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  1. Article ; Online: One-Shot Diagnosis for Atrial Tachycardia: The Utility of a Single Atrial Extrastimulus.

    Nagashima, Koichi

    JACC. Clinical electrophysiology

    2024  

    Language English
    Publishing date 2024-03-25
    Publishing country United States
    Document type Editorial
    ZDB-ID 2846739-5
    ISSN 2405-5018 ; 2405-500X ; 2405-500X
    ISSN (online) 2405-5018 ; 2405-500X
    ISSN 2405-500X
    DOI 10.1016/j.jacep.2024.02.030
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  2. Article ; Online: Epitope Binning of Monoclonal and Polyclonal Antibodies by Biolayer Interferometry.

    Nagashima, Kaito / Mousa, Jarrod J

    Methods in molecular biology (Clifton, N.J.)

    2023  Volume 2673, Page(s) 17–32

    Abstract: Understanding the epitopes of antibodies elicited by infection and vaccination is often useful in immunogen design. In this chapter, we describe biolayer interferometry (BLI)-based methods to evaluate such epitopes and permit simultaneous analysis of ... ...

    Abstract Understanding the epitopes of antibodies elicited by infection and vaccination is often useful in immunogen design. In this chapter, we describe biolayer interferometry (BLI)-based methods to evaluate such epitopes and permit simultaneous analysis of antibodies from several sources, including monoclonal antibodies (mAbs) and polyclonal serum antibodies (pAbs). Using previously characterized antibodies with known epitopes as controls, the distribution of epitopes for the influenza hemagglutinin (HA) is shown for isolated human mAbs and pooled serum from HA-immunized mice. This method is versatile, high-throughput, and can be adapted to several antigens.
    MeSH term(s) Humans ; Animals ; Mice ; Epitopes ; Antibodies, Monoclonal ; Influenza, Human ; Hemagglutinins ; Interferometry/methods ; Antibodies, Viral ; Epitope Mapping/methods ; Hemagglutinin Glycoproteins, Influenza Virus
    Chemical Substances Epitopes ; Antibodies, Monoclonal ; Hemagglutinins ; Antibodies, Viral ; Hemagglutinin Glycoproteins, Influenza Virus
    Language English
    Publishing date 2023-05-31
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-3239-0_2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Creating and evaluating the score to assess overdose: the OD score.

    Nagashima, Kazuki / Yasuno, Nobuhiro / Watanabe, Machiko

    BMC emergency medicine

    2024  Volume 24, Issue 1, Page(s) 5

    Abstract: Background: During disasters (including epidemics such as coronavirus disease 2019), the capacity of emergency departments is exceeded, thereby hindering the administration of appropriate lifesaving measures. Furthermore, the number of overdose patients ...

    Abstract Background: During disasters (including epidemics such as coronavirus disease 2019), the capacity of emergency departments is exceeded, thereby hindering the administration of appropriate lifesaving measures. Furthermore, the number of overdose patients increases because of the stress overload during emergency situation. The fact that overdose patients are forced to be transported to medical facilities that do not typically treat them is becoming worrisome. Moreover, there is no definitive score for overdose. This study aimed to create a patient-specific scoring system to assess overdose.
    Methods: This was a retrospective single-center study. The evidence-based OD score was evaluated on a scale of 0-15. Further, logistic analysis and receiver operating characteristic (ROC) curve analysis were performed to evaluate the score.
    Results: Overall, 262 patients (including 118 overdose patients) receiving care at the intensive care unit of Japan's Teikyo University Hospital in 2021 were targeted. Regarding the total OD score, ROC analysis revealed a cutoff of 8 (area under the curve [AUC]: 0.99, 95% confidence interval [CI]: 0.980-0.997, sensitivity: 0.95, specificity: 0.95, p < 0.05), which was considered to indicate an overdose. Of the items evaluated in the OD score, the scenario at the location of the patient's discovery (adjusted odds ratio [AOR]: 16.8, 95% CI: 5.0-255.9, p = 0.002) and recent experience of mental anxiety (AOR: 55.7, 95% CI: 2.8-5399.5, p = 0.03) significantly predicted an overdose in multivariable logistic regression analysis. External validation revealed that the OD score could also identify overdose in patients treated in a cohort from 2022 (average cutoff: 8.6, average AUC: 1.0, p < 0.0001).
    Conclusions: The OD score could accurately assess overdose patients. Medical facilities that do not frequently address overdose patients will benefit from the use of this score.
    MeSH term(s) Humans ; Retrospective Studies ; Drug Overdose/diagnosis ; Drug Overdose/epidemiology ; Anxiety ; Area Under Curve ; COVID-19/epidemiology
    Language English
    Publishing date 2024-01-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 2050431-7
    ISSN 1471-227X ; 1471-227X
    ISSN (online) 1471-227X
    ISSN 1471-227X
    DOI 10.1186/s12873-023-00923-6
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  4. Article ; Online: One electrogram tracing tells all: What is the mechanism of this tachycardia and where is the catheter positioned?

