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Article ; Online: 2-Aryl-3H-1,3-benzazaphosphole Oxides: Synthesis, Optical Properties, and Excited State Intramolecular Proton Transfer.

Nakagomi, Hiroaki / Murayama, Nina / Takegami, Rika / Fujii, Kaori / Kitakado, Rio / Kimura, Yoshifumi / Minoura, Mao / Nakano, Haruyuki / Matano, Yoshihiro

Chemistry (Weinheim an der Bergstrasse, Germany)

2024 , Page(s) e202400807

Abstract: Inclusion of a heteroatom to the phosphole ring is a promising strategy to intrinsically modulate the optical properties of phosphole derivatives. We report on a series of 2-aryl-3H-1,3-benzazaphosphole oxides that were efficiently prepared via ... ...

Abstract	Inclusion of a heteroatom to the phosphole ring is a promising strategy to intrinsically modulate the optical properties of phosphole derivatives. We report on a series of 2-aryl-3H-1,3-benzazaphosphole oxides that were efficiently prepared via sequential C-P cross-coupling, dehydrative [3 + 2] cycloaddition, and ring-oxidation reactions. The inclusion of one nitrogen atom into the benzophosphole framework caused red shifting of the absorption and emission maxima, reflecting the greater stabilization of the LUMO level. 2-(2-Hydroxyphenyl)benzazaphosphole oxide underwent excited state intramolecular proton transfer and emitted a weak fluorescence from the excited state of the N-H tautomer.
Language	English
Publishing date	2024-04-08
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1478547-X
ISSN	1521-3765 ; 0947-6539
ISSN (online)	1521-3765
ISSN	0947-6539
DOI	10.1002/chem.202400807
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Article ; Online: Bladder cancer with urinary diversion by a sigmoid colon conduit after transverse colon stoma.

Aoki, Tadashi / Furuya, Ryota / Fukasawa, Masanari / Nozawa, Munehiro / Takihana, Yoshio / Sudoh, Makoto / Nakagomi, Hiroshi

IJU case reports

2023 Volume 7, Issue 1, Page(s) 46–49

Abstract: Introduction: Sigmoid conduit is one of the methods for achieving urinary diversion, but it is performed less frequently than ileal conduit and ureterostomy. Herein, we report a case in which a sigmoid colon conduit was performed after nephrostomy and ... ...

Abstract	Introduction: Sigmoid conduit is one of the methods for achieving urinary diversion, but it is performed less frequently than ileal conduit and ureterostomy. Herein, we report a case in which a sigmoid colon conduit was performed after nephrostomy and transverse colostomy. Case presentation: A 70-year-old man was referred to our hospital because of a bladder tumor. Computed tomography and transurethral biopsy revealed advanced bladder cancer with ureteral and rectal invasion. Despite drug therapy, the tumor progressed. Thus, nephrostomy and transverse colostomy were performed for urinary and fecal diversion, respectively. Subsequently, chemotherapy was administered for 8 months. As nephrostomy-related complications occurred frequently during chemotherapy, a sigmoid colon conduit was performed instead of nephrostomy for urinary diversion to improve the patient's quality of life. Conclusion: In patients with advanced bladder cancer requiring a double stoma of the urinary and fecal tracts, sigmoid colon conduit may be selected as a urinary diversion method.
Language	English
Publishing date	2023-11-08
Publishing country	Australia
Document type	Case Reports
ISSN	2577-171X
ISSN (online)	2577-171X
DOI	10.1002/iju5.12665
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Article ; Online: Mirabegron for overactive bladder in frail patients 80 years or over (HOKUTO study).

Nakagomi, Hiroshi / Mitsui, Takahiko / Shimura, Hiroshi / Ihara, Tatsuya / Kira, Satoru / Sawada, Norifumi / Takeda, Masayuki

BMC urology

2022 Volume 22, Issue 1, Page(s) 40

Abstract: Background: We assessed the efficacy and safety of mirabegron, a β: Methods: OAB patients aged ≥ 80 years were enrolled in this prospective, single-arm observational study. OAB was diagnosed based on the OAB symptom score (OABSS); i.e., a total score ...

