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  1. AU="Nagler, Rafael"
  2. AU=REIS ALICE H.
  3. AU="Omid Miry"
  4. AU="Vargas, Cristian A"
  5. AU="Kramer, Mordechai"
  6. AU="Ben Mustapha, Imen"
  7. AU="Kong, Xueqian"
  8. AU="Phan, Ngoc Minh Hien"
  9. AU="Khan, Tazeen"
  10. AU="Adzhubei, Ivan A"
  11. AU="Alicia Reyes-Arellano"
  12. AU="L. Marcus Wilhelmsson"
  13. AU=Filocamo Giovanni
  14. AU="Andrea Terán-Valdez"
  15. AU=Cleverley Joanne AU=Cleverley Joanne
  16. AU="Feng, Shiguang"
  17. AU="De Falco, Antonio"
  18. AU="Plenter, R J"
  19. AU="Malarz, Janusz"

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  1. Artikel ; Online: Survival Probabilities Related to Histology, Grade and Stage in Patients With Salivary Gland Tumors.

    Israel, Yair / Rachmiel, Adi / Gourevich, Konstantin / Nagler, Rafael

    Anticancer research

    2019  Band 39, Heft 2, Seite(n) 641–647

    Abstract: Background: The diversity of malignant salivary gland tumors challenges the study of survival rates. The current study evaluated patient survival rates using Kaplan-Meier analysis and examined the relative effects of histology, grade and stage on ... ...

    Abstract Background: The diversity of malignant salivary gland tumors challenges the study of survival rates. The current study evaluated patient survival rates using Kaplan-Meier analysis and examined the relative effects of histology, grade and stage on survival.
    Materials and methods: Using the Kaplan-Meier model, cancer-specific (CSS) and disease-free (DFS) survival probabilities were calculated as a function of time.
    Results: Of 101 patients, 79 survived and 22 died of their disease. The probability of CSS was 0.83, 0.73 and 0.61 at 5, 10 and 15 years, respectively; corresponding probability of DFS was 0.69, 0.59 and 0.54, respectively.
    Conclusion: CSS and the DFS probabilities in patients with salivary malignancies were quite high at 5 years, although these rates dropped over the long-term; the lethal effect of the malignancy is often delayed and prolonged. Tumor histology, grade and stage are well established factors in predicting prognosis. Although the subgroups of patients with MECA and SCC were too small to allow adequate statistical analysis, clear tendencies for devastating effects of poor differentiation in SCC and higher grade in MECA were shown. That is, 2/4 patients with high-grade MECA died from their disease, while only 1/15 with low-intermediate grade MECA died from their disease. Similarly, 2/4 patients with poorly differentiated SCC died from their disease, while only 1/5 with well-to-moderately-differentiated SCC died from their disease. Factors such as molecular markers should be further studied in an effort to improve prognosis prediction.
    Mesh-Begriff(e) Cell Differentiation ; Disease-Free Survival ; Genetic Markers/genetics ; Humans ; Kaplan-Meier Estimate ; Neoplasm Grading ; Neoplasm Staging ; Probability ; Prognosis ; Retrospective Studies ; Salivary Gland Neoplasms/metabolism ; Salivary Gland Neoplasms/mortality ; Salivary Gland Neoplasms/pathology ; Survival Rate
    Chemische Substanzen Genetic Markers
    Sprache Englisch
    Erscheinungsdatum 2019-01-24
    Erscheinungsland Greece
    Dokumenttyp Journal Article
    ZDB-ID 604549-2
    ISSN 1791-7530 ; 0250-7005
    ISSN (online) 1791-7530
    ISSN 0250-7005
    DOI 10.21873/anticanres.13158
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  2. Artikel ; Online: Cigarette smoke, saliva, the translocator protein 18 kDa (TSPO), and oral cancer.

    Nagler, Rafael / Weizman, Abraham / Gavish, Avishai

    Oral diseases

    2019  Band 25, Heft 8, Seite(n) 1843–1849

    Abstract: Oral squamous cell carcinoma (OSCC) incidence is induced primarily by cigarette smoke (CS). The 5-year survival rate for advanced OSCC stands at only 20%. Studies exploring underlying mechanisms of OSCC development have suggested free radicals such as ... ...

