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Article: Minimally Invasive Coracoclavicular Ligament Reconstruction Using Semitendinosus Autograft in a Case of Cho's Type IIC Lateral End Clavicle Fracture With Torn Conoid and Trapezoid Ligaments.

Ray, Shirsha / Nair, Vinod

2022 Volume 14, Issue 12, Page(s) e32761

Abstract: Clavicle fractures are a common clinical problem that accounts for about 10% of all fractures. Cho's type II fractures compromise the integrity of the coracoclavicular ligament and are thus inherently unstable, necessitating a lengthy healing period and ... ...

Abstract	Clavicle fractures are a common clinical problem that accounts for about 10% of all fractures. Cho's type II fractures compromise the integrity of the coracoclavicular ligament and are thus inherently unstable, necessitating a lengthy healing period and being associated with a high rate of nonunion or malunion. The lowering of these rates is largely dependent on restoring the stability of the distal clavicle. In our case report, a 60-year-old male came to the OPD with complaints of pain over the right shoulder for two days following a fall with his arm in an adducted position. He also complained of an inability to abduct the right shoulder beyond 45 degrees. A plain radiograph was done, which was suggestive of a right lateral end clavicle fracture with increased coracoclavicular distance compared to the uninvolved shoulder. He was taken up for surgery after routine laboratory investigations and pre-anaesthesia check-up and minimally invasive coracoclavicular ligament reconstruction was done using a semitendinosus autograft. Intra-operatively, both the conoid and trapezoid ligaments showed tears. A universal shoulder immobilizer was applied post-surgery and continued for six weeks. Pendular exercises of the shoulder were started as per tolerance, and the patient responded well to surgery.
Language	English
Publishing date	2022-12-20
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.32761
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Assessment of urban air quality from Twitter communication using self-attention network and a multilayer classification model

Kumbalaparambi, Thushara Sudheish / Menon, Ratish / Radhakrishnan, Vishnu P / Nair, Vinod P

Environ Sci Pollut Res. 2023 Jan., v. 30, no. 4 p.10414-10425

2023

Abstract: Social media platforms are one of the prominent new-age methods used by public for spreading awareness or drawing attention on an issue or concern. This study demonstrates how the twitter responses of public can be used for qualitative monitoring of air ... ...

Abstract	Social media platforms are one of the prominent new-age methods used by public for spreading awareness or drawing attention on an issue or concern. This study demonstrates how the twitter responses of public can be used for qualitative monitoring of air pollution in an urban area. Tweets discussing about air quality in Delhi, India, were extracted during 2019–2020 using a machine learning technique based on self-attention network. These tweets were cleaned, sorted, and classified into 3-class quality viz. poor air quality, good air quality, and noise or neutral tweets. The present study used a multilayer classification model with first layer as an embedding layer and second layer as bi-directional long-short term memory (BiLSTM) layer. A method was then devised for estimating PM₂.₅ concentration from the tweets using ‘spaCy’ similarity analysis of classified tweets and data extracted from Continuous Ambient Air Quality Monitoring Stations (CAAQMS) in Delhi for the study period. The accuracy of this estimation was found to be high (80–99%) for extreme air quality conditions (extremely good or severe) and lower during moderate variations in air quality. Application of this methodology depended on perceivable changes in air quality, twitter engagement, and environmental consciousness among public.
Keywords	air pollution ; air quality ; consciousness ; neural networks ; urban areas ; India
Language	English
Dates of publication	2023-01
Size	p. 10414-10425.
Publishing place	Springer Berlin Heidelberg
Document type	Article ; Online
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-022-22836-w
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Article: Intraoperative Identification and Mosaicplasty in a Case of Femur Subchondral Osteoid Osteoma.

Patil, Vishal S / Aggarwal, Rishabh / Gupta, Archit / Kumar, Sushant / Nair, Vinod

Cureus

2023 Volume 15, Issue 10, Page(s) e47393

Abstract: Osteoid osteomas (OOs) are non-malignant primary bone abnormalities marked by a central nidus surrounded by reactive sclerosis. They typically manifest as aggravated nocturnal pain that responds to non-steroidal anti-inflammatory drugs (NSAIDs). These ... ...

