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Artikel: Impact of Hyperoxia after Graft Reperfusion on Lactate Level and Outcomes in Adults Undergoing Orthotopic Liver Transplantation.

Reydellet, Laurent / Le Saux, Audrey / Blasco, Valery / Nafati, Cyril / Harti-Souab, Karim / Armand, Romain / Lannelongue, Ariane / Gregoire, Emilie / Hardwigsen, Jean / Albanese, Jacques / Chopinet, Sophie

Journal of clinical medicine

2023 Band 12, Heft 8

Abstract: Background: Hyperoxia is common during liver transplantation (LT), without being supported by any guidelines. Recent studies have shown the potential deleterious effect of hyperoxia in similar models of ischemia-reperfusion. Hyperoxia after graft ... ...

Abstract	Background: Hyperoxia is common during liver transplantation (LT), without being supported by any guidelines. Recent studies have shown the potential deleterious effect of hyperoxia in similar models of ischemia-reperfusion. Hyperoxia after graft reperfusion during orthotopic LT could increase lactate levels and worsen patient outcomes. Methods: We conducted a retrospective and monocentric pilot study. All adult patients who underwent LT from 26 July 2013 to 26 December 2017 were considered for inclusion. Patients were classified into two groups according to oxygen levels before graft reperfusion: the hyperoxic group (PaO Results: A total of 222 liver transplant recipients were included. Arterial lactatemia after graft revascularization was significantly higher in the hyperoxic group (6.03 ± 4 mmol/L) than in the nonhyperoxic group (4.81 ± 2 mmol/L), Conclusions: In the hyperoxic group, the arterial lactatemia, the hepatic cytolysis peak, the mechanical ventilation and the postoperative ileus were higher than in the nonhyperoxic group, suggesting that hyperoxia worsens short-term outcomes and could lead to increase ischemia-reperfusion injury after liver transplantation. A multicenter prospective study should be performed to confirm these results.
Sprache	Englisch
Erscheinungsdatum	2023-04-18
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm12082940
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Prognostic factors after acute mesenteric ischemia: which patients require specific management?

De Pietro, Remi / Martin, Julie / Tradi, Farouk / Chopinet, Sophie / Barraud, Marine / Gaudry, Marine / Bourenne, Jeremy / Nafati, Cyril / Boussen, Salah / Guidon, Catherine / Bartoli, Michel / Mege, Diane

International journal of colorectal disease

2023 Band 38, Heft 1, Seite(n) 242

Abstract: Purpose: Diagnosis and treatment of AMI are a real issue for implicating physicians. In the literature, only one AMI stroke center has reported its results so far, with increasing survival rates. Our aim was to analyze acute mesenteric ischemia (AMI) ... ...

Abstract	Purpose: Diagnosis and treatment of AMI are a real issue for implicating physicians. In the literature, only one AMI stroke center has reported its results so far, with increasing survival rates. Our aim was to analyze acute mesenteric ischemia (AMI) related mortality and predictive factors, in a single academic center, before creating a dedicated intestinal stroke center. Methods: All the patients with an AMI, between January 2015 and December 2020, were retrospectively included. They were divided into 2 groups according to the early mortality: death during the first 30 days and alive. The 2 groups were compared. Results: 173 patients (57% of men), were included, with a mean age of 68 ± 16 years. Overall mortality rate was 61%. Mortality occurred within the first 30 days in 78% of dead cases. Dead patients were significantly older, more frequently admitted from intensive care, with more serious clinical, laboratory and radiological characteristics. We have identified 3 protective factors - history of abdominal surgery (Odd Ratio = 0.1; 95%CI = 0.01-0.8, p = 0.03), medical management with curative anticoagulation (OR = 0.09; 95%CI = 0.02-0.5, p = 0.004) and/or antiplatelets (OR = 0.04; 95%CI = 0.006-0.3, p = 0.001)-, and 2 predictive factors of mortality - age > 70 years (OR = 7; 95%CI = 1.4-37, p = 0.02) and previous history of coronaropathy (OR = 13; 95%CI = 1.7-93, p = 0.01). Conclusions: AMI is a severe disease with high morbidity and mortality rates. Even if its diagnosis is still difficult because of non-specific presentation, its therapeutic management needs to be changed in order to improve survival rates, particularly in patients older than 70 years with history of coronaropathy. Developing a dedicated organization would improve the diagnosis and the management of patients with AMI.
Mesh-Begriff(e)	Male ; Humans ; Middle Aged ; Aged ; Aged, 80 and over ; Mesenteric Ischemia/therapy ; Mesenteric Ischemia/diagnosis ; Prognosis ; Retrospective Studies ; Treatment Outcome ; Stroke ; Acute Disease ; Risk Factors ; Ischemia
Sprache	Englisch
Erscheinungsdatum	2023-09-30
Erscheinungsland	Germany
Dokumenttyp	Journal Article
ZDB-ID	84975-3
ISSN	1432-1262 ; 0179-1958
ISSN (online)	1432-1262
ISSN	0179-1958
DOI	10.1007/s00384-023-04540-4
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Left ventricular longitudinal strain variations assessed by speckle-tracking echocardiography after a passive leg raising maneuver in patients with acute circulatory failure to predict fluid responsiveness: A prospective, observational study.

