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  1. Article: Role play - An effective tool to teach communication skills in pediatrics to medical undergraduates.

    Nair, Bindu T

    Journal of education and health promotion

    2019  Volume 8, Page(s) 18

    Abstract: Purpose: Communication skills are essential for medical practice throughout the life of a doctor. Traditional undergraduate medical teaching in pediatrics focuses on teaching students with theoretical and practical knowledge of diseases, their diagnosis, ...

    Abstract Purpose: Communication skills are essential for medical practice throughout the life of a doctor. Traditional undergraduate medical teaching in pediatrics focuses on teaching students with theoretical and practical knowledge of diseases, their diagnosis, and treatment modalities. This study was done to use role play as a tool to teach basic communication skills to the final-year undergraduate students in pediatrics and to assess perceptions of students and faculty for using role play to teach counseling and communication skills in pediatrics.
    Methods: It was an observational, questionnaire-based study conducted in the Department of Pediatrics on the final-year medical undergraduates. Two modules for role play on common pediatric topics were designed and role play was conducted. At the end of the session, student and faculty feedback were taken by a prevalidated questionnaire with both close (using the 5-point Likert scale) and open-ended questions. In pre- and post-role play sessions, communication skills assessment scoring was done. Statistical evaluation of the collected data was then carried out using SPSS 22.
    Results: A total of 98 final-year students participated in this study. Role play was found to be the most preferred tool (33%) for teaching communication skills to the students. Majority of the students (88.78%) and faculty (91.67%) felt that role play helped in teaching communicating skills. Comparison of pre- and post-role play scores on communication skills showed statistically significant improvement (
    Conclusion: Role play can be used as an effective tool to teach communication skills to undergraduate medical students in pediatrics.
    Language English
    Publishing date 2019-01-29
    Publishing country India
    Document type Journal Article
    ZDB-ID 2715449-X
    ISSN 2319-6440 ; 2277-9531
    ISSN (online) 2319-6440
    ISSN 2277-9531
    DOI 10.4103/jehp.jehp_162_18
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Extraction of an eco-friendly natural dye from Eleutherine bulbosa (Miller) Urban bulbs, its application as a cotton fabric colorant and chemical characterization

    Kumizhi Kizhakkinayil, Manjula / Nair, Bindu Rajeswari

    Journal of Natural Fibers. 2022 Oct. 28, v. 19, no. 14 p.9039-9051

    2022  

    Abstract: In recent years, natural dyes are gaining importance in textile dyeing applications as they are renewable and biodegradable. In the present study, we selected Eleutherine bulbosa bulbs as a source of natural colorant for dyeing cotton fabrics. Water was ... ...

    Abstract In recent years, natural dyes are gaining importance in textile dyeing applications as they are renewable and biodegradable. In the present study, we selected Eleutherine bulbosa bulbs as a source of natural colorant for dyeing cotton fabrics. Water was used for the extraction of dye, a step toward eco-friendly dyeing. The dyeing was carried out with different mordants and color fastness properties were determined. Relatively higher color strength values were obtained with Myrobalan fruit extract (Mfe- 4.267) and Pomegranate rind extract (Pre- 2.731) as mordants. With Mfe and Pre good color strength values were retained even after detergent wash (3.103 and 1.865) or light exposure (3.689 and 2.395). A combination of Eleutherine dye with turmeric extract was also experimented. Results showed better color strength values with Mfe (4.304) and Pre (3.120). The color retainability after detergent wash (2.960 and 2.100) or light exposure (4.186 and 2.911) was also good with these mordants. Results revealed that E. bulbosa could be used as a source of an ecofriendly dye for cotton fabrics, and the dye-fixing is most effective with the natural mordant myrobalan. The composition of dye extract was analyzed by LCMS technique, 15 compounds were detected, most of which are quinone derivatives.
    Keywords biodegradability ; color ; cotton ; cotton fabric ; detergents ; dyeing ; fruit extracts ; mordants ; natural dyes ; pomegranates ; quinones ; turmeric ; Eleutherine bulbosa ; natural dye ; mordant ; color strength ; eco-friendly
    Language English
    Dates of publication 2022-1028
    Size p. 9039-9051.
    Publishing place Taylor & Francis
    Document type Article ; Online
    ZDB-ID 2182715-1
    ISSN 1544-046X ; 1544-0478
    ISSN (online) 1544-046X
    ISSN 1544-0478
    DOI 10.1080/15440478.2021.1982109
    Database NAL-Catalogue (AGRICOLA)