Abstract	Osteoid osteomas (OOs) are non-malignant primary bone abnormalities marked by a central nidus surrounded by reactive sclerosis. They typically manifest as aggravated nocturnal pain that responds to non-steroidal anti-inflammatory drugs (NSAIDs). These growths are most frequently found within the intracortical bone and the diaphysis of elongated bones. Within the realm of uncommon conditions, intra-articular OOs (IAOOs) exhibit distinctive presentations, often leading to postponed or inaccurate diagnoses. We present a patient with OO at the distal femur, accessible through the knee joint, which was intraoperatively identified and localized using a
Language	English
Publishing date	2023-10-20
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.47393
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Article: A Case of Chronic Rupture of Achilles Tendon Managed Using a Combination of Multiple Surgical Techniques.

Nair, Vinod / Solunke, Swaroop / Patil, Vishal S / Jawa, Satyam / Abhyankar, Rushikesh

Cureus

2023 Volume 15, Issue 4, Page(s) e37171

Abstract: Achilles tendon rupture is a common injury that occurs due to sudden dorsiflexion of the plantar-flexed foot. Both acute and chronic ruptures are frequently misdiagnosed and mistreated. Acute Achilles tendon rupture commonly occurs in middle-aged ... ...

Abstract	Achilles tendon rupture is a common injury that occurs due to sudden dorsiflexion of the plantar-flexed foot. Both acute and chronic ruptures are frequently misdiagnosed and mistreated. Acute Achilles tendon rupture commonly occurs in middle-aged individuals (30-40 years). Although several operative procedures are available for Achilles tendon repair, the management of choice remains controversial and debatable. A 27-year-old male came to our clinic complaining of pain over the left ankle for the last five months. History revealed trauma caused by a heavy metal object five months ago. Physical examination revealed tenderness and swelling over the left heel. Ankle plantar flexion was restricted, and painful and squeeze test was positive. Magnetic resonance imaging was suggestive of a tear of the Achilles tendon in the left ankle. Surgical management was done with multiple techniques which included flexor hallucis longus tendon graft augmentation, end-to-end suturing (Krackow technique), V-Y plasty, and bioabsorbable suture anchor. Although complications such as scar stiffness and wound gaping are common in such cases, the postoperative outcome was excellent in our case according to the American Orthopedic Foot and Ankle Score.
Language	English
Publishing date	2023-04-05
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.37171
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Article ; Online: Impact of Biotin Supplementation on Human Chorionic Gonadotropin Immunoassays Utilizing Biotin-Streptavidin Binding Methods in Urine.

Goodrum, Jenna M / Nair, Vinod S / Moore, Chad / Crouch, Andre K / Eichner, Daniel / Miller, Geoffrey D

Clinical chemistry

2023 Volume 69, Issue 7, Page(s) 754–762

Abstract: Background: Human chorionic gonadotropin (hCG) detection is indicative of pregnancy and can be indicative of some forms of cancerous tumors. The hCG drug itself, however, is a performance enhancing substance used by male athletes to increase ... ...

Abstract	Background: Human chorionic gonadotropin (hCG) detection is indicative of pregnancy and can be indicative of some forms of cancerous tumors. The hCG drug itself, however, is a performance enhancing substance used by male athletes to increase testosterone production. Antidoping testing for hCG is conducted in urine, often on immunoanalyzer platforms, many of which utilize biotin-streptavidin dependent immunoassays in which the presence of biotin in samples is a known confounding factor. While biotin interference in serum has been well-studied, the extent of biotin interference in urine has not. Methods: Ten active male individuals underwent a 2-week hCG administration protocol concurrent with supplementation with biotin (20 mg/day) or placebo. Urine and serum samples were collected throughout the study and analyzed for hCG and biotin concentrations. Results: Urinary biotin levels in the hCG + biotin group increased 500-fold over baseline and 29-fold over corresponding serum biotin levels after biotin supplementation. When using a biotin-dependent immunoassay, the hCG + placebo group produced hCG-positive results (hCG ≥ 5 mIU/mL) in 71% of urine samples, while the hCG + biotin group produced positive results in only 19% of samples. Both groups had elevated hCG values in serum measurements by a biotin-dependent immunoassay and in urine when using a biotin-independent immunoassay. Urinary hCG measurements and biotin levels from the hCG + biotin group showed a negative correlation (Spearman r = -0.46, P < 0.0001) when measured using a biotin-dependent immunoassay. Conclusions: Biotin supplementation can severely suppress urinary hCG values in assays utilizing biotin-streptavidin binding methods and therefore these types of assays are not recommended for use in urine samples containing high levels of biotin. Clinicaltrials.gov Registration Number: NCT05450900.
MeSH term(s)	Pregnancy ; Female ; Humans ; Male ; Streptavidin ; Biotin ; Chorionic Gonadotropin ; Immunoassay/methods ; Dietary Supplements
Chemical Substances	Streptavidin (9013-20-1) ; Biotin (6SO6U10H04) ; Chorionic Gonadotropin
Language	English
Publishing date	2023-05-29
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80102-1
ISSN	1530-8561 ; 0009-9147
ISSN (online)	1530-8561
ISSN	0009-9147
DOI	10.1093/clinchem/hvad060
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Article ; Online: Assessment of urban air quality from Twitter communication using self-attention network and a multilayer classification model.