Roy, Clemence / Duclos, Gary / Nafati, Cyril / Gardette, Mickael / Lopez, Alexandre / Pastene, Bruno / Gaudray, Eliott / Boussuges, Alain / Antonini, François / Leone, Marc / Zieleskiewicz, Laurent

PloS one

2021 Band 16, Heft 9, Seite(n) e0257737

Abstract: Background: An association was reported between the left ventricular longitudinal strain (LV-LS) and preload. LV-LS reflects the left cardiac function curve as it is the ratio of shortening over diastolic dimension. The aim of this study was to ... ...

Abstract	Background: An association was reported between the left ventricular longitudinal strain (LV-LS) and preload. LV-LS reflects the left cardiac function curve as it is the ratio of shortening over diastolic dimension. The aim of this study was to determine the sensitivity and specificity of LV-LS variations after a passive leg raising (PLR) maneuver to predict fluid responsiveness in intensive care unit (ICU) patients with acute circulatory failure (ACF). Methods: Patients with ACF were prospectively included. Preload-dependency was defined as a velocity time integral (VTI) variation greater than 10% between baseline (T0) and PLR (T1), distinguishing the preload-dependent (PLD+) group and the preload-independent (PLD-) group. A 7-cycles, 4-chamber echocardiography loop was registered at T0 and T1, and strain analysis was performed off-line by a blind clinician. A general linear model for repeated measures was used to compare the LV-LS variation (T0 to T1) between the two groups. Results: From June 2018 to August 2019, 60 patients (PLD+ = 33, PLD- = 27) were consecutively enrolled. The VTI variations after PLR were +21% (±8) in the PLD+ group and -1% (±7) in the PLD- group (p<0.01). Mean baseline LV-LS was -11.3% (±4.2) in the PLD+ group and -13.0% (±4.2) in the PLD- group (p = 0.12). LV-LS increased in the whole population after PLR +16.0% (±4.0) (p = 0.04). The LV-LS variations after PLR were +19.0% (±31) (p = 0.05) in the PLD+ group and +11.0% (±38) (p = 0.25) in the PLD- group, with no significant difference between the two groups (p = 0.08). The area under the curve for the LV-LS variations between T0 and T1 was 0.63 [0.48-0.77]. Conclusion: Our study confirms that LV-LS is load-dependent; however, the variations in LV-LS after PLR is not a discriminating criterion to predict fluid responsiveness of ICU patients with ACF in this cohort.
Mesh-Begriff(e)	Adult ; Aged ; Echocardiography, Doppler/methods ; Female ; Fluid Therapy ; Humans ; Intensive Care Units ; Leg/physiology ; Male ; Middle Aged ; Prospective Studies ; Sensitivity and Specificity ; Shock/diagnostic imaging ; Shock/drug therapy ; Shock/physiopathology ; Stroke Volume ; Treatment Outcome ; Vasoconstrictor Agents/therapeutic use
Chemische Substanzen	Vasoconstrictor Agents
Sprache	Englisch
Erscheinungsdatum	2021-09-30
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Observational Study
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0257737
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Acute severe hepatitis in adult-onset Still's disease: case report and comprehensive review of a life-threatening manifestation.

