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Article: Association between Systemic Factors and Vitreous Fluid Cytokines in Proliferative Diabetic Retinopathy.

Sato, Tomohito / Okazawa, Rina / Nagura, Koichi / Someya, Hideaki / Nishio, Yoshiaki / Enoki, Toshio / Ito, Masataka / Takeuchi, Masaru

Journal of clinical medicine

2023 Volume 12, Issue 6

Abstract: Proliferative diabetic retinopathy (PDR) is a vision-threatening complication of diabetes mellitus (DM). Systemic and intraocular factors are intricately related to PDR, and vitreous fluid (VF) cytokines are representative intraocular biomarkers. However, ...

Abstract	Proliferative diabetic retinopathy (PDR) is a vision-threatening complication of diabetes mellitus (DM). Systemic and intraocular factors are intricately related to PDR, and vitreous fluid (VF) cytokines are representative intraocular biomarkers. However, the associations between systemic factors and VF cytokines and their influence on PDR pathology are unclear. This study aimed to examine the correlation between systemic factors and VF cytokines and analyze their contributions to the pathology of PDR using multivariate analyses. We conducted a retrospective observational study on 26 PDR eyes of 25 patients with type 2 DM, and 30 eyes of 30 patients with idiopathic macular hole or epiretinal membrane as controls. Fifteen systemic and laboratory tests including blood pressure (BP) and body mass index (BMI), and 27 cytokines in VF were analyzed. BP and BMI correlated positively with VF levels of IL-6 and IP-10 in PDR patients, while no significant correlation was found between systemic factors and VF cytokines in controls. MCP-1 and VEGF-A in VF separately clustered with different systemic factors in controls, but these cytokines lost the property similarity with systemic factors and acquired property similarity with each other in PDR. Systemic factors contributed to only 10.4%, whereas VF cytokines contributed to 42.3% out of 52.7% variance of the whole PDR dataset. Our results suggest that intraocular factors play a major role in the pathology of PDR, whereas systemic factors may have limited effects, and that BP and BMI control in PDR could be useful interventions to improve intraocular immune condition.
Language	English
Publishing date	2023-03-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm12062354
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Article ; Online: Retinal Morphologic Features in Patients with Large Macular Holes Treated by Autologous Neurosensory Retinal Transplantation.

Kitahata, Shohei / Inoue, Tatsuya / Nagura, Koichi / Nakamura, Kentaro / Tanaka, Shin / Maruyama-Inoue, Maiko / Kadonosono, Kazuaki

Ophthalmology. Retina

2022 Volume 7, Issue 5, Page(s) 406–412

Abstract: Purpose: To investigate the time courses of morphologic changes in the transplanted grafts, including the retinal layer, the ellipsoid zone (EZ) and the visual acuity (VA) after autologous retinal transplantation (ART) in patients with primary large ... ...