    Abstract Oral squamous cell carcinoma (OSCC) incidence is induced primarily by cigarette smoke (CS). The 5-year survival rate for advanced OSCC stands at only 20%. Studies exploring underlying mechanisms of OSCC development have suggested free radicals such as reactive oxygen species generated by CS as contributing to OSCC, with effects enhanced by transition metal ions iron and copper contained in the saliva. Located on the outer mitochondrial membrane of various cell types, the 18-kDa translocator protein (TSPO) is up-regulated under pathological conditions such as cancer and inflammation. We focused on studying the interaction between TSPO, CS, salivary effects, and OSCC. Increased TSPO expression in OSCC tumors correlates significantly with reduced patient survival rate, indicating the possible role of TSPO in OSCC pathogenesis. We speculate that TSPO in OSCC is dysfunctional or mutated, rendering it ineffective in promoting apoptosis and blocking malignant transformation. Basal, precancer lower function of TSPO may diminish the TSPO capacity for pro-apoptotic and anti-cancer activity, resulting in development of OSCC. In order to overcome this, TSPO over-expression is induced, unfortunately with no benefit, as it is a malfunctioning TSPO, similar to cases where over-expression of a mutated form of the p53 gene in tumors is associated with carcinogenesis.
    Mesh-Begriff(e) Carcinoma, Squamous Cell/metabolism ; Carcinoma, Squamous Cell/pathology ; Humans ; Mitochondria/drug effects ; Mouth Neoplasms/metabolism ; Mouth Neoplasms/pathology ; Receptors, GABA/metabolism ; Saliva/metabolism ; Smoking/adverse effects
    Chemische Substanzen Receptors, GABA ; TSPO protein, human
    Sprache Englisch
    Erscheinungsdatum 2019-10-01
    Erscheinungsland Denmark
    Dokumenttyp Journal Article ; Review
    ZDB-ID 1290529-x
    ISSN 1601-0825 ; 1354-523X
    ISSN (online) 1601-0825
    ISSN 1354-523X
    DOI 10.1111/odi.13178
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Kaplan-Meier analysis of salivary gland tumors: prognosis and long-term survival.

    Israel, Yair / Rachmiel, Adi / Gourevich, Konstantin / Nagler, Rafael

    Journal of cancer research and clinical oncology

    2019  Band 145, Heft 8, Seite(n) 2123–2130

    Abstract: Purpose: We evaluated the impact of various tumor related parameters on survival probability in a cohort of patients with malignant salivary tumors, using the Kaplan-Meier analysis.: Methods: We measured patients up to 15 years following therapy, ... ...

    Abstract Purpose: We evaluated the impact of various tumor related parameters on survival probability in a cohort of patients with malignant salivary tumors, using the Kaplan-Meier analysis.
    Methods: We measured patients up to 15 years following therapy, looking at T N M stage, grade perineural invasion and extra-parenchymal spread.
    Results: Of 101 patients diagnosed with various salivary malignant tumors in our medical center, 79 patients survived while 22 died with disease (DWD). The impact of distant metastasis (M+) was devastating (survival probability at 60 months and at 180 months dropped from 0.93 (M-) to 0.40 (M+) and from 0.67 to 0.40, respectively, p = 0.0001), the impact of perineural invasion was severe (at 180 months the probability of survival dropped from 0.75 to 0.21, p = 0.002). Higher stage tumor also decreased survival (from 0.82 to 0.53 at 180 months, p = 0.002) as did poor histological grade (from 0.85 to 0.48 at 180 months, p = 0.019). Neck metastasis (N+) impact was quite moderate (at 180 months the probability of survival dropped from 0.69 to 0.58, p = 0.044) while neither tumor size (T) nor extra-parenchymal spread significantly affected survival.
    Conclusions: Salivary tumor location and its potential to infiltrate nerves and blood vessels and to metastasize is the most telling parameter. Systemic therapy aimed at halting distant metastatic spread is the most effective therapeutic goal. Dissection of N0 neck metastasis is not necessarily a valuable treatment.
    Mesh-Begriff(e) Carcinoma, Adenoid Cystic/diagnosis ; Carcinoma, Adenoid Cystic/mortality ; Carcinoma, Adenoid Cystic/pathology ; Carcinoma, Mucoepidermoid/diagnosis ; Carcinoma, Mucoepidermoid/mortality ; Carcinoma, Mucoepidermoid/pathology ; Carcinoma, Squamous Cell/diagnosis ; Carcinoma, Squamous Cell/mortality ; Carcinoma, Squamous Cell/pathology ; Cohort Studies ; Female ; Humans ; Kaplan-Meier Estimate ; Male ; Neoplasm Metastasis ; Neoplasm Staging ; Prognosis ; Retrospective Studies ; Salivary Gland Neoplasms/diagnosis ; Salivary Gland Neoplasms/mortality ; Salivary Gland Neoplasms/pathology ; Survival Rate
    Sprache Englisch
    Erscheinungsdatum 2019-06-11
    Erscheinungsland Germany
    Dokumenttyp Journal Article
    ZDB-ID 134792-5
    ISSN 1432-1335 ; 0171-5216 ; 0084-5353 ; 0943-9382
    ISSN (online) 1432-1335
    ISSN 0171-5216 ; 0084-5353 ; 0943-9382
    DOI 10.1007/s00432-019-02953-9
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Mortality rates and prognostic factors in patients with malignant salivary tumors.

