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Article: Study of HLA-G gene 14-bp ins/del and codon 93 (CAC/CAT) polymorphisms association with spontaneous abortion in a Tunisian population.

Belkahla, Sana / Nahvi, Insha / Khan, Hena

2023 Volume 26, Issue 1, Page(s) 103–109

Abstract: In the recent years, spontaneous abortion (SA) frequency increased awareness about medical and social-economic related problems. Human leukocyte antigen-G (HLA-G) is a non-classic HLA I molecule initially described in trophoblastic tissue in foeto- ... ...

Abstract	In the recent years, spontaneous abortion (SA) frequency increased awareness about medical and social-economic related problems. Human leukocyte antigen-G (HLA-G) is a non-classic HLA I molecule initially described in trophoblastic tissue in foeto-maternal interface. HLA-G polymorphism association with SA has been extensively studied. One amongst the foremost studied variants was HLA-G 14-bp Insertion (Ins)/Deletion (Del) polymorphism. Nevertheless, such a study was not performed in Tunisian population yet. We aim to investigate two HLA-G polymorphisms, 14-bp Ins/Del 3'UTR, and for the first time, codon 93 (CAC/CAT) polymorphisms association with SA risk in the Tunisian population. The results revealed HLA-G 14-bp Ins/Del polymorphism and CIns haplotype association with SA. No association of the HLA-G codon 93 (CAC/CAT) polymorphism to SA was observed. Considering both polymorphism together, female's homozygosity for 14-bp Ins/Del and for codon 93 (CAC/CAT) polymorphism may increase the risk of SA susceptibility.
Language	English
Publishing date	2023-08-16
Publishing country	Nigeria
Document type	Journal Article
ZDB-ID	2111906-5
ISSN	1118-4841
ISSN	1118-4841
DOI	10.29063/ajrh2022/v26i1.11
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: A Review on Nanocarrier Mediated Treatment and Management of Triple Negative Breast Cancer: A Saudi Arabian Scenario.

Nahvi, Insha / Belkahla, Sana / Biswas, Supratim / Chakraborty, Suparna

Frontiers in oncology

2022 Volume 12, Page(s) 953865

Abstract: People have continued to be petrified by the devastating effects of cancer for decades and thus a pursuit for developing anticancer agents have seen an ever-increasing trend in the past few decades. Globally, breast cancer is the most common malignancy ... ...

Abstract	People have continued to be petrified by the devastating effects of cancer for decades and thus a pursuit for developing anticancer agents have seen an ever-increasing trend in the past few decades. Globally, breast cancer is the most common malignancy in women and the second most common cause of cancer-related deaths. In Saudi Arabia, breast cancer is the most common type of cancer among women, constituting almost 14.2% of the total cancer burden. Triple-negative breast cancer (TNBC) is a subtype of breast cancer, which is a pathologically diverse disease of higher grade characterized by the absence of the estrogen receptor (ER), the progesterone receptor (PR), and the human epidermal growth factor receptor 2 (HER2) expressions. Despite the considerable advancements achieved in the therapeutic management of cancer, TNBC remains an unbeatable challenge, which requires immediate attention as it lacks conventional targets for treatment, leading to a poor clinical prognosis. The present research goals are directed toward the development and implementation of treatment regimens with enhanced bioavailability, targetability, minimized systemic toxicity, and improved outcomes of treatment options. The present treatment and management scenario of TNBC continues to provoke oncologists as well as nanomedical scientists to develop novel and efficient nanotherapies. Lately, scientific endeavors have addressed the importance of enhanced availability and targeted cellular uptake with minimal toxicity, which are achieved by the application of nano drug-carriers. This review intends to summarize the incidence rates of TNBC patients, the importance of nanotherapeutic options for patients suffering from TNBC, the identification of promising molecular targets, and challenges associated with the development of targeted nanotherapeutics with special reference to the Saudi Arabian context.
Language	English
Publishing date	2022-07-22
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2022.953865
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Article ; Online: Soy Isoflavones Induce Cell Death by Copper-Mediated Mechanism: Understanding Its Anticancer Properties.