Abstract	Purpose: To investigate the time courses of morphologic changes in the transplanted grafts, including the retinal layer, the ellipsoid zone (EZ) and the visual acuity (VA) after autologous retinal transplantation (ART) in patients with primary large macular holes (MHs). Design: Single-center, retrospective cohort study. Subjects: The study included 17 eyes of 17 patients who had undergone ART. All patients fulfilled the following criteria: (1) MH was the only disease-causing anatomic abnormality of the macula; (2) they could be followed up for at least 12 months after ART surgery; (3) they had no other systemic disorders; and (4) the MH was > 400 μm in diameter. Methods: Data of all patients who underwent assessment of the VA and spectral-domain (SD)-OCT at 1, 3, 6, and 12 months after surgery were analyzed. The morphologic features of the graft and the EZ were measured by SD-OCT. Main outcome measures: Changes in the morphologic features of the graft (graft thickness, overall graft area, graft length, area of outer retina, and EZ) and VA over 1 year after surgery. Results: Closure of the MH was achieved in all patients. The VA was 0.59 ± 0.27 (logarithm of the minimal angle of resolution units) at 1-year postsurgery compared with 0.84 ± 0.22 before surgery (P < 0.05). The retinal layers gradually became smoothly connected. Although a decrease in graft thickness and overall graft area was observed, the length and area of the outer retina were maintained throughout the follow-up period. The presence of the EZ was observed in 9 patients (52.9%) and our analyses revealed significantly greater improvement of VA in these patients than in those without the EZ (P < 0.05). Moreover, the incidence of macular edema (ME) was higher in the group without the EZ (P = 0.04; chi-square test). Conclusion: Patients showed significant improvements of the VA. Morphologically, the layers were gradually connected to each other, and the outer retina was particularly maintained. Especially, patients in whom an EZ was restored in the graft showed a low prevalence of ME and greater improvement of the VA. Financial disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article.
MeSH term(s)	Humans ; Retinal Perforations/diagnosis ; Retinal Perforations/surgery ; Retinal Perforations/complications ; Retrospective Studies ; Retina ; Macular Edema/etiology ; Macula Lutea
Language	English
Publishing date	2022-12-11
Publishing country	United States
Document type	Journal Article
ISSN	2468-6530
ISSN (online)	2468-6530
DOI	10.1016/j.oret.2022.12.004
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Article ; Online: Epidemiology and characteristics of common forms of anterior uveitis at initial presentation in a tertiary facility in Japan.

Okazawa, Rina / Iwai, Seima / Nagura, Koichi / Sora, Daisuke / Sato, Tomohito / Takayama, Kei / Harimoto, Kozo / Kanda, Takayuki / Takeuchi, Masaru

Japanese journal of ophthalmology

2022 Volume 67, Issue 1, Page(s) 22–31

Abstract: Purpose: To elucidate detailed epidemiological profile of common types of anterior uveitis (AU) in real-world clinical setting of a tertiary facility in Japan, and to evaluate the characteristic clinical findings at initial presentation.: Study design! ...

Abstract	Purpose: To elucidate detailed epidemiological profile of common types of anterior uveitis (AU) in real-world clinical setting of a tertiary facility in Japan, and to evaluate the characteristic clinical findings at initial presentation. Study design: Retrospective cohort study. Methods: Clinical charts of 275 patients (335 eyes) aged 52.5 ± 19.1 years were reviewed retrospectively. Herpetic AU was diagnosed by multiplex polymerase chain reaction tests using aqueous humor. Time of uveitis onset, gender, laterality, disease course since the initial onset of AU, visual acuity (VA) and intraocular pressure (IOP) at first visit, and definitive diagnosis were collected from clinical charts. Results: Acute AU (AAU) was the most common (21.8%) form of AU; followed by herpetic AU (20.7%) comprising Herpes Simplex Virus (HSV) (8.0%), Varicella Zoster Virus (VZV) (9.1%) and cytomegalo virus (CMV) (3.6%); scleritis (13.5%); diabetic iritis (7.6%), and Posner-Schlossman syndrome (5.5%). Unilateral AU constituted 78.2%, and VA less than 20/30 accounted for 31.2%. Of all the eyes, 16.1% had an IOP higher than 20 mmHg, out of which 37.0% had herpetic AU, followed by scleritis in 25.9%, and Posner-Schlossman syndrome (PSS) in 11.1%. AU patients over 60 years of age were 40.4%, in which 34.2% had herpetic AU, followed by scleritis in 14.4% and AAU in 13.5%. Herpetic AU patients were significantly older and had higher IOP compared with AAU patients. Conclusion: The most frequent AU was AAU, followed by herpetic AU. Herpetic AU patients were older and had higher intraocular pressure than AAU patients, although VA was equally impaired in both groups.
MeSH term(s)	Humans ; Middle Aged ; Aged ; Herpes Zoster Ophthalmicus/diagnosis ; Retrospective Studies ; Eye Infections, Viral/diagnosis ; Eye Infections, Viral/epidemiology ; Japan/epidemiology ; Scleritis ; Herpesvirus 3, Human/genetics ; Uveitis, Anterior/diagnosis ; Uveitis, Anterior/epidemiology ; Glaucoma ; Acute Disease ; Glaucoma, Open-Angle ; Aqueous Humor ; DNA, Viral/analysis
Chemical Substances	DNA, Viral
Language	English
Publishing date	2022-11-08
Publishing country	Japan
Document type	Journal Article
ZDB-ID	82032-5
ISSN	1613-2246 ; 0021-5155
ISSN (online)	1613-2246
ISSN	0021-5155
DOI	10.1007/s10384-022-00961-w
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Article ; Online: Clinical relevance of fibrin membranous structures in the intra-photoreceptor outer segment separation on spectral domain optical coherence tomography (SD-OCT) in initial-onset acute Vogt-Koyanagi-Harada disease.

