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Article ; Online: Lessons Learned so Far from the Pandemic

Feride Marim / Dilek Karadogan / Tugba Sismanlar Eyuboglu / Nagehan Emiralioglu / Canan Gunduz Gurkan / Zehra Nur Toreyin / Fatma Tokgoz Akyil / Aycan Yuksel / Huseyin Arikan / Irem Serifoglu / Tugba Ramasli Gursoy / Abdulsamet Sandal / Metin Akgun

Eurasian Journal of Medicine, Vol 52, Iss 2, Pp 202-

A Review on Pregnants and Neonates with COVID-19

2020 Volume 210

Keywords	Medicine (General) ; R5-920
Language	English
Publishing date	2020-06-01T00:00:00Z
Publisher	AVES
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: An example of national scientific collaboration during the COVID-19 pandemic

Dilek Karadoğan / Nagehan Emiralioğlu / Fatma T. Akyil / Canan G. Gürkan / Aycan Yüksel / Feride Marim / Zehra N. Töreyin / Hüseyin Arikan / Tuğba Ş. Eyüboğlu / İrem Şerifoğlu / Abdulsamet Sandal / Tuğba R. Gürsoy / Metin Akgün

Population Medicine, Vol 2, Iss September, Pp 1-

Turkish Thoracic Society Early Career Members Taskforce Group’s contribution to accessing reliable scientific knowledge

2020 Volume 6

Keywords	scientific knowledge ; covid-19 ; early career members ; Medicine ; R ; covid19
Language	English
Publishing date	2020-09-01T00:00:00Z
Publisher	European Publishing
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Prospective evaluation of hydroxychloroquine in pediatric interstitial lung diseases

Matthias Griese / Meike Köhler / Sabine Witt / Daniela Sebah / Matthias Kappler / Martin Wetzke / Nicolaus Schwerk / Nagehan Emiralioglu / Nural Kiper / Kai Kronfeld / Christian Ruckes / Hans Rock / Gisela Anthony / Elias Seidl

Trials, Vol 21, Iss 1, Pp 1-

Study protocol for an investigator-initiated, randomized controlled, parallel-group clinical trial

2020 Volume 9

Abstract: Abstract Background Interstitial lung diseases in children (chILD) are rare and consist of many different entities that affect the parenchyma of the lungs, leading to a chronic lung disease. The natural course of many of these diseases is connected with ... ...

Abstract	Abstract Background Interstitial lung diseases in children (chILD) are rare and consist of many different entities that affect the parenchyma of the lungs, leading to a chronic lung disease. The natural course of many of these diseases is connected with a high morbidity and significant mortality. Symptomatic treatment consists of oxygen supplementation, adequate nutrition adapted to the high energy demand generated by the disease due to the increased breathing effort required, as well as immunization against respiratory pathogens to prevent exacerbations through respiratory infections. No proven pharmacological treatments are available to date. This placebo-controlled study aims to evaluate the efficacy and safety of the mid-term use of hydroxychloroquine in chILD. Methods and design The study is an explorative, prospective, randomized, double-blind, placebo-controlled investigation of hydroxychloroquine (HCQ) in chILD. Patients can be included into the trial when diagnosed with a chronic (≥ 3 weeks’ duration) diffuse parenchymal lung disease (chILD) (1) genetically defined, (2) histologically defined or (3) diagnosed with idiopathic pulmonary hemorrhage (hemosiderosis). The study contains of two different study blocks, a START and a STOP block, which can be initiated in any sequence. Each patient can participate in each block only once. In the START block subjects are randomized to parallel groups for 4 weeks treatment, then the placebo group is switched to the active drug. In the STOP block, subjects taking HCQ are randomized into parallel groups treated with placebo or HCQ. Discussion This study is the first international, investigator-initiated, prospective and controlled investigation of a pharmacological treatment in chILD. The block design was selected as it has the advantage of accommodating patients who are initiating or withdrawing from HCQ therapy, thus allowing the participation of those who were previously started on off-label HCQ. The cross-over design and selected outcome parameters enables us to ...
Keywords	chILD ; Interstitial lung disease ; Hydroxychloroquine ; Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2020-04-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Lack of Correlation of Sinonasal and Otologic Reported Symptoms With Objective Measurements Among Patients With Primary Ciliary Dyskinesia