Abstract	Background: We assessed the efficacy and safety of mirabegron, a β Methods: OAB patients aged ≥ 80 years were enrolled in this prospective, single-arm observational study. OAB was diagnosed based on the OAB symptom score (OABSS); i.e., a total score of ≥ 3 points and an urgency score of ≥ 2 points. Patients who received 50 mg mirabegron once daily were evaluated at the baseline and at 4, 8, and 12 weeks. The changes from the baseline in the OABSS, International Prostate Symptom Score (IPSS), OAB questionnaire (OAB-q) score, and Vulnerable Elders Survey (VES-13) score were determined. Adverse events, laboratory tests, 12-lead electrocardiography, the QT interval according to Fridericia's formula (QTcF), uroflowmetry, the post-void residual urine volume (PVR), and the Mini-Mental State Examination (MMSE) score were used to assess safety. Results: Forty-three patients (median age: 84 years, range: 80-96 years) were examined. They had high rates of comorbidities and polypharmacy. Mirabegron significantly improved in total score of the OABSS, including urgency and urge incontinence. The total IPSS, IPSS quality-of-life (QOL) index, and OAB-q scores also significantly improved. Mirabegron improved in the VES-13 score. There were no significant changes in laboratory test values, uroflowmetry findings, PVR, the QTcF, or MMSE score. Two patients (4.7%) withdrew from the study after experiencing adverse events. Conclusions: Mirabegron was well tolerated and significantly improved in OAB symptoms, and QOL in older patients. Trial registration The present clinical study was approved by University of Yamanashi Institutional Review Board prior to study initiation (ID1447) and was retrospectively registered with the UMIN Clinical Trials Registry (UMIN-CTR), Japan (UMIN000045996) on Nov 6, 2021.
MeSH term(s)	Acetanilides/adverse effects ; Acetanilides/therapeutic use ; Adrenergic beta-3 Receptor Agonists/adverse effects ; Adrenergic beta-3 Receptor Agonists/therapeutic use ; Aged, 80 and over ; Female ; Frail Elderly ; Humans ; Japan ; Male ; Prospective Studies ; Quality of Life ; Surveys and Questionnaires ; Thiazoles/adverse effects ; Thiazoles/therapeutic use ; Treatment Outcome ; Urinary Bladder, Overactive/drug therapy ; Urological Agents/adverse effects ; Urological Agents/therapeutic use
Chemical Substances	Acetanilides ; Adrenergic beta-3 Receptor Agonists ; Thiazoles ; Urological Agents ; mirabegron (MVR3JL3B2V)
Language	English
Publishing date	2022-03-21
Publishing country	England
Document type	Journal Article ; Observational Study
ZDB-ID	2059857-9
ISSN	1471-2490 ; 1471-2490
ISSN (online)	1471-2490
ISSN	1471-2490
DOI	10.1186/s12894-022-00989-7
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Article ; Online: PIK3CA-AKT pathway predominantly acts in developing ipsilateral breast tumor recurrence long after breast-conserving surgery.

Nakagomi, Hiroshi / Inoue, Masayuki / Hirotsu, Yosuke / Amemiya, Kenji / Mochiduki, Hitoshi / Omata, Masao

Breast cancer research and treatment

2022 Volume 193, Issue 2, Page(s) 349–359

Abstract: Purpose: Ipsilateral breast tumor recurrence (IBTR) after breast-conserving therapy is seen after a long interval, but the clinical classification of Residual Tumor Recurrence (RR) or Double Primary (DP) needs to be validated. We used genome profiling ... ...

Abstract	Purpose: Ipsilateral breast tumor recurrence (IBTR) after breast-conserving therapy is seen after a long interval, but the clinical classification of Residual Tumor Recurrence (RR) or Double Primary (DP) needs to be validated. We used genome profiling to identify the genetic alterations associated with IBTR. Methods: Among 1881 breast cancer patients treated with breast-conserving therapy between 1999 and 2018, IBTR occurred in 52 patients (2.8%). Of these 22 patients who consented for genomic analysis of Primary Breast Cancer (T1) and IBTR (T2) were studied. When the same gene mutations in T1 and T2 were identified, it was classified as genomic residual recurrence gRR, and when no shared mutations identified, it was classified as gDP. The differences between clinical and genomic classification were compared. Furthermore, the pathway of the genes which were responsible for recurrence was also examined. Results: Of 13 clinically diagnosed RRs (cRRs), 11 were gRR and 2 were gDPs, while of 9 cDPs, 6 were gDP and 3 gRR, with a match rate of 17/22 (77%). We searched for genes involved in IBTR: PIK3CA-AKT pathway mutations were found in 12 of 14 gRRs (86%) in T1, and only 2 of 8 gDPs (25%) with significant difference (p = 0.004). When both of PBC and IBTR compared, PIK3CA-AKT pathway abnormalities were 24/28 (86%) in the gRR and 5/16 (31%) in the gDP (p < 0.001). Conclusions: Genome profiling revealed that abnormalities in the PIK3CA-AKT pathway in long-term residential recurrences and are a crucial molecular group in the development of IBTR.
MeSH term(s)	Breast Neoplasms/genetics ; Breast Neoplasms/pathology ; Breast Neoplasms/surgery ; Class I Phosphatidylinositol 3-Kinases/genetics ; Female ; Humans ; Mastectomy, Segmental ; Neoplasm Recurrence, Local/pathology ; Proto-Oncogene Proteins c-akt/genetics
Chemical Substances	Class I Phosphatidylinositol 3-Kinases (EC 2.7.1.137) ; PIK3CA protein, human (EC 2.7.1.137) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1)
Language	English
Publishing date	2022-03-25
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	604563-7
ISSN	1573-7217 ; 0167-6806
ISSN (online)	1573-7217
ISSN	0167-6806
DOI	10.1007/s10549-022-06570-y
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Article ; Online: Co-ingestion of traditional Japanese barley mixed rice (Mugi gohan) with yam paste in healthy Japanese adults decreases postprandial glucose and insulin secretion in a randomized crossover trial.