Motegi, Shuntaro / Nagura, Koichi / Yoneda, Keisuke / Harimoto, Kozo / Sato, Tomohito / Herbort, Carl P / Takeuchi, Masaru

Acta ophthalmologica

2022 Volume 101, Issue 3, Page(s) e286–e293

Abstract: Purpose: The purpose of the study was to investigate clinical relevance of fibrin membranous structure (FMS) in the photoreceptor outer segments on spectral-domain optical coherence tomography (SD-OCT) in untreated initial-onset acute Vogt-Koyanagi- ... ...

Abstract	Purpose: The purpose of the study was to investigate clinical relevance of fibrin membranous structure (FMS) in the photoreceptor outer segments on spectral-domain optical coherence tomography (SD-OCT) in untreated initial-onset acute Vogt-Koyanagi-Harada (VKH) disease. Methods: Clinical charts of 39 patients (78 eyes) diagnosed with initial-onset VKH disease were retrospectively reviewed. Age, gender, period from the onset of symptoms to first visit, visual acuity (VA), intraocular pressure (IOP), anterior chamber cells, serous retinal detachment (SRD), SD-OCT findings, as well as fluorescein (FA), and indocyanine green angiography (ICGA) were collected. Results: FMS was observed in 24 out of 39 VKH patients in either eye (61.5%). VKH patients with FMS (FMS group) were significantly younger and had the shorter period from the onset of symptoms to the first visit compared with those without FMS (non-FMS group). Mean logMAR VA and proportion of pooling of dye, mean central retinal thickness (CRT) were significantly higher in FMS group than in non-FMS group. In contrast, hyperfluorescence of the optic disc on FA was more in non-FMS group than in FMS group. Significant positive correlations between CRT and logMAR VA or IOP were only observed in the FMS group. Total amount of corticosteroids was significantly greater in FMS group than in non-FMS group. However, there were no significant differences in LogMAR VA and IOP between two groups at 6 months after treatment initiation. Conclusion: FMS on SD-OCT is a critical feature observed in the early stage of initial-onset acute VKH disease, which is more common in younger patients and is related to the disease activity.
MeSH term(s)	Humans ; Uveomeningoencephalitic Syndrome/diagnosis ; Tomography, Optical Coherence ; Fibrin/therapeutic use ; Retrospective Studies ; Clinical Relevance ; Fluorescein Angiography/methods ; Retina
Chemical Substances	Fibrin (9001-31-4)
Language	English
Publishing date	2022-10-11
Publishing country	England
Document type	Journal Article
ZDB-ID	2408333-1
ISSN	1755-3768 ; 1755-375X
ISSN (online)	1755-3768
ISSN	1755-375X
DOI	10.1111/aos.15268
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Article ; Online: Foveal microstructure and visual function in patients with lamellar macular hole, epiretinal membrane foveoschisis or macular pseudohole.

