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Article ; Online: Awareness and information resources concerning emergency telephone consultation services in older adults in an aging community in Japan.

Nakamura, Akihisa / Kotani, Kazuhiko

2024 Volume 24, Issue 5, Page(s) 501–503

MeSH term(s)	Humans ; Japan ; Aged ; Male ; Female ; Aged, 80 and over ; Telephone ; Referral and Consultation ; Health Knowledge, Attitudes, Practice ; Emergency Medical Services
Language	English
Publishing date	2024-03-20
Publishing country	Japan
Document type	Letter
ZDB-ID	2113849-7
ISSN	1447-0594 ; 1444-1586
ISSN (online)	1447-0594
ISSN	1444-1586
DOI	10.1111/ggi.14866
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Article: Telemental health in rural areas: a systematic review.

Watanabe, Jun / Teraura, Hiroyuki / Nakamura, Akihisa / Kotani, Kazuhiko

Journal of rural medicine : JRM

2023 Volume 18, Issue 2, Page(s) 50–54

Abstract: Objective: ...

Abstract	Objective:
Language	English
Publishing date	2023-04-05
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2768933-5
ISSN	1880-4888 ; 1880-487X
ISSN (online)	1880-4888
ISSN	1880-487X
DOI	10.2185/jrm.2022-059
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Article ; Online: Regional Variations in Coronavirus Disease 2019 Mortality in Japan: An Ecological Study.

Nakamura, Akihisa / Kotani, Kazuhiko / Hatakeyama, Shuji / Obayashi, Senichi / Nagai, Ryozo

JMA journal

2023 Volume 6, Issue 4, Page(s) 397–403

Abstract: Introduction: As the characteristics of coronavirus disease 2019 (COVID-19) vary across regions and countries, the relationship between regional characteristics, such as the distribution of physicians and hospital beds, and COVID-19 mortality was ... ...

Abstract	Introduction: As the characteristics of coronavirus disease 2019 (COVID-19) vary across regions and countries, the relationship between regional characteristics, such as the distribution of physicians and hospital beds, and COVID-19 mortality was assessed in the 47 prefectures of Japan. Methods: This ecological study was based on the number of patients with COVID-19 by prefecture during the seventh wave of COVID-19 in Japan (June-October 2022). COVID-19 mortality was indexed as the number of COVID-19 deaths divided by the number of new COVID-19 cases. Data on regional factors, such as population size, number of physicians, and hospital beds by prefecture, were obtained from government statistics. Correlations between regional characteristics and COVID-19 mortality index were analyzed by dividing the 47 prefectures into two groups at the median level of population size (more populated group [MPG] ≥ 1.6 million and less populated group [LPG] < 1.6 million). Results: The COVID-19 mortality index (mean 12.7, minimum-maximum: 4.7-25.7) was correlated negatively with the number of physicians per hospital bed (r = -0.386, Conclusions: The data may suggest a need of improvement in the distribution of physicians and hospital beds in the healthcare system in regions with smaller and older populations to reduce the rate of COVID-19.
Language	English
Publishing date	2023-09-27
Publishing country	Japan
Document type	Journal Article
ZDB-ID	3053329-6
ISSN	2433-3298 ; 2433-328X
ISSN (online)	2433-3298
ISSN	2433-328X
DOI	10.31662/jmaj.2023-0052
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Article ; Online: Age and Sex Differences in the Use of Emergency Telephone Consultation Services in Saitama, Japan: A Population-Based Observational Study.

Nakamura, Akihisa / Manabe, Toshie / Teraura, Hiroyuki / Kotani, Kazuhiko

International journal of environmental research and public health

2019 Volume 17, Issue 1

Abstract: The frequency of use of emergency telephone consultation (ETC) services, which is a telephone triage system in Japan, was explored to determine age- and sex-related trends on symptoms/events among Japanese adults. Data were obtained from records of the ... ...