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  3. Article ; Online: How Palliative Care Helped Me Make an Important Decision in My Life.

    Nair, Bindu

    Journal of pain & palliative care pharmacotherapy

    2015  Volume 29, Issue 4, Page(s) 404–405

    Abstract: The author writes about her father's illness and how her knowledge of palliative care and "dying with dignity" helped her make important decisions for her father in his last days. She and her family members were able to give him the kind of care he ... ...

    Abstract The author writes about her father's illness and how her knowledge of palliative care and "dying with dignity" helped her make important decisions for her father in his last days. She and her family members were able to give him the kind of care he needed and desired. He could enjoy the time he had left, and the family had the satisfaction of serving him when he needed them.
    MeSH term(s) Decision Making ; Family/psychology ; Female ; Humans ; Male ; Palliative Care/psychology
    Language English
    Publishing date 2015
    Publishing country England
    Document type Journal Article ; Personal Narratives
    ZDB-ID 2078852-6
    ISSN 1536-0539 ; 1536-0288
    ISSN (online) 1536-0539
    ISSN 1536-0288
    DOI 10.3109/15360288.2015.1082008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Comparative evaluation of survivin expression in leukoplakia, lichen planus, and oral squamous cell carcinoma: An immunohistochemical study.

    Angelin, D / Nair, Bindu J

    Journal of cancer research and therapeutics

    2020  Volume 16, Issue 3, Page(s) 569–574

    Abstract: Background: Screening for oral squamous cell carcinomas (OSCCs) and oral premalignant lesions may decrease the devastating morbidity and mortality associated with the disease. This has led to widespread research for the identification of molecular-based ...

    Abstract Background: Screening for oral squamous cell carcinomas (OSCCs) and oral premalignant lesions may decrease the devastating morbidity and mortality associated with the disease. This has led to widespread research for the identification of molecular-based biomarkers. Among them, survivin is a recently characterized protein which is a member of the inhibitor of apoptosis family. The aim of this study is evaluating the expression of survivin in oral leukoplakia, oral lichen planus, and OSCC compared with normal mucosa.
    Materials and methods: The retrospective study consisted of twenty cases of oral leukoplakia, oral lichen planus, and OSCC in the age group of 20-70 years. Twenty cases of normal mucosa made up the control group. Immunohistochemical staining was performed with the use of survivin polyclonal antibody. Grades of expression of survivin were evaluated. Kruskal-Wallis test was used for statistical analysis.
    Results: The expression of survivin was higher in OSCC (80%) when compared to oral leukoplakia (70%), oral lichen planus (45%), and normal mucosa (35%). The variation in the expression of survivin between the samples was statistically significant with P = 0.015 (Kruskal-Wallis test significant at 0.01 level).
    Conclusion: It is concluded that survivin can be identified as a useful tool for the identification of potentially malignant disorders at higher risk for progression into invasive carcinoma.
    MeSH term(s) Adult ; Aged ; Biomarkers, Tumor/metabolism ; Female ; Humans ; Immunohistochemistry/methods ; Leukoplakia, Oral/metabolism ; Leukoplakia, Oral/pathology ; Lichen Planus, Oral/metabolism ; Lichen Planus, Oral/pathology ; Male ; Middle Aged ; Mouth Neoplasms/metabolism ; Mouth Neoplasms/pathology ; Precancerous Conditions/metabolism ; Precancerous Conditions/pathology ; Retrospective Studies ; Squamous Cell Carcinoma of Head and Neck/metabolism ; Squamous Cell Carcinoma of Head and Neck/pathology ; Survivin/metabolism ; Young Adult
    Chemical Substances BIRC5 protein, human ; Biomarkers, Tumor ; Survivin
    Keywords covid19
    Language English
    Publishing date 2020-07-23
    Publishing country India
    Document type Comparative Study ; Journal Article
    ZDB-ID 2187633-2
    ISSN 1998-4138 ; 0973-1482
    ISSN (online) 1998-4138
    ISSN 0973-1482
    DOI 10.4103/jcrt.JCRT_421_19
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: SCAR Marker Development for the Identification of Elite Germplasm of Moringa Oleifera Lam.-A Never Die Plant