Nakamura, Kentaro / Inoue, Tatsuya / Nagura, Koichi / Tanaka, Yui / Arasaki, Rei / Asaoka, Ryo / Yanagi, Yasuo / Maruyama-Inoue, Maiko / Kadonosono, Kazuaki

Eye (London, England)

2021 Volume 36, Issue 12, Page(s) 2247–2252

Abstract: Purpose: To compare the foveal microstructures, such as the prevalence of epiretinal proliferation (EP) and residual ellipsoid zone (EZ), in eyes with lamellar macular hole (LMH), epiretinal retinal membrane (ERM) foveoschisis and macular pseudohole ( ... ...

Abstract	Purpose: To compare the foveal microstructures, such as the prevalence of epiretinal proliferation (EP) and residual ellipsoid zone (EZ), in eyes with lamellar macular hole (LMH), epiretinal retinal membrane (ERM) foveoschisis and macular pseudohole (MPH), and to investigate the association of the foveal microstructure with visual functions. Method: In addition to the prevalence of EP, we calculated the residual EZ index within 1mm and 3 mm (rEZ1 and rEZ3) in all examined eyes. Comparisons were conducted to baseline characteristics (logMAR visual acuity [logMAR VA], metamorphopsia score [Mave], central retinal thickness [CRT], the prevalence of EP, rEZ1 and rEZ3) between MPH, ERM foveoschisis and LMH subgroups. The relationships (1) between logMAR VA and each of age, type (MPH, ERM foveoschisis and LMH), the prevalence of EP, rEZ1, rEZ3, spherical equivalent (SE) and CRT and (2) between Mave and each of variables were investigated. Results: Fifty-one eyes of 48 patients were enroled. The mean age was 65.2 ± 11.1 years. Ten eyes were diagnosed as LMH, 22 eyes as ERM foveoschisis and 19 eyes as MPH, respectively. There was a significant difference in CRT only between LMH and ERM foveoschisis (p = 0.023). There was a tendency toward significance in rEZ1 between LMH and ERM foveoschisis (p = 0.057), but not in rEZ3. The optimal model for logMAR VA included age, rEZ1, SE and CRT. On the other hand, the optimal model for Mave included the prevalence of EP, rEZ1 and SE. Conclusion: Microstructural observations are useful to predict visual functions in LMH, ERM foveoshisis and MPH.
MeSH term(s)	Humans ; Middle Aged ; Aged ; Epiretinal Membrane/epidemiology ; Epiretinal Membrane/complications ; Retinal Perforations/epidemiology ; Tomography, Optical Coherence ; Retrospective Studies ; Fovea Centralis
Language	English
Publishing date	2021-11-19
Publishing country	England
Document type	Journal Article
ZDB-ID	91001-6
ISSN	1476-5454 ; 0950-222X
ISSN (online)	1476-5454
ISSN	0950-222X
DOI	10.1038/s41433-021-01818-1
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Article ; Online: Retinal haemorrhages on ultra-widefield red channel images and perfusion status in central retinal vein occlusion.

Tanaka, Shin / Tanaka, Yui / Inoue, Tatsuya / Nagura, Koichi / Arasaki, Rei / Okawa, Kazuyoshi / Kitahata, Shohei / Nakamura, Kentaro / Kastube, Shiro / Yanagi, Yasuo / Maruyama-Inoue, Maiko / Kadonosono, Kazuaki

Eye (London, England)

2022 Volume 37, Issue 11, Page(s) 2305–2309

Abstract: Purpose: To evaluate the relationship between retinal haemorrhages detected on Ultra-widefield (UWF) red channel images and perfusion status in eyes with acute central retinal vein occlusion (CRVO).: Methods: UWF fundus images were split into green ... ...

