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  1. Book ; Thesis: Die Wertigkeit der postoperativen Routine-Röntenaufnahme am OP-Tag nach thoraxchirurgischer Intervention

    Nagy, Péter

    prospektive Erhebung in der Abteilung Thoraxchirurgie der Ruhrlandklinik Essen

    2017  

    Institution Universität Duisburg-Essen
    Author's details vorgelegt von Péter Nagy
    Language German
    Size 63 Blätter, Illustrationen
    Publishing place Duisburg ; Essen
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Universität Duisburg-Essen, 2018
    HBZ-ID HT019763905
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2018 E 1317 order for loan Magazin

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  2. Article ; Online: Recent advances in sulfur biology and chemistry.

    Nagy, Péter

    Redox biology

    2023  Volume 63, Page(s) 102716

    MeSH term(s) Sulfur ; Biology
    Chemical Substances Sulfur (70FD1KFU70)
    Language English
    Publishing date 2023-04-24
    Publishing country Netherlands
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2701011-9
    ISSN 2213-2317 ; 2213-2317
    ISSN (online) 2213-2317
    ISSN 2213-2317
    DOI 10.1016/j.redox.2023.102716
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Enstrophy change of the Reynolds-Orr solution in channel flow.

    Nagy, Péter Tamás

    Physical review. E

    2022  Volume 105, Issue 3-2, Page(s) 35108

    Abstract: The plane Poiseuille flow is one of the elementary flow configurations. Although its laminar-turbulent transition mechanism has been investigated intensively in the last century, the significant difference in the critical Reynolds number between the ... ...

    Abstract The plane Poiseuille flow is one of the elementary flow configurations. Although its laminar-turbulent transition mechanism has been investigated intensively in the last century, the significant difference in the critical Reynolds number between the experiments and the theory lacks a clear explanation. In this paper, an attempt is made to reduce this gap by analyzing the solution of the Reynolds-Orr equation. Recent published results have shown that the usage of enstrophy (the volume integral of the squared vorticity) instead of the kinetic energy as the norm of perturbations predicts higher Reynolds numbers in the two-dimensional case. In addition, other research show has shown an improvement of the original Reynolds-Orr energy equation using the weighted norm in a tilted coordinate system. In this paper the enstrophy is used in three dimensions combined with the tilted coordinate system approach. The zero-enstrophy-growth constraint is applied to the classical Reynolds-Orr equation, and then the solution is further refined in the tilted coordinate system. The results are compared to direct numerical simulations published previously.
    Language English
    Publishing date 2022-04-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2844562-4
    ISSN 2470-0053 ; 2470-0045
    ISSN (online) 2470-0053
    ISSN 2470-0045
    DOI 10.1103/PhysRevE.105.035108
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Co-opted cytosolic proteins form condensate substructures within membranous replication organelles of a positive-strand RNA virus.

    Lin, Wenwu / Nagy, Peter D

    The New phytologist

    2024  

    Abstract: Positive-strand RNA viruses co-opt organellar membranes for biogenesis of viral replication organelles (VROs). Tombusviruses also co-opt pro-viral cytosolic proteins to VROs. It is currently not known what type of molecular organization keeps co-opted ... ...

    Abstract Positive-strand RNA viruses co-opt organellar membranes for biogenesis of viral replication organelles (VROs). Tombusviruses also co-opt pro-viral cytosolic proteins to VROs. It is currently not known what type of molecular organization keeps co-opted proteins sequestered within membranous VROs. In this study, we employed tomato bushy stunt virus (TBSV) and carnation Italian ringspot virus (CIRV) - Nicotiana benthamiana pathosystems to identify biomolecular condensate formation in VROs. We show that TBSV p33 and the CIRV p36 replication proteins sequester glycolytic and fermentation enzymes in unique condensate substructures associated with membranous VROs. We find that p33 and p36 form droplets in vitro driven by intrinsically disordered region. The replication protein organizes partitioning of co-opted host proteins into droplets. VRO-associated condensates are critical for local adenosine triphosphate production to support energy for virus replication. We find that co-opted endoplasmic reticulum membranes and actin filaments form meshworks within and around VRO condensates, contributing to unique composition and structure. We propose that p33/p36 organize liquid-liquid phase separation of co-opted concentrated host proteins in condensate substructures within membranous VROs. Overall, we demonstrate that subverted membranes and condensate substructures co-exist and are critical for VRO functions. The replication proteins induce and connect the two substructures within VROs.
    Language English
    Publishing date 2024-03-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 208885-x
    ISSN 1469-8137 ; 0028-646X
    ISSN (online) 1469-8137
    ISSN 0028-646X
    DOI 10.1111/nph.19691
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    In stock of ZB MED Bonn / Germany

