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  1. Article ; Online: Production scheme for diagnostic-therapeutic radioisotopes by accelerator neutrons.

    Nagai, Yasuki

    Proceedings of the Japan Academy. Series B, Physical and biological sciences

    2021  Volume 97, Issue 6, Page(s) 292–323

    Abstract: Interest has been growing in the development of medical radioisotopes used for noninvasive nuclear medicine imaging of disease and cancer therapy. Especially the development of an alternative production scheme ... ...

    Abstract Interest has been growing in the development of medical radioisotopes used for noninvasive nuclear medicine imaging of disease and cancer therapy. Especially the development of an alternative production scheme of
    MeSH term(s) Molybdenum ; Neutrons ; Radioisotopes ; Radiopharmaceuticals ; Technetium
    Chemical Substances Radioisotopes ; Radiopharmaceuticals ; Technetium (7440-26-8) ; Molybdenum (81AH48963U)
    Language English
    Publishing date 2021-06-11
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 161781-3
    ISSN 1349-2896 ; 0386-2208
    ISSN (online) 1349-2896
    ISSN 0386-2208
    DOI 10.2183/pjab.97.017
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  2. Article ; Online: 99Mo Production via 100Mo(n,2n)99Mo using accelerator neutrons

    Nagai Yasuki

    EPJ Web of Conferences, Vol 66, p

    2014  Volume 10007

    Abstract: A new production method of 99Mo using accelerator neutrons via the 100Mo(n,2n)99Mo reaction was proposed. Intense neutrons with a most probable energy of 14 MeV can be produced by bombarding Be or C with 40 MeV deuteron beams. Research and development ... ...

    Abstract A new production method of 99Mo using accelerator neutrons via the 100Mo(n,2n)99Mo reaction was proposed. Intense neutrons with a most probable energy of 14 MeV can be produced by bombarding Be or C with 40 MeV deuteron beams. Research and development works of 99Mo produced by neutrons from the 3H(d,n)4He reaction were carried out. High quality 99mTc was obtained by employing a sublimation method. Accelerator neutrons are shown to have a great potential to produce a wide variety of radioisotopes.
    Keywords Physics ; QC1-999 ; Science ; Q
    Language English
    Publishing date 2014-03-01T00:00:00Z
    Publisher EDP Sciences
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Glucotoxicity-induced suppression of Cox6a2 expression provokes β-cell dysfunction via augmented ROS production.

    Nagai, Yasuki / Matsuoka, Taka-Aki / Shimo, Naoki / Miyatsuka, Takeshi / Miyazaki, Satsuki / Tashiro, Fumi / Miyazaki, Jun-Ichi / Katakami, Naoto / Shimomura, Iichiro

    Biochemical and biophysical research communications

    2021  Volume 556, Page(s) 134–141

    Abstract: Oxidative stress is a deteriorating factor for pancreatic β-cells under chronic hyperglycemia in diabetes. However, the molecular mechanism underlying the increase in oxidative stress in β-cells under diabetic conditions remains unclear. We demonstrated ... ...

    Abstract Oxidative stress is a deteriorating factor for pancreatic β-cells under chronic hyperglycemia in diabetes. However, the molecular mechanism underlying the increase in oxidative stress in β-cells under diabetic conditions remains unclear. We demonstrated previously that the selective alleviation of glucotoxicity ameliorated the downregulation of several β-cell factors, including Cox6a2. Cox6a2 encodes a subunit of the respiratory chain complex IV in mitochondria. In this study, we analyzed the role of Cox6a2 in pancreatic β-cell function and its pathophysiological significance in diabetes mellitus. Cox6a2-knockdown experiments in MIN6-CB4 cells indicated an increased production of reactive oxygen species as detected by CellROX Deep Red reagent using flow cytometry. In systemic Cox6a2-knockout mice, impaired glucose tolerance was observed under a high-fat high-sucrose diet. However, insulin resistance was reduced when compared with control littermates. This indicates a relative insufficiency of β-cell function. To examine the transcriptional regulation of Cox6a2, ATAC-seq with islet DNA was performed and an open-chromatin area within the Cox6a2 enhancer region was detected. Reporter gene analysis using this area revealed that MafA directly regulates Cox6a2 expression. These findings suggest that the decreased expression of Cox6a2 increases the levels of reactive oxygen species and that Mafa is associated with decreased Cox6a2 expression under glucotoxic conditions.
    MeSH term(s) Animals ; Cell Line ; Diabetes Mellitus, Experimental/metabolism ; Electron Transport Complex IV/biosynthesis ; Electron Transport Complex IV/genetics ; Electron Transport Complex IV/metabolism ; Gene Expression Regulation ; Glucose/metabolism ; Glucose Intolerance/genetics ; HEK293 Cells ; Humans ; Insulin/metabolism ; Insulin Resistance/genetics ; Insulin-Secreting Cells/metabolism ; Insulin-Secreting Cells/pathology ; Maf Transcription Factors, Large/metabolism ; Mice, Inbred C57BL ; Mice, Knockout ; Mitochondria/metabolism ; Muscle Proteins/biosynthesis ; Muscle Proteins/deficiency ; Muscle Proteins/genetics ; Oxidative Stress ; Reactive Oxygen Species/metabolism ; Transcription, Genetic ; Mice
    Chemical Substances Insulin ; Maf Transcription Factors, Large ; Mafa protein, mouse ; Muscle Proteins ; Reactive Oxygen Species ; Cox6a2 protein, mouse (EC 1.9.3.1) ; Electron Transport Complex IV (EC 1.9.3.1) ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2021-04-08
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 205723-2
    ISSN 1090-2104 ; 0006-291X ; 0006-291X
    ISSN (online) 1090-2104 ; 0006-291X
    ISSN 0006-291X
    DOI 10.1016/j.bbrc.2021.03.148
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    Zs.A 116: Show issues Location:
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  4. Article ; Online: A case of ectopic ACTH syndrome due to DDAVP-sensitive but V1b receptor-negative bronchial typical carcinoid with lymphatic metastasis and plasma ProGRP elevation.

