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  1. Article ; Online: Integrated bioinformatics and wet-lab analysis revealed cell adhesion prominent genes CDC42, TAGLN and GSN as prognostic biomarkers in colonic-polyp lesions.

    Tabatabaei, Elmira Sadat / Mazloomnejad, Radman / Rejali, Leili / Forouzesh, Flora / Naderi-Noukabadi, Fatemeh / Khanabadi, Binazir / Salehi, Zahra / Nazemalhosseini-Mojarad, Ehsan

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 10307

    Abstract: Colorectal cancers are derived from intestinal polyps. Normally, alterations in cell adhesion genes expression cause deviation from the normal cell cycle, leading to cancer development, progression, and invasion. The present study aimed to investigate ... ...

    Abstract Colorectal cancers are derived from intestinal polyps. Normally, alterations in cell adhesion genes expression cause deviation from the normal cell cycle, leading to cancer development, progression, and invasion. The present study aimed to investigate the elusive expression pattern of CDC42, TAGLN, and GSN genes in patients with high and low-risk polyp samples, and also colorectal cancer patients and their adjacent normal tissues. In upcoming study, 40 biopsy samples from Taleghani Hospital (Tehran, Iran) were collected, consisting of 20 colon polyps and 20 paired adjacent normal tissues. The expression of the nominated genes CDC42, TAGLN, and GSN was analyzed using quantitative polymerase chain reaction (Q-PCR) and relative quantification was determined using the 2
    MeSH term(s) Humans ; Colonic Polyps/genetics ; Colonic Polyps/pathology ; Prognosis ; Cell Adhesion ; Iran ; Adenoma/genetics ; Colorectal Neoplasms/pathology ; Biomarkers ; Computational Biology ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/analysis
    Chemical Substances Biomarkers ; Biomarkers, Tumor
    Language English
    Publishing date 2023-06-26
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-37501-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Prevalence of binary-toxin genes (

    Azimirad, Masoumeh / Naderi Noukabadi, Fatemeh / Lahmi, Farhad / Yadegar, Abbas

    Gastroenterology and hepatology from bed to bench

    2019  Volume 11, Issue Suppl 1, Page(s) 59–65

    Abstract: Aim: In this study we investigated the prevalence of binary toxin genes, : Background: C. difficile: Methods: Totally, 930 patients suspected of having CDI was included in this study. All samples were treated with methanol and cultured on ... ...

    Abstract Aim: In this study we investigated the prevalence of binary toxin genes,
    Background: C. difficile
    Methods: Totally, 930 patients suspected of having CDI was included in this study. All samples were treated with methanol and cultured on selective C. difficile agar plates. The
    Results: Analysis of the PCR results showed a prevalence of 85.2% (144/169) for toxigenic
    Conclusion: This is the first report for the prevalence of binary toxin genes in
    Language English
    Publishing date 2019-01-25
    Publishing country Iran
    Document type Journal Article
    ZDB-ID 2569124-7
    ISSN 2008-4234 ; 2008-2258
    ISSN (online) 2008-4234
    ISSN 2008-2258
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: A novel stop codon mutation in STK11 gene is associated with Peutz-Jeghers Syndrome and elevated cancer risk: a case study.

    Khanabadi, Binazir / Najafgholizadeh Seyfi, Diba / Rejali, Leili / Taleghani, Mohammad Yaghoob / Tavallaei, Mehdi / Shahrokh, Shabnam / Daskar Abkenar, Elahe / Naderi Noukabadi, Fatemeh / Asadzadeh Aghdaei, Hamid / Nazemalhosseini Mojarad, Ehsan

    Gastroenterology and hepatology from bed to bench

    2023  Volume 16, Issue 3, Page(s) 341–346

    Abstract: Based on the analysis of patients with Peutz-Jeghers syndrome (PJS), Serine threonine kinase11 (STK11) is known as a tumor suppressor gene, which is involved in cell polarization, regulation of apoptosis, and DNA damage response. In this case report ... ...