    Honma, Taiga / Hirata, Shu / Nagashima, Koichi / Okumura, Yasuo

    Journal of cardiovascular electrophysiology

    2023  Volume 34, Issue 6, Page(s) 1488–1490

    MeSH term(s) Humans ; Tachycardia, Ventricular/surgery ; Catheters ; Catheter Ablation/adverse effects ; Electrocardiography
    Language English
    Publishing date 2023-05-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1025989-2
    ISSN 1540-8167 ; 1045-3873
    ISSN (online) 1540-8167
    ISSN 1045-3873
    DOI 10.1111/jce.15957
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2863: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Evaluation of newly developed wearable ear canal thermometer, mimicking the application to activities on sports and labor fields.

    Kato, Issei / Watanabe, Hironori / Nagashima, Kei

    The journal of physiological sciences : JPS

    2023  Volume 73, Issue 1, Page(s) 15

    Abstract: We evaluated the reliability of a newly developed wearable ear canal thermometer based on three different experiments, in which ear canal and rectal temperature ( ... ...

    Abstract We evaluated the reliability of a newly developed wearable ear canal thermometer based on three different experiments, in which ear canal and rectal temperature (T
    MeSH term(s) Humans ; Body Temperature ; Thermometers ; Ear Canal ; Reproducibility of Results ; Cold Temperature ; Hot Temperature ; Wearable Electronic Devices
    Language English
    Publishing date 2023-07-18
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2234472-X
    ISSN 1880-6562 ; 1880-6546
    ISSN (online) 1880-6562
    ISSN 1880-6546
    DOI 10.1186/s12576-023-00874-4
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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.360: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Non-invasive and wearable thermometer for continuous monitoring of core body temperature under various convective conditions.

    Matsunaga, D / Tanaka, Y / Seyama, M / Nagashima, K

    Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

    2020  Volume 2020, Page(s) 4377–4380

    Abstract: We describe the design of a thermometer that can be worn during everyday activities for monitoring core body temperature (CBT) at the skin surface. This sensor estimates the CBT by measuring the heat flux from the body core based on a thermal conductive ... ...

    Abstract We describe the design of a thermometer that can be worn during everyday activities for monitoring core body temperature (CBT) at the skin surface. This sensor estimates the CBT by measuring the heat flux from the body core based on a thermal conductive model. The heat flux is usually affected by the ambient convective conditions (e.g. air conditioner or posture), which in turn affects the model's accuracy. Thus, we analytically investigated heat conduction and designed a sensor interface that would be robust to convection changes. We performed an in vitro experiment and a preliminary in vivo experiment. The accuracy of CBT in an in vitro experiments was 0.1°C for convective values ranging from 0 to 1.2 m/s. The wearable thermometer has high potential as non-invasive CBT monitor.
    MeSH term(s) Body Temperature ; Hot Temperature ; Monitoring, Physiologic ; Thermometers ; Wearable Electronic Devices
    Language English
    Publishing date 2020-10-05
    Publishing country United States
    Document type Journal Article
    ISSN 2694-0604
    ISSN (online) 2694-0604
    DOI 10.1109/EMBC44109.2020.9176403
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  7. Article ; Online: Coronary computed tomography-angiography for traumatic coronary artery transection.

    Nagashima, Kenta / Hayashida, Tomohiro / Yamada, Eiji / Ishibashi, Naoki / Mimura, Naoki / Kashitani, Nobuhiro

    Acute medicine & surgery

    2024  Volume 11, Issue 1, Page(s) e946

    Abstract: Background: Penetrating thoracic trauma with coronary artery transection is a lethal injury, but is rare. We report a case of a cardiac stab wound with coronary artery transection that was successfully treated after preoperative diagnosis.: Case ... ...

    Abstract Background: Penetrating thoracic trauma with coronary artery transection is a lethal injury, but is rare. We report a case of a cardiac stab wound with coronary artery transection that was successfully treated after preoperative diagnosis.
    Case presentation: A 36-year-old man was transferred to our emergency department with a left chest stab wound. A coronary computed tomography-angiography scan, including coronary angiography, revealed left hemopneumothorax and left anterior descending branch transection, with ischemic changes in the left ventricular myocardium. Given the diagnosis of coronary artery transection and the absence of injury to the surrounding arteries, we were able to perform coronary artery bypass surgery using the left internal thoracic artery. The patient's postoperative course was good, and he was discharged on foot without major complications 18 days after surgery.
    Conclusion: Unless a resuscitative thoracotomy is required, a preoperative computed tomography scan, including coronary angiography, may be useful for accurate preoperative diagnosis for patients at high risk of myocardial or coronary artery injury.
    Language English
    Publishing date 2024-04-04
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2751184-4
    ISSN 2052-8817 ; 2052-8817
    ISSN (online) 2052-8817
    ISSN 2052-8817
    DOI 10.1002/ams2.946
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  8. Article ; Online: Coexistence of a Classical Nodoventricular Accessory Pathway With a Left-Sided Mahaim Accessory Pathway.