    Israel, Yair / Rachmiel, Adi / Gourevich, Konstantin / Nagler, Rafael

    Medical oncology (Northwood, London, England)

    2019  Band 36, Heft 7, Seite(n) 65

    Abstract: Malignancies of the salivary glands represent a multifarious disease. Evaluating the prognostic factors of these malignancies may help predict patient outcome and aid decision-making in choosing the most suitable therapy. We examined the role of various ... ...

    Abstract Malignancies of the salivary glands represent a multifarious disease. Evaluating the prognostic factors of these malignancies may help predict patient outcome and aid decision-making in choosing the most suitable therapy. We examined the role of various salivary tumorigenic, clinical and therapeutic features in a cohort of 101 patients diagnosed and treated for primary malignant salivary tumors. These include histo-pathological diagnosis, stage, grade and T, N, M values as well as the existence of perineural invasion and extra-parenchymal spread. We also identified the salivary gland involved, the sub-compartment specific location of the tumor and the therapy administered. All these were related to mortality. Of the 101 patients examined, 79 survived and 22 died due to the disease. Tumor staging, distant metastasis and perineural invasion were highly significant predictors of increased lethality. Histo-pathological grading was also a predictor but to a lesser degree. Neither neck metastasis nor tumor size or type had a significant impact on lethality. Performing neck dissections did not decrease lethality rate. Location of the tumor in the parotid gland and more so in its deep lobe adversely affected lethality; extra-parenchymal spread also had an adverse effect. Our results seem to indicate hematogenous rather than lymphogenous spread of metastasis from malignant salivary tumors. The highest therapeutic priority should be achieving full local control of the disease by safe removal of the primary salivary tumor, accompanied by regional control of perineural invasion and extra-parenchymal spread and appropriate systemic treatment aimed at eradicating distant metastasis.
    Mesh-Begriff(e) Humans ; Israel/epidemiology ; Neoplasm Staging ; Parotid Neoplasms/mortality ; Parotid Neoplasms/pathology ; Parotid Neoplasms/therapy ; Prognosis ; Salivary Gland Neoplasms/mortality ; Salivary Gland Neoplasms/pathology ; Salivary Gland Neoplasms/therapy
    Sprache Englisch
    Erscheinungsdatum 2019-06-05
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 1201189-7
    ISSN 1559-131X ; 0736-0118 ; 1357-0560
    ISSN (online) 1559-131X
    ISSN 0736-0118 ; 1357-0560
    DOI 10.1007/s12032-019-1284-y
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  5. Artikel ; Online: Non-primary salivary malignancies: A 22-year retrospective study.

    Israel, Yair / Rachmiel, Adi / Gourevich, Konstantin / Nagler, Rafael

    Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery

    2019  Band 47, Heft 9, Seite(n) 1351–1355

    Abstract: Purpose: Most salivary gland malignancies are primary tumors, but in our medical center one of six is non-primary. The relative scarcity of such reports justifies studying them.: Subjects & methods: We studied patients' demographic and clinical ... ...

