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  1. Article: Microbial contamination profile change over a 4‐year period in nonoperated cleft soft palate

    Roode, Gieljam Johannes / Bütow, Kurt‐Wilhelm / Naidoo, Sharan

    Journal of applied microbiology. 2022 Jan., v. 132, no. 1

    2022  

    Abstract: AIMS: Surgical site infection is a major concern in cleft soft palate. Knowledge of the type, number and antimicrobial resistance of pathogens present preoperatively contribute to treatment success. The aim of this study is to determine whether or not ... ...

    Abstract AIMS: Surgical site infection is a major concern in cleft soft palate. Knowledge of the type, number and antimicrobial resistance of pathogens present preoperatively contribute to treatment success. The aim of this study is to determine whether or not the microbial contamination (diversity) preoperatively has changed since 2015. METHODS AND RESULTS: Swabs were taken from the surgical site in 103 consecutive patients who presented for primary repair of the soft palate cleft. These were sent for microscopy, culture and sensitivity testing. Swabs were taken before disinfecting the site. Results were tabled and compared with two previous studies from the same facility. Out of 103 patients, 100 patients showed positive cultures with 42 different pathogenic micro‐organisms identified. Most dominant pathogen was Klebsiella pneumoniae, 45.6%, increased by 28% from the previous two studies, with 93.6% of these pathogens resistant to one or more antimicrobials. Most of the other identified pathogens showed an alarming increase in occurrence, with a wide resistance to antimicrobials. CONCLUSIONS: The increase in number and diversity of microbial contamination as well as their resistance to antimicrobials is a real concern. Ways of preventing postoperative infection in a natural way need to be explored. SIGNIFICANCE: Surgeons need to be aware of constant changes in micro‐organisms.
    Keywords Klebsiella pneumoniae ; anti-infective agents ; antibiotic resistance ; microbial contamination ; microorganisms ; microscopy ; palate ; pathogens
    Language English
    Dates of publication 2022-01
    Size p. 665-674.
    Publishing place John Wiley & Sons, Ltd
    Document type Article
    Note JOURNAL ARTICLE
    ZDB-ID 1358023-1
    ISSN 1365-2672 ; 1364-5072
    ISSN (online) 1365-2672
    ISSN 1364-5072
    DOI 10.1111/jam.15193
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 259: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Microbial contamination profile change over a 4-year period in nonoperated cleft soft palate.

    Roode, Gieljam Johannes / Bütow, Kurt-Wilhelm / Naidoo, Sharan

    Journal of applied microbiology

    2021  Volume 132, Issue 1, Page(s) 665–674

    Abstract: Aims: Surgical site infection is a major concern in cleft soft palate. Knowledge of the type, number and antimicrobial resistance of pathogens present preoperatively contribute to treatment success. The aim of this study is to determine whether or not ... ...

    Abstract Aims: Surgical site infection is a major concern in cleft soft palate. Knowledge of the type, number and antimicrobial resistance of pathogens present preoperatively contribute to treatment success. The aim of this study is to determine whether or not the microbial contamination (diversity) preoperatively has changed since 2015.
    Methods and results: Swabs were taken from the surgical site in 103 consecutive patients who presented for primary repair of the soft palate cleft. These were sent for microscopy, culture and sensitivity testing. Swabs were taken before disinfecting the site. Results were tabled and compared with two previous studies from the same facility. Out of 103 patients, 100 patients showed positive cultures with 42 different pathogenic micro-organisms identified. Most dominant pathogen was Klebsiella pneumoniae, 45.6%, increased by 28% from the previous two studies, with 93.6% of these pathogens resistant to one or more antimicrobials. Most of the other identified pathogens showed an alarming increase in occurrence, with a wide resistance to antimicrobials.
    Conclusions: The increase in number and diversity of microbial contamination as well as their resistance to antimicrobials is a real concern. Ways of preventing postoperative infection in a natural way need to be explored.
    Significance: Surgeons need to be aware of constant changes in micro-organisms.
    MeSH term(s) Cleft Palate/microbiology ; Cleft Palate/surgery ; Humans ; Klebsiella pneumoniae ; Palate, Soft/abnormalities ; Surgical Wound Infection/microbiology
    Language English
    Publishing date 2021-07-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 1358023-1
    ISSN 1365-2672 ; 1364-5072
    ISSN (online) 1365-2672
    ISSN 1364-5072
    DOI 10.1111/jam.15193
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 259: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Ectomesenchymal Chondromyxoid Tumor: A Rare Association With an Asymmetrical Soft Palate Cleft.

