General Hospital; Kuala Lumpur: University of Malaya Research Ethics Committee; and Klang: Malaysian Department of Health) have approved the research protocol version 7 (13 August 2018). The RCT and other results will be submitted for publication.
    Trial registration: ACTRN12616000046404.
    Mesh-Begriff(e) Anti-Bacterial Agents/therapeutic use ; Australia/epidemiology ; Child, Preschool ; Double-Blind Method ; Female ; Follow-Up Studies ; Hospitalization/statistics & numerical data ; Humans ; Incidence ; Infant ; Malaysia/epidemiology ; Male ; New Zealand/epidemiology ; Pneumonia/drug therapy ; Pneumonia/epidemiology ; Retrospective Studies ; Time Factors ; Treatment Outcome
    Chemische Substanzen Anti-Bacterial Agents
    Sprache Englisch
    Erscheinungsdatum 2019-04-24
    Erscheinungsland England
    Dokumenttyp Journal Article ; Multicenter Study ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2018-026411
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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