Abstract	Purpose: To evaluate the relationship between retinal haemorrhages detected on Ultra-widefield (UWF) red channel images and perfusion status in eyes with acute central retinal vein occlusion (CRVO). Methods: UWF fundus images were split into green and red channels using ImageJ software. The retinal haemorrhages were calculated quantitatively with both the green and red channel images, resulting in green channel haemorrhages (GCH) and red channel haemorrhages (RCH). The nonperfusion area (NPA) was also calculated from fluorescein angiography in each eye. The relationships between both the GCH and RCH with the NPA were investigated. Results: Thirty-two eyes of 32 patients with acute CRVO (18 men, 14 women) were included. The mean GCH and RCH values were 10.4% ± 8.2% and 1.7% ± 1.7%, respectively. The mean NPA was 39.2% ± 28.8%. Significant correlations were seen between the GCH and NPA (r = 0.38; P = 0.022) and RCH and NPA (r = 0.44; P = 0.010, linear regression analysis). Multivariate analysis suggested that only the RCHs were correlated significantly with the NPA. Conclusions: Retinal haemorrhages detected by UWF red channel imaging were less compared to green channel imaging and associated closely with retinal NPAs in eyes with acute CRVO. UWF red channel imaging allowed us to identify ischaemia-related haemorrhage.
MeSH term(s)	Male ; Humans ; Female ; Retinal Vein Occlusion/complications ; Retinal Vessels ; Retinal Hemorrhage/complications ; Visual Acuity ; Fluorescein Angiography/methods ; Perfusion ; Retinal Vein
Language	English
Publishing date	2022-12-21
Publishing country	England
Document type	Journal Article
ZDB-ID	91001-6
ISSN	1476-5454 ; 0950-222X
ISSN (online)	1476-5454
ISSN	0950-222X
DOI	10.1038/s41433-022-02337-3
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Article ; Online: Long-term follow-up of a case of amyloidosis-associated chorioretinopathy.

Nagura, Koichi / Inoue, Tatsuya / Ching, Jared / Sato, Akinori / Kitahata, Shohei / Maruyama-Inoue, Maiko / Takeuchi, Masaru / Kadonosono, Kazuaki

American journal of ophthalmology case reports

2020 Volume 19, Page(s) 100846

Abstract: Purpose: To describe the findings of long-term follow-up of a case of amyloidosis-associated chorioretinopathy by multimodal imagings, including optical coherence tomography (OCT).: Observations: A 47-year-old woman who had been diagnosed as having ... ...

Abstract	Purpose: To describe the findings of long-term follow-up of a case of amyloidosis-associated chorioretinopathy by multimodal imagings, including optical coherence tomography (OCT). Observations: A 47-year-old woman who had been diagnosed as having systemic amyloidosis was found to have a best corrected visual acuity of 20/13 in both eyes at the age of 41, which subsequently decreased to 20/100 in the left eye and 20/20 in the right eye at age 47. Visual field examination demonstrated worsening of the central scotoma during the follow-up period. Funduscopic examination revealed bilateral white deposits along the choroidal vessels, which became more pronounced over time, along with diffuse pigmentary changes. The fluorescein angiography and indocyanine green angiography findings were consistent not only with atrophic lesions, but also with amyloid deposition (i.e., staining of the vessels).At the baseline, macula OCT revealed a thick hyporeflective band at the choriocapillaris, however, at the last follow-up, it revealed an absent ellipsoid zone, and bilateral progressive retinal pigment epithelium irregularities in both eyes. Conclusions: Patients diagnosed as having amyloidosis-related chorioretinopathy may have maintained visual function at the first detection of retinal amyloid deposition, and a number of years may elapse before the patient manifests visual deterioration.
Language	English
Publishing date	2020-08-02
Publishing country	United States
Document type	Case Reports
ISSN	2451-9936
ISSN (online)	2451-9936
DOI	10.1016/j.ajoc.2020.100846
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Article ; Online: Association Between Retinal Artery Angle and Visual Function in Eyes With Idiopathic Epiretinal Membrane.