Muller, Romain / Briantais, Antoine / Faucher, Benoit / Borentain, Patrick / Nafati, Cyril / Blasco, Valery / Gregoire, Emilie / Bernit, Emmanuelle / Seguier, Julie / Meunier, Benoit / Harlé, Jean-Robert / Ebbo, Mikael / Schleinitz, Nicolas

Clinical rheumatology

2020 Band 40, Heft 6, Seite(n) 2467–2476

Abstract: Acute severe hepatitis is a rare complication of adult-onset Still's disease (AOSD). This condition is poorly characterized. We performed a review of the medical literature to describe clinical, biological, pathological, and treatment characteristics ... ...

Abstract	Acute severe hepatitis is a rare complication of adult-onset Still's disease (AOSD). This condition is poorly characterized. We performed a review of the medical literature to describe clinical, biological, pathological, and treatment characteristics from AOSD patients with acute severe hepatitis. Their characteristics were compared with AOSD patients without severe hepatitis. Twenty-one cases were collected including a new case reported here. Patients with severe hepatitis were mostly young adults with a median age of 28 years (range: 20 to 55 years). Overall, patients with severe hepatitis had less arthritis, macular rash, sore throat, lymphadenopathy, or splenomegaly than patients without severe hepatitis. Cytopenia was more frequent in case of severe hepatitis. Most patients were treated with steroids, and the use of biotherapies has increased over the last decade. Despite treatment, 49% of patients required liver transplantation and 24% died. Key Points • Acute severe hepatitis in adult-onset Still's disease (AOSD) is associated with liver transplantation and/or death in, respectively, 43% and 24% of cases. • Severe hepatitis is the inaugural manifestation of AOSD in half of cases. Diagnosis is difficult when extra-hepatic clinical manifestations are lacking. • The mechanism of hepatic necrosis in AOSD with severe hepatitis is unknown. Liver biopsy is not specific and should not delay treatment initiation.
Mesh-Begriff(e)	Acute Disease ; Adult ; Arthritis ; Hepatitis ; Humans ; Liver Diseases ; Middle Aged ; Still's Disease, Adult-Onset/complications ; Still's Disease, Adult-Onset/diagnosis ; Young Adult
Sprache	Englisch
Erscheinungsdatum	2020-09-21
Erscheinungsland	Germany
Dokumenttyp	Case Reports ; Journal Article ; Review
ZDB-ID	604755-5
ISSN	1434-9949 ; 0770-3198
ISSN (online)	1434-9949
ISSN	0770-3198
DOI	10.1007/s10067-020-05383-y
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: À propos d'un cas de tamponnade cardiaque secondaire à un cathétérisme veineux jugulaire interne placé sous échographie.

Blasco, Valéry / Richter, Elisa / Nafati, Cyril / Reydellet, Laurent / Harti Souab, Karim / Albanèse, Jacques

Presse medicale (Paris, France : 1983)

2015 Band 44, Heft 5, Seite(n) 556–557

Titelübersetzung	Case report of cardiac tamponade resulting from jugular venous catheterization using ultrasound guidance.
Mesh-Begriff(e)	Cardiac Tamponade/etiology ; Catheterization, Central Venous/adverse effects ; Catheterization, Central Venous/methods ; Female ; Humans ; Jugular Veins/surgery ; Liver Transplantation ; Middle Aged ; Ultrasonography, Interventional/adverse effects
Sprache	Französisch
Erscheinungsdatum	2015-05
Erscheinungsland	France
Dokumenttyp	Case Reports ; Letter
ZDB-ID	120943-7
ISSN	2213-0276 ; 0032-7867 ; 0755-4982 ; 0301-1518
ISSN (online)	2213-0276
ISSN	0032-7867 ; 0755-4982 ; 0301-1518
DOI	10.1016/j.lpm.2014.11.017
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Sleep disorders among French anaesthesiologists and intensivists working in public hospitals: a self-reported electronic survey.

Richter, Elisa / Blasco, Valery / Antonini, François / Rey, Marc / Reydellet, Laurent / Harti, Karim / Nafati, Cyril / Albanèse, Jacques / Leone, Marc

European journal of anaesthesiology

2015 Band 32, Heft 2, Seite(n) 132–137

Abstract: Background: Sleep disorders can affect the health of physicians and patient outcomes.: Objectives: To determine the prevalence of sleep disorders among French anaesthesiologists and intensivists working in a public hospital.: Design: A cross- ... ...