    Yamamuro, Tadashi / Inoue, Kana / Nagai, Yasuki / Azuma, Daisuke / Yamamoto, Aya / Hara, Kantaro / Kohara, Masaharu / Iwata, Takashi / Nakatsuka, Shinichi / Morii, Eiichi / Yamamoto, Tsunehiko

    Endocrine journal

    2018  Volume 65, Issue 12, Page(s) 1161–1169

    Abstract: Ectopic ACTH syndrome (EAS) is a potentially fatal endocrine disease that results from a variety of neuroendocrine tumors (NETs), such as small cell lung cancer (SCLC) and bronchial typical carcinoid. Typical carcinoid is usually slow growing, not ... ...

    Abstract Ectopic ACTH syndrome (EAS) is a potentially fatal endocrine disease that results from a variety of neuroendocrine tumors (NETs), such as small cell lung cancer (SCLC) and bronchial typical carcinoid. Typical carcinoid is usually slow growing, not associated with plasma progastrin releasing peptide (ProGRP) elevation. Here, we report a 47-year-old female smoker with progressive typical carcinoid and plasma ProGRP elevation. Several types of Cushingoid features were found on physical examination. In addition, laboratory examination showed elevated plasma ACTH and serum cortisol levels. These findings indicated ACTH-dependent Cushing's syndrome. Moreover, the serum cortisol level was not suppressed by overnight high-dose dexamethasone treatment, suggesting the presence of an extra-pituitary tumor. Contrast-enhanced brain MRI revealed no pituitary adenoma, which also supported the idea that EAS occurred in the present case. Strikingly, chest computed tomographic (CT) scan showed a single 18-mm peripheral nodule in the right middle lobe of the lung. Tumor marker analysis revealed an elevation in plasma ProGRP. These data suggested a possibility that SCLC secreted ACTH and caused EAS in this patient. Of note, the plasma ACTH level was increased (1.7 fold) in l-desamino-8-D-arginine vasopressin (DDAVP) test, also suggesting the specific clinical feature in this case. After additional imaging examinations, we performed surgical resection with the suspicion of limited SCLC. As a result, pathological examination revealed a vasopressin receptor Ib (V1b) receptor-negative bronchial typical carcinoid with ACTH production and mediastinal lymphatic metastasis. In summary, we present a case of EAS caused by progressive bronchial typical carcinoid with plasma ProGRP elevation. We propose a novel subtype of lung typical carcinoid.
    MeSH term(s) ACTH Syndrome, Ectopic/blood ; ACTH Syndrome, Ectopic/etiology ; ACTH Syndrome, Ectopic/pathology ; Adrenocorticotropic Hormone/blood ; Bronchial Neoplasms/blood ; Bronchial Neoplasms/complications ; Bronchial Neoplasms/pathology ; Carcinoid Tumor/blood ; Carcinoid Tumor/complications ; Carcinoid Tumor/pathology ; Deamino Arginine Vasopressin ; Female ; Humans ; Hydrocortisone/blood ; Lymphatic Metastasis/pathology ; Middle Aged ; Peptide Fragments/blood ; Recombinant Proteins/blood
    Chemical Substances Peptide Fragments ; Recombinant Proteins ; pro-gastrin-releasing peptide (31-98) ; Adrenocorticotropic Hormone (9002-60-2) ; Deamino Arginine Vasopressin (ENR1LLB0FP) ; Hydrocortisone (WI4X0X7BPJ)
    Language English
    Publishing date 2018-09-20
    Publishing country Japan
    Document type Case Reports ; Journal Article
    ZDB-ID 1151918-6
    ISSN 1348-4540 ; 0918-8959
    ISSN (online) 1348-4540
    ISSN 0918-8959
    DOI 10.1507/endocrj.EJ18-0052
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    Uh III Zs.207: Show issues Location:
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  5. Article ; Online: Suppression Failure of Cortisol Secretion by Dexamethasone May Occur in Glucagon-like Peptide-1 Receptor Agonist-treated Patients with Diabetic Autonomic Neuropathy.

