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Article ; Online: The Effectiveness of High-Fidelity Simulation on Clinical Competence Among Nursing Students.

Nair, Manju Avinash / Muthu, Priyalatha / Abuijlan, Israa A M

2024 Volume 10, Page(s) 23779608241249357

Abstract: Introduction: Clinical competence is a pre-requisite for every student nurse to showcase their proficiency in providing quality nursing care. Effective clinical experience during the study period plays a pivotal role in developing clinical competence ... ...

Abstract	Introduction: Clinical competence is a pre-requisite for every student nurse to showcase their proficiency in providing quality nursing care. Effective clinical experience during the study period plays a pivotal role in developing clinical competence among nursing students. Hence, the purpose of the study was to find the effectiveness of high fidelity simulation (HFS) on clinical competence among nursing students. Objectives: The objectives of the study were to determine the impact of HFS on level of clinical competence among nursing students, to find the association between selected demographic characteristics of nursing students with their level of clinical competence and also, to find the association between academic performances of nursing students with their level of competence. Method: The current study employed a quasi-experimental study design. Sixty-five nursing students from second year Bachelor of Science in Nursing (BSN) program were selected using consecutive sampling technique. The data was collected using demographic data form, objective structured clinical examination (OSCE) grade performa, and academic score sheet. SPSS version 24 was used to analyze data. Results: The study revealed a significant impact of HFS on clinical competence of nursing students. Majority (52.3%) of the nursing students obtained high level clinical competence following the HFS. The findings showed a significant association between gender and medium of instruction with the level of clinical competence of nursing students. Further, there was a significant correlation between academic performance and level of clinical competence of the nursing students. Conclusion: HFS served as a useful pedagogical approach in fulfilling the clinical learning outcomes. It further facilitated readiness of nursing students in second year BSN in terms of developing competence and confidence for clinical placement at the hospital for the third year of their study. However, further research is required to determine if HFS can be used in developing clinical reasoning skills in nursing students.
Language	English
Publishing date	2024-05-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	2865437-7
ISSN	2377-9608 ; 2377-9608
ISSN (online)	2377-9608
ISSN	2377-9608
DOI	10.1177/23779608241249357
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Understanding Long-Term Outcomes of Public Health Strategy in Palliative Care at Micro Level: Impact of Home-Based Palliative Care Services under Local Self-Government Institutions in Kerala, India.

Nair, Manju / Augustine, Anupama

Indian journal of palliative care

2022 Volume 28, Issue 1, Page(s) 7–12

Abstract: Objectives: Palliative care units under Local Self-Government Institutions (LSGIs) are increasing in number in the state of Kerala, India, since the announcement of the Pain and Palliative Care Policy, 2008. Whether these units are functioning with a ... ...

Abstract	Objectives: Palliative care units under Local Self-Government Institutions (LSGIs) are increasing in number in the state of Kerala, India, since the announcement of the Pain and Palliative Care Policy, 2008. Whether these units are functioning with a view to materialise the long-term objectives, following the guidelines stipulated by the Government of Kerala and serve the neediest patients with quality care are a matter of debate. Hence, a microlevel study of the palliative care unit is attempted. The aims of the study were to understand the extent to which the structure and nature of functioning of the Pain and Palliative Care Unit under LSGI comply with guidelines set by the Pain and Palliative Care Policy of the Government of Kerala and to check whether the palliative care services are reaching the needy and, if so, are they provided to patients in good quality. Materials and methods: The award winning Pain and Palliative Care Unit attached to LSGI is selected for analysis and a hybrid research design is followed. Data are collected from 25 patients and their caregivers selected randomly. Mean score of satisfaction level on the basis of Quality care questionnaire -Palliative care is used. Results: Sample unit complies with the revised guidelines of 2015, Pain and Palliative Care Policy. It serves the neediest patients and the quality of care is satisfactory. Conclusion: The study reaffirms the strength of the public health model in palliative care which can provide quality care to the neediest patients.
Language	English
Publishing date	2022-01-06
Publishing country	United States
Document type	Journal Article
ISSN	0973-1075
ISSN	0973-1075
DOI	10.25259/IJPC_4_21
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Article ; Online: An account of Section Crispidium of Fissidens Subgen. Pachyissidens in Western Ghats of India with description of a new variety and an extension range

Kurungottu Muliyil Manjula / Chandrasekharan Nair Manju

Taiwania, Vol 65, Iss 3, Pp 295-

2020 Volume 314

Abstract: The present paper provides an account of section Crispidium (Müll. Hal.) Pursell & Brugg.-Nann. of Fissidens Hedw. subgenus Pachyfissidens (Müll. Hal.) Kindb. in Western Ghats, India along with description of a new variety F. crispulus var. ... ...

