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Article ; Online: Immunohistochemical Study of MDM2 Expression in Odontogenic Keratocyst and Dentigerous Cyst

Najmeh Jafari / Seyed Hoseein Tabatabaei / Fatemeh Kerdegari

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd, Vol 31, Iss 9, Pp 7022-

2023 Volume 7029

Abstract: Introduction: Dentigerous cyst and odontogenic keratocyst (OKC) are two of the most common developmental odontogenic cysts. Different developmental mechanism and biological behavior of OKC is due to unknown factors inherent in the epithelium or enzymatic ...

Abstract	Introduction: Dentigerous cyst and odontogenic keratocyst (OKC) are two of the most common developmental odontogenic cysts. Different developmental mechanism and biological behavior of OKC is due to unknown factors inherent in the epithelium or enzymatic activity in the wall. P53 plays a role in determining the pathways for DNA repair، apoptosis، angiogenesis and genomic stability and is negatively confronted with the MDM2 oncoprotein. Aim of this study was to evaluate the expression of MDM2 as an important indicator of proliferation and cell cycle regulation in OKC and dentigerous cyst. Methods: In this descriptive-cross-sectional study، MDM2 expression in the suprabasal and basal epithelium regions of 15 samples from each of the dentigerous cysts and OKC was assessed using immunohistochemistry. Finally، the data were entered into the SPSS16 software and analyzed using the t-test. Results: MDM2 expression in the suprabasal and basal epithelium regions in OKC was higher than dentigerous cyst، but there was not seen a statically significant difference (P: 0.551)، (P: 0.825). The expression level of this marker in both groups in the suprabasal region was significantly higher than the basal region (P: 0.005)، (P: 0.004). Conclusion: Higher expression of MDM2 in OKC، especially in the suprabasal areas، could indicate a secondary role of this protein in the pathogenesis، growth and spread of this cyst and the proliferation، apoptosis and differentiation processes confirm the neoplastic nature and specific biological behavior of this lesion.
Keywords	mdm2 ; dentigerous cyst ; odontogenic keratocyst ; Medicine (General) ; R5-920
Language	Persian
Publishing date	2023-12-01T00:00:00Z
Publisher	Shahid Sadoughi University of Medical Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Evaluation of Mast Cell Density in Mucoepidermoid Carcinoma and Pleomorphic Adenoma

Azadeh Jalili / Najmeh Jafari / Seyed Hosein Tabatabaei

Journal of Dentistry, Vol 24, Iss 2, Pp 245-

2023 Volume 249

Abstract: Statement of the Problem: Mast cells are round to elliptical cells that originate from bone marrow stem cells and enter the peripheral blood. By releasing inflammatory mediators, these cells are involved in type I hypersensitivity, wound healing, defense ...

Abstract	Statement of the Problem: Mast cells are round to elliptical cells that originate from bone marrow stem cells and enter the peripheral blood. By releasing inflammatory mediators, these cells are involved in type I hypersensitivity, wound healing, defense against pathogens, increased blood vessel formation, and destruction of the extracellular matrix. There are contradictory results regarding the role of mast cells in tumor lesions.Purpose: Considering the contradictory results and few studies on the density of mast cells in salivary tumors, the present study investigated and compared the density of mast cells in two common salivary gland tumors.Materials and Method: In the cross-sectional study after reviewing the records of patients referred to the Pathology Department of the School of Dentistry and Shahid Sadoughi Hospital in Yazd, 15 blocks of each of the mucoepidermoid carcinoma and pleomorphic adenoma tumors were taken. After Giemsa staining of the samples, the average of stained cells in 10 random fields under 400× magnification was counted. The results were analyzed using statistical tests of t-test, ANOVA, Chi-square, and Mann-Whitney in SPSS ver. 22.Results: The average mast cell counts in pleomorphic adenoma (4.2) was higher than muco-epidermoid carcinoma (1.7) but there was no significant relationship (p= 0.305). In mucoepidermoid carcinoma, the numbers of mast cells increased with increasing tumor grade (low: 0/467 moderate: 1/567 high: 2/983) and there was a significant relationship (p= 0.009).Conclusion: According to the results of the present study, it seems that the mast cells accumulation may be secondarily associated with inflammatory responses due to cell accumulation and tissue destruction by tumor cells.
Keywords	mast cells ; carcinoma mucoepidermoid ; adenoma pleomorphic ; Medicine ; R ; Dentistry ; RK1-715
Subject code	616
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	Shiraz University of Medical Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The Relationship between Pender's Health Promotion Model Constructs and Applying Nutritional Supplements in Patients with Hypertension

Parastoo . Golshiri / Arash Najimi / Najmeh Jafari

مجله دانشکده پزشکی اصفهان, Vol 38, Iss 597, Pp 798-

2021 Volume 803

Abstract: Background: This study aimed to investigate the relationship between Pender's Health Promotion Model constructs and applying nutritional supplements in patients with hypertension in rural areas of Isfahan Township, Iran. Methods: In a cross-sectional ... ...