    Nagai, Yasuki / Mukai, Kosuke / Otsuki, Michio / Kimura, Takekazu / Kozawa, Junji / Nishizawa, Hitoshi / Maeda, Norikazu / Matsuoka, Taka-Aki / Iwahashi, Hiromi / Imagawa, Akihisa / Shimomura, Iichiro

    Internal medicine (Tokyo, Japan)

    2018  Volume 58, Issue 7, Page(s) 949–953

    Abstract: Two diabetic women (case 1, 75 years old; case 2, 49 years old) being treated with glucagon-like peptide-1 (GLP-1) receptor agonists (GLP-1 RAs) showed no suppression of cortisol secretion on a dexamethasone suppression test (DST). However, its secretion ...

    Abstract Two diabetic women (case 1, 75 years old; case 2, 49 years old) being treated with glucagon-like peptide-1 (GLP-1) receptor agonists (GLP-1 RAs) showed no suppression of cortisol secretion on a dexamethasone suppression test (DST). However, its secretion was suppressed after switching from GLP-1 RAs to insulin. We also checked the cortisol secretion by a DST in five consecutive inpatients (case 3-7) being treated with GLP-1 RAs. The coefficients of R-R interval variation at rest and during deep breathing were lower in the two false-positive cases (case 1 and 2) than in the five true-negative cases (case 3-6). GLP-1 RAs can be switched to insulin in order to eliminate the slow absorption effect of dexamethasone by GLP-1 RAs if a DST is planned in diabetic patients receiving GLP-1 RAs.
    MeSH term(s) Aged ; Blood Glucose/drug effects ; Dexamethasone ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/metabolism ; Diabetic Neuropathies/drug therapy ; Diabetic Neuropathies/metabolism ; Drug Interactions ; False Positive Reactions ; Female ; Glucagon-Like Peptide-1 Receptor/agonists ; Humans ; Hydrocortisone/metabolism ; Hypoglycemic Agents/pharmacology ; Hypoglycemic Agents/therapeutic use ; Insulin/therapeutic use ; Male ; Middle Aged
    Chemical Substances Blood Glucose ; Glucagon-Like Peptide-1 Receptor ; Hypoglycemic Agents ; Insulin ; Dexamethasone (7S5I7G3JQL) ; Hydrocortisone (WI4X0X7BPJ)
    Language English
    Publishing date 2018-12-18
    Publishing country Japan
    Document type Case Reports ; Journal Article
    ZDB-ID 32371-8
    ISSN 1349-7235 ; 0021-5120 ; 0918-2918
    ISSN (online) 1349-7235
    ISSN 0021-5120 ; 0918-2918
    DOI 10.2169/internalmedicine.1585-18
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    Zs.A 240: Show issues Location:
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  6. Article: [Report by the 99Mo-99mTc stable Supply Working Group].

    Kusakabe, Kiyoko / Arano, Yasushi / Kosuda, Shigeru / Honda, Noriwaza / Tamaki, Nagara / Inoue, Tomio / Shibata, Tokushi / Nagai, Yasuki

    Kaku igaku. The Japanese journal of nuclear medicine

    2012  Volume 49, Issue 1, Page(s) 21–22

    MeSH term(s) Japan ; Molybdenum ; Nuclear Reactors ; Particle Accelerators ; Radiopharmaceuticals/supply & distribution ; Technetium
    Chemical Substances Radiopharmaceuticals ; Technetium (7440-26-8) ; Molybdenum (81AH48963U)
    Language Japanese
    Publishing date 2012-02
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 603723-9
    ISSN 0022-7854
    ISSN 0022-7854
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