Farhan, Mohd / El Oirdi, Mohamed / Aatif, Mohammad / Nahvi, Insha / Muteeb, Ghazala / Alam, Mir Waqas

Molecules (Basel, Switzerland)

2023 Volume 28, Issue 7

Abstract: Cancer incidence varies around the globe, implying a relationship between food and cancer risk. Plant polyphenols are a class of secondary metabolites that have recently attracted attention as possible anticancer agents. The subclass of polyphenols, ... ...

Abstract	Cancer incidence varies around the globe, implying a relationship between food and cancer risk. Plant polyphenols are a class of secondary metabolites that have recently attracted attention as possible anticancer agents. The subclass of polyphenols, known as isoflavones, includes genistein and daidzein, which are present in soybeans and are regarded as potent chemopreventive agents. According to epidemiological studies, those who eat soy have a lower risk of developing certain cancers. Several mechanisms for the anticancer effects of isoflavones have been proposed, but none are conclusive. We show that isoflavones suppress prostate cancer cell growth by mobilizing endogenous copper. The copper-specific chelator neocuproine decreases the apoptotic potential of isoflavones, whereas the iron and zinc chelators desferroxamine mesylate and histidine do not, confirming the role of copper. Reactive oxygen species (ROS) scavengers reduce isoflavone-induced apoptosis in these cells, implying that ROS are cell death effectors. Our research also clearly shows that isoflavones interfere with the expression of the two copper transporter genes,
MeSH term(s)	Copper/pharmacology ; Copper/metabolism ; Reactive Oxygen Species/metabolism ; Cell Line, Tumor ; Isoflavones/pharmacology ; Genistein/pharmacology ; Cell Death ; Glycine max/metabolism ; Polyphenols
Chemical Substances	Copper (789U1901C5) ; Reactive Oxygen Species ; Isoflavones ; Genistein (DH2M523P0H) ; Polyphenols
Language	English
Publishing date	2023-03-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules28072925
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Effect of Mo doping in NiO nanoparticles for structural modification and its efficiency for antioxidant, antibacterial applications.

Alam, Mir Waqas / BaQais, Amal / Mir, Tanveer Ahmad / Nahvi, Insha / Zaidi, Noushi / Yasin, Amina

Scientific reports

2023 Volume 13, Issue 1, Page(s) 1328

Abstract: Novel molybdenum (Mo)-doped nickel oxide (NiO) Nanoparticles (NPs) were synthesized by using a simple sonochemical methodology and the synthesized NPs were investigated for antioxidant, and antibacterial applications. The X-ray diffraction (XRD) analysis ...

Abstract	Novel molybdenum (Mo)-doped nickel oxide (NiO) Nanoparticles (NPs) were synthesized by using a simple sonochemical methodology and the synthesized NPs were investigated for antioxidant, and antibacterial applications. The X-ray diffraction (XRD) analysis revealed that the crystal systems of rhombohedral (21.34 nm) and monoclinic (17.76 nm) were observed for pure NiO and Mo-doped NiO NPs respectively. The scanning electron microscopy (SEM) results show that the pure NiO NPs possess irregular spherical shape with an average particle size of 93.89 nm while the Mo-doped NiO NPs exhibit spherical morphology with an average particle size of 85.48 nm. The ultraviolet-visible (UV-Vis) spectrum further indicated that the pure and Mo-doped NiO NPs exhibited strong absorption band at the wavelengths of 365 and 349 nm, respectively. The free radical scavenging activity of NiO and Mo-doped NiO NPs was also investigated by utilizing several biochemical assays. The Mo-doped NiO NPs showed better antioxidant activity (84.2%) towards ABTS. + at 200 µg/mL in comparison to their pure counterpart which confirmed that not only antioxidant potency of the doped NPs was better than pure NPs but this efficacy was also concentration dependant as well. The NiO and Mo-doped NiO NPs were further evaluated for their antibacterial activity against gram-positive (Staphylococcus aureus and Bacillus subtilis) and gram-negative (Pseudomonas aeruginosa and Escherichia coli) bacterial strains. The Mo-doped NiO NPs displayed better antibacterial activity (25 mm) against E. coli in comparison to the pure NPs. The synthesized NPs exhibited excellent aptitude for multi-dimensional applications.
MeSH term(s)	Antioxidants/pharmacology ; Molybdenum/pharmacology ; Escherichia coli ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/chemistry ; Nanoparticles/chemistry ; Metal Nanoparticles/chemistry ; Microbial Sensitivity Tests ; X-Ray Diffraction
Chemical Substances	Antioxidants ; nickel monoxide (C3574QBZ3Y) ; Molybdenum (81AH48963U) ; Anti-Bacterial Agents
Language	English
Publishing date	2023-01-24
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-28356-y
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Article: Advances and development of prostate cancer, treatment, and strategies: A systemic review.