    Z 868: Show issues

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  5. Article ; Online: Co-opted membranes, lipids, and host proteins: what have we learned from tombusviruses?

    Nagy, Peter D

    Current opinion in virology

    2022  Volume 56, Page(s) 101258

    Abstract: Positive-strand RNA viruses replicate in intracellular membranous structures formed after virus-driven intensive manipulation of subcellular organelles and membranes. These unique structures are called viral-replication organelles (VROs). To build VROs, ... ...

    Abstract Positive-strand RNA viruses replicate in intracellular membranous structures formed after virus-driven intensive manipulation of subcellular organelles and membranes. These unique structures are called viral-replication organelles (VROs). To build VROs, the replication proteins coded by (+)RNA viruses co-opt host proteins, including membrane-shaping, lipid synthesis, and lipid-modification enzymes to create an optimal microenvironment that (i) concentrates the viral replicase and associated host proteins and the viral RNAs; (ii) regulates enzymatic activities and spatiotemporally the replication process; and (iii) protects the viral RNAs from recognition and degradation by the host innate immune defense. Tomato bushy stunt virus (TBSV), a plant (+)RNA virus, serves as an advanced model to study the interplay among viral components, co-opted host proteins, lipids, and membranes. This review presents our current understanding of the complex interaction between TBSV and host with panviral implications.
    Language English
    Publishing date 2022-09-24
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2611378-8
    ISSN 1879-6265 ; 1879-6257
    ISSN (online) 1879-6265
    ISSN 1879-6257
    DOI 10.1016/j.coviro.2022.101258
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  6. Article ; Online: Disentangling Tics and Functional Ticlike Symptoms.

    Nagy, Peter / Fogarasi, Andras

    Pediatric neurology

    2023  Volume 147, Page(s) 165

    MeSH term(s) Humans ; Tics ; Tic Disorders/diagnosis ; Tourette Syndrome
    Language English
    Publishing date 2023-04-18
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 639164-3
    ISSN 1873-5150 ; 0887-8994
    ISSN (online) 1873-5150
    ISSN 0887-8994
    DOI 10.1016/j.pediatrneurol.2023.04.010
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2260: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Subversion of selective autophagy for the biogenesis of tombusvirus replication organelles inhibits autophagy.

    Kang, Yuanrong / Lin, Wenwu / Nagy, Peter D

    PLoS pathogens

    2024  Volume 20, Issue 3, Page(s) e1012085

    Abstract: Elaborate viral replication organelles (VROs) are formed to support positive-strand RNA virus replication in infected cells. VRO formation requires subversion of intracellular membranes by viral replication proteins. Here, we showed that the key ATG8f ... ...

