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  1. Article ; Online: An In Vitro Study to Evaluate and Compare the Hemocompatibility of Titanium and Zirconia Implant Materials after Sandblasted and Acid-etched Surface Treatment.

    Rajan, Arjun / Sivarajan, Sujith / Vallabhan, Chitra G / Nair, Anjana S / Jayakumar, Shilpa / Pillai, Arya S

    The journal of contemporary dental practice

    2018  Volume 19, Issue 12, Page(s) 1448–1454

    Abstract: Aim: This study was aimed to investigate the hemocompatibility of zirconia and titanium implant materials after surface treatment with sandblasting and acid etching (SLA).: Materials and methods: Sixty specimens were procured from manufacturers of ... ...

    Abstract Aim: This study was aimed to investigate the hemocompatibility of zirconia and titanium implant materials after surface treatment with sandblasting and acid etching (SLA).
    Materials and methods: Sixty specimens were procured from manufacturers of dimension 10mm × 3mm, thirty of each were prefabricated medical grade titanium (Ti-6Al-4V) and thirty of sintered zirconia. Silicon carbide grit papers of 240 to 1200pm, was used to polish the specimen surface. The surfaces were rinsed with water to remove any remnant particles after polishing. Later ultrasonic cleaning was done for 5 minutes using distilled water. The control specimens included 15 specimens each from titanium (groups A1) and zirconia (groups B1). The remaining 15 specimens (groups A2 and B2) were sandblasted using alumina particles of 150 microns particle size and using 20% hydrochloric acid, acid etching was done for 30 seconds. The specimens were scanned under electron microscope after surface treatment for analysis purpose and evaluated for surface characteristics. Before the exposure of specimens to blood, percentage hemolysis, prothrombin, platelet aggregation and activation, and thrombin time values were calculated. one mL of blood was added to each specimen for testing. The values before and after the exposure of specimens to blood were noted. Using a t-test, the values noted were statistically Results: A
    Conclusion: Surface treatment with sandblasting and acid etching (SLA) using 150 microns alumina particles and 20% hydrochloric acid increased the surface roughness of the titanium and zirconia implant materials and polished titanium showed maximum hemocompatibility.
    Clinical significance: The implant's success depends on its biocompatibility and its property of osseointegration. The adverse interaction between blood and the artificial surface is detected by the hemocompatibility test for medical materials, to know if the surface can activate or destruct the blood components. The success of implant placement also depends on the interaction between the blood and the specimen.
    MeSH term(s) Acid Etching, Dental ; Biocompatible Materials ; Dental Etching/methods ; Dental Materials ; Dental Prosthesis Design ; In Vitro Techniques ; Materials Testing/methods ; Titanium ; Zirconium
    Chemical Substances Biocompatible Materials ; Dental Materials ; Zirconium (C6V6S92N3C) ; Titanium (D1JT611TNE) ; zirconium oxide (S38N85C5G0)
    Language English
    Publishing date 2018-12-01
    Publishing country India
    Document type Comparative Study ; Journal Article
    ISSN 1526-3711
    ISSN (online) 1526-3711
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Adverse events associated with Covishield vaccination among healthcare workers in a tertiary hospital in South India.

    T Sathyapalan, Dipu / Moni, Merlin / Prasanna, Preetha / Marwaha, Vishal / Bala Madathil, Sai / Edathadathil, Fabia / Jose, Sony A / Pavithran, Sheela / Muralikrishanan, Rajasree / Ramachandran, Nigith / P R, Roshni / T S, Tinu / Nair, Anjana S / Kuriachan, Sanitha / Louis Palatty, Princy

    Vaccine: X

    2022  Volume 12, Page(s) 100210

    Abstract: Background: Vaccination is the most important prophylactic measure taken to curb COVID-19 pandemics. This study was undertaken to throw light on the safety of Covishield vaccine among health care workers (HCWs) and to assess the co-variates associated ... ...