Belkahla, Sana / Nahvi, Insha / Biswas, Supratim / Nahvi, Irum / Ben Amor, Nidhal

Frontiers in cell and developmental biology

2022 Volume 10, Page(s) 991330

Abstract: The most common type of cancer in the present-day world affecting modern-day men after lung cancer is prostate cancer. Prostate cancer remains on the list of top three cancer types claiming the highest number of male lives. An estimated 1.4 million new ... ...

Abstract	The most common type of cancer in the present-day world affecting modern-day men after lung cancer is prostate cancer. Prostate cancer remains on the list of top three cancer types claiming the highest number of male lives. An estimated 1.4 million new cases were reported worldwide in 2020. The incidence of prostate cancer is found predominantly in the regions having a high human development index. Despite the fact that considerable success has been achieved in the treatment and management of prostate cancer, it remains a challenge for scientists and clinicians to curve the speedy advancement of the said cancer type. The most common risk factor of prostate cancer is age; men tend to become more vulnerable to prostate cancer as they grow older. Commonly men in the age group of 66 years and above are the most vulnerable population to develop prostate cancer. The gulf countries are not far behind when it came to accounting for the number of individuals falling prey to the deadly cancer type in recent times. There has been a consistent increase in the incidence of prostate cancer in the gulf countries in the past decade. The present review aims at discussing the development, diagnostics
Language	English
Publishing date	2022-09-09
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2737824-X
ISSN	2296-634X
ISSN	2296-634X
DOI	10.3389/fcell.2022.991330
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Article: Novel Nd-N/TiO

Alam, Mir Waqas / Khalid, N R / Naeem, Sumaira / Niaz, N A / Ahmad Mir, Tanveer / Nahvi, Insha / Souayeh, Basma / Zaidi, Noushi

Materials (Basel, Switzerland)

2022 Volume 15, Issue 19

Abstract: In this study, photocatalysis was employed to degrade a wastewater pollutant (AB-29 dye) under visible light irradiation. For this purpose, nitrogen (N)- and neodymium (Nd)-doped ... ...

Abstract	In this study, photocatalysis was employed to degrade a wastewater pollutant (AB-29 dye) under visible light irradiation. For this purpose, nitrogen (N)- and neodymium (Nd)-doped TiO
Language	English
Publishing date	2022-09-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma15196658
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Article: Electrochemical Methodologies for Investigating the Antioxidant Potential of Plant and Fruit Extracts: A Review.

Alam, Mir Waqas / Najeeb, Jawayria / Naeem, Sumaira / Usman, Sheikh Muhammad / Nahvi, Insha / Alismail, Fai / Abuzir, Alaaedeen / Farhan, Mohd / Nawaz, Allah

Antioxidants (Basel, Switzerland)

2022 Volume 11, Issue 6

Abstract: In recent years, the growing research interests in the applications of plant and fruit extracts (synthetic/stabilization materials for the nanomaterials, medicinal applications, functional foods, and nutraceuticals) have led to the development of new ... ...

Abstract	In recent years, the growing research interests in the applications of plant and fruit extracts (synthetic/stabilization materials for the nanomaterials, medicinal applications, functional foods, and nutraceuticals) have led to the development of new analytical techniques to be utilized for identifying numerous properties of these extracts. One of the main properties essential for the applicability of these plant extracts is the antioxidant capacity (AOC) that is conventionally determined by spectrophotometric techniques. Nowadays, electrochemical methodologies are emerging as alternative tools for quantifying this particular property of the extract. These methodologies address numerous drawbacks of the conventional spectroscopic approach, such as the utilization of expensive and hazardous solvents, extensive sample pre-treatment requirements, long reaction times, low sensitivity, etc. The electrochemical methodologies discussed in this review include cyclic voltammetry (CV), square wave voltammetry (SWV), differential pulse voltammetry (DPV), and chronoamperometry (CAP). This review presents a critical comparison between both the conventional and electrochemical approaches for the quantification of the parameter of AOC and discusses the numerous applications of the obtained bioextracts based on the AOC parameter.
Language	English
Publishing date	2022-06-20
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox11061205
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Article ; Online: Cerium Oxide Nanorods Synthesized by

Alam, Mir Waqas / Naeem, Sumaira / Usman, Sheikh Muhammad / Kanwal, Qudsia / BaQais, Amal / Aldughaylibi, Fatimah Saeed / Nahvi, Insha / Zaidi, Noushi

Molecules (Basel, Switzerland)

2022 Volume 27, Issue 23

Abstract: In this study, cerium oxide nanorods ( ... ...