    Abstract Elaborate viral replication organelles (VROs) are formed to support positive-strand RNA virus replication in infected cells. VRO formation requires subversion of intracellular membranes by viral replication proteins. Here, we showed that the key ATG8f autophagy protein and NBR1 selective autophagy receptor were co-opted by Tomato bushy stunt virus (TBSV) and the closely-related carnation Italian ringspot virus. Knockdown of ATG8f or NBR1 in plants led to reduced tombusvirus replication, suggesting pro-viral function for selective autophagy. BiFC and proximity-labeling experiments showed that the TBSV p33 replication protein interacted with ATG8f and NBR1 to recruit them to VROs. In addition, we observed that several core autophagy proteins, such as ATG1a, ATG4, ATG5, ATG101 and the plant-specific SH3P2 autophagy adaptor proteins were also re-localized to TBSV VROs, suggesting that TBSV hijacks the autophagy machinery in plant cells. We demonstrated that subversion of autophagy components facilitated the recruitment of VPS34 PI3 kinase and enrichment of phospholipids, such as phosphatidylethanolamine and PI3P phosphoinositide in the VRO membranes. Hijacking of autophagy components into TBSV VROs led to inhibition of autophagic flux. We also found that a fraction of the subverted ATG8f and NBR1 was sequestered in biomolecular condensates associated with VROs. We propose that the VRO-associated condensates trap those autophagy proteins, taking them away from the autophagy pathway. Overall, tombusviruses hijack selective autophagy to provide phospholipid-rich membranes for replication and to regulate the antiviral autophagic flux.
    MeSH term(s) Tombusvirus/physiology ; Saccharomyces cerevisiae/genetics ; Intracellular Membranes/metabolism ; Virus Replication/physiology ; Phospholipids/metabolism ; Viral Proteins/genetics ; Viral Proteins/metabolism ; Autophagy ; Organelles/metabolism ; RNA, Viral/genetics
    Chemical Substances Phospholipids ; Viral Proteins ; RNA, Viral
    Language English
    Publishing date 2024-03-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2205412-1
    ISSN 1553-7374 ; 1553-7374
    ISSN (online) 1553-7374
    ISSN 1553-7374
    DOI 10.1371/journal.ppat.1012085
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  8. Article ; Online: Host protein chaperones, RNA helicases and the ubiquitin network highlight the arms race for resources between tombusviruses and their hosts.

    Nagy, Peter D

    Advances in virus research

    2020  Volume 107, Page(s) 133–158

    Abstract: Positive-strand RNA viruses need to arrogate many cellular resources to support their replication and infection cycles. These viruses co-opt host factors, lipids and subcellular membranes and exploit cellular metabolites to built viral replication ... ...

    Abstract Positive-strand RNA viruses need to arrogate many cellular resources to support their replication and infection cycles. These viruses co-opt host factors, lipids and subcellular membranes and exploit cellular metabolites to built viral replication organelles in infected cells. However, the host cells have their defensive arsenal of factors to protect themselves from easy exploitation by viruses. In this review, the author discusses an emerging arms race for cellular resources between viruses and hosts, which occur during the early events of virus-host interactions. Recent findings with tomato bushy stunt virus and its hosts revealed that the need of the virus to exploit and co-opt given members of protein families provides an opportunity for the host to deploy additional members of the same or associated protein family to interfere with virus replication. Three examples with well-established heat shock protein 70 and RNA helicase protein families and the ubiquitin network will be described to illustrate this model on the early arms race for cellular resources between tombusviruses and their hosts. We predict that arms race for resources with additional cellular protein families will be discovered with tombusviruses. These advances will fortify research on interactions among other plant and animal viruses and their hosts.
    MeSH term(s) Host-Pathogen Interactions ; Molecular Chaperones ; RNA Helicases ; RNA, Viral/genetics ; Tombusvirus/genetics ; Ubiquitin ; Virus Replication
    Chemical Substances Molecular Chaperones ; RNA, Viral ; Ubiquitin ; RNA Helicases (EC 3.6.4.13)
    Keywords covid19
    Language English
    Publishing date 2020-07-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 195-8
    ISSN 1557-8399 ; 0065-3527
    ISSN (online) 1557-8399
    ISSN 0065-3527
    DOI 10.1016/bs.aivir.2020.06.006
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    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.166: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Aqueous Extracts of Organic Mulch Materials Have Nematicide and Repellent Effect on Meloidogyne incognita Infective Juveniles

    Petrikovszki Renáta / Tóth Ferenc / Nagy Péter I

    Journal of Nematology, Vol 55, Iss 1, Pp 1034-

    A Laboratory Study

    2023  Volume 1039

    Abstract: While the nematicidal effectiveness of mulching against root-knot nematodes (Meloidogyne spp.) is calculated within organic crop protection, underlying mechanisms are not yet fully explored. Laboratory experiments were set up to determine whether mulch- ... ...