Abstract	The frequency of use of emergency telephone consultation (ETC) services, which is a telephone triage system in Japan, was explored to determine age- and sex-related trends on symptoms/events among Japanese adults. Data were obtained from records of the initial year of ETC services in Saitama Prefecture (from October 2014 to September 2015). Residents who used the ETC services were divided into four age groups (20-39, 40-64, 65-74, and ≥75 years old). The number of calls per 1000 persons (call rate, CR) was compared between the groups. The annual CR for the top 10 symptoms/events were assessed. The annual CR was 2.6/1000 persons. The annual CR was significantly higher for women (2.9) than for men (2.3) (
MeSH term(s)	Adult ; Age Factors ; Aged ; Emergencies ; Female ; Humans ; Japan ; Male ; Middle Aged ; Referral and Consultation ; Sex Factors ; Telemedicine ; Triage ; Young Adult
Language	English
Publishing date	2019-12-26
Publishing country	Switzerland
Document type	Journal Article ; Observational Study
ISSN	1660-4601
ISSN (online)	1660-4601
DOI	10.3390/ijerph17010185
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Article ; Online: Safety and efficacy of elbasvir/grazoprevir for the treatment of chronic hepatitis C: current evidence.

Morikawa, Kenichi / Nakamura, Akihisa / Shimazaki, Tomoe / Sakamoto, Naoya

Drug design, development and therapy

2018 Volume 12, Page(s) 2749–2756

Abstract: Treatments for hepatitis C virus (HCV) have advanced greatly, becoming more efficacious with fewer adverse events, due to the availability of direct-acting antiviral agents, which target specific steps in the HCV life cycle. Recently, a combination ... ...

Abstract	Treatments for hepatitis C virus (HCV) have advanced greatly, becoming more efficacious with fewer adverse events, due to the availability of direct-acting antiviral agents, which target specific steps in the HCV life cycle. Recently, a combination regimen consisting of the HCV nonstructural protein 5A inhibitor elbasvir (EBR) and the HCV NS3/4A protease inhibitor grazoprevir (GZR) was approved for the treatment of patients with chronic HCV and genotypes (Gts) 1 and 4 in various countries. In Phase III trials, the combination of EBR/GZR (fixed-dose combination table or single agent) for 12 or 16 weeks of treatment with or without ribavirin resulted in a high sustained virological response at 12 weeks in treatment-naïve and treatment-experienced patients with HCV Gt 1a, 1b, 4, or 6, including special populations, such as individuals with advanced chronic kidney disease, HCV-HIV coinfection, and compensated cirrhosis. In this review, we focus on the mode of action, pharmacokinetics, clinical applications, efficacy, and safety profile of EBR/GZR, including special populations who have been considered refractory from the extensive evidence of clinical trials.
MeSH term(s)	Amides ; Antiviral Agents/adverse effects ; Antiviral Agents/chemistry ; Antiviral Agents/therapeutic use ; Benzofurans/adverse effects ; Benzofurans/chemistry ; Benzofurans/therapeutic use ; Carbamates ; Cyclopropanes ; Hepacivirus/drug effects ; Hepatitis C, Chronic/drug therapy ; Hepatitis C, Chronic/virology ; Humans ; Imidazoles/adverse effects ; Imidazoles/chemistry ; Imidazoles/therapeutic use ; Molecular Conformation ; Quinoxalines/adverse effects ; Quinoxalines/chemistry ; Quinoxalines/therapeutic use ; Sulfonamides
Chemical Substances	Amides ; Antiviral Agents ; Benzofurans ; Carbamates ; Cyclopropanes ; Imidazoles ; Quinoxalines ; Sulfonamides ; grazoprevir (4O2AB118LA) ; elbasvir (632L571YDK)
Language	English
Publishing date	2018-09-05
Publishing country	New Zealand
Document type	Journal Article ; Review
ZDB-ID	2451346-5
ISSN	1177-8881 ; 1177-8881
ISSN (online)	1177-8881
ISSN	1177-8881
DOI	10.2147/DDDT.S133697
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Article ; Online: Severe spruelike enteropathy and collagenous colitis caused by olmesartan.

Kaneko, Shiho / Matsuda, Kana / Mizuta, Yasuko / Shiratori, Shoya / Kishi, Kazuma / Nakamura, Akihisa / Yagisawa, Masataka / Ehira, Nobuyuki / Uebayashi, Minoru / Kobayashi, Hiroya

BMC gastroenterology

2021 Volume 21, Issue 1, Page(s) 350

Abstract: Background: Olmesartan, which is an angiotensin II receptor blocker, reportedly causes spruelike enteropathy, with intestinal villous atrophy as its typical histopathological finding. Interestingly, collagenous and/or lymphocytic gastritis and colitis ... ...

