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Book ; Online: Make Life Visible

Toyama, Yoshiaki / Miyawaki, Atsushi / Nakamura, Masaya / Jinzaki, Masahiro

2020

Author's details	edited by Yoshiaki Toyama, Atsushi Miyawaki, Masaya Nakamura, Masahiro Jinzaki
Keywords	Neurosciences ; Immunology ; Cell biology ; Molekül ; Molekülstruktur ; Visualisierung ; Computergrafik
Subject	Computergraphik ; Digitalgraphik ; Digitalgrafik ; Graphische Datenverarbeitung ; Sichtbarmachung ; Datenvisualisierung ; Visuelle Darstellung ; Molekülbau ; Molekularstruktur ; Molekülgeometrie ; Molekulare Geometrie ; Moleküle
Subject code	612.8
Language	English
Size	1 Online-Ressource (IX, 292 p. 137 illus., 106 illus. in color)
Edition	1st ed. 2020
Publisher	Springer Singapore ; Imprint: Springer
Publishing place	Singapore
Document type	Book ; Online
HBZ-ID	HT020260941
ISBN	978-981-13-7908-6 ; 9789811379079 ; 9789811379093 ; 9789811379109 ; 981-13-7908-4 ; 9811379076 ; 9811379092 ; 9811379106
DOI	10.1007/978-981-13-7908-6
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Book ; Online: Make Life Visible

Toyama, Yoshiaki / Miyawaki, Atsushi / Nakamura, Masaya / Jinzaki, Masahiro

2020

Keywords	Immunology ; Neurosciences ; Cellular biology (cytology) ; Medicine ; Cell biology
Size	1 electronic resource (292 pages)
Publisher	Springer Nature
Publishing place	Singapore
Document type	Book ; Online
Note	English ; Open Access
HBZ-ID	HT021030068
ISBN	978-981-13-7908-6 ; 981-13-7908-4
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article: Chronological transitions of hepatocyte growth factor treatment effects in spinal cord injury tissue.

Okano, Yuji / Kase, Yoshitaka / Suematsu, Yu / Nakamura, Masaya / Okano, Hideyuki

Inflammation and regeneration

2024 Volume 44, Issue 1, Page(s) 10

Abstract: Inflammatory responses are known to suppress neural regeneration in patients receiving stem cell-based regenerative therapy for spinal cord injury (SCI). Consequently, pathways involved in neurogenesis and immunomodulation, such as the hepatocyte growth ... ...

Abstract	Inflammatory responses are known to suppress neural regeneration in patients receiving stem cell-based regenerative therapy for spinal cord injury (SCI). Consequently, pathways involved in neurogenesis and immunomodulation, such as the hepatocyte growth factor (HGF)/MET signaling cascade, have garnered significant attention. Notably, various studies, including our own, have highlighted the enhanced recovery of locomotor functions achieved in SCI animal models by combining HGF pretreatment and human induced stem cell-derived neural stem/progenitor cell (hiPSC-NS/PC) transplantation. However, these studies implicitly hypothesized that the functionality of HGF in SCI would be time consistent and did not elucidate its dynamics. In the present article, we investigated the time-course of the effect of HGF on SCI, aiming to uncover a more precise mechanism for HGF administration, which is indispensable for developing crystallizing protocols for combination therapy. To this end, we performed a detailed investigation of the temporal variation of HGF using the RNA-seq data we obtained in our most recent study. Leveraging the time-series design of the data, which we did not fully exploit previously, we identified three components in the effects of HGF that operate at different times: early effects, continuous effects, and delayed effects. Our findings suggested a concept where the three components together contribute to the acceleration of neurogenesis and immunomodulation, which reinforce the legitimacy of empirically fine-tuned protocols for HGF administration and advocate the novel possibility that the time-inconsistent effects of HGF progressively augment the efficacy of combined therapy.
Language	English
Publishing date	2024-03-13
Publishing country	England
Document type	Journal Article
ZDB-ID	2051471-2
ISSN	1880-9693 ; 0389-4290
ISSN	1880-9693 ; 0389-4290
DOI	10.1186/s41232-024-00322-9
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Visually assessing work performance using a smartwatch via day-to-day fluctuations in heart rate variability.

Okawara, Hiroki / Shiraishi, Yasuyuki / Sato, Kazuki / Nakamura, Masaya / Katsumata, Yoshinori

Digital health

2024 Volume 10, Page(s) 20552076241239240

Abstract: Objective: To optimize workplace health promotion, a simple method for quantifying allostatic load response is needed. This study examines the feasibility of optimizing objective anxiety and presenteeism monitoring using daily smartwatch-measured ultra- ... ...

