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  1. Article ; Online: Design, synthesis, and docking studies of novel pyrazole-based scaffolds and their evaluation as VEGFR2 inhibitors in the treatment of prostate cancer.

    Soliman, Dalia H / Nafie, Mohamed S

    RSC advances

    2023  Volume 13, Issue 30, Page(s) 20443–20456

    Abstract: Since VEGFR-2 plays a crucial role in tumor growth, angiogenesis, and metastasis, it is a prospective target for cancer treatment. In this work, a series of 3-phenyl-4-(2-substituted phenylhydrazono)- ... ...

    Abstract Since VEGFR-2 plays a crucial role in tumor growth, angiogenesis, and metastasis, it is a prospective target for cancer treatment. In this work, a series of 3-phenyl-4-(2-substituted phenylhydrazono)-1
    Language English
    Publishing date 2023-07-10
    Publishing country England
    Document type Journal Article
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/d3ra02579a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: N-allyl quinoxaline derivative exhibited potent and selective cytotoxicity through EGFR/VEGFR-mediated apoptosis: In vitro and in vivo studies.

    Nafie, Mohamed S / Ali, Mohab A / Youssef, Magdy M

    Journal of biochemical and molecular toxicology

    2024  Volume 38, Issue 4, Page(s) e23690

    Abstract: The cytotoxic activity, EGFR/VEGFR2 target inhibition, apoptotic activity, RT-PCR gene expression, in vivo employing a solid-Ehrlich carcinoma model, and in silico investigations for highlighting the binding affinity of eight quinoxaline derivatives were ...

    Abstract The cytotoxic activity, EGFR/VEGFR2 target inhibition, apoptotic activity, RT-PCR gene expression, in vivo employing a solid-Ehrlich carcinoma model, and in silico investigations for highlighting the binding affinity of eight quinoxaline derivatives were tested for anticancer activities. The results showed that compound 8 (N-allyl quinoxaline) had potent cytotoxicity against A594 and MCF-7 cancer cells with IC
    MeSH term(s) Humans ; Structure-Activity Relationship ; Sorafenib/pharmacology ; Molecular Docking Simulation ; Quinoxalines/pharmacology ; Apoptosis ; Antineoplastic Agents/chemistry ; ErbB Receptors/metabolism ; Cell Proliferation ; Molecular Structure ; Drug Screening Assays, Antitumor ; Protein Kinase Inhibitors/pharmacology
    Chemical Substances Sorafenib (9ZOQ3TZI87) ; Quinoxalines ; Antineoplastic Agents ; ErbB Receptors (EC 2.7.10.1) ; Protein Kinase Inhibitors ; EGFR protein, human (EC 2.7.10.1)
    Language English
    Publishing date 2024-03-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1410020-4
    ISSN 1099-0461 ; 1095-6670
    ISSN (online) 1099-0461
    ISSN 1095-6670
    DOI 10.1002/jbt.23690
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2201: Show issues Location:
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  3. Article ; Online: A quinoxaline-based derivative exhibited potent and selective anticancer activity with apoptosis induction in PC-3 cells through Topo II inhibition.

    Elsakka, Mayada E G / Tawfik, Mohamed M / Barakat, Lamiaa A A / Nafie, Mohamed S

    Journal of biomolecular structure & dynamics

    2024  , Page(s) 1–19

    Abstract: Quinoxaline constitutes a variety of derivatives that exhibit a range of biological characteristics, including anti-inflammatory and antitumor effects, and their importance in therapeutic chemistry is rising. The cytotoxicity effects of four quinoxaline ... ...

    Abstract Quinoxaline constitutes a variety of derivatives that exhibit a range of biological characteristics, including anti-inflammatory and antitumor effects, and their importance in therapeutic chemistry is rising. The cytotoxicity effects of four quinoxaline compounds (
    Language English
    Publishing date 2024-03-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 49157-3
    ISSN 1538-0254 ; 0739-1102
    ISSN (online) 1538-0254
    ISSN 0739-1102
    DOI 10.1080/07391102.2024.2327538
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    Zs.A 2093: Show issues Location:
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  4. Article ; Online: Discovery of PIM-1 kinase inhibitors based on the 2,5-disubstituted 1,3,4-oxadiazole scaffold against prostate cancer: Design, synthesis, in vitro and in vivo cytotoxicity investigation.

