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  1. AU="Nakae, Mami"
  2. AU="Blake, Christine E"
  3. AU=Pareek Anil
  4. AU="Shokrollahi, Mitra"
  5. AU="Charles?Luce"
  6. AU="Denadai, Rafael"
  7. AU="Ambrosino, Teresa"
  8. AU=Antipova Tatiana
  9. AU="Moens, Pierre D J"
  10. AU="Abdel-Megied, Ahmed M."
  11. AU="Jain, Aseem"
  12. AU="Marcos, Jose F"
  13. AU="Furr-Stimming, Erin"
  14. AU="Schüle, Birgit"
  15. AU="Travieso-González, Alejandro"
  16. AU=Turilli Emily Samuela
  17. AU="Rueckert, Erroll H"
  18. AU=Keestra-Gounder A. Marijke
  19. AU="María José Endara"
  20. AU="Li, Lin-Zi"
  21. AU="Shirvanian, Moein"
  22. AU="Capaldo, Bianca D"
  23. AU="Matose, Takunda"
  24. AU=Plouffe Brian D.
  25. AU=Kuter David J
  26. AU="Moore, I D"
  27. AU="Schreibing, Felix"
  28. AU=Kang Keunsoo
  29. AU="de Pedro-Múñez, Álvaro"

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  1. Artikel ; Online: Study of post-opening stability of active ingredients in hand sanitizers.

    Kobayashi, Ryo / Murai, Ryosei / Sato, Yuki / Nakae, Mami / Nirasawa, Shinya / Asanuma, Koichi / Kuronuma, Koji / Takahashi, Satoshi

    Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy

    2022  Band 28, Heft 12, Seite(n) 1605–1609

    Abstract: Introduction: Hand disinfection plays an important role in infection control. Currently, hand sanitizers containing ethanol and chlorhexidine gluconate as active ingredients are widely used. Most of hand sanitizers have a defined expiration date for use. ...

    Abstract Introduction: Hand disinfection plays an important role in infection control. Currently, hand sanitizers containing ethanol and chlorhexidine gluconate as active ingredients are widely used. Most of hand sanitizers have a defined expiration date for use. However, there was no rule about the expiration date after opening defined with the evidence. Therefore, we examined the fluctuation of active ingredients and disinfection effect after opening the bottle.
    Method: Twelve hand sanitizers from 44 to 921 days after opening set in different places in the hospital were examined and unopened hand sanitizer used as a control. Chlorhexidine gluconate and ethanol of each samples were measured by high performance liquid chromatography and gas chromatography, respectively. The correlation between the concentration of each ingredient obtained and the number of days after opening, bottle weight, storage temperature and humidity was analyzed. A time-kill test based on ASTM E2315-03 was performed to confirm the actual disinfection effect.
    Results: It was observed that active ingredients had not been decreased up to 921 days after opening and were not affected by storage conditions after opening. In addition, a decrease of disinfection effect was not observed in any sample.
    Conclusions: We found that hand sanitizers do not need to be discard after a number of days have passed because the active ingredients are retained even after opening in it.
    Mesh-Begriff(e) Chlorhexidine/analogs & derivatives ; Chlorhexidine/pharmacology ; Ethanol/analysis ; Hand ; Hand Disinfection/methods ; Hand Sanitizers ; Humans
    Chemische Substanzen Hand Sanitizers ; Ethanol (3K9958V90M) ; chlorhexidine gluconate (MOR84MUD8E) ; Chlorhexidine (R4KO0DY52L)
    Sprache Englisch
    Erscheinungsdatum 2022-08-16
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 1355399-9
    ISSN 1437-7780 ; 1341-321X
    ISSN (online) 1437-7780
    ISSN 1341-321X
    DOI 10.1016/j.jiac.2022.08.012
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Pseudo-outbreak of

    Nagano, Yutaro / Kuronuma, Koji / Kitamura, Yasuo / Nagano, Kanami / Yabe, Hayato / Kudo, Sayaka / Sato, Toyotaka / Nirasawa, Shinya / Nakae, Mami / Horiuchi, Motohiro / Yokota, Shin-Ichi / Fujiya, Yoshihiro / Saito, Atsushi / Takahashi, Satoshi / Chiba, Hirofumi

    Infection control and hospital epidemiology

    2023  Band 44, Heft 11, Seite(n) 1809–1815

    Abstract: Background: Mycobacterium lentiflavum: Methods: Cases of : Results: Altogether, 22 isolates of : Conclusions: WGS analysis identified that the cause ... ...

