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  1. Book ; Online ; E-Book: Bone marrow niche

    Nagasawa, Takashi

    microenvironments critical for immune cell development

    (Current topics in microbiology and immunology ; 434)

    2021  

    Author's details Takashi Nagasawa editor
    Series title Current topics in microbiology and immunology ; 434
    Collection
    Keywords Electronic books
    Language English
    Size 1 Online-Ressource (vii, 134 Seiten), Illustrationen, Diagramme
    Publisher Springer
    Publishing place Cham
    Publishing country Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT021193083
    ISBN 978-3-030-86016-5 ; 9783030860158 ; 3-030-86016-7 ; 3030860159
    DOI 10.1007/978-3-030-86016-5
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Identification of microenvironmental niches for hematopoietic stem cells and lymphoid progenitors-bone marrow fibroblastic reticular cells with salient features.

    Omatsu, Yoshiki / Nagasawa, Takashi

    International immunology

    2021  Volume 33, Issue 12, Page(s) 821–826

    Abstract: Most lineages of blood cells, including immune cells, are generated from hematopoietic stem cells (HSCs) in bone marrow throughout adult life. Since HSCs cannot expand on their own, they require and contact the special microenvironments, termed niches ... ...

    Abstract Most lineages of blood cells, including immune cells, are generated from hematopoietic stem cells (HSCs) in bone marrow throughout adult life. Since HSCs cannot expand on their own, they require and contact the special microenvironments, termed niches for their maintenance. HSC niches comprise supportive cells that provide adjacent HSCs with critical signals, including cytokines. Although bone marrow microenvironments have been thought to be complex, recent studies have demonstrated that the bone marrow-specific population of fibroblastic reticular cells with long processes, termed CXC chemokine ligand 12 (CXCL12)-abundant reticular (CAR) cells, which overlap strongly with leptin receptor (LepR)-expressing (LepR+) cells, is the major cellular component of niches for HSCs and lymphoid progenitors. CAR cells have salient features, expressing much higher levels of critical HSC niche factors than any other cell populations and function as self-renewing mesenchymal stem cells. Human counterpart of CAR cells is present and affected in diseases, including leukemia. Foxl1+ telocytes recently identified as the niche for intestinal stem cells share some features with CAR cells, suggesting that CAR cells might serve as a prototype for fibroblastic reticular cells creating niche for long-lived cells, including tissue stem cells and memory lymphocytes. These findings provided the basis for future mechanistic studies on the cross-talk between hematopoietic cells and microenvironments in both health and disease.
    MeSH term(s) Animals ; Bone Marrow/immunology ; Fibroblasts/immunology ; Hematopoietic Stem Cells/immunology ; Humans ; Stem Cell Niche/immunology
    Language English
    Publishing date 2021-10-20
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1013745-2
    ISSN 1460-2377 ; 0953-8178
    ISSN (online) 1460-2377
    ISSN 0953-8178
    DOI 10.1093/intimm/dxab092
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: CXCL12/SDF-1 and CXCR4.

    Nagasawa, Takashi

    Frontiers in immunology

    2015  Volume 6, Page(s) 301

    Language English
    Publishing date 2015
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2015.00301
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  4. Article: [Bone and Stem Cells. Bone marrow microenvironment niches for hematopoietic stem and progenitor cells].

    Nagasawa, Takashi

    Clinical calcium

    2014  Volume 24, Issue 4, Page(s) 517–526

    Abstract: In bone marrow, the special microenvironments known as niches control proliferation and differentiation of hematopoietic stem and progenitor cells (HSPCs) . However, the identity and functions of the niches has been a subject of longstanding debate. ... ...

    Abstract In bone marrow, the special microenvironments known as niches control proliferation and differentiation of hematopoietic stem and progenitor cells (HSPCs) . However, the identity and functions of the niches has been a subject of longstanding debate. Although it has been reported previously that osteoblasts lining the bone surface act as HSC niches, their precise role in HSC maintenance remains unclear. On the other hand, the adipo-osteogenic progenitors with long processes, termed CXCL12-abundant reticular (CAR) cells, which preferentially express the chemokine CXCL12, stem cell factor (SCF) , leptin receptor and PDGF receptor-β were identified in the bone marrow. Recent studies revealed that endothelial cells of bone marrow vascular sinuses and CAR cells provided niches for HSCs. The identity and functions of various other candidate HSC niche cells, including nestin-expressing cells and Schwann cells would also be discussed in this review.
    MeSH term(s) Animals ; Bone Marrow/metabolism ; Bone and Bones/cytology ; Bone and Bones/metabolism ; Cell Differentiation/physiology ; Hematopoietic Stem Cells/cytology ; Hematopoietic Stem Cells/metabolism ; Humans ; Osteoblasts/cytology ; Osteoblasts/metabolism ; Stem Cells/cytology ; Stem Cells/metabolism
    Language Japanese
    Publishing date 2014-04
    Publishing country Japan
    Document type English Abstract ; Journal Article ; Review
    ZDB-ID 2386417-5
    ISSN 0917-5857
    ISSN 0917-5857
    DOI CliCa1404517526
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  5. Article ; Online: CXC chemokine ligand 12 (CXCL12) and its receptor CXCR4.