Abstract	The present paper provides an account of section Crispidium (Müll. Hal.) Pursell & Brugg.-Nann. of Fissidens Hedw. subgenus Pachyfissidens (Müll. Hal.) Kindb. in Western Ghats, India along with description of a new variety F. crispulus var. nelliampathiae. Fissidens subangustus Fleisch. is also recorded here as new report for Kerala State. A brief taxonomic description, line drawing illustration and identification key to the species of the section are provided to facilitate their future easier identification.
Keywords	fissidens ; f. crispulus var. nelliampathiae ; india ; pachyissidens ; taxanomic key ; western ghats ; Biology (General) ; QH301-705.5
Language	English
Publishing date	2020-06-01T00:00:00Z
Publisher	National Taiwan University
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Antibacterial and Immunomodulatory Properties of Stem Cells from Human Exfoliated Deciduous Teeth: An

Tyagi, Akanksha / Shetty, Jayaprakasha / Shetty, Shriya / Kumar, Basavarajappa Mohana / Shetty, Alandur Veena / Nair, Manju Raman

International journal of clinical pediatric dentistry

2023 Volume 16, Issue Suppl 3, Page(s) 240–246

Abstract: Stem cells from human exfoliated deciduous teeth (SHED) provide an important autologous source for stem cell-based regenerative therapies with their easy acquisition and multipotency. However, the understanding of their antibacterial and immunomodulatory ...

Abstract	Stem cells from human exfoliated deciduous teeth (SHED) provide an important autologous source for stem cell-based regenerative therapies with their easy acquisition and multipotency. However, the understanding of their antibacterial and immunomodulatory properties is limited. This How to cite this article: Tyagi A, Shetty J, Shetty S,
Language	English
Publishing date	2023-12-12
Publishing country	India
Document type	Journal Article
ISSN	0974-7052
ISSN	0974-7052
DOI	10.5005/jp-journals-10005-2683
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Article ; Online: Sagacious Perceptive on Marburg Virus Foregrounding the Recent Findings: A Critical Review.

Baby, Bilha / Rajendran, Rajalakshmi / Nair, Manju M / Raghavan, Roshni P

Infectious disorders drug targets

2022 Volume 22, Issue 8, Page(s) 13–18

Abstract: Infectious diseases are defined as a group of diseases caused by any infecting microorganism which are highly potent to severely affect human life. The end can vary from critical infection to mortality. Most infectious diseases are reported with a rapid ... ...

Abstract	Infectious diseases are defined as a group of diseases caused by any infecting microorganism which are highly potent to severely affect human life. The end can vary from critical infection to mortality. Most infectious diseases are reported with a rapid rate of transmission. Marburg virus disease is a kind of infectious viral disease usually manifested as hemorrhagic fever. The latest reported case of Marburg virus disease confirmed by WHO was on 6th August 2021 in the south-western province of Guinea. Marburg virus disease exhibit similar manifestations to that of infection with the Ebola virus. Though not widely spread to emerge as a pandemic, Marburg virus disease remains a serious threat to human life. This review emphasizes the novel current facts determined through various studies related to Marburg virus infection. From these promising theories, the review tries to put forward the importance of various study conclusions, which are likely to have a major impact on the health sector in the near future.
Language	English
Publishing date	2022-03-14
Publishing country	United Arab Emirates
Document type	Journal Article
ZDB-ID	2234298-9
ISSN	2212-3989 ; 1871-5265
ISSN (online)	2212-3989
ISSN	1871-5265
DOI	10.2174/1871526522666220510103618
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Article: Diagnosis and treatment of herpes simplex 1 virus infection in pregnancy.

Lee, Rachel / Nair, Manju

Obstetric medicine

2017 Volume 10, Issue 2, Page(s) 58–60

Abstract: A nulliparous woman presented at 21 weeks' gestation with a 72-h history of a rash on her left arm. Initially isolated to the forearm, it had quickly spread, becoming multiple itchy fluid-filled blisters. Blood tests showed mild neutrophilia and raised ... ...