    Abstract Background: Mycobacterium lentiflavum
    Methods: Cases of
    Results: Altogether, 22 isolates of
    Conclusions: WGS analysis identified that the cause of
    Mesh-Begriff(e) Humans ; Hospitals, General ; Japan/epidemiology ; Retrospective Studies ; Nontuberculous Mycobacteria ; Mycobacterium Infections, Nontuberculous/epidemiology ; Mycobacterium Infections, Nontuberculous/microbiology ; Water
    Chemische Substanzen Water (059QF0KO0R)
    Sprache Englisch
    Erscheinungsdatum 2023-04-25
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 639378-0
    ISSN 1559-6834 ; 0195-9417 ; 0899-823X
    ISSN (online) 1559-6834
    ISSN 0195-9417 ; 0899-823X
    DOI 10.1017/ice.2023.68
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel: Genotypes and transmission routes of noroviruses causing sporadic acute gastroenteritis among adults and children, Japan, 2015–2019

    Honjo, Saho / Kuronuma, Koji / Fujiya, Yoshihiro / Nakae, Mami / Ukae, Susumu / Nihira, Hiroshi / Yamamoto, Masaki / Akane, Yusuke / Kondo, Kenji / Takahashi, Satoshi / Kimura, Hirokazu / Tsutsumi, Hiroyuki / Kawasaki, Yukihiko / Tsugawa, Takeshi

    Infection, genetics, and evolution. 2022 Oct., v. 104

    2022  

    Abstract: Noroviruses (NoVs) are major causes of acute viral gastroenteritis at all ages worldwide. The molecular epidemiology of sporadic cases remains poorly understood, especially in adults. Additionally, no studies have analyzed the transmission route in ... ...

    Abstract Noroviruses (NoVs) are major causes of acute viral gastroenteritis at all ages worldwide. The molecular epidemiology of sporadic cases remains poorly understood, especially in adults. Additionally, no studies have analyzed the transmission route in sporadic acute gastroenteritis. In this study, we investigated cases of very mild sporadic NoV acute gastroenteritis in adults (medical staff) who do not visit the outpatient clinic and child outpatients. We also evaluated genotype differences between adults and children and possible transmission routes in adults during 5 years. The number of NoV positives were 58 in adults and 124 in children. In adults, the NoV positivity rate in this study was higher (64.4%) than that in previous reports of outpatients (10%) and inpatients (5%) in the United State. This finding suggested that the NoV positivity rate might be high in adults with very mild acute gastroenteritis. In adults, human-to-human transmission rates from children and food-borne transmission (raw oysters) were 21.6% (11/51) and 19.6% (10/51), respectively. Among adults, GII.2, GII.4, and GII.17 were the predominant genotypes, with rates of 32.7%, 30.9%, and 21.8%, respectively. Among children, GII.4 and GII.2 were the predominant genotypes, with rates of 45.5% and 40.6%, respectively. GII.17 was only detected in 0.8% (1/123) of children. Trends in NoV genotypes are expected to differ depending on the patient's age. Investigating sporadic cases including the patient's background (age and transmission route) may be helpful to monitor the trend of NoV strains, forecast prevalent NoV GII genotypes, and develop NoV vaccines.
    Schlagwörter Japan ; Norovirus ; children ; evolution ; genotype ; infection ; molecular epidemiology ; patients ; viral gastroenteritis
    Sprache Englisch
    Erscheinungsverlauf 2022-10
    Erscheinungsort Elsevier B.V.
    Dokumenttyp Artikel
    ZDB-ID 2037068-4
    ISSN 1567-1348
    ISSN 1567-1348
    DOI 10.1016/j.meegid.2022.105348
    Datenquelle NAL Katalog (AGRICOLA)

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  4. Artikel ; Online: Genotypes and transmission routes of noroviruses causing sporadic acute gastroenteritis among adults and children, Japan, 2015-2019.

