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  1. Article ; Online: Mechanical strain determines the site-specific localization of inflammation and tissue damage in arthritis

    Isabelle Cambré / Djoere Gaublomme / Arne Burssens / Peggy Jacques / Nadia Schryvers / Amélie De Muynck / Leander Meuris / Stijn Lambrecht / Shea Carter / Pieter de Bleser / Yvan Saeys / Luc Van Hoorebeke / George Kollias / Matthias Mack / Paul Simoens / Rik Lories / Nico Callewaert / Georg Schett / Dirk Elewaut

    Nature Communications, Vol 9, Iss 1, Pp 1-

    2018  Volume 14

    Abstract: Pro-inflammatory factors implicated for the onset of arthritis often have systematic effects, yet arthritis symptoms are mostly limited to the joints. Here the authors show that mechanical strain at the joints promotes the recruitment of monocyte and ... ...

    Abstract Pro-inflammatory factors implicated for the onset of arthritis often have systematic effects, yet arthritis symptoms are mostly limited to the joints. Here the authors show that mechanical strain at the joints promotes the recruitment of monocyte and their differentiation into bone-eroding osteoclast to contribute this tissue specificity.
    Keywords Science ; Q
    Language English
    Publishing date 2018-11-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Mechanical strain determines the site-specific localization of inflammation and tissue damage in arthritis

    Isabelle Cambré / Djoere Gaublomme / Arne Burssens / Peggy Jacques / Nadia Schryvers / Amélie De Muynck / Leander Meuris / Stijn Lambrecht / Shea Carter / Pieter de Bleser / Yvan Saeys / Luc Van Hoorebeke / George Kollias / Matthias Mack / Paul Simoens / Rik Lories / Nico Callewaert / Georg Schett / Dirk Elewaut

    Nature Communications, Vol 9, Iss 1, Pp 1-

    2018  Volume 14

    Abstract: Pro-inflammatory factors implicated for the onset of arthritis often have systematic effects, yet arthritis symptoms are mostly limited to the joints. Here the authors show that mechanical strain at the joints promotes the recruitment of monocyte and ... ...

    Abstract Pro-inflammatory factors implicated for the onset of arthritis often have systematic effects, yet arthritis symptoms are mostly limited to the joints. Here the authors show that mechanical strain at the joints promotes the recruitment of monocyte and their differentiation into bone-eroding osteoclast to contribute this tissue specificity.
    Keywords Science ; Q
    Language English
    Publishing date 2018-11-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    More links

    Kategorien

  3. Article ; Online: RORγt inhibition selectively targets IL-17 producing iNKT and γδ-T cells enriched in Spondyloarthritis patients

    Koen Venken / Peggy Jacques / Céline Mortier / Mark E. Labadia / Tine Decruy / Julie Coudenys / Kathleen Hoyt / Anita L. Wayne / Robert Hughes / Michael Turner / Sofie Van Gassen / Liesbet Martens / Dustin Smith / Christian Harcken / Joseph Wahle / Chao-Ting Wang / Eveline Verheugen / Nadia Schryvers / Gaëlle Varkas /
    Heleen Cypers / Ruth Wittoek / Yves Piette / Lieve Gyselbrecht / Serge Van Calenbergh / Filip Van den Bosch / Yvan Saeys / Gerald Nabozny / Dirk Elewaut

    Nature Communications, Vol 10, Iss 1, Pp 1-

    2019  Volume 15

    Abstract: The role of innate T cell subsets in the pathogenesis of spondyloarthritis (SpA) is not well understood. Here, the authors examine the role of invariant natural killer T (iNKT) and γδ-T cells in SpA and show that disease-derived iNKT and γδ-T cells have ... ...

    Abstract The role of innate T cell subsets in the pathogenesis of spondyloarthritis (SpA) is not well understood. Here, the authors examine the role of invariant natural killer T (iNKT) and γδ-T cells in SpA and show that disease-derived iNKT and γδ-T cells have unique and Th17-skewed phenotype and gene expression profiles within inflamed joints.
    Keywords Science ; Q
    Language English
    Publishing date 2019-01-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    More links

    Kategorien

  4. Article ; Online: RORγt inhibition selectively targets IL-17 producing iNKT and γδ-T cells enriched in Spondyloarthritis patients

    Koen Venken / Peggy Jacques / Céline Mortier / Mark E. Labadia / Tine Decruy / Julie Coudenys / Kathleen Hoyt / Anita L. Wayne / Robert Hughes / Michael Turner / Sofie Van Gassen / Liesbet Martens / Dustin Smith / Christian Harcken / Joseph Wahle / Chao-Ting Wang / Eveline Verheugen / Nadia Schryvers / Gaëlle Varkas /
    Heleen Cypers / Ruth Wittoek / Yves Piette / Lieve Gyselbrecht / Serge Van Calenbergh / Filip Van den Bosch / Yvan Saeys / Gerald Nabozny / Dirk Elewaut

    Nature Communications, Vol 10, Iss 1, Pp 1-

    2019  Volume 15

    Abstract: The role of innate T cell subsets in the pathogenesis of spondyloarthritis (SpA) is not well understood. Here, the authors examine the role of invariant natural killer T (iNKT) and γδ-T cells in SpA and show that disease-derived iNKT and γδ-T cells have ... ...

    Abstract The role of innate T cell subsets in the pathogenesis of spondyloarthritis (SpA) is not well understood. Here, the authors examine the role of invariant natural killer T (iNKT) and γδ-T cells in SpA and show that disease-derived iNKT and γδ-T cells have unique and Th17-skewed phenotype and gene expression profiles within inflamed joints.
    Keywords Science ; Q
    Language English
    Publishing date 2019-01-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    More links

    Kategorien

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