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  1. Article ; Online: Bisphenol A (BPA) exposure aggravates hepatic oxidative stress and inflammatory response under hypertensive milieu - Impact of low dose on hepatocytes and influence of MAPK and ER stress pathways.

    Nagarajan, Manikandan / Maadurshni, Gobichettipalayam Balasubramaniam / Manivannan, Jeganathan

    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

    2023  Volume 183, Page(s) 114197

    Abstract: Human exposure to the hazardous chemical, Bisphenol A (BPA), is almost ubiquitous. Due to the prevalence of hypertension (CVD risk factor) in the aged human population, it is necessary to explore its adverse effect in hypertensive subjects. The current ... ...

    Abstract Human exposure to the hazardous chemical, Bisphenol A (BPA), is almost ubiquitous. Due to the prevalence of hypertension (CVD risk factor) in the aged human population, it is necessary to explore its adverse effect in hypertensive subjects. The current study exposed the Nω-nitro-l-arginine methyl ester (L-NAME) induced hypertensive Wistar rats to human exposure relevant low dose of BPA (50 μg/kg) for 30 days period. The liver biochemical parameters, histopathology, immunohistochemistry, gene expression (RT-qPCR), trace elements (ICP-MS), primary rat hepatocytes cell culture and metabolomic (1H NMR) assessments were performed. Results illustrate that BPA exposure potentiates/aggravates hypertension induced tissue abnormalities (hepatic fibrosis), oxidative stress, ACE activity, malfunction of the antioxidant system, lipid abnormalities and inflammatory factor (TNF-α and IL-6) expression. Also, in cells, BPA increased ROS generation, mitochondrial dysfunction and lipid peroxidation without any impact on cytotoxicity and caspase 3 and 9 activation. Notably, BPA exposure modulate lipid metabolism (cholesterol and fatty acid) in primary hepatocytes. Finally, the influence of ERK1/2, p38MAPK, ER stress and oxidative stress during relatively high dose of BPA elicited cytotoxicity was observed. Therefore, a precise hazardous risk investigation of BPA exposure in hypertensive populations is highly recommended.
    MeSH term(s) Humans ; Rats ; Animals ; Aged ; Rats, Wistar ; Liver ; Hepatocytes ; Oxidative Stress ; Benzhydryl Compounds/pharmacology ; Hypertension/chemically induced
    Chemical Substances bisphenol A (MLT3645I99) ; Benzhydryl Compounds
    Language English
    Publishing date 2023-11-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 782617-5
    ISSN 1873-6351 ; 0278-6915
    ISSN (online) 1873-6351
    ISSN 0278-6915
    DOI 10.1016/j.fct.2023.114197
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Power and Area Efficient Cascaded Effectless GDI Approximate Adder for Accelerating Multimedia Applications Using Deep Learning Model.

    Nagarajan, Manikandan / Muthaiah, Rajappa / Teekaraman, Yuvaraja / Kuppusamy, Ramya / Radhakrishnan, Arun

    Computational intelligence and neuroscience

    2022  Volume 2022, Page(s) 3505439

    Abstract: Approximate computing is an upsurging technique to accelerate the process through less computational effort while keeping admissible accuracy of error-tolerant applications such as multimedia and deep learning. Inheritance properties of the deep learning ...

    Abstract Approximate computing is an upsurging technique to accelerate the process through less computational effort while keeping admissible accuracy of error-tolerant applications such as multimedia and deep learning. Inheritance properties of the deep learning process aid the designer to abridge the circuitry and also to increase the computation speed at the cost of the accuracy of results. High computational complexity and low-power requirement of portable devices in the dark silicon era sought suitable alternate for Complementary Metal Oxide Semiconductor (CMOS) technology. Gate Diffusion Input (GDI) logic is one of the prompting alternatives to CMOS logic to reduce transistors and low-power design. In this work, a novel energy and area efficient 1-bit GDI-based full swing Energy and Area efficient Full Adder (EAFA) with minimum error distance is proposed. The proposed architecture was constructed to mitigate the cascaded effect problem in GDI-based circuits. It is proved by extending the proposed 1-bit GDI-based adder for different 16-bit Energy and Area Efficient High-Speed Error-Tolerant Adders (EAHSETA) segmented as accurate and inaccurate adder circuits. The proposed adder's design metrics in terms of delay, area, and power dissipation are verified through simulation using the Cadence tool. The proposed logic is deployed to accelerate the convolution process in the Low-Weight Digit Detector neural network for real-time handwritten digit classification application as a case study in the Intel Cyclone IV Field Programmable Gate Array (FPGA). The results confirm that our proposed EAHSETA occupies fewer logic elements and improves operation speed with the speed-up factor of 1.29 than other similar techniques while producing 95% of classification accuracy.
    MeSH term(s) Computer Simulation ; Deep Learning ; Diffusion ; Multimedia ; Semiconductors
    Language English
    Publishing date 2022-03-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2388208-6
    ISSN 1687-5273 ; 1687-5273
    ISSN (online) 1687-5273
    ISSN 1687-5273
    DOI 10.1155/2022/3505439
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: A Novel Random Error Approximate Adder-Based Lightweight Medical Image Encryption Scheme for Secure Remote Monitoring of Health Data

    Nagarajan Manikandan / Rajappa Muthaiah / Yuvaraja Teekaraman / Ramya Kuppusamy / Arun Radhakrishnan

    Security and Communication Networks, Vol

    2021  Volume 2021

    Abstract: In the present global scenario, social distancing is an inevitable one. The need for social distancing and advancements of technology to facilitate the patients and doctors around the world mandated the telemedicine and remote monitoring of patience ... ...

    Abstract In the present global scenario, social distancing is an inevitable one. The need for social distancing and advancements of technology to facilitate the patients and doctors around the world mandated the telemedicine and remote monitoring of patience details as the pivotal way to diagnose the disease. In this, it is essential to transmit the patient’s information such as X-ray and scan images of them to the doctor in the remote location. Preventing the medical data from the technological adversaries is the need of the hour. Infinitesimal attacks in medical images may cost human lives. This work proposes a lightweight, secure medical image encryption scheme for the remote monitoring of health data. The proposed encryption scheme uses computationally less complex weighted shift approximate adder (WSAA)–based encryption logic. The scheme uses a 256-bit key for the encryption process that strengthens the encryption and robust against various attacks. The proposed encryption scheme deploys the WSAA for diffusing the pixel values. A unique way of key distribution for pixel-wise encryption within the image is proposed that avoids the need for separate logic for the pixel-wise confusion. The proposed Encryption scheme is evaluated for its entropy and horizontal, vertical, diagonal correlation, histogram, key space, and sensitivity. Experimental results affirm that the proposed scheme significantly good with less computational complexity. The peak signal-to-noise ratio (PSNR) value of the decrypted image is infinity, and this matches the ideal requirement of the medical encryption scheme.
    Keywords Technology (General) ; T1-995 ; Science (General) ; Q1-390
    Subject code 518
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher Hindawi-Wiley
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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