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  1. Article ; Online: Design of a fractional-order atmospheric model via a class of ACT-like chaotic system and its sliding mode chaos control.

    Naik, Manisha Krishna / Baishya, Chandrali / Veeresha, Pundikala / Baleanu, Dumitru

    Chaos (Woodbury, N.Y.)

    2023  Volume 33, Issue 2, Page(s) 23129

    Abstract: Investigation of the dynamical behavior related to environmental phenomena has received much attention across a variety of scientific domains. One such phenomenon is global warming. The main causes of global warming, which has detrimental effects on our ... ...

    Abstract Investigation of the dynamical behavior related to environmental phenomena has received much attention across a variety of scientific domains. One such phenomenon is global warming. The main causes of global warming, which has detrimental effects on our ecosystem, are mainly excess greenhouse gases and temperature. Looking at the significance of this climatic event, in this study, we have connected the ACT-like model to three climatic components, namely, permafrost thaw, temperature, and greenhouse gases in the form of a Caputo fractional differential equation, and analyzed their dynamics. The theoretical aspects, such as the existence and uniqueness of the obtained solution, are examined. We have derived two different sliding mode controllers to control chaos in this fractional-order system. The influences of these controllers are analyzed in the presence of uncertainties and external disturbances. In this process, we have obtained a new controlled system of equations without and with uncertainties and external disturbances. Global stability of these new systems is also established. All the aspects are examined for commensurate and non-commensurate fractional-order derivatives. To establish that the system is chaotic, we have taken the assistance of the Lyapunov exponent and the bifurcation diagram with respect to the fractional derivative. To perform numerical simulation, we have identified certain values of the parameters where the system exhibits chaotic behavior. Then, the theoretical claims about the influence of the controller on the system are established with the help of numerical simulations.
    Language English
    Publishing date 2023-03-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1472677-4
    ISSN 1089-7682 ; 1054-1500
    ISSN (online) 1089-7682
    ISSN 1054-1500
    DOI 10.1063/5.0130403
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Primary amyloidosis causing diffuse alveolar hemorrhage.

    Shenin, Max / Xiong, Wen / Naik, Manisha / Sandorfi, Nora

    Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases

    2010  Volume 16, Issue 4, Page(s) 175–177

    Abstract: Diffuse alveolar hemorrhage is a serious complication that has been described in various disease states including several vasculitic syndromes as well as conditions that may resemble vasculitis clinically. In this article, we present a case of 79-year- ... ...

    Abstract Diffuse alveolar hemorrhage is a serious complication that has been described in various disease states including several vasculitic syndromes as well as conditions that may resemble vasculitis clinically. In this article, we present a case of 79-year-old man, who was admitted with productive cough, blood-tinged sputum, and a positive atypical antineutrophil cytoplasmic antibody pattern on indirect immunofluorescence microscopy. He subsequently developed frank hemoptysis and respiratory failure. Open lung biopsy demonstrated amyloid deposition within blood vessels. He was treated with 1 g of intravenous methylprednisolone over 3 days with rapid improvement in hemoptysis and hypoxemia. This case report and a review of literature illustrate unusual clinical manifestations of vascular amyloidosis that may be confused with vasculitis. Accurate diagnosis of this condition may improve clinical outcome and spare the patient from unwarranted, potentially harmful treatments.
    MeSH term(s) Aged ; Amyloidosis/complications ; Hemoptysis ; Hemorrhage/etiology ; Humans ; Lung Diseases/etiology ; Lung Diseases, Interstitial/etiology ; Lung Diseases, Interstitial/pathology ; Male ; Pulmonary Alveoli/pathology
    Language English
    Publishing date 2010-06
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 1283266-2
    ISSN 1536-7355 ; 1076-1608
    ISSN (online) 1536-7355
    ISSN 1076-1608
    DOI 10.1097/RHU.0b013e3181df8345
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: The use of mycophenolate mofetil for the treatment of systemic sclerosis.

    Shenin, Max / Naik, Manisha / Derk, Chris T

    Endocrine, metabolic & immune disorders drug targets

    2008  Volume 8, Issue 1, Page(s) 11–14

    Abstract: Mycophenolate mofetil (MMF) is an inosine monophosphate dehydrogenase inhibitor, that inhibits the de novo pathway of guanosine nucleotide synthesis, the proliferative responses of T and B lymphocytes as well as antibody production by B-lymphocytes. It ... ...