Matsuoka, Tsubasa / Yamaji, Ayako / Kurosawa, Chihiro / Shinohara, Manabu / Takayama, Ichiro / Nakagomi, Hiromi / Izumi, Keiko / Ichikawa, Yoko / Hariya, Natsuyo / Mochizuki, Kazuki

Asia Pacific journal of clinical nutrition

2023 Volume 32, Issue 1, Page(s) 40–47

Abstract: Background and objectives: Barley mixed rice, "Mugi gohan," is traditionally eaten with yam paste in Japan. Both ingredients contain dietary fiber and reportedly reduce postprandial hyperglycemia. However, evidence supporting the benefits of combining ... ...

Abstract	Background and objectives: Barley mixed rice, "Mugi gohan," is traditionally eaten with yam paste in Japan. Both ingredients contain dietary fiber and reportedly reduce postprandial hyperglycemia. However, evidence supporting the benefits of combining barley mixed rice with yam paste is limited. In this study, we evaluated whether ingesting a combination of barley mixed rice and yam paste affected postprandial blood glucose concentration and insulin secretion. Methods and study design: This study followed an open-label, randomized controlled crossover design, following the unified protocol of the Japanese Association for the Study of Glycemic Index. Fourteen healthy subjects each consumed four different test meals: white rice only, white rice with yam paste, barley mixed rice, and barley mixed rice with yam paste. We measured their postprandial blood glucose and insulin concentrations after every meal, and we calculated the area under curve for glucose and insulin. Results: Participants had significantly reduced area under curve for glucose and insulin after eating barley mixed rice with yam paste compared to when they ate white rice only. Participants had similar area under curve for glucose and insulin after eating barley mixed rice only, or eating white rice with yam paste. Participants had lower blood glucose concentrations 15 min after eating barley mixed rice only, whilst eating white rice with yam paste did not maintain lower blood glucose after 15 min. Conclusions: Eating barley mixed rice with yam paste decreases postprandial blood glucose concentrations and reduces insulin secretion.
MeSH term(s)	Adult ; Humans ; Blood Glucose ; Cross-Over Studies ; Dioscorea ; East Asian People ; Eating ; Hordeum ; Insulin ; Insulin Secretion ; Meals ; Oryza ; Postprandial Period
Chemical Substances	Blood Glucose ; Insulin
Language	English
Publishing date	2023-03-30
Publishing country	Australia
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	1460012-2
ISSN	1440-6047 ; 0964-7058
ISSN (online)	1440-6047
ISSN	0964-7058
DOI	10.6133/apjcn.202303_32(1).0007
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Zs.A 5285: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Mayo Adhesive Probability Score Is Associated with the Operative Time in Laparoscopic Adrenalectomy.

Kira, Satoru / Sawada, Norifumi / Nakagomi, Hiroshi / Ihara, Tatsuya / Furuya, Ryouta / Takeda, Masayuki / Mitsui, Takahiko

Journal of laparoendoscopic & advanced surgical techniques. Part A

2021 Volume 32, Issue 6, Page(s) 595–599

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Adhesives ; Adrenal Gland Neoplasms/surgery ; Adrenalectomy/methods ; Cushing Syndrome/surgery ; Female ; Humans ; Laparoscopy/methods ; Male ; Middle Aged ; Operative Time ; Probability ; Retrospective Studies
Chemical Substances	Adhesives
Language	English
Publishing date	2021-09-03
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1381909-4
ISSN	1557-9034 ; 1092-6429
ISSN (online)	1557-9034
ISSN	1092-6429
DOI	10.1089/lap.2021.0459
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Zs.A 3246: Show issues

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Article ; Online: High-accuracy measurement of rotational eye movement by tracking of blood vessel images.