    Abstract Purpose: Most salivary gland malignancies are primary tumors, but in our medical center one of six is non-primary. The relative scarcity of such reports justifies studying them.
    Subjects & methods: We studied patients' demographic and clinical parameters, salivary tumors/metastasis, diagnosis and treatment, and survival rates.
    Results: Of all our salivary malignancy patients over the last 22 years, 15% (18/119) had non-primary malignant tumors, all located in the parotid glands. Of these, nine had skin cancer (SCC), 3 malignant solid tumors and 6 hematological systemic malignancies. Four had concomitant second malignancy. Mean age was 70.2 ± 13.8 years, 66.7% of the patients were males, 27.8% were smokers, none reported alcohol use. The most prevalent diagnostic tools used were CT (16 patients), FNA (13) and PET-CT (12). Eleven of 18 patients died from the disease despite receiving therapy: 6 SCC patients, 2 CLL patients and all 3 with solid tumors. All four lymphoma patients survived as did another three SCC patients.
    Conclusions: Chemotherapy and radiotherapy for systemic disease prolonged life rather than surgery. Patients with poor prognosis non-primary salivary tumors should be treated conservatively; surgery should be for those without widespread metastases or systemic disease. Sometimes a palliative patient may benefit from tumor debulking.
    Mesh-Begriff(e) Aged ; Aged, 80 and over ; Female ; Humans ; Lymphoma ; Male ; Middle Aged ; Positron Emission Tomography Computed Tomography ; Retrospective Studies ; Salivary Gland Neoplasms ; Survival Rate
    Sprache Englisch
    Erscheinungsdatum 2019-07-03
    Erscheinungsland Scotland
    Dokumenttyp Journal Article
    ZDB-ID 91267-0
    ISSN 1878-4119 ; 1010-5182 ; 0301-0503
    ISSN (online) 1878-4119
    ISSN 1010-5182 ; 0301-0503
    DOI 10.1016/j.jcms.2019.06.018
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  6. Artikel ; Online: Salivary malignancies- medical, demographic and diagnostic analysis.

    Israel, Yair / Rachmiel, Adi / Gourevich, Konstantin / Nagler, Rafael

    Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery

    2019  Band 47, Heft 3, Seite(n) 500–504

    Abstract: We examined systemic medical and demographic characteristics of patients diagnosed with salivary malignant tumors in order to better understand the pathogenesis of the disease. Of 101 patients who received definitive treatment for malignant salivary ... ...

    Abstract We examined systemic medical and demographic characteristics of patients diagnosed with salivary malignant tumors in order to better understand the pathogenesis of the disease. Of 101 patients who received definitive treatment for malignant salivary gland tumors in our medical center, 22 died with disease (DwD) and were compared with the remaining 79 patients (Other). Mean ages were 66.7 years (median 68.0) in DwD group and 58.7 years (median 59.0) in the Others. The difference is significant (p = 0.037). Mucoepidermoid carcinoma was the diagnosis in 27.3% of DwDs and 27.8% of the others, Adenoidcystic carcinoma in 36.4% vs 21.5%, SCC and Acinic cell carcinoma were diagnosed in 18.3% vs 7.6% and 4.6% vs 7.6%, respectively. Alcohol consumption, concomitant malignancies, and chronic illnesses other than hypertension, were similar in the two groups, but hypertension (63.6%) in the DwD group was significantly higher than in the Other group (26.6%), (p = 0.0010). Smoking was also significantly different between the two groups: 50% of the DwD vs. 27.9% of the Others group smoked cigarettes. Similar distribution of the various malignant tumors in both groups emphasizes the relative importance of systemic factors such as smoking, aging and hypertension, in the salivary carcinogenesis process.
    Mesh-Begriff(e) Age Factors ; Aged ; Alcohol Drinking/adverse effects ; Alcohol Drinking/epidemiology ; Carcinoma, Acinar Cell/mortality ; Carcinoma, Acinar Cell/pathology ; Carcinoma, Adenoid Cystic/mortality ; Carcinoma, Adenoid Cystic/pathology ; Carcinoma, Mucoepidermoid/mortality ; Carcinoma, Mucoepidermoid/pathology ; Female ; Humans ; Male ; Middle Aged ; Neoplasm Staging ; Risk Factors ; Salivary Gland Neoplasms/mortality ; Salivary Gland Neoplasms/pathology ; Sex Factors ; Smoking/adverse effects ; Smoking/epidemiology ; Survival Rate
    Sprache Englisch
    Erscheinungsdatum 2019-01-11
    Erscheinungsland Scotland
    Dokumenttyp Journal Article
    ZDB-ID 91267-0
    ISSN 1878-4119 ; 1010-5182 ; 0301-0503
    ISSN (online) 1878-4119
    ISSN 1010-5182 ; 0301-0503
    DOI 10.1016/j.jcms.2019.01.006
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: CRPS: Central aspects related to locus of pain, pathophysiology, and mood.

