Article ; Online: Aptitude of Uropathogenic Escherichia coli in Renal Transplant Recipients: A Comprehensive Review on Characteristic Features, and Production of Extended Spectrum β-Lactamase.
2023 Volume 80, Issue 12, Page(s) 382
Abstract: Urinary tract infection is the most common infection in almost half of the renal transplant patients. The development of UTI in these patients may progress to bacteremia, acute T cell-mediated rejection, impaired allograft function, or allograft loss, ... ...
| Abstract | Urinary tract infection is the most common infection in almost half of the renal transplant patients. The development of UTI in these patients may progress to bacteremia, acute T cell-mediated rejection, impaired allograft function, or allograft loss, along with the increased risk of hospitalization and death. Among various pathogens implicated, Uropathogenic E. coli (UPEC), especially sequence type 131 (ST131), is the most virulent and multidrug-resistant pathogen. High antimicrobial resistance to most β-lactam antibiotics, mediated by extended spectrum β-lactamases (ESBLs) produced by UPEC, is a challenge in the clinical management of UTIs in kidney transplant recipients. Indeed, multidrug resistance to β-lactam antibiotics is a direct consequence of ESBL production. Resistance to other antibiotics such as aminoglycosides, fluoroquinolones, and trimethoprim-sulphamethoxazole has also been reported in ESBLs-producing UPEC, which reduces the therapeutic options, rising healthcare-associated costs and subsequently leads to renal failure or even graft loss. In this review, we aimed to discuss the post-transplant risk factors of UTI, UPEC virulence factors (VF), and the related factors including quorum sensing, and stress resistance genes. Furthermore, we searched for the current treatment strategies and some of the alternate approaches proposed as therapeutic options that may affirm the treatment of ESBL-producing UPEC. |
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| MeSH term(s) | Humans ; Uropathogenic Escherichia coli/genetics ; Escherichia coli Infections/drug therapy ; beta-Lactamases/genetics ; Kidney Transplantation/adverse effects ; Aptitude ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Urinary Tract Infections/drug therapy ; beta-Lactams |
| Chemical Substances | beta-Lactamases (EC 3.5.2.6) ; Anti-Bacterial Agents ; beta-Lactams |
| Language | English |
| Publishing date | 2023-10-21 |
| Publishing country | United States |
| Document type | Journal Article ; Review |
| ZDB-ID | 134238-1 |
| ISSN | 1432-0991 ; 0343-8651 |
| ISSN (online) | 1432-0991 |
| ISSN | 0343-8651 |
| DOI | 10.1007/s00284-023-03476-w |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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