    Abstract Mycophenolate mofetil (MMF) is an inosine monophosphate dehydrogenase inhibitor, that inhibits the de novo pathway of guanosine nucleotide synthesis, the proliferative responses of T and B lymphocytes as well as antibody production by B-lymphocytes. It is indicated for the prophylaxis of organ rejection after allogeneic cardiac, hepatic and renal transplants . It has recently also been used with good success in patients with lupus nephritis . Based on these actions, MMF appears to be a novel agent for the treatment of systemic sclerosis, especially during early disease where an inflammatory infiltrate preceeds the development of fibrosis. Disease modification early on during the inflammatory stage of systemic sclerosis may lead to an overall decrease in fibrotic complications both in relation to cutaneous and internal organ involvement.
    MeSH term(s) Animals ; Anti-Inflammatory Agents, Non-Steroidal/pharmacology ; Anti-Inflammatory Agents, Non-Steroidal/therapeutic use ; Humans ; Mycophenolic Acid/analogs & derivatives ; Mycophenolic Acid/pharmacology ; Mycophenolic Acid/therapeutic use ; Scleroderma, Systemic/drug therapy ; Scleroderma, Systemic/physiopathology
    Chemical Substances Anti-Inflammatory Agents, Non-Steroidal ; Mycophenolic Acid (HU9DX48N0T)
    Language English
    Publishing date 2008-03-11
    Publishing country United Arab Emirates
    Document type Journal Article ; Review
    ZDB-ID 2228325-0
    ISSN 1871-5303
    ISSN 1871-5303
    DOI 10.2174/187153008783928334
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: A prospective open-label study of mycophenolate mofetil for the treatment of diffuse systemic sclerosis.

    Derk, Chris T / Grace, Elizabeth / Shenin, Max / Naik, Manisha / Schulz, Steffan / Xiong, Wen

    Rheumatology (Oxford, England)

    2009  Volume 48, Issue 12, Page(s) 1595–1599

    Abstract: Objective: To evaluate the efficacy and safety of mycophenolate mofetil for the treatment of SSc.: Methods: We recruited 15 patients with dcSSc to take part in an open-label study using mycophenolate mofetil to treat their disease over a 12-month ... ...

    Abstract Objective: To evaluate the efficacy and safety of mycophenolate mofetil for the treatment of SSc.
    Methods: We recruited 15 patients with dcSSc to take part in an open-label study using mycophenolate mofetil to treat their disease over a 12-month period. The primary outcome measure was the modified Rodnan skin score (mRSS), whereas secondary outcomes included the Medsger severity score, pulmonary function studies, 2D echocardiograms and the Short Form Health Survey (SF)-36 questionnaire.
    Results: The mRSS significantly improved in those patients who tolerated the medication for >3 months (P < 0.0001), and there was a statistically significant improvement in the Medsger severity scores of the general (P = 0.05), peripheral vascular involvement (P = 0.05) and skin (P = 0.0003) scores. The SF-36 scores improved (P = 0.05) and the pulmonary function studies showed a trend towards improvement, though not of statistical significance. The mean pulmonary artery pressure by 2D echocardiography did not change.
    Conclusions: In this prospective open-label study of mycophenolate mofetil for the treatment of dcSSc, we observed significant improvements in skin scores, peripheral vascular involvement and patient-perceived health status. Pulmonary function studies did not worsen as expected, but instead showed a trend towards improvement. Controlled trials are needed to further investigate this trend for improved pulmonary function studies.
    MeSH term(s) Adult ; Female ; Humans ; Immunosuppressive Agents/adverse effects ; Immunosuppressive Agents/therapeutic use ; Male ; Middle Aged ; Mycophenolic Acid/adverse effects ; Mycophenolic Acid/analogs & derivatives ; Mycophenolic Acid/therapeutic use ; Prospective Studies ; Respiratory Function Tests ; Scleroderma, Diffuse/drug therapy ; Severity of Illness Index ; Treatment Outcome
    Chemical Substances Immunosuppressive Agents ; Mycophenolic Acid (HU9DX48N0T)
    Language English
    Publishing date 2009-12
    Publishing country England
    Document type Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1464822-2
    ISSN 1462-0332 ; 1462-0324
    ISSN (online) 1462-0332
    ISSN 1462-0324
    DOI 10.1093/rheumatology/kep295
    Database MEDical Literature Analysis and Retrieval System OnLINE

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