    Castanet, Anne-Sophie / Nafie, Mohamed S / Said, Sara A / Arafa, Reem K

    European journal of medicinal chemistry

    2023  Volume 250, Page(s) 115220

    Abstract: PIM-1 kinases play an established role in prostate cancer development and progression. This research work tackles the design and synthesis of new PIM-1 kinase targeting 2,5-disubstituted-1,3,4-oxadiazoles 10a-g&11a-f, and investigation thereof as ... ...

    Abstract PIM-1 kinases play an established role in prostate cancer development and progression. This research work tackles the design and synthesis of new PIM-1 kinase targeting 2,5-disubstituted-1,3,4-oxadiazoles 10a-g&11a-f, and investigation thereof as potential anti-cancer agents through in vitro cytotoxicity assay followed by in vivo studies along with exploration of this chemotype's plausible mechanism of action. In vitro cytotoxicity experiments have disclosed 10f as the most potent derivative against PC-3 cells (IC
    MeSH term(s) Male ; Humans ; Animals ; Mice ; Cell Line, Tumor ; Proto-Oncogene Proteins c-pim-1 ; Staurosporine/pharmacology ; Protein Kinase Inhibitors/chemistry ; Drug Screening Assays, Antitumor ; Antineoplastic Agents/chemistry ; Prostatic Neoplasms/drug therapy ; Oxadiazoles/pharmacology ; Cell Proliferation ; Apoptosis ; Structure-Activity Relationship
    Chemical Substances Proto-Oncogene Proteins c-pim-1 (EC 2.7.11.1) ; 1,3,4-oxadiazole (20O2F20OUR) ; Staurosporine (H88EPA0A3N) ; Protein Kinase Inhibitors ; Antineoplastic Agents ; Oxadiazoles
    Language English
    Publishing date 2023-02-23
    Publishing country France
    Document type Journal Article
    ZDB-ID 188597-2
    ISSN 1768-3254 ; 0009-4374 ; 0223-5234
    ISSN (online) 1768-3254
    ISSN 0009-4374 ; 0223-5234
    DOI 10.1016/j.ejmech.2023.115220
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    Zs.B 784: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  5. Article ; Online: New synthetic silver-doped ZnO nanorods trigger cytotoxicity in MCF-7 through apoptosis and antimicrobial activity.

    Elgazzar, Elsayed / Nafie, Mohamed S / Abul-Nasr, Kareem T

    Journal of biomolecular structure & dynamics

    2022  Volume 41, Issue 20, Page(s) 11193–11203

    Abstract: The structural, composition, and molecular interaction of silver integrated zinc oxide (20 wt.% Ag/ZnO) were investigated by X-ray diffraction (XRD), energy dispersive X-ray analysis (EDX), and Fourier transforms infrared (FTIR) spectrum. The XRD ... ...

    Abstract The structural, composition, and molecular interaction of silver integrated zinc oxide (20 wt.% Ag/ZnO) were investigated by X-ray diffraction (XRD), energy dispersive X-ray analysis (EDX), and Fourier transforms infrared (FTIR) spectrum. The XRD analysis showed the polycrystalline of small crystallite size, whereas the EDX spectrum confirmed the purity of the nanocomposite. The FTIR spectrum indicated the presence of Ag-Zn-O stretching vibration at 1034 cm
    MeSH term(s) Humans ; Zinc Oxide/pharmacology ; Zinc Oxide/chemistry ; Silver/pharmacology ; Silver/chemistry ; MCF-7 Cells ; Molecular Docking Simulation ; Anti-Infective Agents/pharmacology ; Nanotubes/chemistry ; Apoptosis ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/chemistry
    Chemical Substances Zinc Oxide (SOI2LOH54Z) ; Silver (3M4G523W1G) ; Anti-Infective Agents ; disilver oxide (897WUN6G6T) ; Anti-Bacterial Agents
    Language English
    Publishing date 2022-12-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 49157-3
    ISSN 1538-0254 ; 0739-1102
    ISSN (online) 1538-0254
    ISSN 0739-1102
    DOI 10.1080/07391102.2022.2160815
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    Zs.A 2093: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  6. Article ; Online: Exploration of novel VEGFR2 tyrosine kinase inhibitors via design and synthesis of new alkylated indolyl-triazole Schiff bases for targeting breast cancer.