Nagura, Koichi / Inoue, Tatsuya / Zhou, Han Peng / Obata, Ryo / Asaoka, Ryo / Arasaki, Rei / Sato, Akinori / Nakamura, Kentaro / Takeuchi, Masaru / Tanaka, Shin / Yanagi, Yasuo / Maruyama-Inoue, Maiko / Kadonosono, Kazuaki

Translational vision science & technology

2021 Volume 10, Issue 9, Page(s) 35

Abstract: Purpose: This study investigated the relationship between retinal artery angle and visual function in eyes with idiopathic epiretinal membrane (ERM).: Methods: Ultra-wide field fundus imaging was conducted to analyze ERM and normal contralateral eyes. ...

Abstract	Purpose: This study investigated the relationship between retinal artery angle and visual function in eyes with idiopathic epiretinal membrane (ERM). Methods: Ultra-wide field fundus imaging was conducted to analyze ERM and normal contralateral eyes. In addition to the logMAR visual acuity (VA) measurement, the average of the vertical and horizontal metamorphopsia scores (Mave) was measured using m-Charts for each eye. We calculated the retinal artery angle (Yugami correlated angle [YCA]) in all the examined eyes using ImageJ software. The YCAs were then compared between the ERM and normal contralateral eyes. Additionally, the relationship between YCA and visual function was investigated in the ERM eyes. Results: Data from 40 patients with ERM were analyzed. The mean age of the participants was 67.1 ± 8.1 years. The YCA was significantly smaller in the ERM eyes, compared with the contralateral eyes (P < 0.001, respectively; Wilcoxon signed rank test). Among age, axial length, YCAs, central retinal thickness (CRT), and central choroidal thickness (CCT), the optimal model for logMAR VA included age, YCA, and CRT. On the other hand, the optimal model for Mave included YCA and CCT. Conclusions: The retinal artery angle may be useful for predicting visual function in eyes with ERM. Translational relevance: Our established quantitative measurements in fundus photography have potential clinical use in predicting visual function in ERM.
MeSH term(s)	Aged ; Epiretinal Membrane/diagnosis ; Humans ; Middle Aged ; Retinal Artery ; Tomography, Optical Coherence ; Vision Disorders/diagnosis ; Visual Acuity
Language	English
Publishing date	2021-08-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	2674602-5
ISSN	2164-2591 ; 2164-2591
ISSN (online)	2164-2591
ISSN	2164-2591
DOI	10.1167/tvst.10.9.35
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Article ; Online: Using ultra-widefield red channel images to improve the detection of ischemic central retinal vein occlusion.

Sato, Akinori / Asaoka, Ryo / Tanaka, Shin / Nagura, Koichi / Tanaka, Yui / Arasaki, Rei / Okawa, Kazuyoshi / Kitahata, Shohei / Nakamura, Kentaro / Ikeda, Shouko / Inoue, Tatsuya / Yanagi, Yasuo / Maruyama-Inoue, Maiko / Kadonosono, Kazuaki

PloS one

2021 Volume 16, Issue 11, Page(s) e0260383

Abstract: Purpose: To examine the usefulness of red channel fundus imaging to detect the ischemic status in eyes with central retinal vein occlusion (CRVO).: Methods: Ultra-widefield (UWF) fundus images were obtained from 42 eyes with CRVO. Twenty-one eyes ... ...

