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  1. AU="Nakai, Kozo"
  2. AU="Debatin, Jörg F."
  3. AU="Plant, Laura"
  4. AU="Manuel Tisminetzky"
  5. AU="Monaco, Carlo"
  6. AU="Srivastava, Rupesh"
  7. AU="Nathan, Jaimie D"
  8. AU="Schnegelberger, Regina D"
  9. AU=Doshi Paresh
  10. AU="Cecilia Hognon"
  11. AU="Mason, Jeremy K."
  12. AU=Hasumi Hisashi
  13. AU="Swati Sethi"
  14. AU="Martin G. Myers, Jr."
  15. AU="Marcus-Sekura, Carol"
  16. AU="Petagine, Lucy"
  17. AU="Jessa R. Alexander"
  18. AU=Rauner Martina
  19. AU="Richlen, Mindy L"
  20. AU="Merghani, Nada M"
  21. AU=Splitt M P
  22. AU="Zlatanović, Gordana"

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  1. Artikel ; Online: Multiple roles of macrophage in skin.

    Nakai, Kozo

    Journal of dermatological science

    2021  Band 104, Heft 1, Seite(n) 2–10

    Abstract: More than 100 years have passed since Elie Metchnikoff discovered macrophage. Over the recent decade, attracting information about macrophage polarization have been reported. This is because many molecules have been identified as markers of macrophage ... ...

    Abstract More than 100 years have passed since Elie Metchnikoff discovered macrophage. Over the recent decade, attracting information about macrophage polarization have been reported. This is because many molecules have been identified as markers of macrophage polarization. Additionally, mechanistic insights have been demonstrated by experiments with various stimuli-induced macrophage polarization. Historically and simply, macrophages are divided into M1 (classically activated) and M2 (alternatively activated). However, some of them are not specific yet. Studies in the field of cardiology revealed the plasticity of macrophages and their subsets are divided into details: Mhem, MHb, Mox and M4 macrophages. M2 macrophages were further divided in M2a, M2b, M2c and M2d. There appears to be more phenotypes of macrophages. However, there still lack studies in dermatological field. This review summarizes the spectrum of macrophage activation and finding about various roles of macrophages in the dermatological field.
    Sprache Englisch
    Erscheinungsdatum 2021-08-31
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article ; Review
    ZDB-ID 1024446-3
    ISSN 1873-569X ; 0923-1811
    ISSN (online) 1873-569X
    ISSN 0923-1811
    DOI 10.1016/j.jdermsci.2021.08.008
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: What Are Reactive Oxygen Species, Free Radicals, and Oxidative Stress in Skin Diseases?

    Nakai, Kozo / Tsuruta, Daisuke

    International journal of molecular sciences

    2021  Band 22, Heft 19

    Abstract: Oxygen in the atmosphere is a crucial component for life-sustaining aerobic respiration in humans. Approximately 95% of oxygen is consumed as energy and ultimately becomes water; however, the remaining 5% produces metabolites called activated oxygen or ... ...

    Abstract Oxygen in the atmosphere is a crucial component for life-sustaining aerobic respiration in humans. Approximately 95% of oxygen is consumed as energy and ultimately becomes water; however, the remaining 5% produces metabolites called activated oxygen or reactive oxygen species (ROS), which are extremely reactive. Skin, the largest organ in the human body, is exposed to air pollutants, including diesel exhaust fumes, ultraviolet rays, food, xenobiotics, drugs, and cosmetics, which promote the production of ROS. ROS exacerbate skin aging and inflammation, but also function as regulators of homeostasis in the human body, including epidermal keratinocyte proliferation. Although ROS have been implicated in various skin diseases, the underlying mechanisms have not yet been elucidated. Current knowledge on ROS-related and oxidative stress-related skin diseases from basic research to clinical treatment strategies are discussed herein. This information may be applied to the future treatment of skin diseases through the individual targeting of the ROS generated in each case via their inhibition, capture, or regulation.
    Mesh-Begriff(e) Animals ; Free Radicals/metabolism ; Humans ; Oxidative Stress ; Reactive Oxygen Species/metabolism ; Skin Diseases/metabolism ; Skin Diseases/pathology
    Chemische Substanzen Free Radicals ; Reactive Oxygen Species
    Sprache Englisch
    Erscheinungsdatum 2021-10-06
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms221910799
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Involvement of cutavirus in a subset of patients with cutaneous T-cell lymphoma with an unfavorable outcome.