    Abstract Background: Vaccination is the most important prophylactic measure taken to curb COVID-19 pandemics. This study was undertaken to throw light on the safety of Covishield vaccine among health care workers (HCWs) and to assess the co-variates associated with incidence of adverse events.
    Methods: This prospective observational study was conducted in a tertiary care center in South India as part of the HCW vaccination drive. All consenting HCWs who received the first dose of Covishield vaccine and developed ADRs were included in this study. After vaccination, all beneficiaries were monitored for AEFI for a period of half an hour and later followed up through telephone and google survey forms on day 2 and day 7 of vaccination. The data was subsequently collated into spreadsheet format and analyzed.
    Results: The study included 1264 consenting healthcare workers who were predominantly youth, aged 15-24 years (n = 583, 46 %) and with a female preponderance of 76 % (n = 960). Past history of COVID-19 infections was reported among 4.6 % (58) of the study population. Postvaccination symptoms were majorly reported during the first (40 %) and second day (44 %) after vaccination with a high prevalence of both local (n = 1083, 85 %) and systemic symptoms (n = 1065, 84 %). The mean duration of symptoms was observed to be 1.4 ± 0.81 days post vaccination. Symptoms were observed significantly high among females (76.7 %, p = 0.013). The prevalence of systemic (88 % vs 80 %) (p < 0.001) and allergic symptoms (7 % vs 3 %; p = 0.03) were observed to be significantly high among respondents with <25 years of age. The systemic and allergic symptoms following vaccination were reported to be low among healthcare workers who had a previous history of COVID-19 infection.
    Conclusion: COVID vaccination has been observed to be safe and well tolerated with more systemic symptoms reported among younger age group and females.
    Language English
    Publishing date 2022-08-28
    Publishing country England
    Document type Journal Article
    ISSN 2590-1362
    ISSN (online) 2590-1362
    DOI 10.1016/j.jvacx.2022.100210
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Adverse reaction profile of sulfasalazine and its persistence in chronic therapy of rheumatoid arthritis and spondyloarthritis: A multicentric observational study.

    Jayachandran, Mamatha / Koshy, Varghese / David, Rosme / Santhakumari, Vanditha / Padmanabhan, Dakshin Sitaram / Surendran, Sandeep / Tiwari, Arun / Mithun, C B / Singh, Santosh Kumar / Suman, Saroj Kumar / Yadav, Priyank / Singhal, Anuj / Nair, Anjana S / Marwaha, Vishal / Palatty, Princy Louis

    International journal of clinical pharmacology and therapeutics

    2022  Volume 60, Issue 8, Page(s) 327–335

    Abstract: Objectives: Sulfasalazine has been widely used in treatment of rheumatoid arthritis and spondyloarthritis. This study aims to assess persistence with sulfasalazine and also frequency and severity of adverse drug reactions (ADRs) encountered with this ... ...

    Abstract Objectives: Sulfasalazine has been widely used in treatment of rheumatoid arthritis and spondyloarthritis. This study aims to assess persistence with sulfasalazine and also frequency and severity of adverse drug reactions (ADRs) encountered with this very well-established disease-modifying anti-rheumatoid drug.
    Materials and methods: This retrospective study was done in 1,114 patients from medicine and rheumatology outpatient departments of six centers across India. The inclusion criteria was patients taking sulfasalazine. Patients receiving sulfasalazine for rheumatoid arthritis or spondyloarthritis were selected and details on drugs used, duration of taking sulfasalazine, ADRs to sulfasalazine and whether sulfasalazine had to be stopped due to ADRs were analyzed.
    Results: Of the total of patients included in the study, 10.1% had ADRs with sulfasalazine, and stopped the drug. Gastritis, deranged liver enzymes, hepatitis, skin rashes were the most commonly encountered ADRs. Of the total number of patients recruited for the study, 11% were lost to follow-up, as most of the centers were army hospitals and the officers and staff were posted to other places. Sulfasalazine was taken for less than 1 month by 3.8% patients while 12.5% had taken the drug for less than 6 months. Of the study patients, 28.6% had taken the drug for 24 - 60 months and 4.6% (51 patients) had taken it for more than 5 years. It was found that ADRs were most commonly encountered within the first year of using the drug, and persistence was seen in patients on long-term therapy.
    Conclusion: Sulfasalazine is a safe option in chronic therapy of rheumatoid arthritis and spondyloarthritis. Although frequency of ADRs with patients taking sulfasalazine is minimal, it did necessitate the stoppage of drug. If not well tolerated, sulfasalazine would not have been continued for more than 12 months as evidenced from this study.
    MeSH term(s) Antirheumatic Agents/therapeutic use ; Arthritis, Rheumatoid/drug therapy ; Drug Therapy, Combination ; Drug-Related Side Effects and Adverse Reactions ; Humans ; Retrospective Studies ; Spondylarthritis/chemically induced ; Spondylarthritis/diagnosis ; Spondylarthritis/drug therapy ; Sulfasalazine/adverse effects ; Treatment Outcome
    Chemical Substances Antirheumatic Agents ; Sulfasalazine (3XC8GUZ6CB)
    Language English
    Publishing date 2022-06-17
    Publishing country Germany
    Document type Journal Article ; Observational Study
    ZDB-ID 124384-6
    ISSN 0946-1965 ; 0340-0026 ; 0300-9718 ; 0174-4879
    ISSN 0946-1965 ; 0340-0026 ; 0300-9718 ; 0174-4879
    DOI 10.5414/CP204120
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Whole-Genome Sequences of Influenza A(H1N1)pdm09 Virus Isolates from Kerala, India.