Abstract	Background: Olmesartan, which is an angiotensin II receptor blocker, reportedly causes spruelike enteropathy, with intestinal villous atrophy as its typical histopathological finding. Interestingly, collagenous and/or lymphocytic gastritis and colitis occur in some patients. We report the case of a 73-year-old Japanese man with a 2-month clinical history of severe diarrhea and weight loss. There were few reports in which spruelike enteropathy and collagenous colitis were both observed and could be followed up. Case presentation: We report a case of a 73-year-old man with a 2-month clinical history of severe diarrhea and weight loss. He had taken olmesartan for hypertension treatment for 5 years. Endoscopic examination with biopsies revealed intestinal villous atrophy and collagenous colitis. Suspecting enteropathy caused by olmesartan, which was discontinued on admission because of hypotension, we continued to stop the drug. Within 3 weeks after olmesartan discontinuation, his clinical symptoms improved. After 3 months, follow-up endoscopy showed improvement of villous atrophy but not of the thickened collagen band of the colon. However, the mucosa normalized after 6 months, histologically confirming that the preexistent pathology was finally resolved. Conclusions: This report presents a case in which spruelike enteropathy and collagenous colitis were both observed and could be followed up. In unexplained cases of diarrhea, medication history should be reconfirmed and this disease should be considered a differential diagnosis.
MeSH term(s)	Aged ; Colitis/chemically induced ; Colitis/diagnosis ; Colitis, Collagenous/chemically induced ; Colitis, Collagenous/diagnosis ; Diarrhea/chemically induced ; Humans ; Imidazoles/adverse effects ; Male ; Tetrazoles/adverse effects
Chemical Substances	Imidazoles ; Tetrazoles ; olmesartan (8W1IQP3U10)
Language	English
Publishing date	2021-09-23
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	2041351-8
ISSN	1471-230X ; 1471-230X
ISSN (online)	1471-230X
ISSN	1471-230X
DOI	10.1186/s12876-021-01926-y
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Article ; Online: Potential accessibility scores for hospital care in a province of Japan: GIS-based ecological study of the two-step floating catchment area method and the number of neighborhood hospitals.

Nakamura, Takashi / Nakamura, Akihisa / Mukuda, Kengo / Harada, Masanori / Kotani, Kazuhiko

BMC health services research

2017 Volume 17, Issue 1, Page(s) 438

Abstract: Background: For achieving equity of the accessibility to primary healthcare, measuring potential geographical accessibility is essential. The provider-to-population ratio is the most frequently used measure. However, it is difficult to be used in closer ...

Abstract	Background: For achieving equity of the accessibility to primary healthcare, measuring potential geographical accessibility is essential. The provider-to-population ratio is the most frequently used measure. However, it is difficult to be used in closer region because it does not take into consideration the people and health services beyond its boundary. In order to overcome this problem, we measured the potential access to hospital, using both distance measures and the enhanced two-step floating catchment area (E2SFCA) method. The aim of this study was to compare the number of hospitals in the neighborhood and the E2SFCA score with regard to the amount and equity for access to hospitals. Methods: This descriptive study used publicly available data from 2010. The E2SFCA score and number of neighborhood hospitals were obtained from Tochigi province in Japan using a geographic information system. Dataset of four measures by each census tract was obtained. The measures were E2SFCA score, number of hospitals within the 5 km range, number of hospitals within the 10 km range, and number of hospitals within the 15 km range. Correlation and disparity analyses with the Lorenz curve and Gini coefficient were performed. Results: The measures were obtained in a smaller area than municipality considering adjacent areas using a geographical approach. The E2SFCA score was 5.3 [3.2-7.3] hospitals/million (median [quantile range]), compared to 5.6 hospitals/million in total for the given district. The median number of hospitals within the 5 km, 10 km, and 15 km ranges were 1, 39, and 47, respectively. There was no hospital within the 5 km range in one third of the blocks. Both the number of hospitals within the 10 km range and those within the 15 km range were well correlated. Regional difference became smaller as the distance to count the number of hospitals increased. The gap between small number of hospitals and the high E2SFCA score indicated the location of community hospital in depopulated areas. Conclusions: The E2SFCA method is superior for analyzing spatial access to hospital, because it provides information in the closer sub-regions. Regional differences were hardly seen in access to hospital beyond the 10 km range. Further studies in other regions and countries are needed for precise assessment.
MeSH term(s)	Catchment Area, Health ; Geographic Information Systems ; Health Services Accessibility ; Hospitals/statistics & numerical data ; Hospitals/supply & distribution ; Japan ; Primary Health Care ; Spatial Analysis
Language	English
Publishing date	2017-06-26
Publishing country	England
Document type	Journal Article
ZDB-ID	2050434-2
ISSN	1472-6963 ; 1472-6963
ISSN (online)	1472-6963
ISSN	1472-6963
DOI	10.1186/s12913-017-2367-0
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Article ; Online: Prediction of hepatocellular carcinoma using age and liver stiffness on transient elastography after hepatitis C virus eradication.