Abstract	Background: Sleep disorders can affect the health of physicians and patient outcomes. Objectives: To determine the prevalence of sleep disorders among French anaesthesiologists and intensivists working in a public hospital. Design: A cross-sectional survey. Setting: Anaesthesiologists and intensivists working in French public hospitals. Main outcome measures: Sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI) and the Epworth Sleepiness Scale (ESS) was used to assess the degree of excessive daytime sleepiness. Results: Among 1504 responders, 677 (45%) physicians reported sleep disorders. The independent factors associated with sleep disorders were reporting of sleep disorders [odds ratio (OR) 12.04, 95% CI (95% confidence interval) 8.89 to 16.46], sleep time less than 7 h (OR 8.86, 95% CI 6.50 to 12.20), work stress (OR 2.04, 95% CI 1.49 to 2.83), stress at home (OR 1.77, 95% CI 1.24 to 2.53), anxiolytic use (OR 3.69, 95% CI 2.23 to 6.25), psychotropic drug use (OR 3.91, 95% CI 1.51 to 11.52) and excessive daytime sleepiness (OR 1.81, 95% CI 1.34 to 2.45). Six hundred and seventy-six (44%) responders reported excessive daytime sleepiness during their professional activity. The independent factors associated with excessive daytime sleepiness were female sex (OR 1.86, 95% CI 1.49 to 2.34), tea consumption (OR 1.47, 95% CI 1.14 to 1.91), regular practice of nap (OR 1.68, 95% CI 1.34 to 2.09), stress at home (OR 1.31, 95% CI 1.02 to 1.68), more than four extended work shifts monthly (OR 1.25, 95% CI 1.01 to 1.56) and sleep disorders (OR 1.73, 95% CI 1.31 to 2.29). Reporting sleep disorder duration and a sleep time less than 7 h were the two major risk factors for sleep disorders. Female sex was the major risk factor for excessive daytime sleepiness. Conclusion: French anaesthesiologists did not report more sleep disorders than the general population, but their alertness is impaired by a factor of two.
Mesh-Begriff(e)	Adult ; Anesthesiology ; Cross-Sectional Studies ; Data Collection ; Disorders of Excessive Somnolence/epidemiology ; Disorders of Excessive Somnolence/etiology ; Female ; France/epidemiology ; Hospitals, Public ; Humans ; Intensive Care Units ; Male ; Prevalence ; Risk Factors ; Sex Factors ; Sleep Wake Disorders/epidemiology ; Sleep Wake Disorders/etiology
Sprache	Englisch
Erscheinungsdatum	2015-02
Erscheinungsland	England
Dokumenttyp	Journal Article
ZDB-ID	605770-6
ISSN	1365-2346 ; 0265-0215
ISSN (online)	1365-2346
ISSN	0265-0215
DOI	10.1097/EJA.0000000000000110
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Two-dimensional-strain echocardiography in intensive care unit patients: A prospective, observational study.

Nafati, Cyril / Lançon, Victor / Blasco, Valery / Zieleskiewicz, Laurent / Harti, Karim / Wiramus, Sandrine / Kelway, Charlotte / Reydellet, Laurent / Antonini, François / Albanèse, Jacques / Leone, Marc

Journal of clinical ultrasound : JCU

2016 Band 44, Heft 6, Seite(n) 368–374

Abstract: Purpose: Two-dimensional-strain echocardiography (2D-strain) is a promising technique for the early detection of myocardial dysfunction. Our study was aimed to assess its feasibility in the intensive care unit (ICU). Our secondary goal was to determine ... ...

