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  1. AU="Nakame, Ayako"
  2. AU="Paulo Caleb Júnior de Lima Santos"

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  1. Article ; Online: Inflammatory Myofibroblastic Tumor of the Anus: A Case Report.

    Takayama, Tetsuyoshi / Nakame, Ayako / Suzuki, Masaomi / Asano, Hiroshi / Jin, Ling

    Journal of the anus, rectum and colon

    2024  Volume 8, Issue 1, Page(s) 39–42

    Abstract: Inflammatory myofibroblastic tumors (IMTs) are neoplastic lesions characterized by the proliferation of spindle cells with myofibroblastic features and lymphocyte infiltration. Primary lesions can develop in several locations but rarely arise in the ... ...

    Abstract Inflammatory myofibroblastic tumors (IMTs) are neoplastic lesions characterized by the proliferation of spindle cells with myofibroblastic features and lymphocyte infiltration. Primary lesions can develop in several locations but rarely arise in the colon as described herein. The present case was that of a 69-year-old woman who visited our hospital with complaints of bloody bowel discharge and a prolapsed mass from the anus. A 20-mm tumor was identified on visual and digital examination. Lower gastrointestinal endoscopy revealed a pedunculated, elevated lesion above the dentate line, which showed contrast enhancement on abdominal computed tomography. The patient was preoperatively diagnosed with an anal polyp, which was resected transanally. During the procedure, a mobile tumor coated by anal epithelium was observed at the 11 o'clock position above the dentate line. Deeper parts of the tumor were contiguous with the internal anal sphincter (IAS) muscle. Suspecting a neoplastic lesion, we resected the mass
    Language English
    Publishing date 2024-01-25
    Publishing country Japan
    Document type Case Reports
    ISSN 2432-3853
    ISSN (online) 2432-3853
    DOI 10.23922/jarc.2022-043
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: [Two Cases of Surgery Combined with Intraoperative Radiofrequency Ablation for Colorectal Cancer and Synchronous Liver Metastases].

    Shirouzu, Yoshiyuki / Muroya, Daisuke / Nakame, Ayako / Murayama, Midori / Kuratsu, Satoshi / Kadoya, Kazutaka / Kishimoto, Yukiya / Otsuka, Hiroyuki / Sakai, Hisamune / Ishikawa, Hiroto / Hisaka, Toru / Tayama, Keiichiro / Okabe, Masayuki / Okuda, Koji / Tanaka, Hiroyuki

    Gan to kagaku ryoho. Cancer & chemotherapy

    2020  Volume 46, Issue 13, Page(s) 2179–2181

    Abstract: The therapeutic management of simultaneous liver metastasis of colorectal cancer(SCRLM)remains controversial. Although hepatic metastasectomy is the first choice for resectable liver metastasis of colorectal cancer, radiofrequency ablation (RFA)is one of ...

    Abstract The therapeutic management of simultaneous liver metastasis of colorectal cancer(SCRLM)remains controversial. Although hepatic metastasectomy is the first choice for resectable liver metastasis of colorectal cancer, radiofrequency ablation (RFA)is one of the least invasive application for patients who refuse more invasive treatment such as hepatectomy and longterm systemic chemotherapy or for whom such treatment is not suitable. We report 2 cases of SCRLM treated by surgery combined with intraoperative RFA and adjuvant chemotherapy, raising the possibility of local control in the liver for selected patients.
    MeSH term(s) Catheter Ablation ; Chemotherapy, Adjuvant ; Colorectal Neoplasms/drug therapy ; Hepatectomy ; Humans ; Liver Neoplasms/drug therapy ; Liver Neoplasms/secondary ; Liver Neoplasms/surgery ; Treatment Outcome
    Language Japanese
    Publishing date 2020-03-10
    Publishing country Japan
    Document type Case Reports ; Journal Article
    ZDB-ID 604842-0
    ISSN 0385-0684
    ISSN 0385-0684
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: [Regulation of cellular senescence by Bach1].

    Igarashi, Kazuhiko / Ota, Kazushige / Nakame, Ayako

    Nihon rinsho. Japanese journal of clinical medicine

    2009  Volume 67, Issue 7, Page(s) 1423–1428

    Abstract: The tumor suppressor p53 induces cellular senescence, an irreversible form of proliferation arrest, to inhibit carcinogenesis as well as aging of organs and a body. While the major cause of cellular senescence and aging is oxidative stress, little is ... ...

    Abstract The tumor suppressor p53 induces cellular senescence, an irreversible form of proliferation arrest, to inhibit carcinogenesis as well as aging of organs and a body. While the major cause of cellular senescence and aging is oxidative stress, little is known about how the p53 activity is regulated under such conditions. Bach1 inhibits expression of oxidative stress responsive genes by competing with Nrf2, the key activator of oxidative stress response. Bach1 inhibits p53-dependent cellular senescence induced by oxidative stress. Bach1 forms a protein complex with p53, is recruited to p53 target genes, and inhibits their expression. These findings provide completely novel insights into how the activity of p53 is regulated under oxidative stress. Since p53 is the critical tumor suppressor with huge clinical implications, the newly identified mechanism should open new research fields.
    MeSH term(s) Animals ; Basic-Leucine Zipper Transcription Factors/genetics ; Cellular Senescence/physiology ; Genes, p53/physiology ; Humans
    Chemical Substances Bach1 protein, mouse ; Basic-Leucine Zipper Transcription Factors
    Language Japanese
    Publishing date 2009-07
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 390903-7
    ISSN 0047-1852
    ISSN 0047-1852
    Database MEDical Literature Analysis and Retrieval System OnLINE

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