Hoshino, Kiyoshi / Nakagomi, Hiroyuki

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

2015 Volume 2014, Page(s) 6339–6344

Abstract: This study focuses on a technique for measuring the angle of rotational eye movement by tracking the conjunctival blood vessel ends of sclera, instead of grayscale iris patterns used in the existing techniques. It is because the blood vessel images of ... ...

Abstract	This study focuses on a technique for measuring the angle of rotational eye movement by tracking the conjunctival blood vessel ends of sclera, instead of grayscale iris patterns used in the existing techniques. It is because the blood vessel images of sclera have high grayscale contrasts. This technique especially recognizes the contour of the iris to detect the target conjunctival blood vessel end and use the degree of similarity by means of template matching to select automatically the blood vessel end to be tracked. The search region is limited by template matching to achieve low processing cost and high accuracy and resolution even when the background light varies.
MeSH term(s)	Conjunctiva/blood supply ; Eye Movements/physiology ; Humans ; Image Processing, Computer-Assisted/methods ; Iris/blood supply ; Pupil/physiology ; Rotation ; Video Recording
Language	English
Publishing date	2015-01-06
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2694-0604
ISSN (online)	2694-0604
DOI	10.1109/EMBC.2014.6945078
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Article ; Online: Benefit of home parenteral nutrition (HPN) and chemotherapy in patients with invasive lobular carcinoma developed peritoneal metastases.

Inoue, Masayuki / Kimura, Ayako / Oka, Tomomi / Yajima, Aya / Higuchi, Yudai / Endo, Tatsuki / Watanabe, Hideki / Nakagomi, Hiroshi

International cancer conference journal

2022 Volume 11, Issue 2, Page(s) 147–151

Abstract: The benefit of home parenteral nutrition (HPN) for patients with malnutrition due to peritoneal metastasis depends on the type of cancer. During the period 1999-2020, we treated 460 patients with metastatic and stage 4 breast cancer, 23 of whom were ... ...

Abstract	The benefit of home parenteral nutrition (HPN) for patients with malnutrition due to peritoneal metastasis depends on the type of cancer. During the period 1999-2020, we treated 460 patients with metastatic and stage 4 breast cancer, 23 of whom were invasive lobular carcinoma (ILC). Of the 23 patients with ILC, 13 (57%) developed peritoneal metastasis, and 11 died of progression of peritoneal metastasis. Among these 11 patients, 2 patients who underwent surgery due to bowel obstruction, had no improvement, and died 1-4 months after surgery. The prognosis of the other 7 patients under BSC alone was poor, survival time were ranging from 1 to 5 months. The remaining two patients who were able to continue outpatient chemotherapy under HPN were able to prolong their survival time by 18 months and 26 months, respectively. We need to recognize that HPN and chemotherapy may prolong survival time in patients with peritoneal metastasis of ILC, and determine the indication for HPN based on the non-peritoneal life-threatening metastasis, length of treatment, availability of support for HPN management and outpatient chemotherapy, and the patient's willingness to accept it.
Language	English
Publishing date	2022-03-01
Publishing country	Singapore
Document type	Case Reports
ISSN	2192-3183
ISSN (online)	2192-3183
DOI	10.1007/s13691-022-00539-w
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Article ; Online: Cystic degeneration during neo-adjuvant chemotherapy predicts squamous metaplasia of triple negative breast cancer: report of two cases.

Inoue, Masayuki / Kimura, Ayako / Oka, Tomomi / Yajima, Aya / Higuchi, Yudai / Endo, Tatsuki / Watanabe, Hideki / Nakagomi, Hiroshi / Oyama, Toshio

International cancer conference journal

2022 Volume 11, Issue 4, Page(s) 247–252

Abstract: Neo-adjuvant chemotherapy (NAC) has become a standard treatment for advanced breast cancer because of the advantage of monitoring drug sensitivity and enabling breast-conserving therapy. The changes during NAC are also important to know the biological ... ...