    Naidoo, Sharan / Roode, Gieljam J / Bütow, Kurt W / Meer, Shabnum

    The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association

    2021  Volume 59, Issue 7, Page(s) 932–937

    Abstract: Ectomesenchymal chondromyxoid tumor (ECT) is a rare oral lesion first described by Smith et al. in 1995. These tumors are typically painless, slow growing and benign masses occurring predominantly on the anterior tongue dorsum. Prior to this seminal ... ...

    Abstract Ectomesenchymal chondromyxoid tumor (ECT) is a rare oral lesion first described by Smith et al. in 1995. These tumors are typically painless, slow growing and benign masses occurring predominantly on the anterior tongue dorsum. Prior to this seminal report, many ECTs may have been misdiagnosed due to the histological similarities with other lesions. Immunohistochemical stains aid in definitive diagnosis of an ECT. A total of 39 papers since published have reported 96 patients with ECT. Most lesions involve the anterior aspect of the tongue, with only 6 occurring in the posterior tongue and 2 involving the hard palate. ECTs are considered to develop from ectomesenchymal cells of neural crest cells that have migrated to the tongue during embryological development. This paper is of a rare case of ECT of the posterolateral tongue occurring in association with an unusual asymmetrical soft palate cleft. It is postulated that since the tongue develops before the formation of the soft palate, an ECT lesion occurring on the posterior aspect may have a causal contribution to the development of the soft palate cleft.
    MeSH term(s) Cleft Palate/pathology ; Cleft Palate/surgery ; Humans ; Mesenchymoma/pathology ; Mesenchymoma/surgery ; Myoepithelioma/pathology ; Palate, Soft/abnormalities ; Tongue ; Tongue Neoplasms/pathology ; Tongue Neoplasms/surgery
    Language English
    Publishing date 2021-08-30
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 1069409-2
    ISSN 1545-1569 ; 0009-8701 ; 1055-6656
    ISSN (online) 1545-1569
    ISSN 0009-8701 ; 1055-6656
    DOI 10.1177/10556656211035029
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 451: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article: The tensor stitch for soft palate closure revisited.

    Naidoo, Sharan / Bütow, Kurt W

    Annals of maxillofacial surgery

    2016  Volume 5, Issue 2, Page(s) 229–230

    Abstract: The tensor veli palatini muscle is involved in opening of the Eustachian tube during chewing and swallowing, allowing for equilibration of pressure between the middle ear and external environment. In patients with cleft palate, abnormal musculature in ... ...

    Abstract The tensor veli palatini muscle is involved in opening of the Eustachian tube during chewing and swallowing, allowing for equilibration of pressure between the middle ear and external environment. In patients with cleft palate, abnormal musculature in the region of the cleft results in Eustachian tube dysfunction. A palatoplasty with muscle repositioning is advocated to reduce the incidence of otitis media, which is a result of this. A special suture is described which can be incorporated into a palatoplasty procedure to further reduce the incidence of otitis media. This suture is inserted around the tendon of the tensor veli palatini muscle bilaterally, and when activated under tension in the midline, it results in opening of the Eustachian tube with improved middle ear ventilation. This novel suture results in a reduction in the incidence of otitis media due to improved middle ear ventilation and reduces tension across the suture margins.
    Language English
    Publishing date 2016-02-21
    Publishing country India
    Document type Journal Article
    ZDB-ID 2696991-9
    ISSN 2249-3816 ; 2231-0746
    ISSN (online) 2249-3816
    ISSN 2231-0746
    DOI 10.4103/2231-0746.175771
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Nonsyndromic palate Synechia with floor of mouth.

    Naidoo, Sharan / Bütow, Kurt W

    Annals of maxillofacial surgery

    2015  Volume 5, Issue 1, Page(s) 100–103

    Abstract: To discuss the embryological basis, sequela and management of intraoral synechia, and to report on the incidence of this condition at a facial cleft deformity clinic (FCDC), with specific attention to two rare cases of mucosal bands involving the floor ... ...