    Hashida, Yumiko / Nakajima, Kimiko / Higuchi, Tomonori / Nakai, Kozo / Daibata, Masanori

    Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology

    2023  Band 165, Seite(n) 105523

    Abstract: Background: European studies suggest an association between cutavirus (CuV) and cutaneous T-cell lymphoma (CTCL); however, the worldwide prevalence of CuV in patients with CTCL and its prognostic impact remain unknown.: Methods: We investigated the ... ...

    Abstract Background: European studies suggest an association between cutavirus (CuV) and cutaneous T-cell lymphoma (CTCL); however, the worldwide prevalence of CuV in patients with CTCL and its prognostic impact remain unknown.
    Methods: We investigated the prevalence and viral loads of CuV DNA using biopsy specimens from the lesional skins of 141 Japanese patients with cutaneous malignancies, including 55 patients with various types of CTCL.
    Results: CuV DNA was detected significantly more frequently in biopsies from patients with mycosis fungoides (MF) (38% [13/34]; the most common subtype of CTCL) than in those from patients with other cutaneous malignancies (6% [6/107]; P<0.001). The viral-load range in patients with CuV DNA-positive MF was 23-3922 copies/10
    Conclusions: Our results suggest that CuV is associated with MF in a subset of Japanese patients. Large-scale prospective studies are warranted to clarify the role of CuV status, especially regarding the viral genotype, on adverse outcomes in patients with CuV-positive MF.
    Mesh-Begriff(e) Humans ; Phylogeny ; Lymphoma, T-Cell, Cutaneous/genetics ; Lymphoma, T-Cell, Cutaneous/pathology ; Mycosis Fungoides/genetics ; Mycosis Fungoides/metabolism ; Mycosis Fungoides/pathology ; Skin Neoplasms ; Prognosis
    Sprache Englisch
    Erscheinungsdatum 2023-06-15
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1446080-4
    ISSN 1873-5967 ; 1386-6532
    ISSN (online) 1873-5967
    ISSN 1386-6532
    DOI 10.1016/j.jcv.2023.105523
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: A Case of Nevoid Acanthosis Nigricans Successfully Treated with Topical Ketoconazole Plus Urea.

    Matsumoto, Ayaki / Nakai, Kozo / Tsuruta, Daisuke / Sugawara, Koji

    Acta dermatovenerologica Croatica : ADC

    2022  Band 29, Heft 3, Seite(n) 167–168

    Abstract: Dear Editor, Nevoid acanthosis nigricans (AN) is a rare form of benign AN that can be mostly found as a solitary lesion distributed along Blaschko's lines (1). It is not associated with any known syndrome, endocrinopathy, drugs, or internal malignancy. ... ...