Abstract	Purpose: Two-dimensional-strain echocardiography (2D-strain) is a promising technique for the early detection of myocardial dysfunction. Our study was aimed to assess its feasibility in the intensive care unit (ICU). Our secondary goal was to determine if 2D-strain could predict the patient's outcome. Methods: Conventional echocardiography and 2D-strain were performed on 64 consecutive patients admitted to our ICU. Using 2D-strain, the longitudinal deformation of the left ventricle was assessed. Feasibility of 2D-strain, diagnosis performance, and 28-day mortality prediction were determined. Results: 2D-strain measurements could be performed in 77% of our patients. All 2D-strain variables related to ventricular performance were significantly impaired in the patients who died compared with those who survived. Strain global medium was the only independent echocardiographic variable predictor of 28-day mortality rate (odds ratio 0.60; 95% confidence interval 0.43-0.80, p = 0.002). Conclusions: 2D-strain measurement is feasible in ICU patients, enabling identifying early left ventricle dysfunction. Strain global medium is an independent predictor of 28-day mortality. © 2016 Wiley Periodicals, Inc. J Clin Ultrasound 44:368-374, 2016.
Mesh-Begriff(e)	Adult ; Aged ; Critical Care/methods ; Critical Illness ; Echocardiography/methods ; Female ; Heart Ventricles/diagnostic imaging ; Heart Ventricles/physiopathology ; Humans ; Intensive Care Units ; Male ; Middle Aged ; Prospective Studies ; Ventricular Dysfunction, Left/diagnostic imaging ; Ventricular Dysfunction, Left/physiopathology
Sprache	Englisch
Erscheinungsdatum	2016-07-08
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Observational Study
ZDB-ID	189393-2
ISSN	1097-0096 ; 0091-2751
ISSN (online)	1097-0096
ISSN	0091-2751
DOI	10.1002/jcu.22349
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Fatal fulminant primary hepatitis B virus infections with G1896A precore viral mutants in southeastern France.

Panassié, Laure / Borentain, Patrick / Nafati, Cyril / Bernardin, Gilles / Doudier, Barbara / Thibault, Vincent / Gerolami, René / Colson, Philippe

Clinics and research in hepatology and gastroenterology

2012 Band 36, Heft 1, Seite(n) e1–8

Abstract: Fulminant hepatitis has been shown to occur in about 1% of acute hepatitis B virus (HBV) infections, and its mortality rate is nearly 70%. Specific HBV genotypic features have been pointed out in fulminant acute hepatitis B worldwide, but these ... ...

Abstract	Fulminant hepatitis has been shown to occur in about 1% of acute hepatitis B virus (HBV) infections, and its mortality rate is nearly 70%. Specific HBV genotypic features have been pointed out in fulminant acute hepatitis B worldwide, but these associations remain controversial. We describe all four primary HBV infections diagnosed in 2008 in our institution in Marseille, southeastern France, including two fatal cases. HBV genotypes were D or E. Precore G1896A HBV mutants were detected in both fatal fulminant primary HBV infections. Hepatitis B surface antigen and hepatitis B e antigen (HBeAg) were negative in two and three cases, respectively, despite HBV DNA detection. Primary HBV infection remains a cause of death in France. The impact of the precore G1896A mutation on the severity of AHB deserves to be assessed in larger studies in this country.
Mesh-Begriff(e)	Adult ; Fatal Outcome ; Female ; France ; Genotype ; Hepatitis B/genetics ; Hepatitis B/immunology ; Hepatitis B/virology ; Hepatitis B Core Antigens/genetics ; Hepatitis B e Antigens/genetics ; Hepatitis B virus/genetics ; Hepatitis B virus/pathogenicity ; Humans ; Liver Failure, Acute/virology ; Male ; Middle Aged ; Mutation ; Viral Core Proteins/genetics ; Virus Replication
Chemische Substanzen	Hepatitis B Core Antigens ; Hepatitis B e Antigens ; Viral Core Proteins
Sprache	Englisch
Erscheinungsdatum	2012-02
Erscheinungsland	France
Dokumenttyp	Case Reports ; Journal Article
ZDB-ID	2594333-9
ISSN	2210-741X ; 2210-7401
ISSN (online)	2210-741X
ISSN	2210-7401
DOI	10.1016/j.clinre.2011.09.002
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Automatic selection of breathing pattern using adaptive support ventilation.

Arnal, Jean-Michel / Wysocki, Marc / Nafati, Cyril / Donati, Stéphane / Granier, Isabelle / Corno, Gaëlle / Durand-Gasselin, Jacques

Intensive care medicine

2008 Band 34, Heft 1, Seite(n) 75–81

Abstract: Objective: In a cohort of mechanically ventilated patients to compare the automatic tidal volume (VT)-respiratory rate (RR) combination generated by adaptive support ventilation (ASV) for various lung conditions.: Design and setting: Prospective ... ...

