Article ; Online: Stability of serial platelet and urine protein measurements in patients receiving nusinersen for spinal muscular atrophy.
2022 Volume 66, Issue 1, Page(s) 76–79
Abstract: Introduction/aims: Patients undergoing nusinersen treatment for spinal muscular atrophy are subject to measurements of platelet count and urine protein before each injection due to concern for platelet depletion and renal dysfunction according to the ... ...
| Abstract | Introduction/aims: Patients undergoing nusinersen treatment for spinal muscular atrophy are subject to measurements of platelet count and urine protein before each injection due to concern for platelet depletion and renal dysfunction according to the prescribing information. These tests may be uncomfortable or inconvenient and may cause delays in treatment. However, it is still unclear whether these values have been significantly affected by nusinersen treatment. Our aim in this study was to determine whether these measurements ever reached critical values that necessitated withholding treatment at our center. Methods: Records from 57 patients treated with nusinersen at our institution between 2017 and 2020 were retrospectively analyzed. Laboratory values for platelet count, random urine protein, and total urine protein:creatinine ratio were collected from all patients before each procedure. Results: Mean patient age was 28.9 years (range, 2-76 years). Mean platelet count was 307 × 10 Discussion: Although further study on a larger cohort is warranted for more definitive conclusions, it may not be necessary to measure platelet count and urine protein before each nusinersen treatment, particularly in the maintenance phase. |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| MeSH term(s) | Adolescent ; Adult ; Aged ; Child ; Child, Preschool ; Creatinine/urine ; Humans ; Injections, Spinal ; Middle Aged ; Muscular Atrophy, Spinal/drug therapy ; Oligonucleotides/administration & dosage ; Oligonucleotides/adverse effects ; Oligonucleotides/therapeutic use ; Platelet Count ; Proteinuria/urine ; Retrospective Studies ; Spinal Muscular Atrophies of Childhood/drug therapy ; Young Adult | ||||||||||
| Chemical Substances | Oligonucleotides ; nusinersen (5Z9SP3X666) ; Creatinine (AYI8EX34EU) | ||||||||||
| Language | English | ||||||||||
| Publishing date | 2022-05-11 | ||||||||||
| Publishing country | United States | ||||||||||
| Document type | Journal Article | ||||||||||
| ZDB-ID | 438353-9 | ||||||||||
| ISSN | 1097-4598 ; 0148-639X | ||||||||||
| ISSN (online) | 1097-4598 | ||||||||||
| ISSN | 0148-639X | ||||||||||
| DOI | 10.1002/mus.27564 | ||||||||||
| Shelf mark |
|
||||||||||
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
Full text online
More links
Kategorien
In stock of ZB MED Cologne/Königswinter
| Zs.A 1449: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG) |
|||
| Zs.MO 551: Show issues |
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.