    Jones, Sara / Prasad, Raji / Nair, Anjana S / Dharmaseelan, Sanjai / Usha, Remya / Nair, Radhakrishnan R / Pillai, Radhakrishna Madhavan

    Genome announcements

    2017  Volume 5, Issue 28

    Abstract: We report here the whole-genome sequence of six clinical isolates of influenza A(H1N1)pdm09, isolated from Kerala, India. Amino acid analysis of all gene segments from the A(H1N1)pdm09 isolates obtained in 2014 and 2015 identified several new mutations ... ...

    Abstract We report here the whole-genome sequence of six clinical isolates of influenza A(H1N1)pdm09, isolated from Kerala, India. Amino acid analysis of all gene segments from the A(H1N1)pdm09 isolates obtained in 2014 and 2015 identified several new mutations compared to the 2009 A(H1N1) pandemic strain.
    Language English
    Publishing date 2017-07-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2704277-7
    ISSN 2169-8287
    ISSN 2169-8287
    DOI 10.1128/genomeA.00598-17
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Age changes in horizontal condylar angle: a clinical and cephalometric study.

    Sreelal, T / Janardanan, Kavitha / Nair, Amal S / Nair, Anjana S

    Journal of Indian Prosthodontic Society

    2012  Volume 13, Issue 2, Page(s) 108–112

    Abstract: Unlabelled: Determination of condylar inclination is important when restoring the occlusal surfaces of teeth. It is important to know the changing trends in horizontal condylar inclination with age so as to have an idea about the cuspal morphology.: ... ...

    Abstract Unlabelled: Determination of condylar inclination is important when restoring the occlusal surfaces of teeth. It is important to know the changing trends in horizontal condylar inclination with age so as to have an idea about the cuspal morphology.
    Aims and objectives: a) to determine the effect of age changes in horizontal condylar inclination using articulator method and radiographic method (cephalometry) b) to compare the values of horizontal condylar inclination obtained using articulator method with that of cephalometric method c) to ascertain the symmetry of horizontal condylar angle on both right and left side on an articulator. 40 dentulous individuals with Angle's class I occlusion were selected for the study. They were divided into four groups Group I: 20-29 years, Group II: 30-39 years, Group III: 40-49 years, Group IV: 50-59 years. Horizontal condylar inclination was determined on right and left side for each individual using protrusive interocclusal record in a Dentatus (ARL) semiadjustable articulator. Cephalometric recording was carried out twice on the left side, once in centric occlusion position and then in protrusive position. The two radiographs were superimposed to draw a line connecting the shifting position of condylion on an acetate tracing paper. This line when joined with Frankfurt horizontal plane gives the horizontal condylar inclination. Analysis of variance (ANOVA) revealed that there was a significant difference in horizontal condylar angle values in all the four groups which were statistically significant. There is a decrease in horizontal condylar angle values from Group I to Group IV. Horizontal condylar values obtained by articulator method and cephalometric method showed no significant difference for all the four groups tested. When horizontal condylar values obtained on right and left sides of Dentatus articulator were compared there was not much of a significant difference. Horizontal condylar values showed a decreasing trend with increasing age, i.e, as age advances there is a flattening of condylar head. Both articulator and cephalometric method yielded no significantly different values and hence both the methods can be used for determining condylar inclination. The difference in values of horizontal condylar angle on right and left sides were insignificant.
    Language English
    Publishing date 2012-10-19
    Publishing country India
    Document type Journal Article
    ISSN 0972-4052
    ISSN 0972-4052
    DOI 10.1007/s13191-012-0192-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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