Abstract	Objective: In a cohort of mechanically ventilated patients to compare the automatic tidal volume (VT)-respiratory rate (RR) combination generated by adaptive support ventilation (ASV) for various lung conditions. Design and setting: Prospective observational cohort study in the 11-bed medicosurgical ICU of a general hospital. Patients: 243 patients receiving 1327 days of invasive ventilation on ASV. Measurements: Daily collection of ventilator settings, breathing pattern, arterial blood gases, and underlying clinical respiratory conditions categorized as: normal lungs, ALI/ARDS, COPD, chest wall stiffness, or acute respiratory failure. Results: Overall the respiratory mechanics differed significantly with the underlying conditions. In passive patients ASV delivered different VT-RR combinations based on the underlying condition, providing higher VT and lower RR in COPD than in ALI/ARDS: 9.3ml/kg (8.2-10.8) predicted body weight (PBW) and 13 breaths/min (11-16) vs. 7.6ml/kg (6.7-8.8) PBW and 18 breaths/min (16-22). In patients actively triggering the ventilator the VT-RR combinations did not differ between COPD, ALI/ARDS, and normal lungs. Conclusions: ASV selects different VT-RR combinations based on respiratory mechanics in passive, mechanically ventilated patients.
Mesh-Begriff(e)	Aged ; Critical Care ; Female ; France ; Humans ; Male ; Middle Aged ; Monitoring, Physiologic ; Prospective Studies ; Pulmonary Disease, Chronic Obstructive/physiopathology ; Respiration, Artificial/methods ; Respiratory Distress Syndrome, Adult/physiopathology ; Respiratory Mechanics/physiology ; Tidal Volume/physiology
Sprache	Englisch
Erscheinungsdatum	2008-01
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80387-x
ISSN	1432-1238 ; 0342-4642 ; 0340-0964 ; 0935-1701
ISSN (online)	1432-1238
ISSN	0342-4642 ; 0340-0964 ; 0935-1701
DOI	10.1007/s00134-007-0847-0
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Liver transplantation for acute liver failure related to autochthonous genotype 3 hepatitis E virus infection.

Aherfi, Sarah / Borentain, Patrick / Raissouni, Ferdaous / Le Goffic, Aude / Guisset, Michel / Renou, Christophe / Grimaud, Jean-Charles / Hardwigsen, Jean / Garcia, Stéphane / Botta-Fridlund, Danielle / Nafati, Cyril / Motte, Anne / Le Treut, Yves Patrice / Colson, Philippe / Gerolami, René

Clinics and research in hepatology and gastroenterology

2014 Band 38, Heft 1, Seite(n) 24–31

Abstract: Hepatitis E virus of genotype 3 (HEV-3) is an emerging cause of sporadic autochthonous acute hepatitis in Europe. Although spontaneous outcome of hepatitis E is usually favorable, fulminant liver failure has been described worldwide. In Europe, ... ...

Abstract	Hepatitis E virus of genotype 3 (HEV-3) is an emerging cause of sporadic autochthonous acute hepatitis in Europe. Although spontaneous outcome of hepatitis E is usually favorable, fulminant liver failure has been described worldwide. In Europe, autochthonous hepatitis E associated with fulminant hepatic failure and leading to liver transplantation has been exceptionally reported. We report here four cases of fulminant and sub-fulminant hepatitis E proposed for liver transplantation in Marseille University hospitals between July 2006 and March 2010. HEV diagnosis relied on detection of anti-HEV IgM antibodies and HEV RNA in serum samples. All cases were men, with no travel history in hyperendemic areas. HEV sequence analyses revealed genotype 3 HEV in the four patients. Liver histology indicated severe acute hepatitis in all of them, pre-existing fibrosis being found in two cases. Two patients underwent liver transplantation, and the two other patients could not be transplanted due to septic complications and died. HEV testing should be performed for the initial evaluation of every acute liver failure regardless of the epidemiological and clinical context. With respect to the potentially fulminant evolution of HEV genotype 3 infections, treatment with ribavirin of severe acute hepatitis E should be considered.
Mesh-Begriff(e)	Adult ; Europe ; Genotype ; Hepatitis E/complications ; Hepatitis E virus/classification ; Hepatitis E virus/genetics ; Humans ; Liver Failure, Acute/surgery ; Liver Failure, Acute/virology ; Liver Transplantation ; Male ; Middle Aged
Sprache	Englisch
Erscheinungsdatum	2014-02
Erscheinungsland	France
Dokumenttyp	Case Reports ; Journal Article
ZDB-ID	2594333-9
ISSN	2210-741X ; 2210-7401
ISSN (online)	2210-741X
ISSN	2210-7401
DOI	10.1016/j.clinre.2013.05.013
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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