    Abstract To discuss the embryological basis, sequela and management of intraoral synechia, and to report on the incidence of this condition at a facial cleft deformity clinic (FCDC), with specific attention to two rare cases of mucosal bands involving the floor of the mouth and palate. Review of the literature and a retrospective analysis of FCDC and case report of two cases. During the period of 30 years (1983-2013), the FCDC - University of Pretoria has managed in excess of 4000 cases. A review of the clinic statistics revealed only six cases in which intraoral synechiae occurred. The rarity of this condition at the FCDC is in keeping with the rare incidence in the international literature. Four syndromic cases were identified. Three cases were cleft palate lateral synechia syndrome, and one was an orofacial digital syndrome. Two nonsyndromic cases were identified, and both cases involved the floor of the mouth and palate. The attending physicians and surgeons should be aware of the most appropriate timing for management of this condition, in order to avoid unwanted sequelae. Supportive care should be provided, and emergency airway protocol should be available for all cases. A differential diagnosis should be considered which includes syndromic conditions.
    Language English
    Publishing date 2015-09-14
    Publishing country India
    Document type Case Reports
    ZDB-ID 2696991-9
    ISSN 2249-3816 ; 2231-0746
    ISSN (online) 2249-3816
    ISSN 2231-0746
    DOI 10.4103/2231-0746.161102
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Pierre Robin sequence: Subdivision, data, theories, and treatment - Part 2: Syndromic and nonsyndromic Pierre Robin sequence.

    Bütow, Kurt-W / Morkel, Jean A / Naidoo, Sharan / Zwahlen, Roger Arthur

    Annals of maxillofacial surgery

    2016  Volume 6, Issue 1, Page(s) 35–37

    Abstract: Context: The disorder currently accepted as Pierre Robin syndrome/anomaly/sequence (PRS) has been plagued by controversy ever since initially being described. Controversy exists not only about the appropriate terminology and etiopathogenesis of the ... ...

    Abstract Context: The disorder currently accepted as Pierre Robin syndrome/anomaly/sequence (PRS) has been plagued by controversy ever since initially being described. Controversy exists not only about the appropriate terminology and etiopathogenesis of the disorder but also about its management. Clinical findings and treatment outcomes of a large database of 266 PRS cases were compared with the current state of knowledge in the scientific literature, relating to history, clinical description, diagnostic criteria, epidemiology, theories of oligohydramnios, mandibular catch-up growth, midfacial hyperplasia, and the early management.
    Aims of part 2: Contribute to the sparse scientific knowledge about pathogenesis and involved genetics.
    Subjects and methods: An analysis of this large database was conducted focusing on genetic involvement, family history, and the incidence of additional syndromes.
    Results: Beside of differences related to clinical signs of dyspnea, feeding problems and mortality rates, various concomitant syndromes, and genetic abnormalities were found in cases of Fairbairn-Robin triad (FRT) and Siebold-Robin sequence (SRS), in addition to differences in relation to clinical signs of dyspnea, feeding problems, and mortality rates.
    Conclusion: Multiple FRT cases presented with various concomitant syndromes and genetic abnormalities, but only one type occurred in two SRS cases. The latter presented a significantly different mortality rate when compared to the FRT subgroup.
    Language English
    Publishing date 2016-08-11
    Publishing country India
    Document type Journal Article
    ZDB-ID 2696991-9
    ISSN 2249-3816 ; 2231-0746
    ISSN (online) 2249-3816
    ISSN 2231-0746
    DOI 10.4103/2231-0746.186134
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Pierre Robin sequence: Subdivision, data, theories, and treatment - Part 4: Recommended management and treatment of Pierre Robin sequence and its application.

    Bütow, Kurt-W / Naidoo, Sharan / Zwahlen, Roger Arthur / Morkel, Jean A

    Annals of maxillofacial surgery

    2016  Volume 6, Issue 1, Page(s) 44–49

    Abstract: Context: The disorder currently accepted as Pierre Robin syndrome/anomaly/sequence (PRS) has been plagued by controversy ever since initially being described. Controversy exists not only about the appropriate terminology and etiopathogenesis of the ... ...

    Abstract Context: The disorder currently accepted as Pierre Robin syndrome/anomaly/sequence (PRS) has been plagued by controversy ever since initially being described. Controversy exists not only about the appropriate terminology and etiopathogenesis of the disorder but also about its management. Therefore, clinical findings and treatment outcomes of a large database of 266 PRS cases were compared with the current state of knowledge in the scientific literature related to history, clinical description, diagnostic criteria, epidemiology, theories of oligohydramnios, mandibular catch-up growth, midfacial hyperplasia, and early management.
    Aims of part 4: To provide a systematic treatment protocol for Fairbairn-Robin triad (FRT) and Siebold Robin sequence (SRS) patients based on clinical findings and experience with 266 PRS cases.
    Subjects and methods: A plethora of treatment modalities and their outcome in literature have been compared to those applied in this database and their outcomes.
    Results: The management of SRS/FRT depends on various factors including compromised airways, feeding difficulties, as well as the sequence of the reconstructive ladder.
    Conclusion: Based on the novel PRS subdivisions, a stepwise sequential treatment approach is outlined, addressing the particular needs of each disorder systematically.
    Language English
    Publishing date 2016-08-11
    Publishing country India
    Document type Journal Article
    ZDB-ID 2696991-9
    ISSN 2249-3816 ; 2231-0746
    ISSN (online) 2249-3816
    ISSN 2231-0746
    DOI 10.4103/2231-0746.186136
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Pierre Robin sequence: Subdivision, data, theories, and treatment - Part 3: Prevailing controversial theories related to Pierre Robin sequence.

