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  1. Article ; Online: Predicting roles of IL-27 and IL-32 in determining the severity and outcome of COVID-19.

    Zamani, Batool / Najafizadeh, Maedeh / Motedayyen, Hossein / Arefnezhad, Reza

    International journal of immunopathology and pharmacology

    2022  Volume 36, Page(s) 3946320221145827

    Abstract: Objective: Immune changes play fundamental roles in the pathogenesis and severity of coronavirus disease 2019 (COVID-19). Previous studies have revealed alterations in immune responses of patients with non-severe and severe COVID-19. Therefore, this ... ...

    Abstract Objective: Immune changes play fundamental roles in the pathogenesis and severity of coronavirus disease 2019 (COVID-19). Previous studies have revealed alterations in immune responses of patients with non-severe and severe COVID-19. Therefore, this study investigated whether interleukin-27 (IL-27) and interleukin-32 (IL-32) levels may be considered as predicting factors for determining the severity and outcome of COVID-19.
    Methods: The blood samples were collected from 50 non-severe and severe patients infected with COVID-19 and 25 healthy subjects. The serum samples were isolated from the whole blood. The levels of IL-27 and IL-32 were measured by enzyme-linked immunosorbent assay and percentages of some immune cells were studied by cell counter.
    Results: The levels of IL-27 and IL-32 were significantly higher in COVID-19 patients than healthy subjects (
    Conclusion: Change in IL-27 level along with the frequencies of some immune cells may serve as a predictor of the severity and outcome of COVID-19.
    MeSH term(s) Humans ; Interleukin-27 ; COVID-19/therapy
    Chemical Substances Interleukin-27
    Language English
    Publishing date 2022-12-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 645171-8
    ISSN 2058-7384 ; 0394-6320
    ISSN (online) 2058-7384
    ISSN 0394-6320
    DOI 10.1177/03946320221145827
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Blood culture-negative infective endocarditis presenting with atypical dermatologic manifestation: A rare case report and review of the literature.

    Najafizadeh, Maedeh / Dashti, Fatemeh / Pahlevani, Hamed / Kamalizad, Farzad / Mirazimi, Seyed Mohammad Ali

    Clinical case reports

    2023  Volume 11, Issue 6, Page(s) e7027

    Abstract: Infective endocarditis (IE) rarely presents with cutaneous manifestations due to earlier diagnosis and treatment. We present a case of middle-aged male patient presenting with an erythematous papular rash in the upper extremities and left knee, further ... ...

    Abstract Infective endocarditis (IE) rarely presents with cutaneous manifestations due to earlier diagnosis and treatment. We present a case of middle-aged male patient presenting with an erythematous papular rash in the upper extremities and left knee, further progressing into painful ulcers with crusted and necrotic center in the arms and fingers. These cutaneous lesions were further followed by shaking chills and fever, which brought the patient to our hospital. Laboratory evaluation revealed elevated ESR (erythrocyte sedimentation rate) and C-reactive protein. Blood cultures taken were negative. Biopsy of the skin lesions were consistent with cutaneous leukocytoclastic vasculitis, and the gram smear revealed gram-positive cocci. The patient developed dyspnea and chest pain, which raised suspicion for IE. TEE (transesophageal echocardiography) demonstrated mild LV diastolic dysfunction, 1+ tricuspid valve regurgitation, mild mitral regurgitation, and vegetation-like lesions on the surface of mitral valve leaflets, consequently IE was confirmed. In conclusion, clinicians must look carefully for skin manifestations in cases with high likelihood of IE, even when other typical symptoms are absent.
    Language English
    Publishing date 2023-05-30
    Publishing country England
    Document type Case Reports
    ZDB-ID 2740234-4
    ISSN 2050-0904
    ISSN 2050-0904
    DOI 10.1002/ccr3.7027
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Association between hypertension and clinical outcomes in COVID-19 patients: a case-controlled study.

    Aslanbeigi, Fatemeh / Rahimi, Habiballah / Malekipour, Adeleh / Pahlevani, Hamed / Najafizadeh, Maedeh / Ehteram, Hassan / Izadpanah, Fatemeh / Haddad Kashani, Hamed

    Annals of medicine and surgery (2012)

    2023  Volume 85, Issue 7, Page(s) 3258–3263

    Abstract: The outbreak of coronavirus disease 2019 (COVID-19), which was originated from a severe acute respiratory syndrome-coronavirus-2 (SARS-COV-2) infection, has become an international public health emergency. The aim of this study was to assess the clinical ...

    Abstract The outbreak of coronavirus disease 2019 (COVID-19), which was originated from a severe acute respiratory syndrome-coronavirus-2 (SARS-COV-2) infection, has become an international public health emergency. The aim of this study was to assess the clinical symptoms and physical findings in both hypertensive and nonhypertensive patients infected with COVID-19.
    Methods: A retrospective observational case-control study with diagnosis of COVID-19 by laboratory-confirmed test was conducted on 280 consecutive unselected patients. This was a single-center study. The demographics, laboratory, and clinical findings data were extracted from the hospital registry database.
    Results: Of our 280 patients in the study, there were 149 men (53%) and 138 (50%) were older than 60 years (mean=67.75), and also 50 in-hospital deaths occurred (mortality rate, 17%). Total 19(6.9%) were taking opioid, and smoking. There were no significant differences in the rate of fever, cough, sputum production, gastrointestinal symptoms, myalgia, and headache in the both hypertensive and nonhypertensive groups. The prevalence of underlying diseases was significantly higher in older patients in comparison with younger ones (
    Conclusion: Hypertension is associated with a poor prognosis and higher mortality among COVID-19 patients. Optimizing blood pressure is essential during the management of COVID-19. Our research implies the importance of early care and education of old patient with hypertension and other comorbidities.
    Language English
    Publishing date 2023-06-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 2745440-X
    ISSN 2049-0801
    ISSN 2049-0801
    DOI 10.1097/MS9.0000000000000391
    Database MEDical Literature Analysis and Retrieval System OnLINE

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