    Ravi, Drisya / Siril, E. A. / Nair, Bindu R.

    Plant molecular biology reporter. 2021 Dec., v. 39, no. 4

    2021  

    Abstract: Moringa oleifera Lam. (drumstick) belongs to the family Moringaceae that is originated from sub-Himalayan tracts of Northern India distributed worldwide in the tropics and sub-tropics. Immature pods and fresh leaves are widely used as vegetable and are ... ...

    Abstract Moringa oleifera Lam. (drumstick) belongs to the family Moringaceae that is originated from sub-Himalayan tracts of Northern India distributed worldwide in the tropics and sub-tropics. Immature pods and fresh leaves are widely used as vegetable and are rich source of minerals and vitamins. In the present work, we made an attempt to develop and use a set of RAPD-SCAR marker for the identification of superior germplasm of M. oleifera from the accessions collected from South India. Initially, 120 trees were surveyed based on total fruit yield, and single fruit weight from Karnataka, Kerala, and Tamil Nadu states of India; 23 plants had 50% higher fruit yield and single fruit weight than average and were selected as Candidate Plus Trees (CPTs). On the basis of morphological and biochemical analysis, CPT17 was selected as elite germplasm. Random amplified polymorphic DNA (RAPD) analysis of CPTs indicated 89.61% polymorphism among 23 CPTs. These markers could be used in marker-assisted selection and breeding programs in M. oleifera. Further, an attempt to develop a set of RAPD-SCAR marker for the identification of superior germplasm of M. oleifera was made. RAPD primer OPA-19 (CAAACGTCGG) revealed a unique band (1500-bp) in CPT17. The specific RAPD band was recovered from the gel, cloned, and sequenced. BLAST analysis of the CPT17 specific sequences revealed that no considerable similarity with known protein. Based on these unique characterized sequences, specific primers for CPT17 were designed. Specific amplification profile of this primer proved it as a SCAR marker (F2R2) for CPT17 genotype.
    Keywords Moringa oleifera ; fruit weight ; fruit yield ; gels ; genotype ; germplasm ; marker-assisted selection ; molecular biology ; random amplified polymorphic DNA technique ; subtropics ; vegetables ; India
    Language English
    Dates of publication 2021-12
    Size p. 850-861.
    Publishing place Springer US
    Document type Article
    ZDB-ID 2018592-3
    ISSN 1572-9818 ; 0735-9640
    ISSN (online) 1572-9818
    ISSN 0735-9640
    DOI 10.1007/s11105-021-01300-y
    Database NAL-Catalogue (AGRICOLA)

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  6. Article: Comparative evaluation of survivin expression in leukoplakia, lichen planus, and oral squamous cell carcinoma: An immunohistochemical study

    Angelin, D / Nair, Bindu J

    J Cancer Res Ther

    Abstract: Background: Screening for oral squamous cell carcinomas (OSCCs) and oral premalignant lesions may decrease the devastating morbidity and mortality associated with the disease. This has led to widespread research for the identification of molecular-based ... ...