Kumbalaparambi, Thushara Sudheish / Menon, Ratish / Radhakrishnan, Vishnu P / Nair, Vinod P

Environmental science and pollution research international

2022 Volume 30, Issue 4, Page(s) 10414–10425

Abstract	Social media platforms are one of the prominent new-age methods used by public for spreading awareness or drawing attention on an issue or concern. This study demonstrates how the twitter responses of public can be used for qualitative monitoring of air pollution in an urban area. Tweets discussing about air quality in Delhi, India, were extracted during 2019-2020 using a machine learning technique based on self-attention network. These tweets were cleaned, sorted, and classified into 3-class quality viz. poor air quality, good air quality, and noise or neutral tweets. The present study used a multilayer classification model with first layer as an embedding layer and second layer as bi-directional long-short term memory (BiLSTM) layer. A method was then devised for estimating PM
MeSH term(s)	Humans ; Social Media ; Air Pollution/analysis ; Communication ; India
Language	English
Publishing date	2022-09-08
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-022-22836-w
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Article ; Online: Scanning Electron Microscopy.

Fischer, Elizabeth R / Hansen, Bryan T / Nair, Vinod / Hoyt, Forrest H / Schwartz, Cindi L / Dorward, David W

Current protocols

2024 Volume 4, Issue 5, Page(s) e1034

Abstract: Scanning electron microscopy (SEM) remains distinct in its ability to allow topographical visualization of structures. Key elements to consider for successful examination of biological specimens include appropriate preparative and imaging techniques. ... ...

Abstract	Scanning electron microscopy (SEM) remains distinct in its ability to allow topographical visualization of structures. Key elements to consider for successful examination of biological specimens include appropriate preparative and imaging techniques. Chemical processing induces structural artifacts during specimen preparation, and several factors need to be considered when selecting fixation protocols to reduce these effects while retaining structures of interest. Particular care for proper dehydration of specimens is essential to minimize shrinkage and is necessary for placement under the high-vacuum environment required for routine operation of standard SEMs. Choice of substrate for mounting and coating specimens can reduce artifacts known as charging, and a basic understanding of microscope settings can optimize parameters to achieve desired results. This article describes fundamental techniques and tips for routine specimen preparation for a variety of biological specimens, preservation of labile or fragile structures, immune-labeling strategies, and microscope imaging parameters for optimal examination by SEM. © 2024 The Authors. Current Protocols published by Wiley Periodicals LLC. Basic Protocol 1: Chemical preparative techniques for preservation of biological specimens for examination by SEM Alternate Protocol 1: Practical considerations for the preparation of soft tissues Alternate Protocol 2: Removal of debris from the exoskeleton of invertebrates Alternate Protocol 3: Fixation of colonies grown on agar plates Alternate Protocol 4: Stabilization of polysaccharide structures with alcian blue and lysine Alternate Protocol 5: Preparation of non-adherent particulates in solution for SEM Support Protocol 1: Application of thin layer of adhesive on substrate to improve adherence Support Protocol 2: Poly-L-lysine coating specimen substrates for improved adherence Support Protocol 3: Microwave processing of biological specimens for examination by SEM Basic Protocol 2: Critical point drying of specimens Alternate Protocol 6: Chemical alternative to critical point drying Basic Protocol 3: Sputter coating Alternate Protocol 7: Improved bulk conductivity through "OTOTO" Basic Protocol 4: Immune-labeling strategies Alternate Protocol 8: Immune-labeling internal antigens with small gold probes Alternate protocol 9: Quantum dot or fluoronanogold preparations for correlative techniques Basic Protocol 5: Exposure of internal structures by mechanical fracturing Basic Protocol 6: Exposure of internal structures of tissues by fracturing with liquid nitrogen Basic Protocol 7: Anaglyph production from stereo pairs to produce 3D images.
MeSH term(s)	Microscopy, Electron, Scanning/methods ; Specimen Handling/methods ; Animals
Language	English
Publishing date	2024-05-08
Publishing country	United States
Document type	Journal Article
ISSN	2691-1299
ISSN (online)	2691-1299
DOI	10.1002/cpz1.1034
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Article ; Online: Prevalence of carboxy-Δ

Nair, Vinod S / Heybroek, Mari / Boyle, Emily / Rogers, Mason / Campbell, Thane / Eichner, Daniel / Hill, Kevin

Drug testing and analysis

2024

Abstract: ... ...