Abstract	Objective: To optimize workplace health promotion, a simple method for quantifying allostatic load response is needed. This study examines the feasibility of optimizing objective anxiety and presenteeism monitoring using daily smartwatch-measured ultra-short heart rate variability (HRV). Methods: Office workers without diagnosed disease prospectively performed 30 s HRV self-measurement each morning for two months and responded to the State-Trait Anxiety Inventory (STAI) and Work Limitation Questionnaire (WLQ). Logistic regression analysis examined daily HRV parameters in the high-trait anxiety group (HTA, STAI ≥ 40) using mean and variance HRV, age, self-reported gender, and body mass index (BMI). The ideal cutoff value enabled comparison of WLQ using the Mann-Whitney Results: Compared to the low-trait anxiety group, HTA exhibited higher variance of the log-transformed coefficient of component variance of high-frequency component (LnccvHF) and low-frequency per HF (Lnccv L/H), in addition to differences in the means of these HRV parameters. In addition to BMI (odds ratio [OR] = 0.92, Conclusions: By focusing on HRV dispersion status, this simple and instantly applicable daily HRV monitoring system enables optimized quantitative monitoring of anxiety and productivity.
Language	English
Publishing date	2024-03-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	2819396-9
ISSN	2055-2076
ISSN	2055-2076
DOI	10.1177/20552076241239240
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Regenerative medicine strategies for chronic complete spinal cord injury.

Hashimoto, Shogo / Nagoshi, Narihito / Nakamura, Masaya / Okano, Hideyuki

Neural regeneration research

2023 Volume 19, Issue 4, Page(s) 818–824

Abstract: Spinal cord injury is a condition in which the parenchyma of the spinal cord is damaged by trauma or various diseases. While rapid progress has been made in regenerative medicine for spinal cord injury that was previously untreatable, most research in ... ...

Abstract	Spinal cord injury is a condition in which the parenchyma of the spinal cord is damaged by trauma or various diseases. While rapid progress has been made in regenerative medicine for spinal cord injury that was previously untreatable, most research in this field has focused on the early phase of incomplete injury. However, the majority of patients have chronic severe injuries; therefore, treatments for these situations are of fundamental importance. The reason why the treatment of complete spinal cord injury has not been studied is that, unlike in the early stage of incomplete spinal cord injury, there are various inhibitors of neural regeneration. Thus, we assumed that it is difficult to address all conditions with a single treatment in chronic complete spinal cord injury and that a combination of several treatments is essential to target severe pathologies. First, we established a combination therapy of cell transplantation and drug-releasing scaffolds, which contributes to functional recovery after chronic complete transection spinal cord injury, but we found that functional recovery was limited and still needs further investigation. Here, for the further development of the treatment of chronic complete spinal cord injury, we review the necessary approaches to the different pathologies based on our findings and the many studies that have been accumulated to date and discuss, with reference to the literature, which combination of treatments is most effective in achieving functional recovery.
Language	English
Publishing date	2023-10-16
Publishing country	India
Document type	Journal Article ; Review
ZDB-ID	2388460-5
ISSN	1876-7958 ; 1673-5374
ISSN (online)	1876-7958
ISSN	1673-5374
DOI	10.4103/1673-5374.382230
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Automatic measurement of the Cobb angle for adolescent idiopathic scoliosis using convolutional neural network.

Maeda, Yoshihiro / Nagura, Takeo / Nakamura, Masaya / Watanabe, Kota

Scientific reports

2023 Volume 13, Issue 1, Page(s) 14576

Abstract: This study proposes a convolutional neural network method for automatic vertebrae detection and Cobb angle (CA) measurement on X-ray images for scoliosis. 1021 full-length X-ray images of the whole spine of patients with adolescent idiopathic scoliosis ( ... ...

Abstract	This study proposes a convolutional neural network method for automatic vertebrae detection and Cobb angle (CA) measurement on X-ray images for scoliosis. 1021 full-length X-ray images of the whole spine of patients with adolescent idiopathic scoliosis (AIS) were used for training and segmentation. The proposed AI algorithm's results were compared with those of the manual method by six doctors using the intraclass correlation coefficient (ICC). The ICCs recorded by six doctors and AI were excellent or good, with a value of 0.973 for the major curve in the standing position. The mean error between AI and doctors was not affected by the angle size, with AI tending to measure 1.7°-2.2° smaller than that measured by the doctors. The proposed method showed a high correlation with the doctors' measurements, regardless of the CA size, doctors' experience, and patient posture. The proposed method showed excellent reliability, indicating that it is a promising automated method for measuring CA in patients with AIS.
MeSH term(s)	Humans ; Adolescent ; Scoliosis/diagnostic imaging ; Reproducibility of Results ; Kyphosis ; Spine ; Neural Networks, Computer
Language	English
Publishing date	2023-09-04
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-41821-y
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Regenerative Medicine for Spinal Cord Injury Using Induced Pluripotent Stem Cells.