    Abstract Background: Screening for oral squamous cell carcinomas (OSCCs) and oral premalignant lesions may decrease the devastating morbidity and mortality associated with the disease. This has led to widespread research for the identification of molecular-based biomarkers. Among them, survivin is a recently characterized protein which is a member of the inhibitor of apoptosis family. The aim of this study is evaluating the expression of survivin in oral leukoplakia, oral lichen planus, and OSCC compared with normal mucosa. Materials and Methods: The retrospective study consisted of twenty cases of oral leukoplakia, oral lichen planus, and OSCC in the age group of 20-70 years. Twenty cases of normal mucosa made up the control group. Immunohistochemical staining was performed with the use of survivin polyclonal antibody. Grades of expression of survivin were evaluated. Kruskal-Wallis test was used for statistical analysis. Results: The expression of survivin was higher in OSCC (80%) when compared to oral leukoplakia (70%), oral lichen planus (45%), and normal mucosa (35%). The variation in the expression of survivin between the samples was statistically significant with P = 0.015 (Kruskal-Wallis test significant at 0.01 level). Conclusion: It is concluded that survivin can be identified as a useful tool for the identification of potentially malignant disorders at higher risk for progression into invasive carcinoma.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #32719269
    Database COVID19

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  7. Article ; Online: The efficiency of Cytochrome P450 gene-based markers in accessing genetic variability of drumstick (Moringa oleifera Lam.) accessions.

    Ravi, R S Drisya / Siril, E A / Nair, Bindu R

    Molecular biology reports

    2020  Volume 47, Issue 4, Page(s) 2929–2939

    Abstract: Drumstick (Moringa oleifera Lam.) is an important vegetable as well as forage crop of arid and semi-arid zones of the tropics. The leaves and pods of the plant are rich sources of minerals and vitamins. In the present work, genetic diversity study of 23 ... ...

    Abstract Drumstick (Moringa oleifera Lam.) is an important vegetable as well as forage crop of arid and semi-arid zones of the tropics. The leaves and pods of the plant are rich sources of minerals and vitamins. In the present work, genetic diversity study of 23 genotypes of M. oleifera collected from Kerala, Tamil Nadu and Karnataka states of India was carried out using seven cytochrome P450 (CytP450) markers. By using seven pairs of CytP450 gene-based markers, 88.25% of polymorphism was recorded among the 23 sampled genotypes. The Polymorphic Information Content (PI), Marker Index (MI) and Resolving Power obtained for seven primers were estimated 0.23, 2.96 and 9.83, respectively. The Unweighted Pair Group Method with Arithmetic mean (UPGMA) dendrogram based on this marker data indicate that genotypes from different geographical regions are placed in the same clusters. The dendrogram and Principal Coordinates Analysis (PCoA) plots derived from the binary data matrices were highly concordant. The investigation, in brief, proved that CytP450 based marker system is efficient in the elucidation of genetic diversity in M. oleifera accessions.
    MeSH term(s) Cluster Analysis ; Cytochrome P-450 Enzyme System/genetics ; Cytochrome P-450 Enzyme System/metabolism ; DNA Primers ; Genetic Markers/genetics ; Genetic Variation/genetics ; Genotype ; India ; Moringa oleifera/genetics ; Moringa oleifera/metabolism ; Phylogeny ; Plant Leaves/genetics ; Polymorphism, Genetic/genetics ; Random Amplified Polymorphic DNA Technique/methods
    Chemical Substances DNA Primers ; Genetic Markers ; Cytochrome P-450 Enzyme System (9035-51-2)
    Language English
    Publishing date 2020-03-31
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 186544-4
    ISSN 1573-4978 ; 0301-4851
    ISSN (online) 1573-4978
    ISSN 0301-4851
    DOI 10.1007/s11033-020-05391-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Higher mortality rates associated with rheumatoid arthritis in Saskatchewan, Canada, 2001-2019.