Abstract	Background: This study aimed to investigate the relationship between Pender's Health Promotion Model constructs and applying nutritional supplements in patients with hypertension in rural areas of Isfahan Township, Iran. Methods: In a cross-sectional study, 233 patients with high blood pressure were selected from rural health centers in Isfahan Township. Patient’s dietary intake was assessed by a 3-day dietary questionnaire, and cognitive factors and a commitment to nutritional approach with Pender Health Promotion Model. The relationship between dietary intake and nutritional approach was studied as well. Findings: There was an inverse and significant relationship of 0.316 between sodium intake and knowledge (P < 0.001). Moreover, there was a significant negative correlation of 0.121 between the benefit score and the sodium intake (P = 0.002), but no relationship between other criteria (perceived self-efficacy, behavioral sensation, status affecting, and social support) and sodium intake. Conclusion: The findings of this study showed that there was a significant relationship between Pender Health Promotion Model and nutritional approaches for controlling blood pressure. Therefore, it is recommended to use Pender Health Promotion Components in health units associated with hypertension.
Keywords	health promotion ; blood pressure ; dietary supplements ; sodium ; dietary ; Medicine ; R ; Medicine (General) ; R5-920
Language	Persian
Publishing date	2021-01-01T00:00:00Z
Publisher	Vesnu Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Knowledge, Attitude and Practice of Dental Students in Yazd University of Dental School about HIV and Hepatitis in 2019-2020

Najmeh Jafari / Mohammad Hassan Akhavan karbassi / Seyed Hossein Tabatabaei / Farzaneh Sadeghi

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd, Vol 31, Iss 8, Pp 6900-

2023 Volume 6911

Abstract: ... Author: Najmeh Jafari View Orcid in Profile You can search for this author in PubMed Google Scholar ...

Abstract	Introduction: Healthcare workers, including dental students are at risk of transmission of blood-borne infections like Hepatitis and AIDS because of their continuous contact with blood and other body fluids. Thus it is necessary for them to achieve enough knowledge, proper attitude and right behavior regarding to these diseases through efficient training so they can treat infected patients, which is their ethical and legal duty. The present study was designed to evaluate knowledge, attitude and practice of dental students in School of Dentistry, Shahid Sadoughi University of Medical Sciences about HIV and Hepatitis in 2019-2020. Methods: This observational-descriptive cross-sectional study was conducted on 188 4th, 5th and 6th year dental students of Yazd Faculty of Dentistry, 170 of whom completed the questionnaire. Data were collected using a researcher-made questionnaire including two parts of demographic information and knowledge, attitude and performance questions; data were analyzed using T-Test, ANOVA and chi-score tests and SPSS version 16. Results: The mean score of knowledge, attitude and practice regarding hepatitis and AIDS was 20/77 (out of 30), 32/04 (out of 45) and 46/17 (out of 52), respectively. The students had low knowledge level about prophylaxis treatments after needlestick injuries and screening tests. They also had poor attitude towards treating the infected patients. There was a significant difference in practice between males and females. (P-value<0.05). Conclusion: Dental students performed well in relation to hepatitis and AIDS diseases despite their average knowledge and attitude. Thus there should be an emphasis on knowledge improvement and attitude alternation in Yazd Faculty of Dentistry. Corresponding Author: Najmeh Jafari View Orcid in Profile You can search for this author in PubMed Google Scholar Profile
Keywords	dental students ; hepatitis ; aids ; knowledge ; attitude and practice ; Medicine (General) ; R5-920
Subject code	670
Language	Persian
Publishing date	2023-11-01T00:00:00Z
Publisher	Shahid Sadoughi University of Medical Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Blood lead level in opium dependents and its association with anemia

Behrooz Hashemi Domeneh / Nader Tavakoli / Najmeh Jafari

Journal of Research in Medical Sciences, Vol 19, Iss 10, Pp 939-

A cross-sectional study from the capital of Iran

2014 Volume 943

Abstract: Background: Opium dependence is one of the most challenging health problems in the developing countries as well as Iran. Among several health problems due to opium dependence, there are limited reports indicating the presence of lead in opium. The aim of ...