    Abstract Based on the analysis of patients with Peutz-Jeghers syndrome (PJS), Serine threonine kinase11 (STK11) is known as a tumor suppressor gene, which is involved in cell polarization, regulation of apoptosis, and DNA damage response. In this case report study, we examined STK11 gene sequencing in a 42-year-old woman with mucocuta neous pigmentation and positive family history. Endoscopy and colonoscopy showed >1000 polyps throughout the stomach/colon (PJ-type hamartomas). The larger polyp in the stomach was resected and the small bowel imaging detected multiple jejunum/ileum small polyps. The data released from the sequencing results revealed five alterations in exons 1 to 5. The major mutation in stop codon was reported as converted to the amino acid tryptophan (TRP) to tyrosine (TER). The TGG codon was converted to TAG by mutation. Finally, another novel mutation in STK11 stop codon as a 'de novo' variant was seen. It is predicted that stop codon mutations make the affected person susceptible to developing colorectal cancer.
    Language English
    Publishing date 2023-09-22
    Publishing country Iran
    Document type Case Reports
    ZDB-ID 2569124-7
    ISSN 2008-4234 ; 2008-2258
    ISSN (online) 2008-4234
    ISSN 2008-2258
    DOI 10.22037/ghfbb.v16i2.2751
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: A 29-year-old man presented with acute upper gastrointestinal bleeding.

    Shahrokh, Shabnam / Pishgahi, Mohammad / Ketabi Moghadam, Pardis / Naderi Noukabadi, Fatemeh / Abdehagh, Mohammad Reza / Arab Hosseini, Asghar

    Gastroenterology and hepatology from bed to bench

    2021  Volume 13, Issue Suppl1, Page(s) S159–S161

    Language English
    Publishing date 2021-02-09
    Publishing country Iran
    Document type Journal Article
    ZDB-ID 2569124-7
    ISSN 2008-4234 ; 2008-2258
    ISSN (online) 2008-4234
    ISSN 2008-2258
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Paracrine signals of mesenchymal stem cells induce epithelial to mesenchymal transition in gastric cancer cells.

    Azizi, Parisa / Mazhari, Sogol / Tokhanbigli, Samaneh / Naderi Noukabadi, Fatemeh / Daskar Abkenar, Elahe / Shamsafzali, Esmaeil / Baghaei, Kaveh

    Gastroenterology and hepatology from bed to bench

    2020  Volume 12, Issue Suppl1, Page(s) S51–S57

    Abstract: Aim: Given the high similarity of phenotypical and secretory properties of mesenchymal stem cells and fibroblasts, this study investigated the possibility of inducing EMT process by mesenchymal stem cells.: Background: Annually, more than 13% of ... ...

    Abstract Aim: Given the high similarity of phenotypical and secretory properties of mesenchymal stem cells and fibroblasts, this study investigated the possibility of inducing EMT process by mesenchymal stem cells.
    Background: Annually, more than 13% of deaths worldwide occur due to cancer. One of the main reasons for the high mortality rate is due to the metastasis of cancer stem cells. Induction of metastasis occurs during the EMT process, which can also be stimulated by fibroblast cells.
    Methods: Mesenchymal stem cells (MSCs) were isolated and sub-cultured until passage 3 or 4. AGS cells were co-cultured with MSCs for 4 days. As the positive control group, AGS cells were treated with TGF-β (10ng/ml) for 48h. Finally, the mRNA expression level of Vimentin, β-catenin, Snail, and E-cadherin as the EMT pattern, were evaluated by RT-PCR technique.
    Results: Our findings indicated that AGS cells' crosstalk with MSCs significantly upregulated fibroblast markers including Vimentin and Snail expression. However, no significant changes were identified for β-catenin gene expression. Additionally, AGS treatment with MSCs resulted in diminished E-cadherin in the targeted cells.
    Conclusion: Based on the results, the AGS cells crosstalk with MSCs activates induction of epithelial mesenchymal transition, which is confirmed through the elevation of Vimentin and Snail expression and reduction of E-cadherin expression as a specific epithelial marker. However, it seems that MSc was not effective on Wnt/ β-catenin signal gastric cancer cell line.
    Language English
    Publishing date 2020-02-17
    Publishing country Iran
    Document type Journal Article
    ZDB-ID 2569124-7
    ISSN 2008-4234 ; 2008-2258
    ISSN (online) 2008-4234
    ISSN 2008-2258
    Database MEDical Literature Analysis and Retrieval System OnLINE

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