    Taylor-Gjevre, Regina M / Nair, Bindu V / Jin, Shan / Quail, Jacqueline

    Canadian journal of public health = Revue canadienne de sante publique

    2021  Volume 112, Issue 4, Page(s) 722–732

    Abstract: Objectives: To estimate provincial all-cause mortality rates of Saskatchewan people with rheumatoid arthritis (RA) for comparison with the general population over time and between different geographic regions.: Methods: Saskatchewan provincial ... ...

    Abstract Objectives: To estimate provincial all-cause mortality rates of Saskatchewan people with rheumatoid arthritis (RA) for comparison with the general population over time and between different geographic regions.
    Methods: Saskatchewan provincial administrative health databases (2001-2019) were utilized as data sources. Two RA case definitions were employed: (1) ≥ 3 physician billing diagnoses, at least 1 from a specialist (rheumatologist, general internist or orthopaedic surgeon) within 2 years; (2) ≥ 1 hospitalization diagnosis (ICD-9 code 714, and ICD-10-CA codes M05, M06). Data from these definitions were combined to create an administrative data RA cohort. All-cause mortality rates across geographic regions, between rural/urban residences and between sexes were examined.
    Results: Over an 18-year span, between fiscal-year 2001-2002 and fiscal-year 2018-2019, age- and sex-adjusted mortality rates ranged from 17.10 to 21.04 (95% CI 14.77, 19.44; 18.03, 24.05)/1000 RA person-years, compared with mortality rates for the general Saskatchewan population without RA, which ranged from 9.37 to 10.88 (95% CI 9.23, 9.51; 10.72, 11.05)/1000 person-years. Fiscal-year mortality rate ratios ranged from 1.82 to 2.13 (95% CI 1.56, 2.13; 1.83, 2.46). Provincial mortality rates were higher in men than in women for both general and RA populations. Northern Saskatchewan mortality rates were significantly higher in the general population but did not achieve significance compared with other provincial regions for the RA population. Regression analysis identified age, male sex, RA and geographic region as factors contributing to increased mortality. A trend towards lower mortality rates over time was observed.
    Conclusion: Higher mortality rates were observed in the RA population overall. Men had higher mortality rates, as did residents of Northern Saskatchewan compared with residents of other regions for the general population.
    MeSH term(s) Aged ; Aged, 80 and over ; Arthritis, Rheumatoid/mortality ; Databases, Factual ; Female ; Health Status Disparities ; Humans ; Male ; Mortality/trends ; Saskatchewan/epidemiology
    Language English
    Publishing date 2021-02-17
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 417262-0
    ISSN 1920-7476 ; 0008-4263
    ISSN (online) 1920-7476
    ISSN 0008-4263
    DOI 10.17269/s41997-021-00476-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Early Detection of First Carpometacarpal Joint Osteoarthritis Using Magnetic Resonance Imaging Assessment in Women With High Hypermobility Scores.

    Taylor-Gjevre, Regina M / Nair, Bindu / Lourens, Joe-Ann / Leswick, David / Obaid, Haron

    Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases

    2022  Volume 28, Issue 8, Page(s) 402–408

    Abstract: Objective: The aim of this study was to explore association between hypermobility and osteoarthritis (OA) at the first carpometacarpal (CMC) joint, using magnetic resonance imaging (MRI) to identify early change in women at high risk of developing OA ... ...