Abstract	A nulliparous woman presented at 21 weeks' gestation with a 72-h history of a rash on her left arm. Initially isolated to the forearm, it had quickly spread, becoming multiple itchy fluid-filled blisters. Blood tests showed mild neutrophilia and raised CRP. Skin swabs demonstrated the presence of herpes simplex virus type 1 (HSV1) DNA. There was no history of previous HSV1 exposure. There is scant literature on uncomplicated cutaneous HSV1 since the majority is oral/genital. The incidence of transmission varies and is dependent on site of infection and immunological status. Type-specific serological testing is recommended to identify a primary first episode infection due to the 30-60% vertical transmission rate. Infection is associated with morbidity and mortality for both mother and fetus including maternal encephalitis, acute retinal necrosis, pneumonia and hepatitis. Neonatal disease can be congenital (cutaneous lesions, microcephaly, hydranencephaly, intracranial calcifications, chorioretinitis, microphthalmia and optic nerve atrophy) or acquired (skin, eyes and mouth disease or central nervous system disease or disseminated disease). Prophylactic aciclovir reduces the number of women with active genital lesions at the time of delivery. If primary infection occurs outside of the first trimester and active genital lesions are present, then vaginal delivery should be avoided. If infection has occurred in the first trimester, vaginal birth can be attempted even in the presence of active lesions. There is no available guidance on prophylactic treatment of non-genital HSV1 in pregnancy.
Language	English
Publishing date	2017-02-01
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2612229-7
ISSN	1753-4968 ; 1753-495X
ISSN (online)	1753-4968
ISSN	1753-495X
DOI	10.1177/1753495X16689434
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Article ; Online: Validated HPLC Method for Quantification of a Novel Trk Inhibitor, Larotrectinib in Mice Plasma: Application to a Pharmacokinetic Study.

Tripathy, Harsha K / Nair Manju, S V / Zakkula, Ashok / Bestha, Ram Murthi / Dittakavi, Sreekanth / Mullangi, Ramesh

Drug research

2020 Volume 70, Issue 2-03, Page(s) 101–106

Abstract: Larotrectinib, is an orally active novel small molecule approved for the treatment of solid tumors in pediatrics and adult patients. It acts by inhibiting tropomyosin receptor kinase. In this paper, we report the development and validation of a high- ... ...

Abstract	Larotrectinib, is an orally active novel small molecule approved for the treatment of solid tumors in pediatrics and adult patients. It acts by inhibiting tropomyosin receptor kinase. In this paper, we report the development and validation of a high-performance liquid chromatography (HPLC) method for the quantitation of larotrectinib in mice plasma as per the FDA regulatory guideline. Plasma samples processing was accomplished through simple protein precipitation using acetonitrile enriched with internal standard (IS, enasidenib). The chromatographic analysis was performed using a gradient mobile phase comprising 10 mM ammonium acetate and acetonitrile at a flow-rate of 0.8 mL/min on an X-Terra Phenyl column. The UV detection wave length was set at λ
MeSH term(s)	Animals ; Chromatography, High Pressure Liquid/methods ; Drug Stability ; Drug Storage ; Male ; Mice ; Protein Kinase Inhibitors/analysis ; Protein Kinase Inhibitors/pharmacokinetics ; Pyrazoles/analysis ; Pyrazoles/pharmacokinetics ; Pyrimidines/analysis ; Pyrimidines/pharmacokinetics ; Receptor Protein-Tyrosine Kinases/antagonists & inhibitors ; Reproducibility of Results ; Temperature
Chemical Substances	Protein Kinase Inhibitors ; Pyrazoles ; Pyrimidines ; Receptor Protein-Tyrosine Kinases (EC 2.7.10.1) ; larotrectinib (PF9462I9HX)
Language	English
Publishing date	2020-01-13
Publishing country	Germany
Document type	Journal Article ; Validation Study
ZDB-ID	2703847-6
ISSN	2194-9387 ; 2194-9379
ISSN (online)	2194-9387
ISSN	2194-9379
DOI	10.1055/a-1071-0849
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Article ; Online: Tissue-engineered Maxillofacial Skeletal Defect Reconstruction by 3D Printed Beta-tricalcium phosphate Scaffold Tethered with Growth Factors and Fibrin Glue Implanted Autologous Bone Marrow-Derived Mesenchymal Stem Cells.

Nair, Manju Ananthakrishnan / Shaik, Khadar Vali / Kokkiligadda, Adiseshu / Gorrela, Harsha

Journal of medicine and life

2020 Volume 13, Issue 3, Page(s) 418–425

Abstract: The study aimed to investigate whether a 3D printed beta-tricalcium phosphate (β-TCP) scaffold tethered with growth factors and fibrin glue implanted autologous bone marrow-derived mesenchymal stem cells would provide a 3D platform for bone regeneration ... ...