Yin Ting Lam / Jean-François Papon / Mihaela Alexandru / Andreas Anagiotos / Miguel Armengot / Mieke Boon / Andrea Burgess / Nathalie Caversaccio / Suzanne Crowley / Sinan Ahmed D. Dheyauldeen / Nagehan Emiralioglu / Ela Erdem / Christine van Gogh / Yasemin Gokdemir / Onder Gunaydın / Eric G. Haarman / Amanda Harris / Isolde Hayn / Hasnaa Ismail-Koch /

Bulent Karadag / Céline Kempeneers / Sookyung Kim / Natalie Lorent / Ugur Ozcelik / Charlotte Pioch / Anne-Lise ML Poirrier / Ana Reula / Jobst Roehmel / Panayiotis Yiallouros / Myrofora Goutaki

Clinical and Experimental Otorhinolaryngology, Vol 16, Iss 4, Pp 407-

An International Study

2023 Volume 412

Keywords	Medicine ; R ; Otorhinolaryngology ; RF1-547
Language	English
Publishing date	2023-11-01T00:00:00Z
Publisher	Korean Society of Otorhinolaryngology-Head and Neck Surgery
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Study protocol

Andreas Anagiotos / Myrofora Goutaki / André Coste / Nagehan Emiralioglu / Amanda Harris / Andrea Burgess / Mieke Boon / Philipp Latzin / Jean François Papon / Eric G Haarman / Natalie Lorent / Yin Ting Lam / Mihaela Alexandru / Miguel Armengot / Emilie Bequignon / Ela Erdem / Sara-Lynn Hool / Bulent Karadag / Sookyung Kim /

Ugur Ozcelik / Ana Reula / Jobst Roehmel / Christine van Gogh / Panayiotis Yiallouros / Soeren Marian Zappe

BMJ Open, Vol 11, Iss

the ear–nose–throat (ENT) prospective international cohort of patients with primary ciliary dyskinesia (EPIC-PCD)

2021 Volume 10

Keywords	Medicine ; R
Language	English
Publishing date	2021-10-01T00:00:00Z
Publisher	BMJ Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: ERS International Virtual Congress 2021

Merve Yumrukuz Şenel / Dilek Karadoğan / Ilgım Vardaloğlu / Elif Develi / Selma Çelik / Mina Hızal / Beste Özseren / Aslı Öncel / İlknur Can / Nur Hürsoy / Kübra Uyar / Fatma Gülsüm Karakaş / Berrin Er / Pelin Asfuroğlu / Tuğba Ramaslı Gürsoy / Tuğba Şişmanlar Eyüboğlu / Eylül Pınar Çakır / Dilber Ademhan / Selen Karaoğlanoğlu /

Nagehan Emiralioğlu / Nilufer Aylin Acet Öztürk / Feride Marim / Özge Aydın Güçlü / Nazli Çetin / Dilara Ömer Topçu / Pınar Çelik / Metin Akgün

Turkish Thoracic Journal, Vol 23, Iss 2, Pp 173-

Highlights from the Turkish Thoracic Society Early Career Members

2022 Volume 184

Keywords	Internal medicine ; RC31-1245
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	AVES
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Turkish Thoracic Society Early Career Members Task Force Group’s Virtual Congress Notes

Deniz Kızılırmak / Dilek Karadoğan / Halime Yıldırım / Fatma Tokgöz Akyıl / Tuğba Şişmanlar Eyüboğlu / Nagehan Emiralioğlu / Ümran Özden Sertçelik / Fatma Esra Günaydın / Özlem Ataoğlu / Merve Sinem Oğuz / Selin Çakmakcı / Neslihan Özçelik / Aslı Öncel / Ali Fırıncıoğluları / Bilge Yılmaz Kara / Dilara Ömer Topçu / Selen Karaoğlanoğlu / Nazli Cetin / Fatma Gulsum Karakas /