    Nagler, Rafael M

    Neurology

    2010  Band 75, Heft 2, Seite(n) 109–110

    Mesh-Begriff(e) Affect ; Brain/metabolism ; Brain/physiopathology ; Complex Regional Pain Syndromes/metabolism ; Complex Regional Pain Syndromes/physiopathology ; Complex Regional Pain Syndromes/psychology ; Humans ; Pain/physiopathology ; Receptors, Opioid/metabolism
    Chemische Substanzen Receptors, Opioid
    Sprache Englisch
    Erscheinungsdatum 2010-07-13
    Erscheinungsland United States
    Dokumenttyp Comment ; Editorial
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/WNL.0b013e3181e7cae3
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel: The TSPO Ligands MGV-1 and 2-Cl-MGV-1 Differentially Inhibit the Cigarette Smoke-Induced Cytotoxicity to H1299 Lung Cancer Cells

    Zeineh, Nidal / Nagler, Rafael M / Gabay, Martin / Obeid, Fadi / Kahana, Meygal / Weizman, Abraham / Gavish, Moshe

    Biology. 2021 May 02, v. 10, no. 5

    2021  

    Abstract: TSPO is involved in cigarette smoke (CS)-induced cellular toxicity, which may result in oral and pulmonary diseases and lung cancer. H1299 lung cancer cells were exposed directly to CS. The H1299 cells were pretreated with our TSPO ligands MGV-1 and 2-Cl- ...

    Abstract TSPO is involved in cigarette smoke (CS)-induced cellular toxicity, which may result in oral and pulmonary diseases and lung cancer. H1299 lung cancer cells were exposed directly to CS. The H1299 cells were pretreated with our TSPO ligands MGV-1 and 2-Cl-MGV-1 (Ki = 825 nM for both) at a concentration of 25 µM 24 h prior to CS exposure. Cell death and apoptotic markers were measured, in addition to TSPO expression levels, ATP synthase activity, generation of reactive oxygen species (ROS), depolarization of mitochondrial membrane potential (ΔΨm), cAMP and LDH levels. Pretreatment with MGV-1 and 2-Cl-MGV-1 (25 µM), 24 h prior to CS exposure, differentially attenuated the CS-induced cellular insult as well as cell death in H1299 lung cancer cells. These protective effects included prevention of ATP synthase reversal, ROS generation, depolarization of the mitochondrial membrane and elevation in LDH. The preventive efficacy of 2-Cl-MGV-1 was superior to that achieved by MGV-1. Both ligands did not prevent the elevation in cAMP. These findings may indicate a mild protective effect of these TSPO ligands in CS-related pulmonary and keratinocyte cellular pathology.
    Schlagwörter H-transporting ATP synthase ; apoptosis ; cigarettes ; cytotoxicity ; keratinocytes ; ligands ; lung neoplasms ; membrane potential ; mitochondrial membrane ; protective effect ; reactive oxygen species ; smoke
    Sprache Englisch
    Erscheinungsverlauf 2021-0502
    Erscheinungsort Multidisciplinary Digital Publishing Institute
    Dokumenttyp Artikel
    Anmerkung NAL-AP-2-clean
    ZDB-ID 2661517-4
    ISSN 2079-7737
    ISSN 2079-7737
    DOI 10.3390/biology10050395
    Datenquelle NAL Katalog (AGRICOLA)

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  9. Artikel ; Online: Carbonyl levels and survival rates in oral cancer cells exposed to cigarette smoke.

    Krayzler, Ella / Nagler, Rafael M

    Anticancer research

    2015  Band 35, Heft 4, Seite(n) 1961–1965

    Abstract: Background: Cigarette smoke (CS) is the main inducer of oral cancer, increasing prevalence 4-7 times.: Materials and methods: We examined SCC-25 and SCC-15 suitability for studying CS effects on oral cancer cells, measuring carbonyl levels for free ... ...