Abstract	The study aimed to investigate whether a 3D printed beta-tricalcium phosphate (β-TCP) scaffold tethered with growth factors and fibrin glue implanted autologous bone marrow-derived mesenchymal stem cells would provide a 3D platform for bone regeneration resulting in new bone formation with plasticity. Twenty 3D printed β-TCP scaffolds, ten scaffolds engrained with osteogenic mesenchymal stem cells with fibrin glue (group A), and ten scaffolds used as a control group with β-TCP scaffold and fibrin glue inoculation only (group B) were included in the study. Cell infiltration, migration, and proliferation of human osteogenic stem cells on the scaffolds were executed under both static and dynamic culture conditions. Each scaffold was examined post culture after repeated changes in the nutrient medium at 2, 4 or 8 weeks and assessed for opacity and formation of any bone-like tissues macroscopic, radiographic, and microscopic evaluation. Significant changes in all the prerequisite parameters compiled with an evaluated difference of significance showing maxillofacial skeletal repair via tissue engineering by β-TCP scaffold and MSCs remains will be the most promising alternative to autologous bone grafts and numerous modalities involving a variety of stem cells, growth factors from platelet-rich fibrin.
MeSH term(s)	Calcium Phosphates/pharmacology ; Case-Control Studies ; Cell Survival/drug effects ; Fibrin Tissue Adhesive/pharmacology ; Humans ; Intercellular Signaling Peptides and Proteins/pharmacology ; Maxillofacial Abnormalities/diagnostic imaging ; Maxillofacial Abnormalities/pathology ; Maxillofacial Abnormalities/therapy ; Mesenchymal Stem Cell Transplantation ; Mesenchymal Stem Cells/cytology ; Mesenchymal Stem Cells/drug effects ; Minerals/analysis ; Printing, Three-Dimensional ; Tissue Engineering/methods ; Tissue Scaffolds/chemistry ; Treatment Outcome
Chemical Substances	Calcium Phosphates ; Fibrin Tissue Adhesive ; Intercellular Signaling Peptides and Proteins ; Minerals ; beta-tricalcium phosphate
Language	English
Publishing date	2020-10-09
Publishing country	Romania
Document type	Journal Article
ZDB-ID	2559353-5
ISSN	1844-3117 ; 1844-3109 ; 1844-122X
ISSN (online)	1844-3117 ; 1844-3109
ISSN	1844-122X
DOI	10.25122/jml-2020-0044
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Article: Employment of people with disabilities

Nair, Manju S

Labour & development Vol. 21, No. 1 , p. 109-128

an analysis on nature and determinants

2014 Volume 21, Issue 1, Page(s) 109–128

Author's details	Manju S. Nair
Keywords	Erwerbstätigkeit ; Beruflicher Status ; Behinderte Arbeitskräfte ; Kerala
Language	English
Publisher	Inst
Publishing place	Noida
Document type	Article
ZDB-ID	2437723-5 ; 2812188-0
ISSN	0973-0419
ISSN	0973-0419
Database	ECONomics Information System

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Article ; Online: Macrophage Plasticity in Reproduction and Environmental Influences on Their Function.

Chambers, Megan / Rees, April / Cronin, James G / Nair, Manju / Jones, Nicholas / Thornton, Catherine A

Frontiers in immunology

2021 Volume 11, Page(s) 607328

Abstract: Macrophages are key components of the innate immune system and exhibit extensive plasticity and heterogeneity. They play a significant role in the non-pregnant cycling uterus and throughout gestation they contribute to various processes underpinning ... ...

Abstract	Macrophages are key components of the innate immune system and exhibit extensive plasticity and heterogeneity. They play a significant role in the non-pregnant cycling uterus and throughout gestation they contribute to various processes underpinning reproductive success including implantation, placentation and parturition. Macrophages are also present in breast milk and impart immunomodulatory benefits to the infant. For a healthy pregnancy, the maternal immune system must adapt to prevent fetal rejection and support development of the semi-allogenic fetus without compromising host defense. These functions are dependent on macrophage polarization which is governed by the local tissue microenvironmental milieu. Disruption of this microenvironment, possibly by environmental factors of infectious and non-infectious origin, can affect macrophage phenotype and function and is linked to adverse obstetric outcomes, e.g. spontaneous miscarriage and preterm birth. Determining environmental influences on cellular and molecular mechanisms that control macrophage polarization at the maternal-fetal interface and the role of this in pregnancy complications could support approaches to alleviating adverse pregnancy outcomes.
MeSH term(s)	Animals ; Cell Plasticity/drug effects ; Cellular Microenvironment ; Environmental Exposure/adverse effects ; Environmental Pollutants/adverse effects ; Female ; Humans ; Macrophages/drug effects ; Macrophages/immunology ; Macrophages/metabolism ; Macrophages/pathology ; Phenotype ; Placenta/drug effects ; Placenta/immunology ; Placenta/metabolism ; Placenta/pathology ; Pregnancy ; Pregnancy Complications/chemically induced ; Pregnancy Complications/immunology ; Pregnancy Complications/metabolism ; Pregnancy Complications/pathology ; Pregnancy Outcome ; Reproduction/drug effects ; Risk Factors ; Signal Transduction ; Uterus/drug effects ; Uterus/immunology ; Uterus/metabolism ; Uterus/pathology
Chemical Substances	Environmental Pollutants
Language	English
Publishing date	2021-01-14
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2020.607328
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