Abstract	Background: Opium dependence is one of the most challenging health problems in the developing countries as well as Iran. Among several health problems due to opium dependence, there are limited reports indicating the presence of lead in opium. The aim of this study is to investigate the blood lead level (BLL) in oral and inhalational opium dependents and its association with anemia. Materials and Methods: A cross-sectional study was done among 86 opium dependent patients who were referred to five large detoxification centers in Tehran city and 48 healthy individuals. BLL was assessed using the atomic absorption spectrometry technique. Multivariate analysis of variance and binary logistic regression analysis were performed for statistical assessment using SPSS version 18 for Windows. Results: The highest BLL was detected in oral opium dependent group (mean = 11.75, standard deviation (SD) = 6.06) in comparison to inhalational opium dependent group (mean = 7.07, SD = 3.61) and healthy control group (mean = 6.05, SD = 1.83). Anemia was detected in 38% of oral-opium dependent and 43% of inhalational-opium dependent group. Age (odds ratio (OR): 1.06, 95% confidence interval (CI): 1.03-1.09) and opium dependence (OR: 3.59, 95% CI: 1.69-7.59) were significant predictors of anemia in these patients (P < 0.001). Conclusion: The results of this study confirmed the higher BLL in opium dependents, especially with an oral form of consumption.
Keywords	Anemia ; blood lead level ; Iran ; opium dependent ; Medicine ; R
Subject code	796
Language	English
Publishing date	2014-01-01T00:00:00Z
Publisher	Wolters Kluwer Medknow Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Mental health of medical students in different levels of training

Najmeh Jafari / Amir Loghmani / Ali Montazeri

International Journal of Preventive Medicine, Vol 3, Iss 13, Pp 107-

2012 Volume 112

Abstract: Objectives: Medical education and training can directly contribute to the development of psychological distress in medical students. This can lead to catastrophic consequences such as impaired academic performance, impaired competency, medical errors and ...

Abstract	Objectives: Medical education and training can directly contribute to the development of psychological distress in medical students. This can lead to catastrophic consequences such as impaired academic performance, impaired competency, medical errors and attrition from medical school. This study aimed to assess the prevalence of psychological morbidity among Iranian medical students. Methods: This was a cross-sectional study. Samples of medical students in different levels of training (basic science, clinical clerkship, internship, and residency stage) were entered into the study. The 12-item General Health Questionnaire (GHQ-12) was used to measure psychological morbidity. Both univariate and multivariate analyses were used to report on findings. Results: In all, 220 medical students were invited to take part in the study. Of these, 192 students agreed to fill in the questionnaire. The mean age of respondents was 25.4 (SD = 5.2) and 53% were female. Overall 49.5% of the students scored above the threshold on the GHQ-12 (score > 3.5). The results obtained from logistic regression analysis indicated that female gender and level of training were the most significant contributing factors to increased psychological distress [OR for female gender = 2.99; OR for the basic science group = 6.73]. Conclusions: Psychological distress appears to be common in medical students and significantly varies by gender and level of training. The psychological well-being of medical students needs to be more carefully addressed, and closer attention to eliminating the risk factors is critical to prevent consequent adverse outcomes.
Keywords	Mental health ; Medical students ; GHQ-12 ; Medicine ; R
Subject code	796
Language	English
Publishing date	2012-01-01T00:00:00Z
Publisher	Wolters Kluwer Medknow Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Weight gain during pregnancy in women attending a health center in Isfahan city, Iran

Ziba Farajzadegan / Davood Bahrami / Najmeh Jafari

International Journal of Preventive Medicine, Vol 3, Iss 10, Pp 682-

2012 Volume 686

Abstract: Background: Body mass index (BMI) before pregnancy and weight gaining during pregnancy affect infant birth weight and are associated with unfavorable pregnancy outcomes. The aim of this study was to describe the weight gain pattern of Iranian pregnant ... ...