    Abstract While the nematicidal effectiveness of mulching against root-knot nematodes (Meloidogyne spp.) is calculated within organic crop protection, underlying mechanisms are not yet fully explored. Laboratory experiments were set up to determine whether mulch-derived substances cause mortality directly, or repel Meloidogyne juveniles from crop rhizosphere. Mortality and area choice tests were conducted with mulch-derived extracts, supported by the measurements on tannic acid content and the pH values of extracts as supplementary examinations. In our study, leaf litter and straw extracts were generally found lethal to the juveniles, which is in line with the results from area preference tests. However, compost extract had no effect on Meloidogyne incognita juveniles. Tannic acid content showed positive correlation with mortality only in the case of straw and sycamore leaf litter extracts. Tannic acid and pH weakly correlated with repellent effect of the applied extracts generally. Our results have inspired further experiments to explore nematicidal components of leaf litters, contributing to the development of a new approach in crop protection based on the repellent effect of these materials.
    Keywords area choice ; behavior ; biological control ; compost ; leaf litter mulch ; mortality ; ph ; tannic acid ; wheat straw ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2023-09-01T00:00:00Z
    Publisher Sciendo
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: The centromeric histone CenH3 is recruited into the tombusvirus replication organelles.

    Gonzalez, Paulina Alatriste / Nagy, Peter D

    PLoS pathogens

    2022  Volume 18, Issue 6, Page(s) e1010653

    Abstract: Tombusviruses, similar to other (+)RNA viruses, exploit the host cells by co-opting numerous host components and rewiring cellular pathways to build extensive virus-induced replication organelles (VROs) in the cytosol of the infected cells. Most ... ...

    Abstract Tombusviruses, similar to other (+)RNA viruses, exploit the host cells by co-opting numerous host components and rewiring cellular pathways to build extensive virus-induced replication organelles (VROs) in the cytosol of the infected cells. Most molecular resources are suboptimal in susceptible cells and therefore, tomato bushy stunt virus (TBSV) drives intensive remodeling and subversion of many cellular processes. The authors discovered that the nuclear centromeric CenH3 histone variant (Cse4p in yeast, CENP-A in humans) plays a major role in tombusvirus replication in plants and in the yeast model host. We find that over-expression of CenH3 greatly interferes with tombusvirus replication, whereas mutation or knockdown of CenH3 enhances TBSV replication in yeast and plants. CenH3 binds to the viral RNA and acts as an RNA chaperone. Although these data support a restriction role of CenH3 in tombusvirus replication, we demonstrate that by partially sequestering CenH3 into VROs, TBSV indirectly alters selective gene expression of the host, leading to more abundant protein pool. This in turn helps TBSV to subvert pro-viral host factors into replication. We show this through the example of hypoxia factors, glycolytic and fermentation enzymes, which are exploited more efficiently by tombusviruses to produce abundant ATP locally within the VROs in infected cells. Altogether, we propose that subversion of CenH3/Cse4p from the nucleus into cytosolic VROs facilitates transcriptional changes in the cells, which ultimately leads to more efficient ATP generation in situ within VROs by the co-opted glycolytic enzymes to support the energy requirement of virus replication. In summary, CenH3 plays both pro-viral and restriction functions during tombusvirus replication. This is a surprising novel role for a nuclear histone variant in cytosolic RNA virus replication.
    MeSH term(s) Adenosine Triphosphate/metabolism ; Histones/metabolism ; Host-Pathogen Interactions/genetics ; Humans ; Organelles ; RNA, Viral/genetics ; Saccharomyces cerevisiae/metabolism ; Nicotiana ; Tombusvirus/genetics ; Tombusvirus/metabolism ; Virus Replication/genetics
    Chemical Substances Histones ; RNA, Viral ; Adenosine Triphosphate (8L70Q75FXE)
    Language English
    Publishing date 2022-06-29
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2205412-1
    ISSN 1553-7374 ; 1553-7374
    ISSN (online) 1553-7374
    ISSN 1553-7374
    DOI 10.1371/journal.ppat.1010653
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