Abstract	In this study, cerium oxide nanorods (CeO
Language	English
Publishing date	2022-11-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules27238188
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Electrochemical Methodologies for Investigating the Antioxidant Potential of Plant and Fruit Extracts: A Review

Alam, Mir Waqas / Najeeb, Jawayria / Naeem, Sumaira / Usman, Sheikh Muhammad / Nahvi, Insha / Alismail, Fai / Abuzir, Alaaedeen / Farhan, Mohd / Nawaz, Allah

Antioxidants. 2022 June 20, v. 11, no. 6

2022

Abstract	In recent years, the growing research interests in the applications of plant and fruit extracts (synthetic/stabilization materials for the nanomaterials, medicinal applications, functional foods, and nutraceuticals) have led to the development of new analytical techniques to be utilized for identifying numerous properties of these extracts. One of the main properties essential for the applicability of these plant extracts is the antioxidant capacity (AOC) that is conventionally determined by spectrophotometric techniques. Nowadays, electrochemical methodologies are emerging as alternative tools for quantifying this particular property of the extract. These methodologies address numerous drawbacks of the conventional spectroscopic approach, such as the utilization of expensive and hazardous solvents, extensive sample pre-treatment requirements, long reaction times, low sensitivity, etc. The electrochemical methodologies discussed in this review include cyclic voltammetry (CV), square wave voltammetry (SWV), differential pulse voltammetry (DPV), and chronoamperometry (CAP). This review presents a critical comparison between both the conventional and electrochemical approaches for the quantification of the parameter of AOC and discusses the numerous applications of the obtained bioextracts based on the AOC parameter.
Keywords	antioxidant activity ; dietary supplements ; electrochemistry ; fruits ; spectroscopy ; voltammetry
Language	English
Dates of publication	2022-0620
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox11061205
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Immunity, Sex Hormones, and Environmental Factors as Determinants of COVID-19 Disparity in Women.

Rehman, Suriya / Ravinayagam, Vijaya / Nahvi, Insha / Aldossary, Hanan / Al-Shammari, Maha / Amiri, Mai Saad Al / Kishore, Uday / Al-Suhaimi, Ebtesam A

Frontiers in immunology

2021 Volume 12, Page(s) 680845

Abstract: The current coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome virus 2 (SARS-CoV-2), has resulted in a major global pandemic, causing extreme morbidity and mortality. Few studies appear to suggest a significant impact of ... ...

Abstract	The current coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome virus 2 (SARS-CoV-2), has resulted in a major global pandemic, causing extreme morbidity and mortality. Few studies appear to suggest a significant impact of gender in morbidity and mortality, where men are reported at a higher risk than women. The infectivity, transmissibility, and varying degree of disease manifestation (mild, modest, and severe) in population studies reinforce the importance of a number of genetic and epigenetic factors, in the context of immune response and gender. The present review dwells on several contributing factors such as a stronger innate immune response, estrogen, angiotensin-converting enzyme 2 gene, and microbiota, which impart greater resistance to the SARS-CoV-2 infection and disease progression in women. In addition, the underlying importance of associated microbiota and certain environmental factors in gender-based disparity pertaining to the mortality and morbidity due to COVID-19 in women has also been addressed.
MeSH term(s)	COVID-19/epidemiology ; COVID-19/immunology ; COVID-19/mortality ; Disease Progression ; Female ; Global Health ; Gonadal Steroid Hormones ; Healthcare Disparities ; Humans ; Immunity, Innate ; Male ; Microbiota/immunology ; Risk Factors ; SARS-CoV-2/immunology ; Sex Factors
Chemical Substances	Gonadal Steroid Hormones
Language	English
Publishing date	2021-08-18
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2021.680845
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