Abstract	Purpose: To examine the usefulness of red channel fundus imaging to detect the ischemic status in eyes with central retinal vein occlusion (CRVO). Methods: Ultra-widefield (UWF) fundus images were obtained from 42 eyes with CRVO. Twenty-one eyes were ischemic, and 21 eyes were non-ischemic. Rubeosis was found in 11 ischemic eyes. UWF images were split into red and green channels using ImageJ software. Both the color and red channel images were used to predict the presence or absence of ischemia when examined by masked graders. The sensitivity and specificity of UWF imagings for the detection of ischemia were calculated in Group A (total 42 eyes), Group B (32 eyes excluding non-rubeotic ischemic CRVO) and Group C (31 eyes excluding rubeotic ischemic CRVO), respectively. Moreover, a linear mixed model was conducted to investigate the relationship between the type of images and the accuracy of prediction in each group. Results: No significant difference in the sensitivity of color fundus imaging was seen between Group A and Group B. By contrast, a significant difference in the sensitivity of red channel imaging was seen between Group A and Group B (p = 0.031). The accuracies of the predictions were not associated with the type of image in Group A and Group B, but were significantly associated in Group C (p = 0.026). Conclusions: UWF red channel imaging enabled more accurate detection of the ischemic status, compared with color fundus images, especially in non-rubeotic CRVO eyes.
MeSH term(s)	Aged ; Aged, 80 and over ; Diagnostic Techniques, Ophthalmological ; Female ; Fundus Oculi ; Humans ; Ischemia/diagnosis ; Ischemia/diagnostic imaging ; Male ; Middle Aged ; Optical Imaging ; Retinal Vein Occlusion/diagnosis ; Retinal Vein Occlusion/diagnostic imaging ; Retrospective Studies
Language	English
Publishing date	2021-11-23
Publishing country	United States
Document type	Journal Article
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0260383
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Article ; Online: Relationship Between Optical Coherence Tomography Parameter and Visual Function in Eyes With Epiretinal Membrane.

Murase, Ayaka / Asaoka, Ryo / Inoue, Tatsuya / Nagura, Koichi / Arasaki, Rei / Nakamura, Kentaro / Okawa, Kazuyoshi / Tanaka, Shin / Yanagi, Yasuo / Maruyama-Inoue, Maiko / Kadonosono, Kazuaki

Investigative ophthalmology & visual science

2021 Volume 62, Issue 6, Page(s) 6

Abstract: Purpose: To investigate the associations between visual function and the optical coherence tomography (OCT) parameters in eyes with idiopathic epiretinal membrane (ERM).: Methods: Thirty-nine consecutive eyes with ERM were enrolled. In addition to ... ...

Abstract	Purpose: To investigate the associations between visual function and the optical coherence tomography (OCT) parameters in eyes with idiopathic epiretinal membrane (ERM). Methods: Thirty-nine consecutive eyes with ERM were enrolled. In addition to OCT parameters, such as central retinal thickness (CRT), the area of gap between the ERM and the retinal surface (SUKIMA) was newly defined and calculated from the vertical and horizontal OCT images (SUKIMAv and SUKIMAh). The average of SUKIMAv and SUKIMAh (SUKIMAave) was used for the statistical analysis. The vertical and horizontal metamorphopsia scores (MV, MH) and the average of MV and MH (Mave) were also used for the analysis. Results: The Mave was not significantly associated with logMAR visual acuity (VA) (P = 0.57, linear regression analysis). Analysis using second-order bias-corrected Akaike information criterion model selection identified the age, CRT, and SUKIMAave as being associated with logMAR VA. On the other hand, among the OCT parameters, SUKIMAave and CRT were associated with the Mave. In addition, there was a significant relationship between SUKIMAh and MV (P = 0.011) and between SUKIMAv and MH (P = 0.0014). Conclusions: We identified SUKIMA as a novel OCT parameter that is useful to predict both VA and metamorphopsia in patients with ERM.
MeSH term(s)	Aged ; Aged, 80 and over ; Epiretinal Membrane/diagnostic imaging ; Epiretinal Membrane/physiopathology ; Female ; Humans ; Male ; Middle Aged ; Retina/diagnostic imaging ; Retina/physiopathology ; Retrospective Studies ; Slit Lamp Microscopy ; Tomography, Optical Coherence ; Vision Disorders/physiopathology ; Visual Acuity/physiology
Language	English
Publishing date	2021-05-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	391794-0
ISSN	1552-5783 ; 0146-0404
ISSN (online)	1552-5783
ISSN	0146-0404
DOI	10.1167/iovs.62.6.6
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In stock of ZB MED Cologne/Königswinter

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