    Nafie, Mohamed S / Boraei, Ahmed T A

    Bioorganic chemistry

    2022  Volume 122, Page(s) 105708

    Abstract: According to the World Health Organization (WHO) statistics: In 2020, there were 2.3 million women diagnosed with breast cancer and 685,000 deaths globally. Therefore, searching for new leads for fighting this type of cancer is necessary. VEGFR-2 kinase ... ...

    Abstract According to the World Health Organization (WHO) statistics: In 2020, there were 2.3 million women diagnosed with breast cancer and 685,000 deaths globally. Therefore, searching for new leads for fighting this type of cancer is necessary. VEGFR-2 kinase plays a crucial role in the proliferation, migration, and survival of breast cancer cells so, identifying novel inhibitors for VEGFR-2 could be effective in breast cancer treatment. Accordingly, novel heterocyclic compounds containing indole, 1,2,4-triazole, and glycosyl or allyl moieties were synthesized. The synthesized compounds were evaluated for their cytotoxic and apoptotic activities towards breast cancer cell lines (MCF7). In this regard, compounds 6, 17, and 18 exhibited promising cytotoxic activity against MCF-7 cells with IC
    MeSH term(s) Animals ; Antineoplastic Agents/chemistry ; Breast Neoplasms/pathology ; Cell Proliferation ; Drug Screening Assays, Antitumor ; Female ; Humans ; Molecular Docking Simulation ; Molecular Structure ; Protein Kinase Inhibitors/pharmacology ; Schiff Bases/pharmacology ; Structure-Activity Relationship ; Triazoles/chemistry ; Vascular Endothelial Growth Factor Receptor-2/antagonists & inhibitors
    Chemical Substances Antineoplastic Agents ; Protein Kinase Inhibitors ; Schiff Bases ; Triazoles ; Vascular Endothelial Growth Factor Receptor-2 (EC 2.7.10.1)
    Language English
    Publishing date 2022-03-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 120080-x
    ISSN 1090-2120 ; 0045-2068
    ISSN (online) 1090-2120
    ISSN 0045-2068
    DOI 10.1016/j.bioorg.2022.105708
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    Zs.A 4207: Show issues Location:
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  7. Article ; Online: Design and Synthesis of Novel Pyridine-Based Compounds as Potential PIM-1 Kinase Inhibitors, Apoptosis, and Autophagy Inducers Targeting MCF-7 Cell Lines: In Vitro and In Vivo Studies.

    Shaban, Shrouk M / Eltamany, Elsayed H / Boraei, Ahmed T A / Nafie, Mohamed S / Gad, Emad M

    ACS omega

    2023  Volume 8, Issue 49, Page(s) 46922–46933

    Abstract: 2-((3-Cyano-4,6-dimethylpyridin-2-yl)oxy) ... ...

    Abstract 2-((3-Cyano-4,6-dimethylpyridin-2-yl)oxy)acetohydrazide
    Language English
    Publishing date 2023-11-27
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.3c06700
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  8. Article ; Online: Metabolite profiling and in-silico studies show multiple effects of insecticidal actinobacterium on Spodoptera littoralis.

    Diab, Mohamed Khaled / Mead, Hala Mohamed / Khedr, Mohamad Ahmad / Nafie, Mohamed S / Abu-Elsaoud, Abdelghafar Mohamed / El-Shatoury, Sahar Ahmed

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 3057

    Abstract: The polyphagous pest, Spodoptera littoralis (Boisduval), poses a significant global economic threat by gregariously feeding on over a hundred plant species, causing substantial agricultural losses. Addressing this challenge requires ongoing research to ... ...