    Abstract Background: Cigarette smoke (CS) is the main inducer of oral cancer, increasing prevalence 4-7 times.
    Materials and methods: We examined SCC-25 and SCC-15 suitability for studying CS effects on oral cancer cells, measuring carbonyl levels for free radical-mediated CS effect on survival and time/CS dependence.
    Results: Protein oxidation increased significantly during CS exposure. At all time points, carbonyl levels increased six-fold (p<0.001) in both cell lines. Cell viability decrease was time-dependent. Longer CS exposure led to higher cell mortality. At 120 min, SCC-25 cell survival reduction was 43.7%, (p<0.01). Propidium iodide (PI) assay results matched the Trypan blue assay showing a time-dependent cell viability decrease following CS exposure. At 120 min, cell survival reduction was 37% (p<0.05).
    Conclusion: Cell death is mediated by CS free radicals with pathological process occurring first. Oral cancer cell models SCC-25 and SCC-15 are suitable for studying CS-induced free radical-related damage, potentially leading to the pathogenesis of oral cancer.
    Mesh-Begriff(e) Cell Line, Tumor ; Cell Survival/drug effects ; Free Radicals/metabolism ; Humans ; Mouth Neoplasms/chemically induced ; Mouth Neoplasms/epidemiology ; Mouth Neoplasms/pathology ; Oxidation-Reduction/drug effects ; Saliva/drug effects ; Saliva/metabolism ; Smoking/adverse effects ; Survival Rate
    Chemische Substanzen Free Radicals
    Sprache Englisch
    Erscheinungsdatum 2015-04
    Erscheinungsland Greece
    Dokumenttyp Journal Article
    ZDB-ID 604549-2
    ISSN 1791-7530 ; 0250-7005
    ISSN (online) 1791-7530
    ISSN 0250-7005
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: Cigarette smoke-induced effects on the cell cycle in oral cancer cells: reduction of G2/M fraction.

    Krayzler, Ella / Nagler, Rafael M

    Cancer genomics & proteomics

    2015  Band 12, Heft 2, Seite(n) 73–76

    Abstract: Background: Cigarette smoke (CS) is the main inducer of oral cancer, increasing its prevalence by 4-7 times.: Materials and methods: We examined the suitability of cell models SCC-25 and SCC-15 for studying effects of CS on oral cancer cells and ... ...

    Abstract Background: Cigarette smoke (CS) is the main inducer of oral cancer, increasing its prevalence by 4-7 times.
    Materials and methods: We examined the suitability of cell models SCC-25 and SCC-15 for studying effects of CS on oral cancer cells and whether CS significantly affects the cell cycle using fluorescence-activated cell sorting assays.
    Results: There was significant change in the fraction of SCC-15 cells in pre-G1 state following CS exposure. At 60 and 90 min, increase in the pre-G1 cell fraction was 118% (p<0.05) and 135% (p<0.01) respectively. The G2/M cell fraction was significantly lower following CS exposure. At 90 and 120 min following CS exposure, the G2/M fraction levels had declined by 44% (p<0.05) and 34% (p<0.01) respectively. Results for SCC-25 cells were similar. At 90 and 120 min following CS exposure, the pre-G1 fraction of the cells increased by 230% and 550%, respectively (p<0.01). At 120 min of CS exposure, the fraction of G2/M cells was lower by 47% (p<0.05) compared to controls.
    Conclusion: CS profoundly affects the cell-cycle distribution in both SCC-15 and SCC-25 oral cancer cellular models. Such effects have been associated with DNA damage and carcinogenesis. Both models are useful for studying oral cancer pathogenesis.
    Mesh-Begriff(e) Cell Line, Tumor ; G2 Phase ; Humans ; Mitosis ; Mouth Neoplasms/pathology ; Neoplasms, Squamous Cell/pathology ; Smoking/adverse effects
    Sprache Englisch
    Erscheinungsdatum 2015-03
    Erscheinungsland Greece
    Dokumenttyp Journal Article
    ZDB-ID 2144517-5
    ISSN 1790-6245 ; 1109-6535
    ISSN (online) 1790-6245
    ISSN 1109-6535
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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