    Nagasawa, Takashi

    Journal of molecular medicine (Berlin, Germany)

    2014  Volume 92, Issue 5, Page(s) 433–439

    Abstract: Chemokines were recognized originally for their ability to dictate the migration and activation of leukocytes. However, CXC chemokine ligand 12 (CXCL12, also known as stromal cell-derived factor-1) and its receptor CXCR4 are the first chemokine and ... ...

    Abstract Chemokines were recognized originally for their ability to dictate the migration and activation of leukocytes. However, CXC chemokine ligand 12 (CXCL12, also known as stromal cell-derived factor-1) and its receptor CXCR4 are the first chemokine and receptor that have been shown to be critical for developmental processes, including homing and maintenance of hematopoietic stem cells (HSCs), production of immune cells, homing of primordial germ cells (PGCs), cardiogenesis, arterial vessel branching in some organs, and appropriate assemblies of particular types of neurons. This review focuses on the pathophysiological relevance of CXCL12-CXCR4 signaling in mammals.
    MeSH term(s) Animals ; Chemokine CXCL12/analysis ; Chemokine CXCL12/immunology ; Chemokine CXCL12/metabolism ; Hematopoiesis ; Humans ; Immune System/cytology ; Neoplasms/immunology ; Neoplasms/pathology ; Neovascularization, Physiologic ; Neurogenesis ; Receptors, CXCR4/analysis ; Receptors, CXCR4/immunology ; Receptors, CXCR4/metabolism ; Signal Transduction
    Chemical Substances Chemokine CXCL12 ; Receptors, CXCR4
    Language English
    Publishing date 2014-04-11
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 1223802-8
    ISSN 1432-1440 ; 0946-2716
    ISSN (online) 1432-1440
    ISSN 0946-2716
    DOI 10.1007/s00109-014-1123-8
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  6. Article ; Online: Ebf3

    Nakatani, Taichi / Sugiyama, Tatsuki / Omatsu, Yoshiki / Watanabe, Hitomi / Kondoh, Gen / Nagasawa, Takashi

    Nature communications

    2023  Volume 14, Issue 1, Page(s) 6402

    Abstract: Lympho-hematopoiesis is regulated by cytokines; however, it remains unclear how cytokines regulate hematopoietic stem cells (HSCs) to induce production of lymphoid progenitors. Here, we show that in mice whose CXC chemokine ligand 12 (CXCL12) is deleted ... ...

    Abstract Lympho-hematopoiesis is regulated by cytokines; however, it remains unclear how cytokines regulate hematopoietic stem cells (HSCs) to induce production of lymphoid progenitors. Here, we show that in mice whose CXC chemokine ligand 12 (CXCL12) is deleted from half HSC niche cells, termed CXC chemokine ligand 12 (CXCL12)-abundant reticular (CAR) cells, HSCs migrate from CXCL12-deficient niches to CXCL12-intact niches. In mice whose CXCL12 is deleted from all Ebf3
    MeSH term(s) Mice ; Animals ; Chemokines, CXC ; Ligands ; Hematopoietic Stem Cells/physiology ; Bone Marrow ; Hematopoiesis ; Chemokine CXCL12 ; Stem Cell Niche ; Transcription Factors
    Chemical Substances Chemokines, CXC ; Ligands ; Chemokine CXCL12 ; Ebf3 protein, mouse ; Transcription Factors
    Language English
    Publishing date 2023-10-25
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-023-42047-2
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  7. Article: Cellular Niches for Hematopoietic Stem Cells and Lympho-Hematopoiesis in Bone Marrow During Homeostasis and Blood Cancers.

    Omatsu, Yoshiki / Higaki, Kei / Nagasawa, Takashi

    Current topics in microbiology and immunology

    2021  Volume 434, Page(s) 33–54

    Abstract: Most types of blood cells, including immune cells are generated from hematopoietic stem cells (HSCs) within bone marrow in the adult. Most HSCs are in contact with and require the special microenvironment known as a niche for their maintenance. It has ... ...