Nagoshi, Narihito / Sugai, Keiko / Okano, Hideyuki / Nakamura, Masaya

Spine surgery and related research

2023 Volume 8, Issue 1, Page(s) 22–28

Abstract: Spinal cord injury (SCI) is a devastating injury that causes permanent neurological dysfunction. To develop a new treatment strategy for SCI, a clinical trial of transplantation of human-induced pluripotent stem cell-derived neural precursor cells (NPCs) ...

Abstract	Spinal cord injury (SCI) is a devastating injury that causes permanent neurological dysfunction. To develop a new treatment strategy for SCI, a clinical trial of transplantation of human-induced pluripotent stem cell-derived neural precursor cells (NPCs) in patients in the subacute phase of SCI was recently initiated. The formation of synaptic connections with host neural tissues is one of the therapeutic mechanisms of cell transplantation, and this beneficial efficacy has been directly demonstrated using a chemogenetic tool. This research focuses on the establishment of cell therapy for chronic SCI, which is more challenging owing to cavity and scar formation. Thus, neurogenic NPC transplantation is more effective in forming functional synapses with the host neurons. Furthermore, combinatory rehabilitation therapy is useful to enhance the efficacy of this strategy, and a valid rehabilitative training program has been established for SCI animal models that received NPC transplantation in the chronic phase. Therefore, the use of regenerative medicine for chronic SCI is expected to increase.
Language	English
Publishing date	2023-09-04
Publishing country	Japan
Document type	Journal Article ; Review
ISSN	2432-261X
ISSN (online)	2432-261X
DOI	10.22603/ssrr.2023-0135
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: IL-33-ST2 signaling in fibro-adipogenic progenitors alleviates immobilization-induced muscle atrophy in mice.

Takahashi, Yoshiyuki / Yoda, Masaki / Tsuji, Osahiko / Horiuchi, Keisuke / Watanabe, Kota / Nakamura, Masaya

Skeletal muscle

2024 Volume 14, Issue 1, Page(s) 6

Abstract: Background: The regenerative and adaptive capacity of skeletal muscles reduces with age, leading to severe disability and frailty in the elderly. Therefore, development of effective therapeutic interventions for muscle wasting is important both ... ...

Abstract	Background: The regenerative and adaptive capacity of skeletal muscles reduces with age, leading to severe disability and frailty in the elderly. Therefore, development of effective therapeutic interventions for muscle wasting is important both medically and socioeconomically. In the present study, we aimed to elucidate the potential contribution of fibro-adipogenic progenitors (FAPs), which are mesenchymal stem cells in skeletal muscles, to immobilization-induced muscle atrophy. Methods: Young (2-3 months), adult (12-14 months), and aged (20-22 months) mice were used for analysis. Muscle atrophy was induced by immobilizing the hind limbs with a steel wire. FAPs were isolated from the hind limbs on days 0, 3, and 14 after immobilization for transcriptome analysis. The expression of ST2 and IL-33 in FAPs was evaluated by flow cytometry and immunostaining, respectively. To examine the role of IL-33-ST2 signaling in vivo, we intraperitoneally administered recombinant IL-33 or soluble ST2 (sST2) twice a week throughout the 2-week immobilization period. After 2-week immobilization, the tibialis anterior muscles were harvested and the cross-sectional area of muscle fibers was evaluated. Results: The number of FAPs increased with the progression of muscle atrophy after immobilization in all age-groups. Transcriptome analysis of FAPs collected before and after immobilization revealed that Il33 and Il1rl1 transcripts, which encode the IL-33 receptor ST2, were transiently induced in young mice and, to a lesser extent, in aged mice. The number of FAPs positive for ST2 increased after immobilization in young mice. The number of ST2-positive FAPs also increased after immobilization in aged mice, but the difference from the baseline was not statistically significant. Immunostaining for IL-33 in the muscle sections revealed a significant increase in the number of FAPs expressing IL-33 after immobilization. Administration of recombinant IL-33 suppressed immobilization-induced muscle atrophy in aged mice but not in young mice. Conclusions: Our data reveal a previously unknown protective role of IL-33-ST2 signaling against immobilization-induced muscle atrophy in FAPs and suggest that IL-33-ST2 signaling is a potential new therapeutic target for alleviating disuse muscle atrophy, particularly in older adults.
MeSH term(s)	Humans ; Aged ; Mice ; Animals ; Interleukin-33/metabolism ; Interleukin-1 Receptor-Like 1 Protein/genetics ; Interleukin-1 Receptor-Like 1 Protein/metabolism ; Adipogenesis ; Muscle, Skeletal/metabolism ; Muscular Atrophy/etiology ; Muscular Atrophy/prevention & control ; Muscular Atrophy/metabolism ; Cell Differentiation/physiology
Chemical Substances	Interleukin-33 ; Interleukin-1 Receptor-Like 1 Protein ; Il1rl1 protein, mouse
Language	English
Publishing date	2024-04-01
Publishing country	England
Document type	Journal Article
ZDB-ID	2595637-1
ISSN	2044-5040 ; 2044-5040
ISSN (online)	2044-5040
ISSN	2044-5040
DOI	10.1186/s13395-024-00338-2
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The tibial tubercle-to-trochlear groove distance changes in standing weight-bearing condition: An upright weight-bearing computed tomography analysis.