    Bütow, Kurt-W / Zwahlen, Roger Arthur / Morkel, Jean A / Naidoo, Sharan

    Annals of maxillofacial surgery

    2016  Volume 6, Issue 1, Page(s) 38–43

    Abstract: Context: The disorder currently accepted as Pierre Robin syndrome/anomaly/sequence (PRS) has been plagued by controversy ever since initially being described. Controversy exists not only about the appropriate terminology and etiopathogenesis of the ... ...

    Abstract Context: The disorder currently accepted as Pierre Robin syndrome/anomaly/sequence (PRS) has been plagued by controversy ever since initially being described. Controversy exists not only about the appropriate terminology and etiopathogenesis of the disorder but also about its management. Therefore, clinical findings and treatment outcomes of a large database of 266 PRS cases were compared with the current state of knowledge in the scientific literature related to history, clinical description, diagnostic criteria, epidemiology, theories of oligohydramnios, mandibular catch-up growth, midfacial hyperplasia, and the early management.
    Aim: The aims of Part 3 debate the controversial biological theories relating to PRS.
    Materials and methods: Oligo-/poly-hydramnios, mandibular catch-up growth, and midfacial hyperplasia, the three in the literature most prevailing theories related to PRS, have been compared and discussed with the findings provided by this large database of 266 Siebold-Robin sequence (SRS) and Fairbairn-Robin triad (FRT) cases.
    Results: History and clinical findings evaluated in this database refute the first two theories. Although manifold midfacial appearances were demonstrated in FRT cases, a third of all SRS cases presented with mid-facial hyperplasia.
    Conclusion: The three main biological theories regarding PRS could not be verified after thorough analysis of the database.
    Language English
    Publishing date 2016-08-11
    Publishing country India
    Document type Journal Article
    ZDB-ID 2696991-9
    ISSN 2249-3816 ; 2231-0746
    ISSN (online) 2249-3816
    ISSN 2231-0746
    DOI 10.4103/2231-0746.186135
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Pierre Robin sequence: Subdivision, data, theories, and treatment - Part 1: History, subdivisions, and data.

    Bütow, Kurt-W / Zwahlen, Roger Arthur / Morkel, Jean A / Naidoo, Sharan

    Annals of maxillofacial surgery

    2016  Volume 6, Issue 1, Page(s) 31–34

    Abstract: Context: The disorder currently accepted as Pierre Robin syndrome/anomaly/sequence (PRS) has been plagued by controversy ever since initially being described. Controversy exists not only about the appropriate terminology and etiopathogenesis of the ... ...

    Abstract Context: The disorder currently accepted as Pierre Robin syndrome/anomaly/sequence (PRS) has been plagued by controversy ever since initially being described. Controversy exists not only about the appropriate terminology and etiopathogenesis of the disorder but also about its management. Therefore, clinical findings and treatment outcomes of a large database of 266 PRS cases were compared with the current state of knowledge in scientific literature related to history, clinical description, diagnostic criteria, epidemiology, theories of oligohydramnios, mandibular catch-up growth, midfacial hyperplasia, and the timing of management.
    Aims of part 1: Display disparities of the widely published subject of PRS that exist within the literature.
    Subjects and methods: A literature search related to diagnostic criteria was compared to findings of one of the largest PRS databases worldwide.
    Results: Regarding diagnostic criteria two subdivisions, the Fairbairn-Robin triad (FRT) and the Siebold-Robin sequence (SRS) can be clearly distinguished. Both present with micrognathia and glossoptosis, the former with, the latter, however, without a palatal cleft.
    Conclusions: According to clear diagnostic criteria, PRS has to be subdivided in the future into FRT and SRS cases, as they may require different treatment approaches.
    Language English
    Publishing date 2016-08-25
    Publishing country India
    Document type Journal Article
    ZDB-ID 2696991-9
    ISSN 2249-3816 ; 2231-0746
    ISSN (online) 2249-3816
    ISSN 2231-0746
    DOI 10.4103/2231-0746.186133
    Database MEDical Literature Analysis and Retrieval System OnLINE

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