Canan Gunduz Gurkan / Feride Marim / Tuğba Önyılmaz / Demet Polat Yuluğ / Nilufer Aylin Acet Öztürk / Özge Aydın Güçlü / Tuba Çiftçi Küsbeci / İrem Şerifoğlu / Hüseyin Arıkan / Zehra Nur Töreyin / Pınar Çelik / Metin Akgün

Turkish Thoracic Journal, Vol 23, Iss 2, Pp 162-

European Respiratory Society International Congress 2020

2022 Volume 172

Keywords	Internal medicine ; RC31-1245
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	AVES
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Diffuse alveolar haemorrhage in children

Astrid Madsen Ring / Nicolaus Schwerk / Nural Kiper / Ayse Tana Aslan / Paul Aurora / Roser Ayats / Ines Azevedo / Teresa Bandeira / Julia Carlens / Silvia Castillo-Corullon / Nazan Cobanoglu / Basil Elnazir / Nagehan Emiralioğlu / Tugba Sismanlar Eyuboglu / Michael Fayon / Tugba Ramaslı Gursoy / Claire Hogg / Karsten Kötz / Bülent Karadag /

ERJ Open Research, Vol 9, Iss

an international multicentre study

2023 Volume 2

Abstract: Background Paediatric diffuse alveolar haemorrhage (DAH) is a rare heterogeneous condition with limited knowledge on clinical presentation, treatment and outcome. Methods A retrospective, descriptive multicentre follow-up study initiated from the ... ...

Abstract	Background Paediatric diffuse alveolar haemorrhage (DAH) is a rare heterogeneous condition with limited knowledge on clinical presentation, treatment and outcome. Methods A retrospective, descriptive multicentre follow-up study initiated from the European network for translational research in children's and adult interstitial lung disease (Cost Action CA16125) and chILD-EU CRC (the European Research Collaboration for Children's Interstitial Lung Disease). Inclusion criteria were DAH of any cause diagnosed before the age of 18 years. Results Data of 124 patients from 26 centres (15 counties) were submitted, of whom 117 patients fulfilled the inclusion criteria. Diagnoses were idiopathic pulmonary haemosiderosis (n=35), DAH associated with autoimmune features (n=20), systemic and collagen disorders (n=18), immuno-allergic conditions (n=10), other childhood interstitial lung diseases (chILD) (n=5), autoinflammatory diseases (n=3), DAH secondary to other conditions (n=21) and nonspecified DAH (n=5). Median (IQR) age at onset was 5 (2.0–12.9) years. Most frequent clinical presentations were anaemia (87%), haemoptysis (42%), dyspnoea (35%) and cough (32%). Respiratory symptoms were absent in 23%. The most frequent medical treatment was systemic corticosteroids (93%), hydroxychloroquine (35%) and azathioprine (27%). Overall mortality was 13%. Long-term data demonstrated persistent abnormal radiology and a limited improvement in lung function. Conclusions Paediatric DAH is highly heterogeneous regarding underlying causes and clinical presentation. The high mortality rate and number of patients with ongoing treatment years after onset of disease underline that DAH is a severe and often chronic condition. This large international study paves the way for further prospective clinical trials that will in the long term allow evidence-based treatment and follow-up recommendations to be determined.
Keywords	Medicine ; R
Subject code	610
Language	English
Publishing date	2023-04-01T00:00:00Z
Publisher	European Respiratory Society
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The disease-specific clinical trial network for primary ciliary dyskinesia

Johanna Raidt / Bernard Maitre / Petra Pennekamp / Josje Altenburg / Pinelopi Anagnostopoulou / Miguel Armengot / Lizan D. Bloemsma / Mieke Boon / Melissa Borrelli / Folke Brinkmann / Siobhan B. Carr / Mary P. Carroll / Silvia Castillo-Corullón / André Coste / Renato Cutrera / Eleonora Dehlink / Damien M.S. Destouches / Maria E. Di Cicco / Lucy Dixon /