    Abstract Dear Editor, Nevoid acanthosis nigricans (AN) is a rare form of benign AN that can be mostly found as a solitary lesion distributed along Blaschko's lines (1). It is not associated with any known syndrome, endocrinopathy, drugs, or internal malignancy. Treatments include retinoid, calcipotriol, and laser treatments (2). Herein we report a case of nevoid AN successfully treated with topical ketoconazole plus urea. A 15-year-old woman presented with a 3-year history of asymptomatic plaques on her abdomen that were increasing in size. She had no medical history and no family history and was not obese. Physical examination revealed dark-brownish pigmented plaques on the midline and right side of her abdomen (Figure 1, a). Potassium hydroxide test was negative. Thyroid function test, antinuclear antibody test, and liver and renal function tests were within normal limits. Histological examination of skin biopsy showed hyperkeratosis and papillomatosis with minimal acanthosis and a mild perivascular lymphocytic infiltration in the superficial dermis (Figure 1, b). Some melanophages were observed in the superficial dermis. Based on the clinical features and these histological findings, a diagnosis of nevoid AN was established. Additionally, there were numerous hyphae and spores in the stratum corneum that were confirmed by Grocott staining (Figure 1, c) and periodic acid-Schiff staining (Figure 1, d). Fungal infection was suggested, and the result of a potassium hydroxide test was considered to be pseudo-negative. Topical ketoconazole cream was initially administrated for one month, and the rough surface was markedly improved (Figure 1, e). Subsequently, topical 20 % urea cream was used and the area of skin lesion decreased in size after 6 months (Figure 1, f). We discontinued ketoconazole cream after 2 months. To the best of our knowledge, this is the first case of nevoid AN successfully treated with topical ketoconazole plus urea. Some cases of AN appear to have an associated endocrinopathy (1). However, genetic factors may also play a role in the pathogenesis of AN. It has been reported that mosaic mutation in fibroblast growth factor 3 (FGFR3) is associated with nevoid AN (3). All known mutations in FGFR3 are gain-of-function mutations, and the activity of the FGFR3 signal correlates with the severity of AN. Involvement of fungal infection has not been reported in the pathogenesis of nevoid AN. We did not identify the fungal species in our patient, but Malassezia infection was suggested. In general, potassium hydroxide test can reveal only yeast forms of Malassezia, and pseudo-negative results may often occur. The abundant hyphae and spores in the stratum corneum are a characteristic pathological feature of Malassezia infection, and the obvious effects of ketoconazole may support the Malassezia infection. Since Malassezia is known to promote cytokine production in human keratinocytes (4), an autocrine FGFR3 signal might accelerate the proliferation of keratinocytes such as myeloma cells (5). Urea is the most widely used moisturizer and keratolytic agent, and has been utilized for the treatment of various hyperkeratotic cutaneous diseases. We successfully treated nevoid AN with the combination of topical ketoconazole and urea. This combination therapy may have fewer side-effects than previous reported treatments and could be considered as an optional treatment. Acknowledgment: The patients in this manuscript have given written informed consent to publication of their case details.
    Mesh-Begriff(e) Acanthosis Nigricans/drug therapy ; Adolescent ; Female ; Humans ; Ketoconazole/therapeutic use ; Malassezia ; Skin ; Urea
    Chemische Substanzen Urea (8W8T17847W) ; Ketoconazole (R9400W927I)
    Sprache Englisch
    Erscheinungsdatum 2022-01-06
    Erscheinungsland Croatia
    Dokumenttyp Case Reports ; Journal Article
    ZDB-ID 1180727-1
    ISSN 1847-6538 ; 1330-027X
    ISSN (online) 1847-6538
    ISSN 1330-027X
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: A case of prurigo pigmentosa occurring in a patient with psoriasis vulgaris following a ketogenic diet during the COVID-19 pandemic.

    Oku, Aoi / Nakai, Kozo / Tsuruta, Daisuke

    International journal of dermatology

    2021  Band 60, Heft 11, Seite(n) 1437–1438

    Mesh-Begriff(e) COVID-19 ; Diet, Ketogenic ; Humans ; Pandemics ; Prurigo ; Psoriasis ; SARS-CoV-2
    Sprache Englisch
    Erscheinungsdatum 2021-08-07
    Erscheinungsland England
    Dokumenttyp Case Reports ; Letter
    ZDB-ID 412254-9
    ISSN 1365-4632 ; 0011-9059 ; 1461-1244
    ISSN (online) 1365-4632
    ISSN 0011-9059 ; 1461-1244
    DOI 10.1111/ijd.15833
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  6. Artikel ; Online: Sign of Leser-Trélat Associated with Waldenström's Macroglobulinemia.

    Yoneda, Kozo / Nakai, Kozo / Demitsu, Toshio / Kubota, Yasuo

    Indian journal of dermatology

    2021  Band 66, Heft 2, Seite(n) 225

    Sprache Englisch
    Erscheinungsdatum 2021-05-10
    Erscheinungsland India
    Dokumenttyp Journal Article
    ZDB-ID 416069-1
    ISSN 1998-3611 ; 0019-5154
    ISSN (online) 1998-3611
    ISSN 0019-5154
    DOI 10.4103/ijd.IJD_556_18
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  7. Artikel ; Online: Solitary Reactive Eccrine Duct Proliferation with Prominent Lymphoid Infiltrates (Pseudolymphomatous Syringoma?).

    Nakai, Kozo / Haba, Reiji / Kubota, Yasuo

    Indian journal of dermatology

    2021  Band 66, Heft 2, Seite(n) 225

    Sprache Englisch
    Erscheinungsdatum 2021-05-10
    Erscheinungsland India
    Dokumenttyp Journal Article
    ZDB-ID 416069-1
    ISSN 1998-3611 ; 0019-5154
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    DOI 10.4103/ijd.IJD_517_18
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  8. Artikel ; Online: Cutavirus Infection in Large Plaque Parapsoriasis, a Premalignant Condition of Mycosis Fungoides.