    Abstract Objective: The aim of this study was to explore association between hypermobility and osteoarthritis (OA) at the first carpometacarpal (CMC) joint, using magnetic resonance imaging (MRI) to identify early change in women at high risk of developing OA but without yet established diagnoses.
    Methods: For this observational study, 33 women (aged 30-50 years) with self-reported history of maternal hand OA but without personal diagnoses of OA were recruited. Participants completed a 5-point hypermobility questionnaire. The 20 participants with 2 or more positive responses were categorized with "high hypermobility scores." The remaining 13 were categorized with "low hypermobility scores." Data collection included functional index, hand pain measure, parity, smoking status, and body mass index. Each participant underwent dominant hand radiographic and MRI examination. Imaging studies were interpreted by assessors blinded to hypermobility score categorization.
    Results: No significant differences in age, body mass index, parity, functional index, or pain scores were observed between higher and lower hypermobility score groups. Similarly, there were no significant differences between groups for radiographic changes. However, significantly higher proportions of women with higher hypermobility scores were observed on MRI to have abnormalities of trapezium cartilage (75% vs. 38%), metacarpal cartilage (80% vs. 38%), and trapezium bone (70% vs. 31%); p < 0.05 for all.
    Conclusions: First CMC joint structural abnormalities were more frequently observed in women with higher hypermobility scores. Identification of early preradiographic changes in this group supports the concept that early-life joint laxity may contribute to future OA predisposition. Magnetic resonance imaging may be a preferred imaging test for detection of early cartilage changes in people at high risk of CMC joint OA.
    MeSH term(s) Humans ; Female ; Carpometacarpal Joints/pathology ; Osteoarthritis/diagnostic imaging ; Joint Instability/diagnostic imaging ; Joint Instability/etiology ; Magnetic Resonance Imaging ; Pain
    Language English
    Publishing date 2022-08-18
    Publishing country United States
    Document type Observational Study ; Journal Article
    ZDB-ID 1283266-2
    ISSN 1536-7355 ; 1076-1608
    ISSN (online) 1536-7355
    ISSN 1076-1608
    DOI 10.1097/RHU.0000000000001892
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Comparative analysis of the oxidative stress and antioxidant status in type II diabetics and nondiabetics: A biochemical study.

    Nair, Archana / Nair, Bindu J

    Journal of oral and maxillofacial pathology : JOMFP

    2017  Volume 21, Issue 3, Page(s) 394–401

    Abstract: Background: Diabetes mellitus is a metabolic disorder characterized by hyperglycemia along with biochemical alterations of glucose and lipid peroxidation. It produces free radicals that induce lipid peroxidation which acts as an indicator for oxidative ... ...

    Abstract Background: Diabetes mellitus is a metabolic disorder characterized by hyperglycemia along with biochemical alterations of glucose and lipid peroxidation. It produces free radicals that induce lipid peroxidation which acts as an indicator for oxidative stress in the body. The widely used assay for lipid peroxidation involves measurement of malondialdehyde (MDA). Defensive system in the body consists of antioxidant enzymes which help in scavenging free radicals. Two such antioxidant enzymes are reduced glutathione (GSH) and superoxide dismutase (SOD). In this study MDA, GSH and SOD are assessed in serum and saliva of age- and sex-matched 33 diabetics and nondiabetics.
    Objective: (1) To estimate the levels of MDA, GSH and SOD in saliva and serum of both diabetics and nondiabetics. (2) To correlate the levels of MDA, GSH and SOD in saliva and serum of both diabetics and nondiabetics. (3) To find if serum levels of MDA, GSH and SOD can be predicted from values of the same in saliva, in both groups.
    Materials and methods: Whole unstimulated saliva and venous blood samples obtained after 12 h of overnight fast were transported to the designated laboratory chosen for the study. Supernatants of the centrifuged samples were used for the assays of MDA, GSH and SOD.
    Results: A significant correlation was obtained between serum and saliva values of MDA and GSH, hence the prediction of serum MDA and GSH was possible from their subsequent saliva values. Although the levels of serum and salivary SOD showed a weak positive correlation, prediction of SOD was not possible.
    Conclusion: Saliva can be used as a diagnostic tool for the estimation of MDA, GSH and SOD.
    Language English
    Publishing date 2017-12-29
    Publishing country India
    Document type Journal Article
    ZDB-ID 2390999-7
    ISSN 1998-393X ; 0973-029X
    ISSN (online) 1998-393X
    ISSN 0973-029X
    DOI 10.4103/jomfp.JOMFP_56_16
    Database MEDical Literature Analysis and Retrieval System OnLINE

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