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  1. Article ; Online: Antioxidant, antimicrobial and emulsification properties of exopolysaccharides from lactic acid bacteria of bovine milk: Insights from biochemical and genomic analysis

    Tarannum, Nowshin / Hossain, Tanim Jabid / Ali, Ferdausi / Das, Tuhin K. / Dhar, Kartik / Nafiz, Iqbal Hossain

    LWT. 2023 Aug., v. 186 p.115263-

    2023  

    Abstract: Exopolysaccharides (EPSs) are versatile organic thickeners derived from microbes, offering beneficial bioactive properties. This study focused on isolating new bacterial strains from bovine milk capable of EPS biosynthesis. Out of 63 isolates, four ... ...

    Abstract Exopolysaccharides (EPSs) are versatile organic thickeners derived from microbes, offering beneficial bioactive properties. This study focused on isolating new bacterial strains from bovine milk capable of EPS biosynthesis. Out of 63 isolates, four strains, Lactiplantibacillus sp. ME2b, Lactococcus sp. ME7, Lacticaseibacillus sp. ME17, and Lactobacillus sp. ME27a, exhibited high EPS production, ranging from 0.98 g/L to 2.68 g/L. EPS extracted from these strains had higher carbohydrate and lower protein contents. The EPS extracts showed strong antioxidant activity, demonstrated by DPPH (∼82–89%) and hydroxyl radical scavenging (∼88–91%), and reducing power capacity (3.28–3.65). They also displayed potent antimicrobial activity against Gram-negative and Gram-positive pathogens, including Bacillus cereus, Salmonella typhi, Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa, with stronger inhibition against Gram-positive strains. Additionally, the EPS showed emulsification activity with ME17 showing the highest emulsification index (60%). The EPS extracts exhibited significant anti-inflammatory effects (∼81–84%). Whole genome sequencing of the prominent strain ME2b revealed a 3,281,666 kb genome carrying 3,101 coding sequences including EPS biosynthesis-related genes epsABCDE, wxz, wzy, and glycosyltransferases. These findings underscore significant potential of the EPS in diverse applications, particularly in food and biotechnology sectors, with future efforts aimed at maximizing EPS capacities for industries and driving innovation across multiple sectors.
    Keywords Bacillus cereus ; Escherichia coli ; Lactobacillus ; Lactococcus ; Pseudomonas aeruginosa ; Salmonella Typhi ; Staphylococcus aureus ; antimicrobial properties ; antioxidant activity ; biosynthesis ; biotechnology ; emulsifying ; exopolysaccharides ; genome ; genomics ; glycosyltransferases ; hydroxyl radicals ; lactic acid ; milk ; Genome sequence analysis ; Lactic acid bacteria exopolysaccharide ; Antimicrobial activity ; Anti-inflammatory activity ; Emulsification index
    Language English
    Dates of publication 2023-08
    Publishing place Elsevier Ltd
    Document type Article ; Online
    ZDB-ID 241369-3
    ISSN 0460-1173 ; 0023-6438
    ISSN 0460-1173 ; 0023-6438
    DOI 10.1016/j.lwt.2023.115263
    Database NAL-Catalogue (AGRICOLA)

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  2. Article ; Online: Cytokines and their role as immunotherapeutics and vaccine Adjuvants: The emerging concepts.

    Rahman, Tanjilur / Das, Ayan / Abir, Mehedy Hasan / Nafiz, Iqbal Hossain / Mahmud, Aar Rafi / Sarker, Md Rifat / Emran, Talha Bin / Hassan, Mohammad Mahmudul

    Cytokine

    2023  Volume 169, Page(s) 156268

    Abstract: Cytokines are a protein family comprising interleukins, lymphokines, chemokines, monokines and interferons. They are significant constituents of the immune system, and they act in accordance with specific cytokine inhibiting compounds and receptors for ... ...