    Abstract The polyphagous pest, Spodoptera littoralis (Boisduval), poses a significant global economic threat by gregariously feeding on over a hundred plant species, causing substantial agricultural losses. Addressing this challenge requires ongoing research to identify environmentally safe control agents. This study aimed to elucidate the insecticidal activity of the metabolite (ES2) from a promising endophytic actinobacterium strain, Streptomyces sp. ES2 EMCC2291. We assessed the activity of ES2 against the eggs and fourth-instar larvae of S. littoralis through spectrophotometric measurements of total soluble protein, α- and β-esterases, polyphenol oxidase (PPO), and catalase enzyme (CAT). The assessments were compared to commercial Biosad® 22.8% SC. Untargeted metabolomics using LC-QTOF-MS/MS identified 83 metabolic compounds as chemical constituents of ES2. The median lethal concentration (LC50) of ES2 (165 mg/mL) for treated Spodoptera littoralis eggs showed significant differences in polyphenol oxidase and catalase enzymatic activities, while the LC50 of ES2 (695 mg/mL) for treated S. littoralis fourth instar larvae showed lower significance in α- and β-esterase activities. Molecular docking of ES2 identified seven potent biocidal compounds, showing strong affinity to PPO and catalase CAT proteins in S. littoralis eggs while displaying limited binding to alpha and beta esterase proteins in the larvae. The results contribute to the understanding of ES2 as a promising alternative biopesticide, providing insights for future research and innovative applications in sustainable pest management strategies.
    MeSH term(s) Animals ; Insecticides/pharmacology ; Spodoptera ; Catalase/pharmacology ; Molecular Docking Simulation ; Tandem Mass Spectrometry ; Catechol Oxidase ; Esterases ; Larva
    Chemical Substances Insecticides ; Catalase (EC 1.11.1.6) ; Catechol Oxidase (EC 1.10.3.1) ; Esterases (EC 3.1.-)
    Language English
    Publishing date 2024-02-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-53096-y
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  9. Article ; Online: Synthesis and Anti-Breast Cancer Potency of Mono- and Bis-(pyrazolyl[1,2,4]triazolo[3,4-

    Salem, Mostafa E / Mahrous, Esraa M / Ragab, Eman A / Nafie, Mohamed S / Dawood, Kamal M

    ACS omega

    2023  Volume 8, Issue 38, Page(s) 35359–35369

    Abstract: The target mono- and bis-(6-pyrazolyltriazolo-thiadiazine) ... ...

    Abstract The target mono- and bis-(6-pyrazolyltriazolo-thiadiazine) derivatives
    Language English
    Publishing date 2023-09-11
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.3c05309
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  10. Article ; Online: Synthesis of novel mono- and bis-pyrazolylthiazole derivatives as anti-liver cancer agents through EGFR/HER2 target inhibition.

    Salem, Mostafa E / Mahrous, Esraa M / Ragab, Eman A / Nafie, Mohamed S / Dawood, Kamal M

    BMC chemistry

    2023  Volume 17, Issue 1, Page(s) 51

    Abstract: 3-Bromoacetyl-4-(2-naphthoyl)-1-phenyl-1H-pyrazole (6) was synthesized from 2-acetylnaphthalene and was used as a new key building block for constructing the title targets. Thus, the reaction of 6 with the thiosemicarbazones 7a-d and 9-11 afforded the ... ...

    Abstract 3-Bromoacetyl-4-(2-naphthoyl)-1-phenyl-1H-pyrazole (6) was synthesized from 2-acetylnaphthalene and was used as a new key building block for constructing the title targets. Thus, the reaction of 6 with the thiosemicarbazones 7a-d and 9-11 afforded the corresponding simple naphthoyl-(3-pyrazolyl)thiazole hybrids 8a-d and 12 ~ 14. The symmetric bis-(2-naphthoyl-pyrazol-3-yl)thiazol-2-yl)hydrazono)methyl)phenoxy)alkanes 18a-c and 21a-c were similarly synthesized from reaction of 6 with the appropriate bis-thiosemicarbazones 17a-c and 19a-c, respectively. The synthesized two series of simple and symmetrical bis-molecular hybrid merging naphthalene, thiazole, and pyrazole were evaluated for their cytotoxicity. Compounds 18b,c and 21a showed the most potent cytotoxicity (IC
    Language English
    Publishing date 2023-06-08
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2661-801X
    ISSN (online) 2661-801X
    DOI 10.1186/s13065-023-00921-6
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