Abstract	Background: Body mass index (BMI) before pregnancy and weight gaining during pregnancy affect infant birth weight and are associated with unfavorable pregnancy outcomes. The aim of this study was to describe the weight gain pattern of Iranian pregnant women according to the BMI status at the beginning of pregnancy. Methods: This was a longitudinal cross sectional study. A total of 500 pregnant women in 6th-10th weeks of pregnancy were enrolled and followed up through delivery. Body mass index categories based on first visit weight and total weight gain were calculated. The multiple analysis of variance (MANOVA) was used to compare the mean values of gestational weight gain. Results: At the first care, those with underweight, normal, overweight and obese accounted for 10.7%, 46%, 35.9% and 7.4% of all participating women, respectively. Most of the subjects were in normal range of BMI (46%) at the beginning of the study. As BMI was more at the first visit, the recommended amount of weight gain was less achievable (70% versus 27%). Although the average weight gain in obese women was less than other groups (9±7.9), about 55% of them were over the recommended standards of weight gain. Conclusion: In conclusion, in spite of frequent visits during pregnancy, only half of pregnant women had normal weight gain and most of them had normal BMI at the first visit. This study highlights the importance of considering women with abnormal pre pregnancy BMI and gestational weight gain at an increased risk and providing appropriate care for them to prevent future adverse outcomes.
Keywords	BMI ; Iran ; pregnancy ; weight gain ; Medicine ; R
Subject code	796
Language	English
Publishing date	2012-01-01T00:00:00Z
Publisher	Wolters Kluwer Medknow Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Surveillance system for hepatitis C infection

Najmeh Jafari / Ziba Farajzadegan / Behrooz Ataei

International Journal of Preventive Medicine, Vol 3, Iss 13, Pp 48-

A practical approach

2012 Volume 57

Abstract: Hepatitis C virus (HCV) infection is a serious public health concern throughout the world. Despite its public health prominence, however, how surveillance systems for hepatitis C should be designed is still a challenging issue especially in developing ... ...

Abstract	Hepatitis C virus (HCV) infection is a serious public health concern throughout the world. Despite its public health prominence, however, how surveillance systems for hepatitis C should be designed is still a challenging issue especially in developing countries such as Iran. Establishing a surveillance system needs an ongoing process of case investigation, data collection, analysis of data and also dissemination of data to public health professionals and health care providers. This review article tries to provide the best recommendations for planning and implantation a surveillance system for HCV infection.
Keywords	Epidemiology ; Hepatitis C infection ; Iran ; surveillance system ; Medicine ; R
Language	English
Publishing date	2012-01-01T00:00:00Z
Publisher	Wolters Kluwer Medknow Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Micro-leakage of a Fissure Sealant Cured Using Quartz-tungsten-halogen and Plasma Arc Light Curing Units

Zahra Bahrololoomi / Ali Asghar Soleimani / Najmeh Jafari / Bentolhoda Varkesh

Journal of Dental Research, Dental Clinics, Dental Prospects, Vol 8, Iss 4, Pp 252-

2014 Volume 255

Abstract: Background and aims. Newer curing units such as plasma arc can polymerize the sealants in much shorter curing times. The aim of this study was to compare the effect of two different curing units on the micro-leakage of a fissure sealant material. ... ...

Abstract	Background and aims. Newer curing units such as plasma arc can polymerize the sealants in much shorter curing times. The aim of this study was to compare the effect of two different curing units on the micro-leakage of a fissure sealant material. Materials and methods. Sixty two extracted premolars without caries were randomly divided into two groups of 31 samples. Occlusal surfaces of all teeth were cleansed. Then, teeth surfaces were etched by 37% phosphoric acid. After rinsing and drying, occlusal surfaces of teeth were sealed by a fissure sealant. The sealant was then cured using either a halogen light curing unit or a plasma arc curing light. After sealing, the teeth were thermocycled for 500 cycles. The teeth were then sectioned and examined for micro-leakage. Statistical analyses were performed with Mann-Whitney test. Results. There was no significant difference between two groups regarding micro-leakage (P = 0.42). Conclusion. Results showed that there was no significant difference between two different curing units. Therefore, plasma arc unit might be a useful alternative for sealant polymerization.
Keywords	Dental leakage ; fissure sealants ; polymerization ; Dentistry ; RK1-715 ; Medicine ; R
Subject code	540
Language	English
Publishing date	2014-12-01T00:00:00Z
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Spiritual Well-Being and Quality of Life of Iranian Adults with Type 2 Diabetes

Najmeh Jafari / Ziba Farajzadegan / Amir Loghmani / Mansoureh Majlesi / Noushin Jafari

Evidence-Based Complementary and Alternative Medicine, Vol

2014 Volume 2014

Keywords	Medicine (General) ; R5-920 ; Medicine ; R ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
Language	English
Publishing date	2014-01-01T00:00:00Z
Publisher	Hindawi Publishing Corporation
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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