Nakai, Masato / Yamamoto, Yoshiya / Baba, Masaru / Suda, Goki / Kubo, Akinori / Tokuchi, Yoshimasa / Kitagataya, Takashi / Yamada, Ren / Shigesawa, Taku / Suzuki, Kazuharu / Nakamura, Akihisa / Sho, Takuya / Morikawa, Kenichi / Ogawa, Koji / Furuya, Ken / Sakamoto, Naoya

Scientific reports

2022 Volume 12, Issue 1, Page(s) 1449

Abstract: Liver stiffness measurement (LSM) is a useful tool for assessing advanced liver fibrosis, an important risk factor for hepatocellular carcinoma (HCC) following hepatitis C (HCV) eradication. This study aimed to clarify the non-invasive factors associated ...

Abstract	Liver stiffness measurement (LSM) is a useful tool for assessing advanced liver fibrosis, an important risk factor for hepatocellular carcinoma (HCC) following hepatitis C (HCV) eradication. This study aimed to clarify the non-invasive factors associated with HCC following sustained virological response (SVR) and to identify the low-risk group. 567 patients without history of HCC who achieved SVR at 24 weeks (SVR24) after IFN-free treatment were retrospectively analyzed. The cumulative incidence of HCC and the risk factors were examined using pre-treatment and SVR24 data. The median observation period was 50.2 months. Thirty cases of HCC were observed, and the 4-year cumulative incidence of HCC was 5.9%. In multivariate analysis, significant pre-treatment factors were age ≥ 71 years (hazard ratio [HR]: 3.402) and LSM ≥ 9.2 kPa (HR: 6.328); SVR24 factors were age ≥ 71 years (HR: 2.689) and LSM ≥ 8.4 kPa (HR: 6.642). In cases with age < 71 years and LSM < 8.4 kPa at the time of SVR24, the 4-year cumulative incidence of HCC was as low as 1.1%. Both pre-treatment LSM (≥ 9.2 kPa) and SVR24 LSM (≥ 8.4 kPa) and age (≥ 71 years) are useful in predicting the risk of HCC after SVR with IFN-free treatment. Identification of low-risk individuals may improve the efficiency of follow-up.
MeSH term(s)	Adolescent ; Adult ; Age Factors ; Aged ; Aged, 80 and over ; Antiviral Agents/therapeutic use ; Carcinoma, Hepatocellular/epidemiology ; Carcinoma, Hepatocellular/pathology ; Carcinoma, Hepatocellular/virology ; Drug Therapy, Combination/methods ; Drug Therapy, Combination/statistics & numerical data ; Elasticity Imaging Techniques/statistics & numerical data ; Female ; Follow-Up Studies ; Hepacivirus/isolation & purification ; Hepatitis C, Chronic/diagnosis ; Hepatitis C, Chronic/drug therapy ; Hepatitis C, Chronic/pathology ; Hepatitis C, Chronic/virology ; Humans ; Incidence ; Liver/diagnostic imaging ; Liver/pathology ; Liver/virology ; Liver Neoplasms/epidemiology ; Liver Neoplasms/pathology ; Liver Neoplasms/virology ; Male ; Middle Aged ; Retrospective Studies ; Risk Assessment/methods ; Risk Assessment/statistics & numerical data ; Risk Factors ; Sustained Virologic Response ; Young Adult
Chemical Substances	Antiviral Agents
Language	English
Publishing date	2022-01-27
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-05492-5
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Article ; Online: Durable response without recurrence to Tolvaptan improves long-term survival.