Sasaki, Ryo / Niki, Yasuo / Kaneda, Kazuya / Yamada, Yoshitake / Nagura, Takeo / Nakamura, Masaya / Jinzaki, Masahiro

The Knee

2024 Volume 48, Page(s) 14–21

Abstract: Background: The tibial tubercle-to-trochlear groove (TT-TG) distance and Insall-Salvati (I/S) ratio are widely used to determine the need for distal realignment in conjunction with medial patellofemoral ligament (MPFL) reconstruction in patients with ... ...

Abstract	Background: The tibial tubercle-to-trochlear groove (TT-TG) distance and Insall-Salvati (I/S) ratio are widely used to determine the need for distal realignment in conjunction with medial patellofemoral ligament (MPFL) reconstruction in patients with recurrent patellar dislocation. A TT-TG distance >20 mm and an I/S ratio >1.3 are significant anatomical risk factors for patellar instability. However, these parameters have traditionally been measured using non-weight-bearing (NWB) imaging modalities. As patellar dislocation occurs during weight-bearing actions, these two parameters should be measured under weight-bearing conditions. Thus, this study aimed to measure the TT-TG distance and I/S ratio using upright full-weight-bearing (FWB) computed tomography (CT) scans and compare the data with NWB CT scans. Methods: This study included 49 knee joints of 26 healthy volunteers. CT images were obtained under both FWB and NWB standing conditions using a 320-detector row upright CT scanner. TT-TGs in the axial plane and I/S ratios in the sagittal plane were measured and compared. Results: The average FWB TT-TG distance was 20.3 ± 3.9 mm, whereas the average NWB TT-TG distance was 12.3 ± 4.7 mm. The TT-TG level was significantly higher in the FWB condition than that in the NWB condition (P < 0.001). The I/S ratios were comparable between the FWB and NWB conditions (P = 0.29). Conclusions: The TT-TG distance in the standing weight-bearing condition was larger than the conventional TT-TG distance and surpassed the historical cutoff value of TT-TG, which may affect the indication of additional distal realignment in MPFL reconstruction for patellar instability.
Language	English
Publishing date	2024-03-12
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1200476-5
ISSN	1873-5800 ; 0968-0160
ISSN (online)	1873-5800
ISSN	0968-0160
DOI	10.1016/j.knee.2024.02.015
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Article ; Online: A Review of Treatment Methods Focusing on Human Induced Pluripotent Stem Cell-Derived Neural Stem/Progenitor Cell Transplantation for Chronic Spinal Cord Injury.

Shibata, Takahiro / Tashiro, Syoichi / Nakamura, Masaya / Okano, Hideyuki / Nagoshi, Narihito

Medicina (Kaunas, Lithuania)

2023 Volume 59, Issue 7

Abstract: Cell transplantation therapy using human induced pluripotent stem cell-derived neural stem/progenitor cells (hiPSC-NS/PCs) has attracted attention as a regenerative therapy for spinal cord injury (SCI), and its efficacy in treating the subacute phase of ... ...

Abstract	Cell transplantation therapy using human induced pluripotent stem cell-derived neural stem/progenitor cells (hiPSC-NS/PCs) has attracted attention as a regenerative therapy for spinal cord injury (SCI), and its efficacy in treating the subacute phase of SCI has been reported in numerous studies. However, few studies have focused on treatment in the chronic phase, which accounts for many patients, suggesting that there are factors that are difficult to overcome in the treatment of chronic SCI. The search for therapeutic strategies that focus on chronic SCI is fraught with challenges, and the combination of different therapies is thought to be the key to a solution. In addition, many issues remain to be addressed, including the investigation of therapeutic approaches for more severe injury models of chronic SCI and the acquisition of practical motor function. This review summarizes the current progress in regenerative therapy for SCI and discusses the prospects for regenerative medicine, particularly in animal models of chronic SCI.
MeSH term(s)	Animals ; Humans ; Induced Pluripotent Stem Cells/transplantation ; Cell Differentiation ; Spinal Cord Injuries/therapy ; Neural Stem Cells/transplantation ; Stem Cell Transplantation/methods ; Spinal Cord
Language	English
Publishing date	2023-07-01
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2188113-3
ISSN	1648-9144 ; 1010-660X
ISSN (online)	1648-9144
ISSN	1010-660X
DOI	10.3390/medicina59071235
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