    Hashida, Yumiko / Nakajima, Kimiko / Higuchi, Tomonori / Ujihara, Takako / Nakai, Kozo / Daibata, Masanori

    The Journal of infectious diseases

    2023  

    Abstract: Background: Cutavirus (CuV) is associated with mycosis fungoides; however, the CuV status in parapsoriasis en plaques (PP), a premalignant inflammatory condition of mycosis fungoides, has not been fully delineated.: Methods: Fifty-five Japanese ... ...

    Abstract Background: Cutavirus (CuV) is associated with mycosis fungoides; however, the CuV status in parapsoriasis en plaques (PP), a premalignant inflammatory condition of mycosis fungoides, has not been fully delineated.
    Methods: Fifty-five Japanese patients with chronic inflammatory skin diseases, including 13 patients with PP, were studied.
    Results: CuV DNA was detected significantly more frequently in biopsies of the lesional skin from patients with PP (38% [4/13]) than in those from patients with other inflammatory skin diseases (2% [1/42]; P = 0.009). All CuV-positive PP cases were of the large plaque parapsoriasis (LPP) subtype. The viral loads ranged from 83,450 to 2,164,170 copies/103 cells. We recovered near-full-length CuV sequences from the CuV-positive LPP biopsies, all of which were of the Japanese/Asian genotype. The CuV genome appeared to be present within lymphoid cells infiltrating the epidermis and dermis. CuV NS1 and VP1 gene transcripts were also detected in the affected tissues.
    Conclusions: The preferential detection of high levels of CuV DNA with the expression of viral mRNA suggests a potential role for CuV in the pathogenesis of LPP, making it necessary to study further the impact of CuV, especially regarding the viral genotype, on the outcomes of patients with CuV-positive LPP.
    Sprache Englisch
    Erscheinungsdatum 2023-11-23
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 3019-3
    ISSN 1537-6613 ; 0022-1899
    ISSN (online) 1537-6613
    ISSN 0022-1899
    DOI 10.1093/infdis/jiad521
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  9. Artikel ; Online: Lichenoid drug eruption associated with bisoprolol transdermal patches.

    Asano, Airi / Nakai, Kozo / Tsuruta, Daisuke

    Contact dermatitis

    2021  Band 86, Heft 2, Seite(n) 139–141

    Mesh-Begriff(e) Administration, Cutaneous ; Adrenergic beta-1 Receptor Antagonists/adverse effects ; Bisoprolol/adverse effects ; Delayed-Action Preparations/adverse effects ; Dermatitis, Allergic Contact/diagnosis ; Dermatitis, Allergic Contact/etiology ; Drug Eruptions/diagnosis ; Drug Eruptions/etiology ; Humans ; Transdermal Patch/adverse effects
    Chemische Substanzen Adrenergic beta-1 Receptor Antagonists ; Delayed-Action Preparations ; Bisoprolol (Y41JS2NL6U)
    Sprache Englisch
    Erscheinungsdatum 2021-11-04
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 193121-0
    ISSN 1600-0536 ; 0105-1873
    ISSN (online) 1600-0536
    ISSN 0105-1873
    DOI 10.1111/cod.13995
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  10. Artikel ; Online: PD-L1 positive macrophages were increased in a case of pembrolizumab-induced bullous pemphigoid.

    Nakai, Kozo / Sato, Yasunori / Kubo, Shoji / Tsuruta, Daisuke

    The Journal of dermatology

    2021  Band 48, Heft 3, Seite(n) e146–e148

    Mesh-Begriff(e) Antibodies, Monoclonal, Humanized/adverse effects ; B7-H1 Antigen ; Humans ; Macrophages ; Pemphigoid, Bullous/chemically induced ; Pemphigoid, Bullous/diagnosis ; Pemphigoid, Bullous/drug therapy
    Chemische Substanzen Antibodies, Monoclonal, Humanized ; B7-H1 Antigen ; pembrolizumab (DPT0O3T46P)
    Sprache Englisch
    Erscheinungsdatum 2021-01-13
    Erscheinungsland England
    Dokumenttyp Case Reports ; Letter
    ZDB-ID 800103-0
    ISSN 1346-8138 ; 0385-2407
    ISSN (online) 1346-8138
    ISSN 0385-2407
    DOI 10.1111/1346-8138.15756
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