Nakai, Masato / Suda, Goki / Kubo, Akinori / Tokuchi, Yoshimasa / Kitagataya, Takashi / Yamada, Ren / Shigesawa, Taku / Suzuki, Kazuharu / Nakamura, Akihisa / Kawagishi, Naoki / Ohara, Masatsugu / Umemura, Machiko / Sho, Takuya / Morikawa, Kenichi / Ogawa, Koji / Sakamoto, Naoya

Journal of gastroenterology

2020 Volume 55, Issue 12, Page(s) 1150–1161

Abstract: Background: Decompensated liver cirrhosis patients with refractory ascites or pleural effusion have a poor prognosis. Tolvaptan has been used for treating water retention associated with cirrhosis. However, despite the short-term response, water ... ...

Abstract	Background: Decompensated liver cirrhosis patients with refractory ascites or pleural effusion have a poor prognosis. Tolvaptan has been used for treating water retention associated with cirrhosis. However, despite the short-term response, water retention recurrence is still observed in some cases. This study aimed to clarify the water retention recurrence rate and the relationship between long-term response without recurrence and prognosis. Methods: Altogether, 100 patients with decompensated cirrhosis treated with tolvaptan were retrospectively analyzed. Recurrence was evaluated according to the criteria of the EASL clinical practice guideline. The recurrence rate and prognosis of non-responders, patients with recurrence, and long-term responders were analyzed. The baseline factors related to short-term response, recurrence, and long-term response were also evaluated. Results: Approximately 31.0% of the short-term responders had recurrence. Although there was no significant difference in the prognosis by short-term response (p = 0.07), the long-term responders had a significantly better prognosis than those with recurrence and non-responders (p < 0.01). Low CRP levels and high urinary Na/K ratios were significant factors related to short-term response, and the presence of acute kidney injury was also a factor related to non-response. The low CRP level (relapse: < 1.10 mg/dl, long-term response: < 0.94 mg/dl) was identified as a factor related to recurrence and long-term response. Conclusion: The long-term responders without recurrence had a significantly better prognosis. CRP was a useful predictor for long-term response, whereas renal function parameters were useful predictors for short-term response. Inflammation control may be important for long-term response and prognosis in cirrhosis patients with water retention.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Antidiuretic Hormone Receptor Antagonists/administration & dosage ; Female ; Follow-Up Studies ; Humans ; Liver Cirrhosis/drug therapy ; Liver Cirrhosis/physiopathology ; Male ; Middle Aged ; Prognosis ; Recurrence ; Retrospective Studies ; Time Factors ; Tolvaptan/administration & dosage ; Treatment Outcome ; Young Adult
Chemical Substances	Antidiuretic Hormone Receptor Antagonists ; Tolvaptan (21G72T1950)
Language	English
Publishing date	2020-08-26
Publishing country	Japan
Document type	Journal Article
ZDB-ID	1186495-3
ISSN	1435-5922 ; 0944-1174
ISSN (online)	1435-5922
ISSN	0944-1174
DOI	10.1007/s00535-020-01721-8
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Article: Case Report: Hereditary Fibrosing Poikiloderma With Tendon Contractures, Myopathy, and Pulmonary Fibrosis (POIKTMP) Presenting With Liver Cirrhosis and Steroid-Responsive Interstitial Pneumonia.

Takimoto-Sato, Michiko / Miyauchi, Toshinari / Suzuki, Masaru / Ujiie, Hideyuki / Nomura, Toshifumi / Ikari, Tomoo / Nakamura, Tomohiko / Takahashi, Kei / Matsumoto-Sasaki, Machiko / Kimura, Hirokazu / Kimura, Hiroki / Matsui, Yuichiro / Kitagataya, Takashi / Yamada, Ren / Suzuki, Kazuharu / Nakamura, Akihisa / Nakai, Masato / Sho, Takuya / Ogawa, Koji /

Sakamoto, Naoya / Yamaguchi, Naoko / Otsuka, Noriyuki / Tomaru, Utano / Konno, Satoshi

Frontiers in genetics

2022 Volume 13, Page(s) 870192

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2022-05-05
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2606823-0
ISSN	1664-8021
ISSN	1664-8021
DOI	10.3389/fgene.2022.870192
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