Abstract	Δ
Language	English
Publishing date	2024-01-04
Publishing country	England
Document type	Journal Article
ZDB-ID	2462336-2
ISSN	1942-7611 ; 1942-7603
ISSN (online)	1942-7611
ISSN	1942-7603
DOI	10.1002/dta.3631
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Article: Ovarian Ligament Plication as a Treatment for Patient with Elongated Ovarian Ligament with Recurrent Abdominal Pain in the Absence of Ovarian Torsion.

Rai, Rakhi / Roy, Kallol Kumar / Zangmo, Rinchen / Nair, Vinod / Jain, Aayush

Gynecology and minimally invasive therapy

2022 Volume 11, Issue 4, Page(s) 250–252

Abstract: Elongated ovarian ligament can lead to adnexal torsion. Several cases of ovarian torsion have been reported where the ovarian ligament was elongated, and ovarian detorsion and ovarian ligament plication were done. In our case, a young girl presented with ...

Abstract	Elongated ovarian ligament can lead to adnexal torsion. Several cases of ovarian torsion have been reported where the ovarian ligament was elongated, and ovarian detorsion and ovarian ligament plication were done. In our case, a young girl presented with recurrent left lower abdominal pain, especially after exercise, with normal ovaries found on ultrasound. Laparoscopy was performed given recurrent pelvic pain and found elongated left ovarian ligament with normal ovaries. Considering the possibility of recurrent torsion and detorsion of the ovary due to elongated left ovarian ligament, left ovarian ligament plication was done. The patient remained pain-free till 1 year of follow-up. No such case has been reported in the literature where the ovarian ligament plication was performed without torsion. Hence, elongated ovarian ligament could cause recurrent pelvic pain due to possible torsion, and a simple, easy procedure of ovarian ligament plication can help relieve pain.
Language	English
Publishing date	2022-10-07
Publishing country	India
Document type	Case Reports
ZDB-ID	2696587-2
ISSN	2213-3070
ISSN	2213-3070
DOI	10.4103/gmit.gmit_78_21
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Article ; Online: δ

Nair, Vinod S / Howa, John D / Morrison, Matthew S / Beggs, Lacey / Campbell, Thane / Fedoruk, Matthew / Ahrens, Brian / Eichner, Daniel

Drug testing and analysis

2023 Volume 15, Issue 11-12, Page(s) 1356–1360

Abstract: 19-Norandrosterone (19NA) is the preferred urinary target compound to identify doping with nandrolone or related 19-norsteroids. At concentrations between 2.5 and 15 ng/mL, isotope ratio mass spectrometry (IRMS) is required to establish exogenous origin ... ...

Abstract	19-Norandrosterone (19NA) is the preferred urinary target compound to identify doping with nandrolone or related 19-norsteroids. At concentrations between 2.5 and 15 ng/mL, isotope ratio mass spectrometry (IRMS) is required to establish exogenous origin of urinary 19NA. An absolute difference of 3‰ between urinary 19NA and an endogenous reference compound (ERC) constitutes a finding for exogenous origin of 19NA. Over the last 3 years, 77 samples containing urinary 19NA between 2.5 and 15 ng/mL were analyzed at our laboratory. The measured δ
MeSH term(s)	Swine ; Male ; Humans ; Animals ; Gas Chromatography-Mass Spectrometry/methods ; Estranes/analysis ; Carbon Isotopes/analysis ; Meat/analysis
Chemical Substances	19-norandrosterone (5W4XKU708V) ; Estranes ; Carbon Isotopes
Language	English
Publishing date	2023-03-27
Publishing country	England
Document type	Journal Article
ZDB-ID	2462336-2
ISSN	1942-7611 ; 1942-7603
ISSN (online)	1942-7611
ISSN	1942-7603
DOI	10.1002/dta.3470
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