    Honjo, Saho / Kuronuma, Koji / Fujiya, Yoshihiro / Nakae, Mami / Ukae, Susumu / Nihira, Hiroshi / Yamamoto, Masaki / Akane, Yusuke / Kondo, Kenji / Takahashi, Satoshi / Kimura, Hirokazu / Tsutsumi, Hiroyuki / Kawasaki, Yukihiko / Tsugawa, Takeshi

    Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases

    2022  Band 104, Seite(n) 105348

    Abstract: Noroviruses (NoVs) are major causes of acute viral gastroenteritis at all ages worldwide. The molecular epidemiology of sporadic cases remains poorly understood, especially in adults. Additionally, no studies have analyzed the transmission route in ... ...

    Abstract Noroviruses (NoVs) are major causes of acute viral gastroenteritis at all ages worldwide. The molecular epidemiology of sporadic cases remains poorly understood, especially in adults. Additionally, no studies have analyzed the transmission route in sporadic acute gastroenteritis. In this study, we investigated cases of very mild sporadic NoV acute gastroenteritis in adults (medical staff) who do not visit the outpatient clinic and child outpatients. We also evaluated genotype differences between adults and children and possible transmission routes in adults during 5 years. The number of NoV positives were 58 in adults and 124 in children. In adults, the NoV positivity rate in this study was higher (64.4%) than that in previous reports of outpatients (10%) and inpatients (5%) in the United State. This finding suggested that the NoV positivity rate might be high in adults with very mild acute gastroenteritis. In adults, human-to-human transmission rates from children and food-borne transmission (raw oysters) were 21.6% (11/51) and 19.6% (10/51), respectively. Among adults, GII.2, GII.4, and GII.17 were the predominant genotypes, with rates of 32.7%, 30.9%, and 21.8%, respectively. Among children, GII.4 and GII.2 were the predominant genotypes, with rates of 45.5% and 40.6%, respectively. GII.17 was only detected in 0.8% (1/123) of children. Trends in NoV genotypes are expected to differ depending on the patient's age. Investigating sporadic cases including the patient's background (age and transmission route) may be helpful to monitor the trend of NoV strains, forecast prevalent NoV GII genotypes, and develop NoV vaccines.
    Mesh-Begriff(e) Adult ; Caliciviridae Infections/epidemiology ; Child ; Feces ; Gastroenteritis/epidemiology ; Genotype ; Humans ; Japan/epidemiology ; Molecular Epidemiology ; Norovirus/genetics ; Phylogeny ; Prevalence
    Sprache Englisch
    Erscheinungsdatum 2022-08-08
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2037068-4
    ISSN 1567-7257 ; 1567-1348
    ISSN (online) 1567-7257
    ISSN 1567-1348
    DOI 10.1016/j.meegid.2022.105348
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel: [Four Cases of Bacteremia Caused by Helicobacter cinaedi in the Urological Ward at About the Same Time].

    Hiyama, Yoshiki / Takahashi, Satoshi / Nishiyama, Naotaka / Nakae, Mami / Fujii, Satoshi / Shinagawa, Masaaki / Masumori, Naoya

    Hinyokika kiyo. Acta urologica Japonica

    2017  Band 63, Heft 11, Seite(n) 461–463

    Abstract: Here we report the outbreak of bacteremia caused by Helicobacter cinaedi (H. cinaedi) in the urology ward. Case 1 was a man in his seventies with prostate cancer. Bacteremia caused by H. cinaedi developed 6 days after robot-assisted radical prostatectomy. ...