    Maeda, Soichiro / Nagashima, Koichi / Yasuda, Nao / Tsurumi, Naoki / Kato, Toshiaki / Awaji, Yoshifumi

    JACC. Case reports

    2024  Volume 29, Issue 5, Page(s) 102220

    Abstract: The coexistence of 2 Mahaim pathways represents a diagnostic challenge. We present a case in which the SH/HA intervals were useful for identifying concealed nodoventricular or His-ventricular pathways. ...

    Abstract The coexistence of 2 Mahaim pathways represents a diagnostic challenge. We present a case in which the SH/HA intervals were useful for identifying concealed nodoventricular or His-ventricular pathways.
    Language English
    Publishing date 2024-01-24
    Publishing country Netherlands
    Document type Case Reports
    ISSN 2666-0849
    ISSN (online) 2666-0849
    DOI 10.1016/j.jaccas.2024.102220
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  9. Article: Where is the gap after a 90 W/4 s very-high-power short-duration ablation of atrial fibrillation?: Association with the left atrial-pulmonary vein voltage and wall thickness.

    Hirata, Moyuru / Nagashima, Koichi / Watanabe, Ryuta / Wakamatsu, Yuji / Hirata, Shu / Kurokawa, Sayaka / Okumura, Yasuo

    Journal of arrhythmia

    2024  Volume 40, Issue 2, Page(s) 256–266

    Abstract: Background: Although pulmonary vein isolation (PVI) for atrial fibrillation (AF) utilizing radiofrequency (RF) applications with a very high-power and short-duration (vHPSD) has shortened the procedure time, the determinants of pulmonary vein (PV) gaps ... ...

    Abstract Background: Although pulmonary vein isolation (PVI) for atrial fibrillation (AF) utilizing radiofrequency (RF) applications with a very high-power and short-duration (vHPSD) has shortened the procedure time, the determinants of pulmonary vein (PV) gaps in the first-pass PVI and acute PV reconnections are unclear.
    Methods: An extensive encircling PVI was performed with the QDOT MICRO catheter with a vHPSD (90 W-4 s) in 30 patients with AF (19 men, 64 ± 10 years). The association of the PV gap sites (first-pass PVI failure, acute PV reconnections [spontaneous reconnections or dormant conduction provoked by adenosine triphosphate] or both) with the left atrial (LA) wall thickness and LA bipolar voltage on the PVI line and ablation-related parameters were assessed.
    Results: PV gaps were observed in 29 (6%) of 480 segments (16 segments per patient) in 17 patients (56%). The PV gaps were associated with the LA wall thickness, bipolar voltage, and the number of RF points (LA wall thickness, 2.5 ± 0.5 vs. 1.9 ± 0.4 mm,
    Conclusions: The LA voltage and wall thickness on the PV-encircling ablation line were highly associated with PV gaps using the 90 W/4 s-vHPSD ablation.
    Language English
    Publishing date 2024-02-27
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2696593-8
    ISSN 1883-2148 ; 1880-4276
    ISSN (online) 1883-2148
    ISSN 1880-4276
    DOI 10.1002/joa3.13009
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  10. Article: Pseudo-slow-fast atrioventricular nodal reentrant tachycardia: Is the fast pathway a criminal or innocent bystander?

    Hirata, Shu / Nagashima, Koichi / Watanabe, Ryuta / Wakamatsu, Yuji / Okumura, Yasuo

    Journal of arrhythmia

    2023  Volume 40, Issue 1, Page(s) 143–145

    Abstract: The intracardiac electrograms are shown during scanned single premature ventricular extrastimuli with a decreasing coupling interval in a very short RP tachycardia. What is the diagnosis and is the fast pathway essential for sustaining the tachycardia? ...

    Abstract The intracardiac electrograms are shown during scanned single premature ventricular extrastimuli with a decreasing coupling interval in a very short RP tachycardia. What is the diagnosis and is the fast pathway essential for sustaining the tachycardia?
    Language English
    Publishing date 2023-11-17
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2696593-8
    ISSN 1883-2148 ; 1880-4276
    ISSN (online) 1883-2148
    ISSN 1880-4276
    DOI 10.1002/joa3.12955
    Database MEDical Literature Analysis and Retrieval System OnLINE

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