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  1. Article ; Online: Eosinophils and therapeutic responses to steroids and biologics in COPD: a complex relationship.

    Nair, Parameswaran

    Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia

    2023  Volume 49, Issue 6, Page(s) e20230360

    MeSH term(s) Humans ; Eosinophils ; Biological Products/therapeutic use ; Pulmonary Disease, Chronic Obstructive/drug therapy ; Steroids/therapeutic use ; Leukocyte Count
    Chemical Substances Biological Products ; Steroids
    Language Portuguese
    Publishing date 2023-12-22
    Publishing country Brazil
    Document type Editorial
    ZDB-ID 2223157-2
    ISSN 1806-3756 ; 1806-3713
    ISSN (online) 1806-3756
    ISSN 1806-3713
    DOI 10.36416/1806-3756/e20230360
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Predictors of response to anti-IL-5 biologics.

    Nair, Parameswaran

    Respirology (Carlton, Vic.)

    2020  Volume 25, Issue 11, Page(s) 1123–1125

    Language English
    Publishing date 2020-08-06
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 1435849-9
    ISSN 1440-1843 ; 1323-7799
    ISSN (online) 1440-1843
    ISSN 1323-7799
    DOI 10.1111/resp.13926
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  3. Article ; Online: Normal Blood Eosinophil Counts in Humans.

    Lommatzsch, Marek / Nair, Parameswaran / Virchow, Johann Christian

    Respiration; international review of thoracic diseases

    2024  Volume 103, Issue 4, Page(s) 214–216

    MeSH term(s) Humans ; Eosinophils ; Leukocyte Count ; Asthma
    Language English
    Publishing date 2024-02-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 206674-9
    ISSN 1423-0356 ; 0025-7931
    ISSN (online) 1423-0356
    ISSN 0025-7931
    DOI 10.1159/000537833
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  4. Article ; Online: COVID-19, Obstructive Airway Disease and Eosinophils: A complex interplay.

    Jayakrishnan, B / Nair, Parameswaran

    Sultan Qaboos University medical journal

    2022  Volume 22, Issue 2, Page(s) 163–166

    MeSH term(s) COVID-19 ; Eosinophils ; Humans ; Leukocyte Count ; Pulmonary Disease, Chronic Obstructive
    Language English
    Publishing date 2022-05-26
    Publishing country Oman
    Document type Editorial
    ZDB-ID 2650196-X
    ISSN 2075-0528 ; 2075-0528
    ISSN (online) 2075-0528
    ISSN 2075-0528
    DOI 10.18295/squmj.1.2022.001
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  5. Article ; Online: Persistent Airway Plugs: A Call for Clinical Recognition and Novel Therapies.

    Svenningsen, Sarah / Nair, Parameswaran

    American journal of respiratory and critical care medicine

    2022  Volume 205, Issue 9, Page(s) 977–978

    MeSH term(s) Asthma ; Humans ; Lung ; Mucus
    Language English
    Publishing date 2022-03-04
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202201-0147ED
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  6. Article ; Online: In-vitro Clinical Diagnostics using RNA-Cleaving DNAzymes.

    Ali, Monsur / Nair, Parameswaran / Capretta, Alfredo / Brennan, John David

    Chembiochem : a European journal of chemical biology

    2024  , Page(s) e202400085

    Abstract: Over the last three decades, significant advancements have been made in the development of biosensors and bioassays that use RNA-cleaving DNAzymes (RCDs) as molecular recognition elements. While early examples of RCDs were primarily responsive to metal ... ...

    Abstract Over the last three decades, significant advancements have been made in the development of biosensors and bioassays that use RNA-cleaving DNAzymes (RCDs) as molecular recognition elements. While early examples of RCDs were primarily responsive to metal ions, the past decade has seen numerous RCDs reported for more clinically relevant targets such as bacteria, cancer cells, small metabolites, and protein biomarkers. Over the past 5 years several RCD-based biosensors have also been evaluated using either spiked biological matrixes or patient samples, including blood, serum, saliva, nasal mucus, sputum, urine, and faeces, which is a critical step toward regulatory approval and commercialization of such sensors. In this review, an overview of the methods used to generate RCDs and the properties of key RCDs that have been utilized for in vitro testing is first provided. Examples of RCD-based assays and sensors that have been used to test either spiked biological samples or patient samples are then presented, highlighting assay performance in different sample types. A summary of current prospects and challenges for development of in vitro diagnostic tests incorporating RCDs and a perspective on the future directions of the field is also provided.
    Language English
    Publishing date 2024-04-04
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2020469-3
    ISSN 1439-7633 ; 1439-4227
    ISSN (online) 1439-7633
    ISSN 1439-4227
    DOI 10.1002/cbic.202400085
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  7. Article ; Online: Eosinophil-mucus interplay in severe asthma: Implications for treatment with biologicals.