Abstract	Neo-adjuvant chemotherapy (NAC) has become a standard treatment for advanced breast cancer because of the advantage of monitoring drug sensitivity and enabling breast-conserving therapy. The changes during NAC are also important to know the biological characteristics of the tumor. We experienced two cases with cystic degeneration and enhancement of the cyst wall during NAC for triple negative breast cancer (TNBC). They were diagnosed to have breast cancer with squamous metaplasia. In case 1, a 37-year-old woman with right breast cancer diagnosed as TNBC, T3N3M0, Stage 3b was treated with NAC. MRI showed a cystic degeneration with a diameter of 3.5 cm and enhancement of the cyst wall, and the other nodules were extinguished. The histopathological finding of the surgical specimen revealed solid tubular carcinoma with squamous metaplasia. In case 2, a 58-year-old woman with right breast cancer diagnosed as HER2 enriched subtype, T2N0M0 stage 2 was treated with NAC containing trastuzumab. The post-NAC MRI showed extinguishment of the mass in the right breast, but showed a cystic lesion with 24 mm in diameter and enhancement of its wall in the left breast. She underwent breast conserving surgery for bilateral breast cancer, and histopathological finding of the surgical specimen indicated complete remission of right breast cancer and squamous cell carcinoma developed in the left breast. These changes are impressive and remind us that there are metaplastic changes (especially for squamous metaplasia) with resistance to chemotherapy.
Language	English
Publishing date	2022-06-17
Publishing country	Singapore
Document type	Case Reports
ISSN	2192-3183
ISSN (online)	2192-3183
DOI	10.1007/s13691-022-00553-y
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Article ; Online: TP53-positive clones are responsible for drug-tolerant persister and recurrence of HER2-positive breast cancer.

Watanabe, Hideki / Nakagomi, Hiroshi / Hirotsu, Yosuke / Amemiya, Kenji / Mochizuki, Hitoshi / Inoue, Masayuki / Kimura, Ayako / Omata, Masao

Breast cancer research and treatment

2022 Volume 196, Issue 2, Page(s) 255–266

Abstract: Purpose: The prognosis of HER2-positive breast cancer has improved with the development of anti-HER2 therapies. In order to further improve the prognosis of HER2-positive breast cancer, it is essential to elucidate the cells that survive during the ... ...

Abstract	Purpose: The prognosis of HER2-positive breast cancer has improved with the development of anti-HER2 therapies. In order to further improve the prognosis of HER2-positive breast cancer, it is essential to elucidate the cells that survive during the therapy (drug-tolerant persister DTP). Methods: Of the 2022 breast cancer patients operated at our institution during 2004-2018, 240 (12%) had HER2-positive breast cancer. Neo-adjuvant chemotherapy including trastuzumab (Tr-NAC) was administered to 94 of them. Forty-six of them were complete remission (CR), and 48 were non-CR. After 6.9 ± 3.7 years of follow-up, all 46 CR cases showed no recurrence (Cohort A), and 48 non-CR cases were divided into 31 cases with no recurrence (Cohort B) and 17 cases with recurrence (Cohort C). In addition to clinical backgrounds, we compared genomic profiles for 27 patients (Cohort A; 15/48, B; 7/31, and C; 5/17) who consented to genomic analysis. Results: Genomic abnormalities of TP53 and PIK3CA were frequently observed in biopsy samples pre Tr-NAC, but we found no differences between CR (Cohort A) and non-CR (Cohorts B + C). Then, we examined both of pre and post Tr-NAC samples of Cohort B (7) and C (5) to see the relationship between recurrence and genomic abnormalities. TP53 mutations were significantly more prevalent in Cohort C (5/5, 100%) than cohort B (3/7, 43%) in the surgical sample after treatment (p = 0.04). PyClone analysis of TP53 mutations showed that the cellular frequency of TP53 clones increased in 4 of 5 patients in Cohort C and none of B. On the other hand, we found no enhancement of PIK3CA mutant clones in Cohort C. Conclusions: The DTP after Tr-NAC associated with subsequent relapse had TP53 mutations, suggesting that overcoming DTP with TP53 mutations is the most important clinical challenge. Trial registration: Not applicable.
MeSH term(s)	Humans ; Female ; Breast Neoplasms/drug therapy ; Breast Neoplasms/genetics ; Breast Neoplasms/pathology ; Receptor, ErbB-2/genetics ; Receptor, ErbB-2/metabolism ; Trastuzumab/therapeutic use ; Class I Phosphatidylinositol 3-Kinases/genetics ; Clone Cells/metabolism ; Clone Cells/pathology ; Tumor Suppressor Protein p53/genetics
Chemical Substances	Receptor, ErbB-2 (EC 2.7.10.1) ; Trastuzumab (P188ANX8CK) ; Class I Phosphatidylinositol 3-Kinases (EC 2.7.1.137) ; TP53 protein, human ; Tumor Suppressor Protein p53
Language	English
Publishing date	2022-09-10
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	604563-7
ISSN	1573-7217 ; 0167-6806
ISSN (online)	1573-7217
ISSN	0167-6806
DOI	10.1007/s10549-022-06731-z
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