Nagehan Emiralioglu / Ela Erdem Eralp / Eric G. Haarman / Claire Hogg / Bulent Karadag / Helene E. Kobbernagel / Natalie Lorent / Marcus A. Mall / June K. Marthin / Vendula Martinu / Manjith Narayanan / Ugur Ozcelik / Daniel Peckham / Massimo Pifferi / Petr Pohunek / Eva Polverino / Simon Range / Felix C. Ringshausen / Evie Robson / Jobst Roehmel / Sandra Rovira-Amigo / Francesca Santamaria / Anne Schlegtendal / Zsolt Szépfalusi / Petra Tempels / Guillaume Thouvenin / Nicola Ullmann / Woolf T. Walker / Martin Wetzke / Panayiotis Yiallouros / Heymut Omran / Kim G. Nielsen

ERJ Open Research, Vol 8, Iss

PCD-CTN

2022 Volume 3

Abstract: Primary ciliary dyskinesia (PCD) is a rare genetic disorder characterised by impaired mucociliary clearance leading to irreversible lung damage. In contrast to other rare lung diseases like cystic fibrosis (CF), there are only few clinical trials and ... ...

Abstract	Primary ciliary dyskinesia (PCD) is a rare genetic disorder characterised by impaired mucociliary clearance leading to irreversible lung damage. In contrast to other rare lung diseases like cystic fibrosis (CF), there are only few clinical trials and limited evidence-based treatments. Management is mainly based on expert opinions and treatment is challenging due to a wide range of clinical manifestations and disease severity. To improve clinical and translational research and facilitate development of new treatments, the clinical trial network for PCD (PCD-CTN) was founded in 2020 under the framework of the European Reference Network (ERN)-LUNG PCD Core. Applications from European PCD sites interested in participating in the PCD-CTN were requested. Inclusion criteria consisted of patient numbers, membership of ERN-LUNG PCD Core, use of associated standards of care, experience in PCD and/or CF clinical research, resources to run clinical trials, good clinical practice (GCP) certifications and institutional support. So far, applications from 22 trial sites in 18 European countries have been approved, including >1400 adult and >1600 paediatric individuals with PCD. The PCD-CTN is headed by a coordinating centre and consists of a steering and executive committee, a data safety monitoring board and committees for protocol review, training and standardisation. A strong association with patient organisations and industrial companies are further cornerstones. All participating trial sites agreed on a code of conduct. As CTNs from other diseases have demonstrated successfully, this newly formed PCD-CTN operates to establish evidence-based treatments for this orphan disease and to bring new personalised treatment approaches to patients.
Keywords	Medicine ; R
Subject code	610
Language	English
Publishing date	2022-08-01T00:00:00Z
Publisher	European Respiratory Society
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Unclear Issues Regarding COVID-19

Aycan Yuksel / Dilek Karadogan / Canan Gunduz Gurkan / Fatma Tokgoz Akyil / Zehra Nur Toreyin / Feride Marim / Huseyin Arikan / Tugba Sismanlar Eyuboglu / Nagehan Emiralioglu / Irem Serifoglu / Elif Develi / Selman Celik / Umran Ozden Sertcelik / Tugba Ramasli Gursoy / Mehmet Fatih Elversli / Asli Oncel / Berrin Er / Ali Firincioglulari / Fatma Esra Gunaydin /

Hilal Ozakinci / Neslihan Ozcelik / Dorina Esendagli / Asena Aydin / Neslihan Kose / Merve Ercelik / Pinar Yildiz Gulhan / Ethem Yildiz / Ilim Irmak / Bilge Yilmaz Kara / Selcuk Gurz / Fatma Gulsum Karakas / Metin Akgun

Eurasian Journal of Medicine, Vol 52, Iss 2, Pp 191-

2020 Volume 196

Keywords	Medicine (General) ; R5-920
Language	English
Publishing date	2020-06-01T00:00:00Z
Publisher	AVES
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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