    Abstract Most types of blood cells, including immune cells are generated from hematopoietic stem cells (HSCs) within bone marrow in the adult. Most HSCs are in contact with and require the special microenvironment known as a niche for their maintenance. It has been thought that HSC niches comprise various types of support cells that provide critical signals, including cytokines and extracellular matrix for HSC regulation. However, among these cells, several lines of evidence have demonstrated that the population of bone marrow-specific mesenchymal stem cells, termed CXC chemokine ligand 12 (CXCL12)-abundant reticular (CAR) cells, which overlap strongly with leptin receptor-expressing (LepR
    MeSH term(s) Bone Marrow ; Hematologic Neoplasms/genetics ; Hematopoiesis ; Hematopoietic Stem Cells ; Homeostasis ; Humans ; Neoplasms ; Stem Cell Niche ; Tumor Microenvironment
    Language English
    Publishing date 2021-12-01
    Publishing country Germany
    Document type Journal Article
    ISSN 0070-217X
    ISSN 0070-217X
    DOI 10.1007/978-3-030-86016-5_2
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  8. Article: [Bone and marrow niches for hematopoiesis].

    Nagasawa, Takashi

    Clinical calcium

    2012  Volume 22, Issue 11, Page(s) 1659–1667

    Abstract: Hematopoietic stem cells (HSCs) and their progeny are thought to be regulated by special microenvironments, termed niches in the bone marrow during homeostasis. However, the identity and function of these hematopoietic niches remains unclear. It has been ...

    Abstract Hematopoietic stem cells (HSCs) and their progeny are thought to be regulated by special microenvironments, termed niches in the bone marrow during homeostasis. However, the identity and function of these hematopoietic niches remains unclear. It has been reported that HSCs are in contact with osteoblasts lining the bone surface and osteoblasts act as niches for HSCs (endosteal niche)

    however, other studies suggest that few HSCs reside in the endosteal niche. In contrast, most HSCs are shown to be in contact with endothelial cells (vascular niches) and/or primitive mesenchymal cells, including CXCL12-abundant reticular (CAR) cells or Nestin-expressing cells, which have ability to differentiate into adipocytes as well as osteoblasts. Recent in vivo studies revealed that CAR cells acted as niches for hematopoietic stem and progenitor cells (HSPCs) and that endothelial cells and Nestin-expressing cells acted as niches for HSCs. In addition, marrow nonmyelinating schwann cells might be involved in the maintenance of HSCs. Here we review candidate niches for HSCs and hematopoiesis in the marrow.
    MeSH term(s) Animals ; Bone Marrow Cells/cytology ; Bone and Bones/cytology ; Hematopoiesis/physiology ; Hematopoietic Stem Cells/cytology ; Humans ; Osteoblasts/cytology
    Language Japanese
    Publishing date 2012-11
    Publishing country Japan
    Document type English Abstract ; Journal Article ; Review
    ZDB-ID 2386417-5
    ISSN 0917-5857
    ISSN 0917-5857
    DOI CliCa121116591667
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: [Cytokines which are essential for hematopoiesis].

    Nagasawa, Takashi

    Nihon rinsho. Japanese journal of clinical medicine

    2012  Volume 70 Suppl 2, Page(s) 151–158

    MeSH term(s) Animals ; B-Lymphocytes/physiology ; Blood Platelets/physiology ; Cytokines/physiology ; Erythropoiesis/physiology ; Granulocytes/physiology ; Hematopoiesis/physiology ; Hematopoietic Stem Cells/physiology ; Humans ; Killer Cells, Natural/physiology ; Signal Transduction ; T-Lymphocytes/physiology
    Chemical Substances Cytokines
    Language Japanese
    Publishing date 2012-04
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 390903-7
    ISSN 0047-1852
    ISSN 0047-1852
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  10. Article: [Regulation of immune cell production by bone marrow niches].

    Nagasawa, Takashi

    Seikagaku. The Journal of Japanese Biochemical Society

    2012  Volume 84, Issue 3, Page(s) 163–167

    MeSH term(s) Animals ; Bone Marrow Cells/immunology ; Cellular Microenvironment/immunology ; Chemokine CXCL12 ; Endothelial Cells ; Hematopoiesis/immunology ; Hematopoietic Stem Cells/immunology ; Humans ; Immunologic Memory ; Lymphocytes/immunology ; Osteoblasts ; Stromal Cells
    Chemical Substances Chemokine CXCL12
    Language Japanese
    Publishing date 2012-03
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 282319-6
    ISSN 0037-1017
    ISSN 0037-1017
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