    Abstract Cytokines are a protein family comprising interleukins, lymphokines, chemokines, monokines and interferons. They are significant constituents of the immune system, and they act in accordance with specific cytokine inhibiting compounds and receptors for the regulation of immune responses. Cytokine studies have resulted in the establishment of newer therapies which are being utilized for the treatment of several malignant diseases. The advancement of these therapies has occurred from two distinct strategies. The first strategy involves administrating the recombinant and purified cytokines, and the second strategy involves administrating the therapeutics which inhibits harmful effects of endogenous and overexpressed cytokines. Colony stimulating factors and interferons are two exemplary therapeutics of cytokines. An important effect of cytokine receptor antagonist is that they can serve as anti-inflammatory agents by altering the treatments of inflammation disorder, therefore inhibiting the effects of tumour necrosis factor. In this article, we have highlighted the research behind the establishment of cytokines as therapeutics and vaccine adjuvants, their role of immunotolerance, and their limitations.
    MeSH term(s) Cytokines/metabolism ; Adjuvants, Vaccine ; Interferons/physiology ; Immunologic Factors ; Interleukins/physiology ; Immunotherapy
    Chemical Substances Cytokines ; Adjuvants, Vaccine ; Interferons (9008-11-1) ; Immunologic Factors ; Interleukins
    Language English
    Publishing date 2023-06-13
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1018055-2
    ISSN 1096-0023 ; 1043-4666
    ISSN (online) 1096-0023
    ISSN 1043-4666
    DOI 10.1016/j.cyto.2023.156268
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Pathogenicity and virulence of Marburg virus.

    Abir, Mehedy Hasan / Rahman, Tanjilur / Das, Ayan / Etu, Silvia Naznin / Nafiz, Iqbal Hossain / Rakib, Ahmed / Mitra, Saikat / Emran, Talha Bin / Dhama, Kuldeep / Islam, Ariful / Siyadatpanah, Abolghasem / Mahmud, Shafi / Kim, Bonlgee / Hassan, Mohammad Mahmudul

    Virulence

    2022  Volume 13, Issue 1, Page(s) 609–633

    Abstract: Marburg virus (MARV) has been a major concern since 1967, with two major outbreaks occurring in 1998 and 2004. Infection from MARV results in severe hemorrhagic fever, causing organ dysfunction and death. Exposure to fruit bats in caves and mines, and ... ...

    Abstract Marburg virus (MARV) has been a major concern since 1967, with two major outbreaks occurring in 1998 and 2004. Infection from MARV results in severe hemorrhagic fever, causing organ dysfunction and death. Exposure to fruit bats in caves and mines, and human-to-human transmission had major roles in the amplification of MARV outbreaks in African countries. The high fatality rate of up to 90% demands the broad study of MARV diseases (MVD) that correspond with MARV infection. Since large outbreaks are rare for MARV, clinical investigations are often inadequate for providing the substantial data necessary to determine the treatment of MARV disease. Therefore, an overall review may contribute to minimizing the limitations associated with future medical research and improve the clinical management of MVD. In this review, we sought to analyze and amalgamate significant information regarding MARV disease epidemics, pathophysiology, and management approaches to provide a better understanding of this deadly virus and the associated infection.
    MeSH term(s) Animals ; Chiroptera ; Disease Models, Animal ; Humans ; Marburg Virus Disease/epidemiology ; Marburgvirus/physiology ; Virulence
    Language English
    Publishing date 2022-04-01
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2657572-3
    ISSN 2150-5608 ; 2150-5594
    ISSN (online) 2150-5608
    ISSN 2150-5594
    DOI 10.1080/21505594.2022.2054760
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Beta-Arrestins in the Treatment of Heart Failure Related to Hypertension: A Comprehensive Review.

    Rakib, Ahmed / Eva, Taslima Akter / Sami, Saad Ahmed / Mitra, Saikat / Nafiz, Iqbal Hossain / Das, Ayan / Tareq, Abu Montakim / Nainu, Firzan / Dhama, Kuldeep / Emran, Talha Bin / Simal-Gandara, Jesus

    Pharmaceutics

    2021  Volume 13, Issue 6

    Abstract: Heart failure (HF) is a complicated clinical syndrome that is considered an increasingly frequent reason for hospitalization, characterized by a complex therapeutic regimen, reduced quality of life, and high morbidity. Long-standing hypertension ... ...

    Abstract Heart failure (HF) is a complicated clinical syndrome that is considered an increasingly frequent reason for hospitalization, characterized by a complex therapeutic regimen, reduced quality of life, and high morbidity. Long-standing hypertension ultimately paves the way for HF. Recently, there have been improvements in the treatment of hypertension and overall management not limited to only conventional medications, but several novel pathways and their pharmacological alteration are also conducive to the treatment of hypertension. Beta-arrestin (β-arrestin), a protein responsible for beta-adrenergic receptors' (β-AR) functioning and trafficking, has recently been discovered as a potential regulator in hypertension. β-arrestin isoforms, namely β-arrestin1 and β-arrestin2, mainly regulate cardiac function. However, there have been some controversies regarding the function of the two β-arrestins in hypertension regarding HF. In the present review, we try to figure out the paradox between the roles of two isoforms of β-arrestin in the treatment of HF.
    Language English
    Publishing date 2021-06-05
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics13060838
    Database MEDical Literature Analysis and Retrieval System OnLINE

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