    Abstract Here we report the outbreak of bacteremia caused by Helicobacter cinaedi (H. cinaedi) in the urology ward. Case 1 was a man in his seventies with prostate cancer. Bacteremia caused by H. cinaedi developed 6 days after robot-assisted radical prostatectomy. Case 2 was a man in his sixties with small cell carcinoma of the prostate. Bacteremia developed at 5 days of docetaxel therapy. Case 3 was a man in his fifties with left renal pelvis carcinoma. Bacteremia developed 3 days after laparoscopic left nephroureterectomy. Case 4 was a man in his seventies with right renal pelvic carcinoma and bladder cancer. Bacteremia developed 22 days after laparoscopic right nephroureterectomy and laparoscopic radical cystectomy. Each bacteremia occurred almost simultaneously. Fortunately, all 4 cases were treated by antibiotics successfully and there were no cases of recurrence. Whole environmental inspection of the ward did not reveal H. cinaedi. However, multilocus sequence typing proved the strains in cases 3 and 4 to be the same. Therefore, cross-infection was suspected. H. cinaedi can develop to a pathogen of immunocompromised infection. This report clarified that this pathogen can cause bacteremia in the urology ward.
    Mesh-Begriff(e) Aged ; Bacteremia/diagnosis ; Helicobacter/isolation & purification ; Helicobacter Infections/diagnosis ; Humans ; Male ; Middle Aged
    Sprache Japanisch
    Erscheinungsdatum 2017-11
    Erscheinungsland Japan
    Dokumenttyp Case Reports ; Journal Article
    ZDB-ID 604331-8
    ISSN 0018-1994
    ISSN 0018-1994
    DOI 10.14989/ActaUrolJap_63_11_461
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Clonality investigation of clinical Escherichia coli isolates by polymerase chain reaction-based open-reading frame typing method.

    Saeki, Masachika / Sato, Toyotaka / Furuya, Daisuke / Yakuwa, Yuki / Sato, Yuki / Kobayashi, Ryo / Ono, Mayumi / Nirasawa, Shinya / Tanaka, Makito / Nakafuri, Hirotaka / Nakae, Mami / Shinagawa, Masaaki / Asanuma, Kouichi / Yanagihara, Nozomi / Yokota, Shin-Ichi / Takahashi, Satoshi

    Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy

    2019  Band 26, Heft 1, Seite(n) 38–42

    Abstract: Escherichia coli (E. coli) causes urinary tract infections, pneumonia, surgical site infections, and bloodstream infections and is the important pathogen for both community-acquired and healthcare-associated infections. To investigate the clonality of E.  ...

    Abstract Escherichia coli (E. coli) causes urinary tract infections, pneumonia, surgical site infections, and bloodstream infections and is the important pathogen for both community-acquired and healthcare-associated infections. To investigate the clonality of E. coli is important for infection control and prevention. We aimed to investigate the clonality of clinical E. coli isolates using Cica Geneus E. coli polymerase chain reaction (PCR)-based open-reading frame typing (POT) KIT and clarify the clinical usefulness of this kit. About 124 E. coli isolates obtained from inpatients at Sapporo Medical University Hospital were used. The POT method was used to classify 124 clinical isolates into 87 POT numbers. In addition to the clonality, it was possible to obtain additional information that 20 of the 124 isolates were extended-spectrum β-lactamase (ESBL) producing E. coli (5 isolates of CTX-M-1 group and 15 isolates of CTX-M-9 group) and 13 were sequence type (ST) 131 clone. Furthermore, when these ESBL-producing 20 isolates were compared with pulsed-field gel electrophoresis (PFGE) or multilocus sequence typing (MLST), Simpson's index of diversity was 0.968 in POT method, 0.979 in PFGE, and 0.584 in MLST. POT method had an analytical power similar to that of PFGE. In conclusion, attention should be paid to the difference in the interpretation of the results between the POT method and the PFGE, but POT method may be useful to timely monitor the spread of E. coli in medical facilities.
    Mesh-Begriff(e) Cross Infection ; Electrophoresis, Gel, Pulsed-Field/methods ; Escherichia coli/classification ; Escherichia coli/genetics ; Escherichia coli Infections/microbiology ; Genes, Bacterial/genetics ; Humans ; Multilocus Sequence Typing/methods ; Open Reading Frames/genetics ; Polymerase Chain Reaction/methods
    Sprache Englisch
    Erscheinungsdatum 2019-07-27
    Erscheinungsland Netherlands
    Dokumenttyp Comparative Study ; Journal Article
    ZDB-ID 1355399-9
    ISSN 1437-7780 ; 1341-321X
    ISSN (online) 1437-7780
    ISSN 1341-321X
    DOI 10.1016/j.jiac.2019.06.014
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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