    Venegas Garrido, Carmen / Mukherjee, Manali / Svenningsen, Sarah / Nair, Parameswaran

    Allergology international : official journal of the Japanese Society of Allergology

    2024  

    Abstract: Airway mucus is a hydrogel with unique biophysical properties due to its primary water composition and a small proportion of large anionic glycoproteins or mucins. The predominant mucins in human mucus, MUC5AC and MUC5B, are secreted by specialized cells ...

    Abstract Airway mucus is a hydrogel with unique biophysical properties due to its primary water composition and a small proportion of large anionic glycoproteins or mucins. The predominant mucins in human mucus, MUC5AC and MUC5B, are secreted by specialized cells within the airway epithelium both in normal conditions and in response to various stimuli. Their relative proportions are correlated with specific inflammatory responses and disease mechanisms. The dysregulation of mucin expression is implicated in numerous respiratory diseases, including asthma, COPD, and cystic fibrosis, where the pathogenic role of mucus has been extensively described yet often overlooked. In airway diseases, excessive mucus production or impaired mucus clearance leads to mucus plugging, with secondary airway occlusion that contribute to airflow obstruction, asthma severity and poor control. Eosinophils and Charcot Leyden crystals in sputum contribute to the mucus burden and tenacity. Mucin may also contribute to eosinophil survival. Other mechanisms, including eosinophil-independent IL-13 release, mast-cell activation and non-type-2 (T2) cytokines, are also likely to participate in mucus pathobiology. An accurate assessment of mucus and its clinical and functional consequences require a thorough approach that includes evaluation of cellular predominance in sputum, airway cytokines and other inflammatory markers, mucus characteristics and composition and structural and functional impact measured by advanced lung imaging. This review, illustrated with clinical scenarios, provides an overview of current methods to assess mucus and its relevance to the choice of biologics to treat patients with severe asthma.
    Language English
    Publishing date 2024-03-13
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1336498-4
    ISSN 1440-1592 ; 1323-8930
    ISSN (online) 1440-1592
    ISSN 1323-8930
    DOI 10.1016/j.alit.2024.03.001
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  8. Article ; Online: Response of sputum periostin to anti-T2 biologics treatment in severe asthma.

    Nair, Parameswaran / Radford, Katherine / Nunomura, Satoshi / Mukherjee, Manali / Izuhara, Kenji

    Allergy

    2024  

    Language English
    Publishing date 2024-04-23
    Publishing country Denmark
    Document type Journal Article
    ZDB-ID 391933-x
    ISSN 1398-9995 ; 0105-4538
    ISSN (online) 1398-9995
    ISSN 0105-4538
    DOI 10.1111/all.16131
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  9. Article ; Online: There is more to severe asthma associated with obesity than inflammation.

    Svenningsen, Sarah / Nair, Parameswaran

    Respirology (Carlton, Vic.)

    2021  Volume 26, Issue 4, Page(s) 288–289

    MeSH term(s) Asthma/epidemiology ; Asthma/etiology ; Humans ; Inflammation ; Obesity/complications ; Obesity/epidemiology
    Language English
    Publishing date 2021-02-09
    Publishing country Australia
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 1435849-9
    ISSN 1440-1843 ; 1323-7799
    ISSN (online) 1440-1843
    ISSN 1323-7799
    DOI 10.1111/resp.14012
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  10. Article ; Online: Sampling pattern discrepancy in the application of compressed sensing hyperpolarized xenon-129 lung MRI.

    Tavakkoli, Mitra / Svenningsen, Sarah / Friedlander, Yonni / Konyer, Norman B / Nair, Parameswaran / Noseworthy, Michael D

    NMR in biomedicine

    2024  , Page(s) e5121

    Abstract: Although hyperpolarized (HP) ...

    Abstract Although hyperpolarized (HP)
    Language English
    Publishing date 2024-02-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 1000976-0
    ISSN 1099-1492 ; 0952-3480
    ISSN (online) 1099-1492
    ISSN 0952-3480
    DOI 10.1002/nbm.5121
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